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Stanford University
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3-D Multi-Layer Microstructure Fabrication of Materials
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Having the capability of controlled three-dimensional interconnected spatial distribution of micron-sized features with high aspect ratios is increasingly important in building tissue scaffolds for cells and realizing controlled release mechanisms of drug delivery systems or micro-fluidic devices.Researchers at Stanford have developed a process for fabrication of three-dimensional interconnected c...
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Stanford University
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3D Bronchial Morphology Analysis Package
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This integrated software package enables a user to perform registration, 3D localization and visualization and automated measurement and archiving of the bronchial morphology in serial volumetric CT scans.The software package consists of a Windows compatible front-end optimized to perform the bronchial analysis tasks in a multi-processor environment. It is integrated with a database to store patie...
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Stanford University
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A closed loop glucose control system with automatic meal prediction
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The device will use a combination of feed-forward and feedback control algorithms to determine the required rate of insulin infusion for a patient. The feedback loop will have a desired glucose level set for midway in the normal physiological range and will use a glucose sensor to determine the difference in these levels. This will send a signal to the infusion pump to change the delivery rate to ...
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University of Southern California
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A DC to AC Converter for Light/Radiation
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The invention is a single compact device that produces tuneable bursts of radiation from the microwave to the ultraviolet range of the electromagnetic spectrum. Pulses are of high power, variable duration and may have arbitrary signal encoding....
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University of California, Irvine
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A Diffusive Probe for Quantification of Optical Properties of Superficial Layers
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Researchers at the University of California have developed a fiber-based spectroscopic technique that can be used to quantify optical properties in superficial layers of tissue. In the past, quantitative characterization of superficial epithelial tissues such as skin and oral mucosa has been difficult due to the limiting assumptions in the models that are employed to describe light propagation in ...
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University of California, Los Angeles
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A Knowledge Based Approach for Scenario Specific Content Correlation in a Medical Digital Library
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Researchers in the UCLA Department of Computer Science have developed and reduced to practice algorithms and methods for obtaining information, primarily medical information, from free text sources, such as patient medical records. The techniques involve 3 sets of innovations: (1) keyword extraction and indexing, (2) query expansion and (3) phrase based vector space models of document retrieval....
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Stanford University
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A Method and Apparatus for Performing Adaptive or Tunable Multi-Spectral Imaging
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This invention introduces a method and system to detect a predefined object-of-interest irrespective of illumination by compensating for the unwanted effects of the ambient light. This novel method provides an adaptive imager, which reports only the required data versus existing methods that provide highly redundant information, rely on post-processing for detection of the object-of-interest and t...
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University of California, Irvine
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A Method and Device for the Surgical Treatment of Adolescent Scoliosis Without Fusion
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Researchers at the University of CA have developed a method and apparatus for the surgical treatment of adolescent scoliosis without fusion. The apparatus is an expanding rod which produces a controlled force, slowly over time, under precise external control. It can be completely isolated under the skin. The rod is small, powerful, simple to manufacture, immune to accidental activation, and biolog...
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Stanford University
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A method for editing mesh structures at sub-element accuracy: Brain Imaging
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This invention enables interactive editing of 3D surfaces, both smooth and irregular. It allows users to easily define sub-surfaces of a structure's surface. The user can then select, cut and manipulate sub-surfaces, or can project the extent of sub-surfaces onto 2D views of the structure, independent of the structure's representation. A software tool in JAVA has been developed and deployed in bre...
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Stanford University
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A Method for larger Field of View in CT
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The present invention provides improved CT systems and methods that enjoy substantially increased FOV. The diameter of the in-plane FOV of CT systems according to the present invention can be larger than the in-plane extent of the detector (or source) array. Stanford scientists have created a method that provides CT systems with increased FOV without the expense and complication of larger detector...
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University of California, Irvine
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A Micro-Fluidic Platform for Performing Gel Electrophoresis and Western Analysis
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The Researchers at the University of California are developing a miniaturized, integrated microfluidic device and method ("lab on a chip") that performs gel electrophoresis followed by Western analysis. The technology utilizes a novel design where a single channel serves multiple purposes, including (1) cooling, (2) staining, (3) detaining, (4) electro-blotting.The current invention provides multi...
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University of California, Irvine
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A Micro-Platform for Solubility Characterization of Induced Protein in Cells
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Researchers at the University of California are developing a miniaturized, integrated apparatus and method for incubating cells and performing solubility characterization of induced soluble protein in cells at regular, pre-programmed intervals. This invention provides an integrated, automated way to test cells for soluble protein content during incubation. The apparatus, which is small enough to f...
