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121 listing(s) found for therapeutics

University of California, San Diego	Mouse Model of Crohn’s Disease and Method to Develop Specific Therapeutics
	SUMMARY: UCSD researchers have developed a 2-part invention to aid in the treatment of Crohn’s Disease (CD): 1) A mouse model with a homozygous Nod2 mutation that is the most common CD-predisposing Nod2 mutation found in humans. These mice are hea...

University of California, Los Angeles	5-lipoxygenase, a New Therapeutic and Diagnostic Target for Heart Disease Management
	Heart disease remains by far the major cause of morbidity and mortality in the US and other Western countries. Effective treatments for coronary artery disease (CAD) include statins and blood pressure medications. However, therapies involving different treatment strategies are needed to enhance clinical outcomes for heart disease patients. Researchers at UCLA have identified a 5-Lipoxygenase (5L...

Stanford University	A Live Cell Fluorescent Mitosis Biosensor
	Professor Tobias Meyer, Joshua Jones, and Angie Hahn at Stanford have developed the first live cell biosensor-based fluorescent imaging strategy to quantitatively analyze the timing of the cell cycle phases, M, G1, S, and G2. The cell cycle is a tightly regulated cellular process and failure at critical checkpoints within often results in genetic instability and eventually, cancer. In high content...

University of California, Los Angeles	A MXXXL Motif Confering Endocytosis of Biomolecules
	Endocytosis is an essential process in living cells that ensures proper regulation of the surface expression of membrane receptors and enzymes. This process is generally regulated by specific sequence motif in the cytoplasmic tail of internalizing proteins. The two major internalization motifs reported are tyrosine-based and di-leucine-based signals.Prostate specific membrane antigen (PSMA), a p...

University of California, Los Angeles	A Novel Approach to Process Network Synthesis
	Process network synthesis problems are typically formulated as nonlinear or mixed integer optimization problems. These problems are difficult to solve and optimality in many cases cannot be proven or even attained....

University of Southern California	A Novel Class of Molecules for Treatment of Cancer
	A novel series of compounds (SCs) with novel mechanisms of action as well as activity in a broad range of cancers. These SCs have remarkable anticancer activity against a panel of hormone receptor positive and negative cell lines. In vitro results demonstrate that SCs (25 analogs selected from a list of 900 compounds) are highly potent compounds effective in both hormone receptor positive and nega...

University of California, Los Angeles	A Novel Treatment for Bone Cells that Results in Increased Bone Formation
	Osteoporotic bone loss is a major cause of morbidity and mortality in the aging population. This is a result of increased bone resorption by osteoclastic cells and decreased bone formation by osteoblastic cells with age and after menopause in women. Accumulating evidence suggests that the number and activity of osteoblastic cells decrease with age, however the reason for this change is not clear...

University of California, Los Angeles	A Protein of Mycobacterium Tuberculosis Stimulates Interleukin-12 Production
	UCLA investigators have identified a use for bacterial lipopeptides as a potent inducer of IL-12 production and resulting type 1/Th-1 T-cell response. The technology encompasses a broad range of lipoproteins of defined structure that can be administered to a subject to trigger type 1/Th1 T cell response required for cell-mediated immunity in the context of infection, autoimmune disease or cancer...

University of California, Los Angeles	Anti-Microbial Targeting for Intracellular Pathogens
	Antibiotics are used, often in high doses, to combat many infectious diseases. One such disease is tuberculosis, which is becoming more prevalent in our country and worldwide. Tuberculosis is caused by an intracellular pathogen Mycobacterium tuberculosis. No method currently exists to precisely target the intracellular compartment in which the parasites associated with M.tuberculosis and other i...

University of California, Los Angeles	Anti-Vault Therapy for Multi-Drug Resistance to Chemotherapy
	Vaults are recently discovered large cellular particles made of proteins and unique small RNA. Vaults are present in large quantities in all eukaryotic cells and are thought to mediate transport between the nucleus and the cytoplasm. The size and symmetry of vaults is similar to the transporter of the nuclear pore complex (NPC) with which it is thought to interact. Very recently a high correlati...

University of California, San Francisco	BIO-MARKERS TO PREDICT OUTCOMES OF INTERFERON-BETA TREATMENTOF MULTIPLE SCLEROSIS AND OTHER AUTOIMMUNE DISEASES (SF2003-050)
	Multiple sclerosis (MS) is a common inflammatorydisorder of the central nervous system (CNS) characterized by progressiveneurological dysfunction that afflicts 0.1- 0.2% of the populationin the United States. No curative MS therapy is currently available.The most significant advance in MS therapeutics has been the approvalof interferons a decade ago. Interferon-beta (INFB) has been shown to...

University of California, Irvine	Borna Disease Viral Sequences, Diagnostices And Therapeutics For Nervous System Diseases
	Researchers at the University of California, Irvine, have elucidated the genomic sequence of the BD virus and created an ELISA test for the detection of BD antibodies and consequent diagnosis of the disease (or ruling out of BD infection). Moreover, the researchers have also isolated a glycoprotein that mediates the attachment of the BD virus to host cells. This protein can be used as a potential ...

University of California, Los Angeles	Breakthrough Treatment for the Learning and Memory Deficiencies Associated with Neurofibromatosis Type 1
	Neurofibromatosis Type 1 (NF1) is a severe and disabling neurological disorder that leads to cognitive impairment. As a result, most patients exhibit learning and attention deficits that include compromised visual-spatial function, language skills and executive function. Currently, there are no treatments for the learning disabilities associated with NF1. Recent studies in mice have begun to eluc...

Stanford University	Capillary for Optical Imaging
	This invention introduces a novel capillary that is implanted into an animals body to serve as an imaging guide. An endoscope inserted into the capillary can be used to image deep tissue structures in living animals. Because the capillary remains fixed in place, the endoscope can probe the same location of the animal's body on repeating imaging sessions. This will provide the capability of imaging...

University of California, Los Angeles	Catalyst Doping to Improve Catalyst Lifetime
	ALUMINA-SUPPORTED METAL CATALYSTS The following diagram shows an alumina-supported metal catalyst:The catalyst is typically a powder, having particles of metal (nickel, palladium, platinum) adhered to particles of the support, in this case alumina. The catalyst reacts with a precursor chemical (oil, hydrogen, etc) to facilitate the chemical synthesis of a more useful product. The reaction works b...

University of California, San Francisco	CELL LINE USEFUL FOR STUDYING THE EFFECTS OF UV DAMAGEON DNA REPAIR
	DESCRIPTION: Researchers at the University of California,San Francisco have immortalized a cell line from a patient withan impaired abilityto repair ultraviolet(UV) light-induced DNA damage. Xeroderma Pigmentosum (XP) is anautosomal recessive disease characterized by extreme sensitivity to sunlightand an increased risk for skin cancer. Patients with XP have defectsin oneof eight proteins in...

University of California, Los Angeles	Cell-Type Specific Intracellular Delivery Using 3E10 Mutant
	In vivo methods for cell type specific intracellular delivery of therapeutic molecules, (such as proteins and nucleic acids) to targeted tissue sites have remained limited. Investigators at UCLA have developed a murine monoclonal anti-dsDNA autoantibody mAB 3E10 and its single chain Fv (scFv) fragment. Both the whole antibody and the scFv are transported selectively into the nucleus of skeletal ...

University of California, Los Angeles	Cerberus and FRZB-1, Secretory Molecules with a Regenerative Function and an Inhibitory Activity on WNTS, Respectively
	Soluble growth and neurotrophic factors are valuable for their physiological activities and their utilities in therapeutic, clinical, research, diagnostic, and drug design applications. UCLA researchers have identified the functions of two novel proteins, designated "cerberus" and "frzb-1." Cerberus is expressed as a secreted peptide during embryogenesis of the Xenopus embryo, and is expressed s...

University of California, Los Angeles	Chimeric Germline RNA that Controls Immunoglobulin Class Switching
	Antibody diversity occurs as a consequence of somatic rearrangement in the immunoglobulin region of germline DNA followed by RNA splicing of the transcripts. Although germline transcripts have been shown to be necessary for class switching, their exact role in class switching is unknown. Sequences involved in, and a mechanism of Trans-splicing has been identified in trypanosomes and nematodes, h...

University of California, Los Angeles	Chordin, a Secreted BMP Antagonist
	The study of molecular mechanism within morphogenesis provides substantial therapeutic values since signal molecules involved in the process have potential utilities in regenerating tissues and organs. The chordin gene had previously been studied and its role in organ development elucidated in Xenopus. In situ hybridization data from the study indicated that the gene is expressed in the frog emb...

University of California, Los Angeles	Clinical Tool for Determining Anti-Aggregation Activity of Alzheimer's Therapeutics
	Currently, there are more than twenty therapeutic agents in development for Alzheimer's disease. The tool to measure the therapeutic effectiveness of these agents, however, remains to be the standard memory test that measures memory loss, a late-stage symptom reflective of irreversible neuronal cell death. A more informative clinical tool is therefore needed to monitor the effect of therapy on di...

University of California, Los Angeles	Cloned Vesicular Amine Transporters and Methods for Drug Screeningand Gene Therapy
	Classical neurotransmitters accumulate in the cytoplasm after both synthesis and reuptake from the synapse by the plasma membrane transporter. The neurotransmitters are then transported into and stored within vesicles for subsequent release. Now, for the first time, two vesicular transporters have been cloned by investigators at the UCLA School of Medicine. The cloned transporters recognize amin...

University of California, Berkeley	Combinatorial Purine Libraries as Inhibitors of Cyclin Dependent Kinases
	Abstract:Selective protein kinase inhibitors were developed on the basis of the unexpected binding mode of 2,6,9-trisubstituted purines to the adenosine triphosphate-binding site of the human cyclin-dependent kinase 2 (CDK2). By iterating chemical library synthesis and biological screening, potent inhibitors of the human CDK2-cyclin A kinase complex and of Saccharomyces cerevisiae Cdc28p were iden...

University of California, Berkeley	Combinatorial Purine Libraries as Inhibitors of Cyclin Dependent Kinases
	Abstract:Selective protein kinase inhibitors were developed on the basis of the unexpected binding mode of 2,6,9-trisubstituted purines to the adenosine triphosphate-binding site of the human cyclin-dependent kinase 2 (CDK2). By iterating chemical library synthesis and biological screening, potent inhibitors of the human CDK2-cyclin A kinase complex and of Saccharomyces cerevisiae Cdc28p were iden...

University of California, San Francisco	COMPOSITIONS AND METHODS FOR IDENTIFYING AGENTS THAT MODULATEIGE PRODUCTION AND MAST CELL DEGRANULATION(SF00-074 SF98-005)
	BACKGROUND: Of the approximately 40 million allergy sufferersin the US, about 9.9 million have asthma. Asthma is the most frequent chroniccondition for those under 18. B lymphocytes in allergic individuals synthesizeIgE in response to foreign substances (allergens). The IgE antibodies arespecific to the allergen to which they are elicited. The IgE antibodiesbind to IgE receptors on the surface of ...

Stanford University	Controlling Degradation of Glycoprotein Oligosaccharides by Extracellular Glycosidases
	As the biotech industry makes good on it's long-standing promise of delivering recombinant therapeutics, methods of producing therapeutic biologics such as secreted proteins have been in high demand. But as the industry develops, there is a growing need not only to produce protein but also to improve the homogeny and lasting structural integrity of the proteins produced.This technology enables pro...

University of California, Los Angeles	DAX-1 Promoter: DNA Sequence Driving Adrenal Cortical Cell-Specific Expression
	Members of the nuclear hormone receptor superfamily are ligand-dependent or ligand-independent (orphan) transcription factors that modulate a large number of essential cellular processes. Ligands for ligand-dependent superfamily members include steroid hormones (e.g., estrogen, cortisol), steroid derivatives (e.g., hydroxy steroids), and non-steroids (retinoids). Nuclear hormone receptors are lo...

University of California, Irvine	Development of Diagnostics and Therapeutics for Cornelia de Lange Syndrome
	The product of the NIPBL gene is a global regulator of DNA interactions that control the expression of many classes of genes. It is believed that the abnormalities of CdLS arise because levels and sites of expression of many genes change when NIPBL levels are low. University of California, Irvine researchers have developed a mouse model of CdLS, based on heterozygous mutation of the NIPBL gene, an...

Stanford University	Diagnostics and Targets for Disorders of Collagen and Elastin Metabolism
	Stanford researchers have found that the total content of collagen and elastin is lower in the affected tissues of patients with stress urinary incontinence (SUI) and pelvic organ prolapse (POP).The turnover of collagen and elastin, driven by proteolytic enzymes (metalloproteinases, or MMPs) and their inhibitors (the tissue inhibitors, or TIMPs), is involved in several disorders of the connective ...

Stanford University	Emi1, a New Inhibitor of the Anaphase Promoting Complex and Cell Proliferation
	Dr. Peter Jackson and Dr. Julie Reimann in the Department of Pathology have discovered Emi1, a novel S-phase regulator and inhibitor of the Anaphase Promoting Complex (APC) ubiquitin ligase. This discovery may offer a new means to regulate cell proliferation in cancer and other medical conditions, and the control of APC-dependent processes in other tissues (including brain).Emi1 protein accumulate...