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University of California, Irvine
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A Micro-Platform for the Production of Plasmid Constructs, Cell Transformation, and Validation
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Researchers at the University of California are developing a micro-platfom device which miniaturizes and incorporates the gene expression optimization procedures on a lab-on-a-chip. Specifically, the technology integrates distinct laboratory steps onto a single automated platform that uses microliters of sample. These steps are the insertion of a PCR product into a plasmid (ligation reaction), the...
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University of California, Irvine
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A Microfluidic Device for Gel Electrophoresis with Integrated Thermal Cycling and Sample Elution
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University of California, Irvine researchers are developing a new microfluidic device and method for performing rapid thermal cycling on a small quantity of DNA sample for the purpose of performing PCR. This is followed by purification of the amplified DNA and then an optional step is available on this device to elute a specific band of purified DNA.Compared to currently known microfluidic devices...
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University of California, Irvine
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A New Burr Design
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University of California researchers have addressed these issues with a new burr design which discriminates between hard and soft tissues. As such no protective shield is necessary, it can be used closer to sensitive structures (such as the spinal durra), and powered endoscopic tools are much more possible. Because the burr is much safer near soft tissues, it can be used where there is not complet...
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University of California, Berkeley
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A New Process for Biomolecule Patterning
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Patterning of biomolecules is important in areas like biological analysis, diagnostics and genomics. In addition, molecular patterning could be useful for spatial control of various surface properties such as hydrophobicity and surface charge.Currently, molecules are patterned using lithography, stamping, or using scanning tips. Lithography requires either specially synthesized light-sensitive mol...
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University of California, Berkeley
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A New Process for Biomolecule Patterning
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Patterning of biomolecules is important in areas like biological analysis, diagnostics and genomics. In addition, molecular patterning could be useful for spatial control of various surface properties such as hydrophobicity and surface charge.Currently, molecules are patterned using lithography, stamping, or using scanning tips. Lithography requires either specially synthesized light-sensitive mol...
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University of California, Berkeley
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A New Process for Biomolecule Patterning
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Patterning of biomolecules is important in areas like biological analysis, diagnostics and genomics. In addition, molecular patterning could be useful for spatial control of various surface properties such as hydrophobicity and surface charge.Currently, molecules are patterned using lithography, stamping, or using scanning tips. Lithography requires either specially synthesized light-sensitive mol...
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University of California, Berkeley
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A New Process for Biomolecule Patterning
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Patterning of biomolecules is important in areas like biological analysis, diagnostics and genomics. In addition, molecular patterning could be useful for spatial control of various surface properties such as hydrophobicity and surface charge.Currently, molecules are patterned using lithography, stamping, or using scanning tips. Lithography requires either specially synthesized light-sensitive mol...
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University of California, Berkeley
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A New Process for Biomolecule Patterning
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Patterning of biomolecules is important in areas like biological analysis, diagnostics and genomics. In addition, molecular patterning could be useful for spatial control of various surface properties such as hydrophobicity and surface charge.Currently, molecules are patterned using lithography, stamping, or using scanning tips. Lithography requires either specially synthesized light-sensitive mol...
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University of California, Berkeley
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A New Process for Biomolecule Patterning
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Patterning of biomolecules is important in areas like biological analysis, diagnostics and genomics. In addition, molecular patterning could be useful for spatial control of various surface properties such as hydrophobicity and surface charge.Currently, molecules are patterned using lithography, stamping, or using scanning tips. Lithography requires either specially synthesized light-sensitive mol...
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Stanford University
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A New Regime for Operating Capacitive Micromachined Ultrasonic Transducers
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This invention is a novel operation regime for capacitive micromachined ultrasonic transducers (cMUTs). Its method allows the center of the membrane to be in constant contact with the substrate.Traditionally, cMUTs are operated at a bias voltage lower than the collapse voltage of their membrane. The method of this invention produces a higher electromechanical coupling efficiency than that of a cMU...
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Stanford University
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A Novel System of Image Guidance for Minimally Invasive Medical Interventions
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5,000,000 people worldwide have Atrial Fibrillation with another 240,000 diagnosed every year. Catheter based ablation procedures offer a cure for this problem, with 7,500 performed last year alone. According to Frost and Sullivan, this two billion dollar market is predicted to experience 6-9% annual growth. More rapid growth is limited by poor efficacy (<70%), long procedure time (2-6 hrs), an...
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University of California, Irvine
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A Technique to Make Carbon Nanotube Electrodes
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The present invention includes: 1) the use of carbon nanotubes as electrodes for dielectrophoretic trapping, 2) dielectrophoresis assisted assembly of nano-cuicuit made of macromolecules, and 3) electronically assisted chemical reaction for biological applications. More particularly, the present invention provides a specific dielectrophoresis system using carbon nanotubes as electrodes to pave the...
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University of California, Los Angeles
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A Thin-film Nickel-Titanium Biomedical Implantable Valve: The "NiTi Valve"
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Even in the modern era of device technology, prosthetic heart valves have many inherent problems and limitations as surrogates for defective human heart valves. While mechanical valves remain thrombogenic despite coumadin anticoagulation therapy, valves produced from animal tissue can calcify and suffer limited longevity. Furthermore, because currently available prosthetic heart valves are extrem...
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University of California, Los Angeles
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A Thin-film Nickel-Titanium Biomedical Implantable Valve: The "NiTi Valve"
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Even in the modern era of device technology, prosthetic heart valves have many inherent problems and limitations as surrogates for defective human heart valves. While mechanical valves remain thrombogenic despite coumadin anticoagulation therapy, valves produced from animal tissue can calcify and suffer limited longevity. Furthermore, because currently available prosthetic heart valves are extrem...
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Stanford University
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A Transcutaneous Electrical Nerve Stimulator
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Gastric bypass surgery, gastric pacing, and several implantable devices have been designed to cause weight loss by interfering with gastric emptying and gastric tone. The key limiting factors for these approaches are (1) they are invasive and (2) gastric control cannot be easily titrated. Both of these factors are important since massively obese patients frequently suffer chronic medical illness.T...
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Stanford University
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A Variable Diameter Circular X-ray Collimator
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Stereotactic radiosurgery is carried out using a set of collimators, each having a circular aperture with a fixed diameter. Conventional collimators must be changed manually to form beams of different diameters. This technology describes an automated collimation device that can provide single drive-controlled hexagonal aperture. A stack of two or more hexagonal spanners provide sufficient attenuat...
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Stanford University
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Addressing CMUT Arrays
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Capacitive micromachined ultrasound transducers (CMUT) have recently emerged as a viable alternative to traditional piezoelectric transducers. Conventionally, a CMUT array is fabricated on the front side of a silicon substrate. However, conventional arrangements of the CMUT arrays make inefficient use of the surface area on the front side of the silicon substrate, and require long routing lines to...
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University of California, Irvine
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An Expandable Cage Intended For Use In Performing Lumbar Interbody Spinal Fusions From Posterior
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A Researcher at the University of California, Irvine, has designed a folding cage that can be placed from the posterior, is small enough to slip past the nerve roots and can then expand three to five times its original height. The unique geometry and construction of the compressed cage allows for flexibility in the application procedure and enhanced strength in its expanded form....
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University of California, Irvine
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An Improved Clamp for Performing Circumcisions on Newborn Boys
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University of California, Irvine researchers have recently developed a new clamp that is safer than the Mogen clamp and easier to use than the Gomco clamp. This newly developed clamp is pre-assembled and can include an integrated cutting blade, eliminating the need for a scalpel....
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University of California, Berkeley
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An Inexpensive and Highly Sensitive, Micromachined Pressure Sensor Device
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Micromachined pressure sensors are important for biomedical, automotive, and lab-on-a-chip applications. Most sensors are based either on capacitance changes across a Si cavity or resistance changes in piezoresistive materials as a response to applied pressure.Researchers at the University of California, Berkeley have developed a new type of pressure sensor based on a new mechanical design. The se...
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University of California, Berkeley
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An Inexpensive and Highly Sensitive, Micromachined Pressure Sensor Device
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Micromachined pressure sensors are important for biomedical, automotive, and lab-on-a-chip applications. Most sensors are based either on capacitance changes across a Si cavity or resistance changes in piezoresistive materials as a response to applied pressure.Researchers at the University of California, Berkeley have developed a new type of pressure sensor based on a new mechanical design. The se...