University of California, Los Angeles	Endogenous Protein That Protects Against Osteoclastic Bone Reportion for Therapeutic and Diagnostic Applications
	Osteoporosis is a systemic skeletal disease that affects more than 25 million people. It accounts for more than 1.3 million fractures each year, including 500,000 spine, 250,000 hip and 240,000 wrist fractures annually. Hip fractures are the most serious consequence of osteoporosis, with 5-20% of patients dying within one year, and over 50% of survivors being incapacitated. Osteoporosis is an agi...

University of California, Irvine	FDA-Approved Topically Applied Chemical Compounds for Optical Clearing of Skin to Improve Diagnostics and Laser Therapeutic Applications
	University of California, Irvine researchers have developed a method to reduce the scattering inside the skin and improve the optical clearance. Food and Drug Administration (FDA) approved compounds are applied topically to the human skin for the purpose of reducing light scattering prior to performing light-based diagnostic and therapeutic procedures. The application of such clearing agents impro...

University of California, Los Angeles	Gene Mutation in Patients with Idiopathic Dilated Cardiomyopathy
	Idiopathic dilated cardiomyopathy (formerly called congestive cardiomyopathy is a syndrome characterized by cardiac enlargement and congestive heart failure. Although no etiology is definable the myocardial damage is produced by a combination of toxic, metabolic and infectious agents influenced by the genetics of the individual. Currently diagnosis depends solely on exclusion of other known caus...

University of Southern California	Generation of Human Regulatory T Cells by Bacterial Toxins for the Treatment of Inflammatory Disorders
	An adoptive immunotherapy using ex vivo-generated regulatory T cells may be used for the suppression of undesirable immune response. T cells are to be obtained from the patient's blood, the population of regulatory T cells will be enriched ex vivo and adoptively transferred back to the patient. The novel aspect of this technique is that it generates large numbers of type 1 regulatory T cells, whic...

University of California, Los Angeles	GM-CSF and IL-4 Therapy for the In-Situ Expansion of Dendritic Cells and Enhancement of Vaccine-based Immunity
	Dendritic cells (DC) are a group of professional antigen presenting cells (APC) that provide a central stimulus for the generation of cell-mediated responses against foreign antigens. Dendritic cells are ubiquitously distributed throughout the body, where they pick up antigens, process them, and migrate to T-cell enriched areas of lymphoid tissue to activate corresponding antigen-specific T-cell...

University of California, Irvine	Her2/neu Vaccine Protects Against Tumor Growth
	University of California, Irvine researchers have developed a recombinant polynucleotide encoding Her2/neu target antigen. This recombinant polynucleotide contains two regions of the human Her2/neu molecule which demonstrated the lowest degree of homology with other known normal human proteins as the putative target antigen sequence for a genetic vaccination strategy. This target sequence was chos...

University of California, San Francisco	HIGH THROUGHPUTBIOASSAY FOR MODULATORS OF cAMP CYCLASE AND cAMP KINASE ACTIVITY (SF05-088)
	BACKGROUND: cAMPcyclase and cAMP kinase are well known targets in the arena of cancertherapeutics. Screening compounds for their ability to affect thesetwo enzymes is a commonly used route for lead discovery. The mostwidely used screening assays measure biochemical activity in cellextracts, are expensive and do not provide direct information onwhat is happening within cells. Important variables su...

University of California, Los Angeles	Identification of the First Human Glucose Sensor—A New Target for Treatment of Diabetes, Obesity, and Related Metabolic Disorders
	Energy intake, expenditure and storage in humans and other organisms are highly regulated and disturbances lead to severe problems such as obesity and diabetes. Glucose is a major unit of currency in energy metabolism and the body goes to great lengths to regulate the level of glucose in the blood to ensure adequate delivery to the brain, muscle and other cells and tissues of the body. The cells...

University of California, Los Angeles	Immunoglobulin Superantigen Binding to GP120 from HIV
	The present invention is based upon the discovery that the HIV gp120 envelope glycoprotein is a superantigen for immunoglobulins (Ig). The scientific literature to date has focused exclusively on superantigens that associate with a substantial fraction (typically 1-10%) of T lymphocyte clones. Recent work at the UCLA School of Medicine has shown that certain immunoglobulin molecules also have a ...

University of California, Los Angeles	Improved Tuberculosis Vaccination Strategy Utilizing a Booster Protein for People Vaccinated with BCG
	Tuberculosis (TB) remains one of the world's most important infectious diseases. The causative agent, Mycobacterium tuberculosis, is the leading cause of death of any infectious agent. Each year, approximately 8 million people develop active pulmonary TB and two million die from this disease. The World Health Organization (WHO) has declared TB a global health emergency, the first disease so desig...

University of California, Irvine	Improvement of Catalytic Efficiency and/or Specificity of Non-Native Substrates of Enzymes
	UC researchers have developed an innovative method and means to improve the performance of reporter molecules of enzyme activity. The reporter molecules are designed to be introduced into living cells when they are acted upon by intracellular enzymes. The reporter targets the substrate portion to a particular enzyme or class of enzymes, causing the substrate domain to be subsequently modified by t...

University of California, San Francisco	INETLLECTUAL PROPERTY PORTFOLIO FOR INVESTIGATION OF THERAPIESFOR TYPE 1 DIABETES
	UCSF has amassedan intellectual property portfolio in the area of diabetes researchthat would provide a company with a proprietary position on severalgenes and technologies for developing small molecule, cell therapyand/or gene therapy based treatments for diabetes. Our investigatorshave identified and characterized three human endocrine transcriptionfactors that are required for the differentiati...

University of California, Los Angeles	Intelligent Response-Dependent Stimulation of Cells for Basic Research and Drug Discovery Applications
	Sophisticated systems in nature, such as cells, tissues, and organs in the human body, are capable of responding intelligently to external stimuli. Such sophisticated responses involve the complex interplay of multiple variables comprising external stimuli and internal factors. This interplay can involve synergistic and antagonistic relationship amongst multiple variables. Therefore, it is very d...

University of California, San Francisco	KAPOSI'S SYNDROME HERPESVIRUS PROTEASE AND ASSEMBLY PROTEIN
	Whilerelatively uncommon in HIV-negative individuals, Kaposi's sarcoma associatedherpesvirus (KSHV) is known to cause tumors in approximately one thirdof patients with acquired immunodeficiency syndrome (AIDS). In additionto being especially common among HIV-positive individuals, Kaposi's sarcoma(KS)is also more aggressive. Recent success of HIV chemotherapeutic interventionwith protease inhibitor...

University of California, Los Angeles	Liver X Receptor (LXR) Agonists as Anti-Inflammatory Agents in Macrophage-Dependent Inflammatory Diseases
	The liver X receptors (LXRα and LXRβ) are nuclear receptors activated by oxysterols that are recognized to play an important role in the control of lipid homeostasis....

University of California, Los Angeles	Liver X Receptor (LXR) Ligands as Treatments for Type II Diabetes, Obesity and Related Disorders
	The control of lipid and glucose metabolism are closely linked. In the fed state, insulin stimulates peripheral glucose uptake, suppresses hepatic glucose production, and stimulates de novo lipogenesis. In type II diabetes, insulin resistance, obesity and related disorders, however, these actions of insulin action are impaired. The short-term and long-term effects of the resulting elevated blood...

University of California, Davis	Media for Stem Cell Differentiation into a Hepatocyte Lineage
	Cell culture conditions for differentiating mouse and human embryonic stem cells toward a hepatocyte lineage have been discovered by researchers at the University of California, Davis. These newly described culture conditions also act to maintain primary hepatocyte function. This invention provides for human hepatocyte cell lines that are capable of indefinite replication, while maintaining their ...

University of California, San Francisco	MEDICAL DEVICE TO TREAT INFLAMMATORYAIRWAY DISEASES SUCH AS ASTHMA
	Asthma affects nearly 20 million Americans. It is a chronicdisease of the lungs in which the airways become blocked or narrowedcausing breathing difficulty. Present asthma therapy consists of administrationof asthma medication via oral or nasal (inhaled) pathways, many ofwhich lead to undesirable side effects in sever asthmatics with increaseddosage and or/ extended duration of therapy. UCS...

University of California, Irvine	Method and Apparatus for Spatially Modulated Fluorescence Imaging and Tomography
	University of California researchers have developed a method and apparatus which can provide simultaneous surface and sub-surface mapping of media structure, function and composition. The method disclosed herein allows: Wide field imaging; Subsurface imaging/tomography (depth sensitivity to be assessed as a function of source spatial frequency, wavelength selection and/or amplitude modulation); Sp...

University of California, Los Angeles	Method and Composition for Treatment of Kaposi's Sarcoma
	Kaposi's sarcoma (KS) is a multifocal neoplasm that frequently causes significant morbidity and even mortality in individuals infected with the Human Immunodeficiency Virus (HIV). This invention discloses a method for blocking the growth of KS cells by inhibiting the action of their primary growth factor, which has been identified as interleukin-6 (IL-6). Data indicate that several compounds tha...

University of California, Los Angeles	Method and Composition for Treatment of Kaposi's Sarcoma
	Kaposi's sarcoma (KS) is a multifocal neoplasm that frequently causes significant morbidity and even mortality in individuals infected with the Human Immunodeficiency Virus (HIV). This invention discloses a method for blocking the growth of KS cells by inhibiting the action of their primary growth factor, which has been identified as interleukin-6 (IL-6). Data indicate that several compounds tha...

University of California, Los Angeles	Method for Treating Dermatologic Diseases by Modulating LIR-7
	Considerable effort is devoted to finding more effective therapies for the treatment of dermatologic diseases. Generating much optimism for the development of new therapies is the field of immune response modifiers. The past decade has seen major advances in understanding how a complex network of cell surface interactions controls the immune system cellular activity and associated signaling proce...

University of California, Los Angeles	Method for Using Carbonic Anhydrase IX as a Molecular Marker for Predicting Survival in Advanced Renal Clear Cell Carcinoma
	Renal cell carcinoma (RCC) accounts for 2% of adult cancers. One-third of patients who are diagnosed with RCC have evidence of metastatic disease at the time of diagnosis and up to half of those treated for localized disease eventually relapsed. The high mortality rate in RCC plus the poor prognosis for the metastatic form of the disease post a need for molecular markers that can both diagnose R...

University of California, Los Angeles	Method of Detecting Infectious Form of Prior Protein by New Mechanism of Conversion Involving Disulfide Bond Formation
	Prion diseases are fatal neurodegenerative disorders that affect animals and humans. The best known forms are bovine spongiform encephalopathy ("Mad Cow" disease) in cattle, scrapie in sheep, and Creutzfeldt-Jakob disease in humans. According to the "protein-only" hypothesis, prion proteins are the infectious agents responsible for the illnesses. PrPSc, the infectious form of prion protein, "see...

Stanford University	Methods for Diagnosis and Treatment of Human Autoimmune Diseases by Multiplex Determination of Autoantibody Specificities to Lipids
	Stanford scientists have made a significant discovery regarding the pathology of Multiple Sclerosis (MS). They found that a sample of MS patients have a higher titer of antibodies for specific phospholipids (those phospholipids are present at high concentrations in the myelin sheath) in their spinal fluid when compared to a control group. In order to comprehensively test this observation on the sa...

Stanford University	Methods for Diagnosis and Treatment of Human Autoimmune Diseases by Multiplex Determination of Autoantibody Specificities to Lipids-Part II
	Stanford scientists have made a significant discovery regarding the pathology of Multiple Sclerosis (MS). They found that a sample of MS patients have a higher titer of antibodies for specific phospholipids (those phospholipids are present at high concentrations in the myelin sheath) in their spinal fluid when compared to a control group. In order to comprehensively test this observation on the sa...

University of California, Los Angeles	Methods for Modulating the Activation of a G-Protein Couple Receptor (G2A) Involved in Cell Proliferation, Autoimmunity and Inflammation
	DNA checkpoints are integral components in regulating the growth of eukaryotic cells and are dependant on a variety of post-transcriptional and transcriptional modifications. Oncogenic transformation upstream in the cell cycle signaling pathway often leads to loss of cellular growth control and the induction of malignant potentials. Scientists at UCLA have isolated and sequenced a cell-cycle reg...

Stanford University	Microscopy and Endoscopy in a Freely Moving, Transgenic Mice
	This invention introduces compact, lightweight, and flexible optical microscopy and endoscopy in freely moving transgenic mice, the animal species most commonly used as a model of disease and biological processes. Probing cellular and sub-cellular function in awake behaving mice could provide links between animal behavior and cellular properties. Furthermore, it eliminates the need for anesthesia ...

University of California, San Francisco	MODULATION OF B-CELL CHEMOATTRACTANT/RECEPTOR INTERACTIONAS TREATMENT FOR IMMUNE DISEASE
	Abnormaldevelopment of lymphoid tissue plays a critical role in many autoimmunediseases, such as rheumatoid arthritis and Graves' disease. In addition,the migration of lymphocytes into diseased lymphoid tissue facilitatesthe progression of diseases such as AIDS. UCSF researchers have identifieda pathway, involved both in the development of lymphoid tissue andin the migration of lymphocytes into ly...

University of California, Berkeley	MOUSE LEFTY3 GENE
	Lefty3 is a novel TGFbeta-like secreted molecule with homology to Lefty1 and Lefty2, which have been implicated in left-right asymmetry in mice and humans. We have demonstrated that Lefty inhibits the formation of mesoderm and thus may act to inhibit TGFbeta-like signaling within the embryo. Since TGFbetas have been implicated in a wide array of human diseases, lefty3 may be used as an effective t...