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University of California, Berkeley
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An Inexpensive and Highly Sensitive, Micromachined Pressure Sensor Device
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Micromachined pressure sensors are important for biomedical, automotive, and lab-on-a-chip applications. Most sensors are based either on capacitance changes across a Si cavity or resistance changes in piezoresistive materials as a response to applied pressure.Researchers at the University of California, Berkeley have developed a new type of pressure sensor based on a new mechanical design. The se...
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University of California, Berkeley
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An Inexpensive and Highly Sensitive, Micromachined Pressure Sensor Device
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Micromachined pressure sensors are important for biomedical, automotive, and lab-on-a-chip applications. Most sensors are based either on capacitance changes across a Si cavity or resistance changes in piezoresistive materials as a response to applied pressure.Researchers at the University of California, Berkeley have developed a new type of pressure sensor based on a new mechanical design. The se...
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University of California, Berkeley
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An Inexpensive and Highly Sensitive, Micromachined Pressure Sensor Device
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Micromachined pressure sensors are important for biomedical, automotive, and lab-on-a-chip applications. Most sensors are based either on capacitance changes across a Si cavity or resistance changes in piezoresistive materials as a response to applied pressure.Researchers at the University of California, Berkeley have developed a new type of pressure sensor based on a new mechanical design. The se...
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University of California, Berkeley
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An Inexpensive and Highly Sensitive, Micromachined Pressure Sensor Device
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Micromachined pressure sensors are important for biomedical, automotive, and lab-on-a-chip applications. Most sensors are based either on capacitance changes across a Si cavity or resistance changes in piezoresistive materials as a response to applied pressure.Researchers at the University of California, Berkeley have developed a new type of pressure sensor based on a new mechanical design. The se...
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University of California, Davis
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APPARATUS AND METHOD FOR VISUAL-FIELD TESTING
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DESCRIPTION: Eye diseases such as glaucoma and optic neuropathiesaffect the field of vision.Visual field examination can oftendetermine the type, extent, and location along the visual pathwayof many eye diseases, so tests, such as perimetry testing, arecommonly performed to determine the subject's visual field rangeand sensitivity to light intensity, color, stimulus size, orspatial or temporal p...
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Stanford University
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Application of Nano Carbons and Nano Carbon Tubes to Create Intravascular Devices
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This invention provides applications for the use of nano carbon architectures, such as carbon nanotubes, as backbone structures for intravascular prothesis. These applications include the implantation of carbon nanotubes for the support, replacement, or bypass of compromised vascular tissues. In addition, this invention describes the use nanotubes as delivery vehicles for biological and non biolog...
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Stanford University
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Asymmetric Minimum-Cost MRI Magnet
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A homogeneous field electromagnet having at least two coils in each of two regions. One region has a smaller inner radius than the other region so that the magnet is asymmetrical. The magnet has coils with a smaller radius on one side compared to the other side. This provides the benefit of allowing the magnet to be shorter for a given field of view size (compared to a uniform-radius cylindrical m...
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Stanford University
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Atrial Shaper
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The most devastating effect of untreated atrial fibrillation is stroke. A-Fib patients have an increased risk of stroke because stagnant blood in the left atrium is prone to forming clots. A piece of clot can break off and travel into the cerebral or peripheral vasculature and cause a stroke. This invention is a way to decrease the risk of stroke in A-fib patients by closing off the left atrial ap...
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University of California, Irvine
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Automated, Programmable, High Throughput, Multiplexed Assay System for Cellular and Biological Assays
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Researchers at the University of California have developed a method and apparatus for performing automated, programmable, high-throughput analysis of adherent cells. It uses microscopic structures (cell pallets) patterned in such a manner so that adherent cells can plate against them. These structures are designed to provide a portable scaffolding for one or more adherent cells to be stored or car...
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University of California, Irvine
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Automatic Detection and Diagnostics of Diabetic Retinopathy
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UC researchers have developed a tool to aid in the automated detection of diabetic retinopathy. This novel system provides for blood vessel detection in a clutter (abnormality) environment and allows for efficient recognition of low-contrast minor blood vessels. A computer algorithm using adaptive thresholding and the localized Radon transform detects the normal vascular network from a retinal ima...
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Stanford University
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Automatic Generation of Radiological Teaching Files
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The creation of web-based teaching files for radiology has been a manual and time-consuming task that has discourages many users from contributing their cases. Our system is an automated web-based teaching file system that integrates seamlessly with any DICOM-compatible PACS. Users can, with a few clicks, send clinical image files to our system for anonymisation, automated categorization and teach...