University of California, Berkeley	MOUSE LEFTY3 GENE
	Lefty3 is a novel TGFbeta-like secreted molecule with homology to Lefty1 and Lefty2, which have been implicated in left-right asymmetry in mice and humans. We have demonstrated that Lefty inhibits the formation of mesoderm and thus may act to inhibit TGFbeta-like signaling within the embryo. Since TGFbetas have been implicated in a wide array of human diseases, lefty3 may be used as an effective t...

University of California, Berkeley	MOUSE LEFTY3 GENE
	Lefty3 is a novel TGFbeta-like secreted molecule with homology to Lefty1 and Lefty2, which have been implicated in left-right asymmetry in mice and humans. We have demonstrated that Lefty inhibits the formation of mesoderm and thus may act to inhibit TGFbeta-like signaling within the embryo. Since TGFbetas have been implicated in a wide array of human diseases, lefty3 may be used as an effective t...

University of California, San Francisco	MOUSE MODEL OF HEPATOCELLULARCARCINOMA
	BACKGROUND: Hepatocellular carcinoma (HCC) is the most common formof liver cancer worldwide and accounts for three out of every four casesof primary liver cancer. HCC is the fifth most common cancer worldwidewith a global incidence of one million cases each year. Although less commonin the US than Asia and Africa, where HCC is the most common cancer insome countries, global incidence is inc...

University of California, Los Angeles	Na-K-ATPase Inhibiting Natriuretic Substances
	Blood pressure is a function of the total volume of blood and the resistance to its flow through the circulatory system, which in turn is determined by the degree of constriction of small blood vessels called arterioles. Hypertension, characterized by an abnormally high arterial blood pressure relative to normal blood pressure, is a frequent and dangerous pathological condition that affects a lar...

University of California, Los Angeles	Natural Killer Enhancing Factor
	Natural killer (NK) cells are a population of lymphocytes believed to play a role in the surveillance of tumor growth and metastasis and in the regulation of hematopoiesis. A new factor has been identified that mediates an enhancing effect on NK function. Natural Killer Enhancing Factor, or NKEF, increases the cytotoxic activity of NK cells in in vitro assays, indicating that this product may be...

University of California, Los Angeles	NELL-1 Protein With Activity In Bone Formation
	NELL-1, a secreted protein over-expressed in the premature suture fusion sites of patients with craniosynostosis (CS), had been shown by UCLA Researchers to exhibit osteoblast differentiation and bone formation induction activity more potent than that of BMP. The human Nell-1 gene is primarily localized in the mesenchymal and osteoblast cells at the osteogenic front, along the parasutural bone m...

University of California, Los Angeles	Nell-2 Function and Production of Nell 1 & 2 Proteins
	Researchers at UCLA had previously identified the NELL-1 protein and characterized its osteogenic activity. They recently isolated a new protein, NELL-2, which shares sequence homology to NELL-1 and investigated its function. Neuronal survival activity assay performed on rat cortical neurons treated with NELL2 showed that NELL-2 induces neuronal survival at a level similar to that of basic fibro...

University of California, Los Angeles	Neuro-Endovascular Ultrasound Thrombolysis
	Stroke is the most common life-threatening neurologic disease and is the leading cause of death in the United States, after heart disease and cancer. Among the current U.S. population, some 11 million people have or will have brain aneurysms, which constitute the main cause of non-traumatic subarachnoid hemorrhage. Stroke is defined as the acute brain injury resulting from compromised cerebral b...

University of California, Los Angeles	New Treatment Strategy for Gamma-herpes Virus Associated Malignancies Using Inhibitors of the NF-KB Pathway
	Nasopharyngeal carcinoma (NPC), B cell lymphoma, T cell lymphoma, natural killer cell lymphoma, gastric carcinoma, Kaposi's Sarcoma (KS) and certain lymphoproliferative disorders are associated with the patient's prior infections with a herpes virus (Epstein Barr Virus, EBV or Kaposis sarcoma associated herpesvirus, KSHV). These viruses are characterized by their ability to enter a latent phase ...

University of California, San Francisco	NOVEL ANTI-INFECTIVE SMALL MOLECULES THAT TARGET RNA
	Background: UCSF researchers have synthesized and screened novel compounds, basedon a central chemical scaffold, which show binding to RNA structuresthat are potential therapeutic targets for infectious and viral diseases.RNA-based drug design will benefit the treatment of diseases that relyon unique RNA structures that play essential roles in pathogen viabilityand propagation. For exampl...

University of California, San Francisco	NOVEL BIOMARKERS FOR PROSTATE CANCER
	BACKGROUND: Wound healing is the process of repair that follows injury to the skinand other soft tissues. Wounds may result from mechanical trauma, chemicalor thermal burning, bacterial infection, or from a surgical incision.In addition, pressure ulcers, such as bed sores and diabetic ulcers,might also be considered wounds. Several treatmentsare currently available for the treatment...

University of California, San Francisco	NOVEL COMPONENTS REQUIRED FOR M. TUBERCULOSIS VIRULENCE AND IMMUNOGENESIS
	UCSF researchers have identifiedproteins that are required for Mycobacterium tuberculosis virulenceand immunogenesis. These molecules could be used as targets fordrug development against tuberculosis (TB) disease. They also suggestspecific drug screening assays. M. tuberculosis, the causativeagent of TB, imposes an enormous burden on world health, causingmore deaths annually than any other bacter...

University of California, San Francisco	NOVEL DRUG DISCOVERY TARGETS TO IMPROVE HUMAN AGING (SF2005-004)
	C. elegans reproductive system has been shown toregulate lifespan. Genetic or physical ablation of germ cells resultsin a substantial lifespan extension, but the mechanism by which thiseffect occurs has remained largely unknown. Now researchers at UCSFhave identified 27 C. elegans genes required for the lifespan extensionof germ cell ablated animals, and 2 genesthat enhance the lifespan ex...

University of California, Los Angeles	Novel Gene Therapy for AIDS Using Mutated tRNAs
	A mutant tRNA has been developed for use against HIV-1 integration. Studies indicate that this novel tRNA selectively interrupts viral integration into the genome by targeting key steps in this pathway. Most other contemplated therapeutic approaches act after the virus has integrated into the host cell's DNA and may be less effective once infection is established. A therapeutic strategy would en...

University of California, San Francisco	NOVEL GENES IN THE JNK SIGNALING PATHWAY
	Researchers at UCSF have identified two novel mouse proteins that interact withmammalian Dishevelled in yeast two hybrid assays. As Dishevelled is a highlyconserved component involved in both the Wnt signaling pathway and the JNKsignaling pathway, these new genes represent potential targets for disruptionof the cell cycle for the treatment of cancer and other hyperproliferativedisorders. E...

University of California, San Francisco	NOVEL INDICATIONS FOR TRANSFORMING GROWTH FACTOR BETAMODULATING AGENTS (AGONISTS AND ANTAGONISTS) (SF04-004)
	Transforming growth factor beta (TGFß) is a multi-functionalcytokine that has diverse functions throughout the body and is implicatedin playing a role in a broad range of diseases. Using animal models,UCSF researchers have identified a previously unrecognized physiologicalresponseregulated by TGFß. Since TGF?’s role in regulating this responsehas not been commercially exploited t...

University of California, San Francisco	NOVEL METHOD FOR LOCAL ADMINISTRATION OF THERAPEUTICS TO THE CENTRAL NERVOUS SYSTEM
	Background: Researchers at theUniversity of California have developed a novel and efficient methodof locally delivering therapeutics to target tissues, such as the centralnervous system (CNS). This novel method can be used for CNS deliveryof a variety of anti-inflammatory cytokines, growth factors, or anyother molecule. As a proof of concept, our investigators have successfullytargeted ther...

University of California, Los Angeles	Novel Prognostic Factor and Therapeutic Target in Human Renal Cell Carcinoma
	Renal cell carcinoma (RCC) is a form of kidney cancer that involves malignant transformation of cells of the renal tube. It is the most common type of kidney cancer in adults. In the United States more than 32,000 new cases of RCC are diagnosed every year, and approximately 12,000 people die from the disease annually. RCC metastasizes easily, often spreading to the lungs and other organs. In case...

University of California, Los Angeles	Novel Prostate Specific Membrane Antigen-Based Prostate Cancer Therapy
	Prostate cancer accounted for over 30,000 deaths in 2004, and 230,000 new cases are detected a year in the United States alone. Prostate specific membrane antigen (PSMA), which is highly expressed in prostate cancer cells versus normal prostate tissue, has been an attractive marker for the development of PSMA-targeted prostate cancer therapeutics and diagnostics. Monoclonal antibodies against PSM...

University of California, Los Angeles	Novel Prostate Specific Membrane Antigen-Based Prostate Cancer Therapy
	Prostate cancer accounted for over 30,000 deaths in 2004, and 230,000 new cases are detected a year in the United States alone. Prostate specific membrane antigen (PSMA), which is highly expressed in prostate cancer cells versus normal prostate tissue, has been an attractive marker for the development of PSMA-targeted prostate cancer therapeutics and diagnostics. Monoclonal antibodies against PSM...

University of California, Davis	Novel Receptor-Binding Cyclic Peptides
	The present invention provides novel receptor-binding cyclic peptides (e.g., antagonists) that advantageously display high receptor binding affinity and selectively. More particularly, the present invention provides integrin-binding cyclic peptides, methods for identifying receptor-binding cyclic peptides and for using the cyclic peptides of the present invention for imaging a tumor, organ, or tis...

University of California, Los Angeles	Novel Signaling Molecule Utilized By S. Mutans for Bio-film Formation and Quorum Sensing
	Dental caries is one of the most widespread and costly diseases affecting western and developing countries. Caries arise from acid produced naturally during bacterial metabolism, primarily from oral pathogen Streptococcus mutans. When adherent to the tooth surface in an organized multi-bacterial architectural framework known as biofilm (commonly called "dental plaque"), S. mutans produce large am...

University of California, San Francisco	NOVEL SMALL MOLECULES FOR THE TREATMENT OF PARASITIC DISEASES:TRICHOMONIASIS, MALARIA, CHAGAS DISEASE
	Background: Parasiticdiseases, such as malaria, African sleeping sickness, Chagas diseaseand trichomoniasis, are major worldwide health problems for which newchemotherapy is desperately needed. For example, an estimated five millioncases of the sexually transmitted disease trichomoniasis occur eachyear in the United States alone. Malaria kills over a million peoplea year worldwide and is s...

University of California, San Francisco	NOVEL VEGF-ACTIVATED PROTIEN
	BACKGROUND: Angiogenesis and the formation of new blood vessels areessential for normal tissue growth and repair. However, when unchecked,angiogenesis contributes to pathologies such as proliferative retinopathy,rheumatoid arthritis, juvenile hemangioma, and tumor growth and metastasis.Cancer is currently the leading cause of death in the U.S. in people under85, with over one million diagno...

University of California, Irvine	Nrf1 Deficient Mice as a Model for Liver Cancer and Non-Alcoholic Steatohepatitis
	University of California-Irvine researchers have developed a Cre-lox mouse model that has a conditional mutation of the Nrf1 gene. Researchers have found that deficiency of the Nrf1 gene in liver results hepatic cell death, proliferation, fat accumulation, oxidative stress, and inflammation, followed by the appearance of dysplastic cells and ultimately cancer. The changes observed closely mimics t...

University of California, Los Angeles	Organic Compounds for the Treatment of Myocardial Infarction
	The cellular destruction that accompanies myocardial ischemia, infarction and reperfusion is thought to be related in large part to intracellular overload of calcium. Uncontrolled Ca++ influx, which is thought to occur through "calcium leak channels," leads to progressive metabolic and functional failure of cells, and eventually to cell death. Investigators at UCLA have uncovered a class of comp...

University of California, Los Angeles	Peptide Derivative of Bone Demineralized Matrix Protein Having Physical and Chemical Properties That Differ from Characterized Bone Morphogenic Proteins (BMPs)
	Subsequent to Marshall Urist's observation that partially purified demineralized bone matrix (DBM) induces ectopic bone formation, several bone morphogenic proteins (BMPs) have been identified and characterized from DBM. Urist was convinced that his DBM contained another, more potent, bone-inducing material, which differed significantly in its physical and chemical properties from the characteri...

University of California, Los Angeles	Peptides with Activities Comparable to LL-37; Antimicrobial Peptides of Human Origin
	Blood cells and tissues of humans and other animals possess peptides that serve as natural antibiotics. In humans, these peptides are of two main types: defensins, which have a complex, largely beta-structure and anti-bacterial peptides. An example of the latter had previously been identified and is a 37 residue peptide with a simple alpha-helical structure. This 37 residue peptide, LL-37, is hig...

University of California, Los Angeles	Peptides with Activities Comparable to LL-37; Antimicrobial Peptides of Human Origin
	Blood cells and tissues of humans and other animals possess peptides that serve as natural antibiotics. In humans, these peptides are of two main types: defensins, which have a complex, largely beta-structure and anti-bacterial peptides. An example of the latter had previously been identified and is a 37 residue peptide with a simple alpha-helical structure. This 37 residue peptide, LL-37, is hig...

University of California, Los Angeles	Pore-forming Molecules for use in Bacterial DNA Transformation and Protein Extraction
	The extraction of over-expressed proteins from a cell is often the critical and rate-limiting step to a researcher. Current techniques for retrieving proteins involve a number of harsh chemical and physical methods (such as cycles of freeze-thawing). These methods are often tedious, complex, and time-consuming. Additionally, proteolytic enzymes within the cell can degrade over-expressed proteins ...