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University of California, Davis
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AUTOMATIC LOW-PRESSURE WOUND IRRIGATION
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A University of California researcher has invented a device to provide a simple, quick, disposable sterile system for irrigating wounds that can be used by even the most inexperiencedemergency care providers.Unlike existing wound irrigation systems, this system combines lowcost, sterility, and ease of set-up and use with the reliable delivery of a constant and provenirrigation pressure.The system...
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University of California, Berkeley
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BioMEMS Immunoassay Platform for In-Field Diagnostics
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The rapid diagnosis of infectious diseases is critical for quick containment and effective treatment. The dominant diagnostics technology, ELISA, is cost-effective for diagnosing diseases in a hospital or doctor's office with a laboratory and trained staff. However, ELISA is not a practical solution for the rapid, precise diagnosis of infectious diseases in-the-field.To address this problem, resea...
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University of California, Berkeley
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BioMEMS Immunoassay Platform for In-Field Diagnostics
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The rapid diagnosis of infectious diseases is critical for quick containment and effective treatment. The dominant diagnostics technology, ELISA, is cost-effective for diagnosing diseases in a hospital or doctor's office with a laboratory and trained staff. However, ELISA is not a practical solution for the rapid, precise diagnosis of infectious diseases in-the-field.To address this problem, resea...
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University of California, Berkeley
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BioMEMS Immunoassay Platform for In-Field Diagnostics
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The rapid diagnosis of infectious diseases is critical for quick containment and effective treatment. The dominant diagnostics technology, ELISA, is cost-effective for diagnosing diseases in a hospital or doctor's office with a laboratory and trained staff. However, ELISA is not a practical solution for the rapid, precise diagnosis of infectious diseases in-the-field.To address this problem, resea...
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University of California, Berkeley
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BioMEMS Immunoassay Platform for In-Field Diagnostics
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The rapid diagnosis of infectious diseases is critical for quick containment and effective treatment. The dominant diagnostics technology, ELISA, is cost-effective for diagnosing diseases in a hospital or doctor's office with a laboratory and trained staff. However, ELISA is not a practical solution for the rapid, precise diagnosis of infectious diseases in-the-field.To address this problem, resea...
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University of California, Berkeley
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BioMEMS Immunoassay Platform for In-Field Diagnostics
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The rapid diagnosis of infectious diseases is critical for quick containment and effective treatment. The dominant diagnostics technology, ELISA, is cost-effective for diagnosing diseases in a hospital or doctor's office with a laboratory and trained staff. However, ELISA is not a practical solution for the rapid, precise diagnosis of infectious diseases in-the-field.To address this problem, resea...
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Stanford University
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Breath CO Detector and End-Tidal Sampler
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The Breath CO Detector and End-Tidal Sampler is intended for use in a hospital nursery, clinic, or physician's office for the sampling and analysis of neonatal end-tidal breath for carbon monoxide as an indication of hemolysis and subsequent infant jaundice. The Sampler includes a syringe and plunger for collecting end-tidal breath, a pump for supporting the syringe which can also incrementally wi...
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Stanford University
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Bronchoscopic Anesthesia Device
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Bronchoscopy is a procedure performed to capture images of the bronchus. These images allow for visualization of inflammation and unusual tissue growth in the trachea.This device addresses a common problem with performing bronchoscopy, which is the patient's natural reaction of coughing caused by stimulation of the tracheal tract. Coughing also causes the bronchoscope to need to be removed and len...
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University of California, Irvine
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C-MEMS Technology for Ni Nanowire Formation
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University researchers have developed a method for two and even three level C-MEMS processes to fabricate low resistance contacts to C-MEMS features and to make very high aspect ration structures (> 40). In the present case, researchers used the more familiar Ti/Au combination as contact material; the Au layer melted and changed to a multitude of Au balls at the high pyrolysis temperature, dist...
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Stanford University
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CardioCool TEC Device
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This year, approximately 1.1 million individuals will suffer an acute myocardial infarction (AMI, also known as heart attack). However, the primary methods for treating acute coronary disease are inadequate due to long patient waiting time, reperfusion injury, and failure to achieve normal perfusion in a timely manner. There is a clear need for cardiac protection at a much earlier stage, and myoca...
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Stanford University
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Catheter-Based Three-Dimensional Ultrasonic Imaging
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This invention is a significantly improved system of methods and devices for obtaining three-dimensional images of an internal body site. The nature of the devices allows for radially wide three-dimensional images to be obtained in real time from a device that has a low profile during introduction to the body site of interest. ...
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University of California, Irvine
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Cell Encapsulation on a Microfluidic Platform
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Univeristy of California researchers have developed a novel microfluidic platform for encapsulation of cells in droplets. Cells can be loaded at low or high densities to achieve droplets of 1-5 cells or up to 20-50 cells. Droplet size can be manipulated by channel geometries and flow rates.In contrast with prior batch techniques, this device allows for a smaller minimum droplet size of 100 Â...
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Stanford University
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Cell-Based Metabolic Sensor
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The device is a solid-state sensor that allows detection of dissolved oxygen concentrations in cells using biological cells growing on its active surface. The device is a useful tool for screening to identify pharmaceuticals that modulate metabolic rate of a cell up or down. This is especially useful in cardiovascular and neurological medicine and surgery where depression of metabolic rate can be ...
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Stanford University
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Combination Carotid Artery Stenting With Embolic Protection
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This device is an All-in-One System (AOS) that combines stenting to address stenosis (blockages/narrowings) of the carotid artery with an embolic protection filter.The AOS is a combination of three separate existing devices: 1) the stent and delivery system; 2) the angioplasty balloon and delivery system; and 3) the embolic protection filter and delivery system.Note: Conceptual prototypes of all a...
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University of California, Irvine
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Corneal Transplantation
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Researchers at the University of California, Irvine, have developed a method using an automated microkeratome to provide an essential means of harvesting stem cell tissue of reproducible dimensions. This method is far more consistent than the current manual method for stem cell harvesting. By providing consistency to the procedure, the operation could be based out of hospitals, surgical centers or...
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Stanford University
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Device for Access to Body and Trocar Placement in Laporoscopic Surgery
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Obtaining access from the skin surface to abdominal cavity (to allow laparoscopic trocar placement) is the initial step in laparoscopic surgery. This can be achieved using three of the commonly used laparoscopic access devices. However, these devices are frequently flawed with disadvantages, either associated with complications such as bowel and blood vessel perforation or resulting in bowel or va...
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Stanford University
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Device for Percutaneous Closure of Arteriotomies
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The inventors have developed a novel, patent pending solution for safe, rapid and reliable percutaneous closure of arteriotomies. Percutaneous closure of arteriotomies remains an unmet clinical need because existing closure devices exhibit complications relative to manual pressure, and are used only to close arteriotomies up to 8F in size. In the case of larger arteriotomies, (e.g. aortic stent gr...
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Stanford University
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Device to extract a clot from the neurovasculature during an acute stroke
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The device comprises a coil with a distal filter affixed to a wire. The coil and filter section is made of an elastic material, such as nitinol. It is delivered in a contracted state in a microcatheter through and beyond the clot. Then, the microcatheter is withdrawn so that the distal filter and distal portion of the coil self-expand out of the microcatheter. The microcatheter and apparatus is th...
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Stanford University
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Device to Facilitate Surgical Wound Care
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Surgical incisions are frequently covered with dressings secured to skin surface by tapes in the first few days or weeks after surgery (to avoid staining of clothings by blood/body fluids from surgical incisons, to help maintain adequate hygiene at the wound sites, to avoid exposure of incision sites to water in showering/bathing, as well as to serve some degree of aesthetic/psychologic purposes)....
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Stanford University
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Device to treat degenerative and herniated spinal discs
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The inventors have developed a device to address degenerative spinal disc disease and disc herniation. The proposed approach can access the affected area either via an open surgery or minimally invasive means.Surgical fusion has been the dominant course of surgical treatment for treatment of spinal instability since it was invented in 1900. However, the procedure is highly controversial, according...
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Stanford University
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Devices and Method to Protect Against Embolization
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During stenting procedures, clot and plaque are dispersed into the bloodstream where they can cause serious problems such as stroke. This device provides a way to prevent unwanted materials from embolizing in the body, particularly materials that are dispersed in the distal internal carotid artery (ICA) during carotid stenting. The device consists of a balloon which drives debris in one direction ...
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Stanford University
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Devices that Treat Back Pain
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EPI-X We have a device concept that will revolutionize catheter-based procedures. The Device enables the delivery of applications larger than the diameter of the catheter. This device minimizes the tissue trauma caused by shear forces and blunt expansion that is normally seen when delivering an application with a large crossing profile.Applications:interventional cardiology and radiology procedure...