University of California, Los Angeles	Potential Therapeutic for Catamenial Epilepsy and Pre-menstrual Dysphoric Disorder
	Catamenial epilepsy and premenstrual dysphoric disorder (PMDD) are serious physical and emotional conditions that are linked closely to hormonal changes in the menstrual cycle. PMDD is a severe form of premenstrual syndrome (PMS) characterized by depression, tension, anxiety, and irritability. It is known to affect up to 8% of all women in their reproductive years, and is major disruptive force t...

University of California, Los Angeles	Production of Glutamic Acid Decarboxylase (GAD) and Associated Polypeptides for use in Clinical and Research Applications
	The vast majority of Type 1 diabetes (T1D) patients have sera which contain auto-antibodies and T cells reactive to glutamic acid decarboxylase (GAD) and/or peptide fragments of GAD. The present UCLA invention involves the cloning and production of GAD polypeptides for use in detection of autoantibodies and T cells reactive to GAD in biological samples. This method, therefore, may be developed i...

University of California, Los Angeles	Prophenins: Proline-Rich Antimicrobial Peptides with Repetitive Decamersequence
	Prophenins belong to a new class of antimicrobial peptides discovered in mammalian white blood cells. First isolated from porcine leukocytes, prophenins display exceptionally strong endotoxin (LPS) binding activity as well as antimicrobial activity. The potential of prophenins over other LPS-binding peptides and proteins lies in their small size and their simple but unique structure, composed of...

University of California, Los Angeles	Prophylactic and Chemotherapeutic Method for Treating Tuberculosis
	Tuberculosis (TB) remains one of the world's most important infectious diseases. The causative agent, Mycobacterium tuberculosis, is the leading cause of death of any infectious agent. Each year, approximately 8 million people develop active pulmonary TB and 2 million die from this disease. The World Health Organization has declared TB a global health emergency, the first disease so designated. C...

Stanford University	Quantitative Imaging of Integrin Expression by Positron Emission Tomography and 18F-labeled multimeric RGD Peptides
	Most solid tumors are angiogenesis dependent and anti-angiogenic pharmaceuticals have demonstrated considerable therapeutic promise. A hallmark of angiogenesis in tumors is the expression of integrin avb3. It is highly expressed on tumor cells and tumor vasculatures, but not on normal tissues or quiescent blood vessels. Non-invasive imaging methods to visualize and quantify integrin avb3 expressio...

Stanford University	Radiolabeled RGD Peptides for Integrin Targeted Radiotherapy
	The cell adhesion molecule integrin avb3 is upregulated in association with tumor angiogenesis and metastasis. The unique expression of this G-protein receptor on endothelial cells of growing tumors and on tumor cells of various origins provides a robust platform for developing anti-angiogenic and anti-metastatic strategies. Several promising integrin avb3-blocking peptides, particularly cyclic RG...

Stanford University	Rapid Improvement of and Better Recovery from Radiation Therapy in Anemic Patients
	This invention features methods for modulating the effects of radiation in a patient. These methods include: Enhancing radiosensitivity of tumors in anemic patients by the administration of the FDA approved ARANESP, an EPO isoform, andPotentiating the effects of radiation therapy in anemic patients without any delay due to the correction of anemia prior to initiation of radiotherapy.Erythropoietin...

University of California, Los Angeles	Receptor Interacting Protein 2 (RIP2) in Development of Immune Response
	UCLA investigators have determined that Receptor Interacting Protein 2 (RIP2) has novel functions in regulating Th1 helper T cells and the IL-1/IL-18Toll-like receptor responses of NK cells and presents a target for therapeutic approaches to the treatment of disorders mediated by these cells, including toxic shock and certain autoimmune diseases. Their results suggest that RIP2 plays a pivotal r...

University of California, Los Angeles	Restoration of Impaired Cellular Immune Function
	Infection with Human Immunodeficiency Virus (HIV) leads to immunologic disregulation, dysfunction and abnormalities that result in the development of Acquired Immunodeficiency Syndrome (AIDS). Although less than 1% of lymphocytes in infected subjects are infected with HIV, the vast majority of lymphocytes demonstrate defective function. Drugs currently approved for treatment of HIV-infected subj...

University of California, Los Angeles	Retrocyclin: an Anti-Retroviral Circular Minidefensin
	Defensins are cysteine-rich, cationic antimicrobial peptides expressed by leukocytes and epithelial cells of mammals and birds. These peptides, which can be considered endogenous antibiotics, play an important role in innate host defense against pathogens due to their antibacterial, antifungal and antiviral activities. Three defensin subfamilies exist in vertebrates: alpha-defensins, beta-defensi...

Stanford University	RhoA-derived trojan peptides as specific inhibitors of RhoA-dependent signal transduction
	The invention provides a method for selective inhibition of specific signaling pathways triggered by the small GTPase RhoA without the need of cell transfection. In order to achieve this, recombinant fusion proteins were generated by combining an N-terminal plasma membrane translocating domain of the homeoregion of the D. Melanogaster transcription factor Antennapedia to the three independent down...

University of California, San Francisco	RNAi-BASED ANTI-INFLAMMATORY TREATMENT FOR IRRITABLE BOWELSYNDROME
	BACKGROUND: Stress-related functional bowel disease, includingirritable bowel syndrome, irritable colon syndrome, spastic colonand irritable colon,is a common, often incapacitating gastrointestinal disorder inhumans. It is the most common chronic gastrointestinal disorderin adults andranks equally with the common cold as the leading cause of illness-relatedabsenteeism from the work place. T...

University of California, San Francisco	saRNA-DIRECTEDTRANSCRIPTIONAL ACTIVATION
	BACKGROUND: Currently, there is no dependable and generalizable methodfor the targeted activation of endogenous genes. Efforts in gene therapyhave been forestalled by problems of gene mutagenesis and oncogene activation,resulting in cancer. Yet the pursuit of a method for gene activation remainsan important goal because the ability to selectively upregulate genes actingagainst a diseased st...

Stanford University	Serum Markers of Inflammation in Atherosclerosis
	This invention addresses the need for an improved set of biomarkers for better diagnosis of atherosclerotic cardiovascular disease and better monitoring of the disease process in response to therapeutics. In a comparative proteomic analysis of sera from various genetic models of mice with different degrees of atherosclerotic disease, a team of scientists at Stanford University have identified patt...

University of California, San Francisco	SMALL MOLECULE INHIBITORSOF THE INTERACTION OF THYROID HORMONE RECEPTORS WITH TRANSCRIPTIONALREGULATORS
	BACKGROUND: Thyroid hormone (T3) regulates a multitude of physiologicaleffects ranging from embryonic development to maintenance of adult homeostasis.In adults, T3 regulates basal metabolic rate, heart rate and contractility,fat deposition, and other phenomena. The effects of T3 are mediated bythe thyroid hormone receptors (TRs) and controls expression of T3-regulatedtarget genes. Successfu...

University of California, Los Angeles	Species-Specific Monoclonal Antibodies to Lactobacillus Casei and Actinomyces Naslundii for Quantitative Detection and Therapeutic Intervention
	Dental plaques, a deposit containing bacteria in a glycoprotein matrix, are associated with dental caries and gingivitis, both of which are common dental diseases. S. mutans is the most cariogenic bacteria, but predictive value of caries risk with salivary S. mutans counts alone is controversial. Thus identification of additional cariogenic bacterial species may allow a more accurate assessment o...

University of California, Los Angeles	Specific Delivery of Rifampin to Site of Tuberculosis Infection
	Treatment for tuberculosis infection involves multiple drug therapy using combinations of rifampin, isoniazid, pyrazinamide, and ethambutol. However, rifampin is a highly toxic antibiotic that induces hepatitis, thrombocytopenia, bullous skin rashes and other injury. Drug toxicity is caused by free rifampin in the blood stream that failed to bind human serum albumin (HSA) to which it binds non-s...

University of California, Los Angeles	Specific Inhibitors of Cytokine Signaling
	Cytokines are small protein molecules, which exert diverse biological activities including the generation of immune responses, inflammatory reactions, remodeling of tissues, angiogenesis and neoplastic transformation of cells. Cytokines act through the activation of STAT (signal transducer and activator of transcription) signaling pathways. The abnormal regulation of STAT signaling has been asso...

Stanford University	Substrate-Reporter Complexes for Drug Screening, Imaging, Diagnosis and Drug Delivery Applications
	Researchers at Stanford University have developed a method for producing reporter (luciferase)-bound substrates for high-throughput screening, detection of pathogens, and imaging and drug delivery applications. This method allows for the imaging of enzymatic activity both in vitro and in vivo, in live cells, and whole organisms.The reporter-substrate conjugates are produced by attaching luciferin ...

Stanford University	Synthetic Class-II HLA-Peptides Modulate Immune Responses in an Allele Unrestricted Manner
	Major histocompatibility complex molecules present self and foreign protein fragments to T lymphocytes and are the major molecular targets of organ transplant rejection and autoimmune diseases. Already more than a decade ago, the Stanford researchers Drs. Clayberger and Krensky, were able to show that synthetic peptides, which correspond to regions of certain human lymphocyte antigen (HLA) class I...

University of California, Los Angeles	Targeted Prophylactic and Chemotherapeutic Agents Againstmycobacterium Tuberculosis
	Mycobacterium tuberculosis is one of the world's most important pathogens. It infects 2 billion people worldwide and causes 8 million new cases of pulmonary tuberculosis and 3 million deaths annually. Indeed, tuberculosis is the world's leading cause of death from a single infectious agent. The rising incidence of tuberculosis worldwide in large part is due to the AIDs epidemic and has been acco...

University of California, Los Angeles	Targeting Lentiviral Vectors to Specific Cells and Tissues
	Current gene therapy strategies are hindered by the inability to target genes to specific cell types. ...

University of California, Los Angeles	Targeting Lentiviral Vectors to Specific Cells and Tissues
	Current gene therapy strategies are hindered by the inability to target genes to specific cell types. ...

University of California, Davis	Technology for Engineering Antibodies with Infinite Affinity for their Antigen
	Technology for engineering antibodies to bind irreversibly to their receptor has been developed by UC Davis researchers. This technology, enabling the formation of permanent antibody-antigen complexes has a number of potential applications in chemistry and biology, including: targeted medical imagingtargeted medical therapies (e.g. cancer therapeutics)synthetic tag to replace avidin-biotinn...

Stanford University	Temporally precise, genetically targeted optical control of neural circuitry
	Temporally precise, noninvasive control of neural circuitry is a long-sought goal of neuroscientists and biomedical engineers. For this purpose, the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, was engineered by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons. Blue-light ill...

University of California, Los Angeles	Treatment of Polycystic Kidney Disease: Pharmacological Compounds and In-Vitro Screening System
	According to the Polycystic Kidney Disease (PKD) Foundation, PKD is the most common genetic disease of the kidney. PKD affects 600,000 Americans and 12.5 million individuals in the world. Treatment for PKD, which includes dialysis or transplantation, is only available for kidney failure. Through in vitro and in vivo studies, UCLA researchers have identified compounds that are effective in treati...

University of California, Los Angeles	Ultra-Low Dielectric Constants (ULDC) Materials for Microelectronics and eTextiles
	Intensive research is being conducted on low dielectric constant materials. These include fluorinated silica glass, air gap formation, influorinated polymers, polyarythers, inorganic-organic hybrids, porous polymers and other materials. These exhibit dielectric constants in the range of 1.8 to 2.9....

University of California, Los Angeles	Use of a Gene and Related Mouse Model for the Study and Development of Therapeutics for Neuropsychiatric Disorders
	UCLA investigators have characterized an association between the expression of a single gene and behavioral learning associated with forebrain function. The gene is preferentially expressed in the cell bodies and dendrites of post-natal neurons of the forebrain. Since the gene is not expressed until after birth, it does not appear to be involved in development. To assess the physiological role o...

University of California, Los Angeles	Use of Secondary Lymphoid Organ Chemokine to Induce Anti-tumor Response by Stimulating Cell-mediated Immune Response and Inhibiting Angiogenesis
	Chemokines are a group of homologous yet functionally divergent proteins that mediate leukocyte migration and activation and play a role in regulating angiogenesis. Secondary lymphoid organ chemokine (SLC, also referred to as Exodus-2 or 6Ckine) is a chemokine expressed by high endothelial venules in T-cell zones of spleen and lymph nodes. It strongly attracts naïve T-cells and mature dendri...

University of California, Los Angeles	Vaccination Against Tumor-Associated Herpesviruses
	PREVENTION: Nasopharyngeal carcinoma (NPC), B cell lymphoma, T cell lymphoma, natural killer cell lymphoma, gastric carcinoma, Kaposi's Sarcoma (KS) and certain lymphoproliferative disorders are associated with the patient's prior infection with a herpesvirus (Epstein Barr Virus, EBV or Kaposis sarcoma associated herpesvirus, KSHV). A preventive vaccination is needed because not only does herpes...

University of California, Irvine	Yeast Retrotransposons as a Model to Study HIV and Screen for HIV Anti-Retro Therapeutics
	From a screen of 4,457 S. cerevisae knockout strains, University of California, Irvine (UCI) researchers have discovered over one hundred host factor genes that affect the replication of the retrovirus-like element Ty3. Of these, 64 exhibited increased and 66 decreased Ty3 transposition compared with the parental strain. Previous studies for Ty host factors have reported a large number of genes, i...




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