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University of California, Davis
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DISTAL RADIUS FIXATION SYSTEM
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A researcher at the University of California has developed aself-contained fixation system for distal radius fractures andmalunion deformations.Current practice employs external fixationdevices for fractures but not for malunions.Most existingexternal fixation systems for distal radial fractures do not allowfor three-dimensional correction of fracture or maluniondeformities.The few systems that ...
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University of California, Los Angeles
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Droplet-Based On-Chip Sample Preparation For Mass Spectrometry
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Sample processing for mass spectrometry applications, such as matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS) is currently done manually, that is, with pipettes. Depending on the samples in preparation, this step can involve thousands of steps and days of work. Some cases of sample preparation can be done with droplet dispensing robots but the process is still time-consum...
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Stanford University
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Drug Delivery Stent Platform
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Arterial stenting is applied to over 60% of balloon angioplasties for treating cardiovascular disease. However, stented arteries encounter accelerated rates of restenosis. No prior platform allowed evaluation or local management of in-stent restenosis without perturbing the very system under examination. Researchers at Stanford University have developed a stent-based drug delivery system that redu...
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University of California, Irvine
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Early detection of Dental Caries Using Optical Coherence Tomography (OCT)
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Researchers at the University of California, Irvine are investigating the use of Optical Coherence Tomography (OCT) as an in vivo, non-invasive modality for the diagnosis, preventive treatment, and therapy in patients with high caries risk, large numbers of poorly accessible restorations, or developmental abnormalities. The method involves scanning for dental caries with high-resolution real-time ...
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Stanford University
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Electrocautery Device
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For minor surgical bleeding that can be controlled with electrocautery, the standard method to control such situation is to use a suction device to remove the small amount of blood in the area, allowing identification of the exact bleeding site, and then to use electrocautery to cauterize the bleeding tissues to achieve bleeding control. This is a multi-step process for both open and laparoscopic ...
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Stanford University
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Electrode Probes for Interventional MRI
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In MRI, it is generally thought that a tuned receiver coil is needed to detect an MRI signal. This invention provides a method of using electrodes implanted in the tissue and impedance matched to the preamplifier to detect MRI signals. The tissue between the electrodes forms a parallel resistor capacitor that effectively closes the loop formed by the electrodes and feedwires. The sensitivity is de...
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Stanford University
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Electroosmotic micropumps with planar features
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Two types of electroosmotic micropumps with planar features have been invented that can be built and integrated with microfabricated devices. These pumps address the challenge posed by applications requiring high fluidic pressures in IC or microsystems applications. Electroosmotic pumping is induced by the application of electric field to a fluid channel with charged walls. The working liquids can...
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Stanford University
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Endoscopic Targeting Method and System
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The invention provides a system for enhancing the ability of a surgeon to access a target site within a patient. The system includes a data file containing volumetric scan data of a region of the patient that includes the target site, a display device, and a movable imagining tool for producing on the display device, an image of visible patient structure seen by the tool. A computer in the system ...
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Stanford University
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Endovascular Treatment of Wide Neck Cerebral Aneurysms
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Wide neck cerebral aneurysms pose a high risk of rupture and potential death. Most patients diagnosed with this type of aneurysm are treated with craniotomy (open skull surgery). Although non-invasive alternatives exist, they are currently effective only on a narrow segment of these aneurysms with amenable geometries/anatomy.The inventors have developed a device that will allow for non-invasive en...
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Stanford University
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Engineered Tissue for Organ Restoration
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The rapidly expanding field of tissue engineering promises to provide tissue supplements to replace diseased parts of organs. Most procedures described today will require extensive operations and will often result in distortion of the target organs architecture. Additionally, these same procedures might inhibit engraftment of the cells of the transplanted tissue. While at Stanford University, Dr. ...
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Stanford University
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Enhancement of Cell Survival following Cell Transplantation
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The principle of restoring diseased heart muscle through cell transplantation receives scientific and public attention increasingly. This invention utilizes a substance which prevents cell death to treat cells prior to their transplantation. The treatment promotes survival, engraftment and functional improvement of the recipient heart. The cellular yield following treatment of the cells with our m...
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University of California, Davis
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Enzyme Catalyzed Metallic Nanoparticle Synthesis at Room Temperature
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Metallic nanoparticles are a core component of modern nanotechnology, yet their production still suffers major limitations. The heart of this new approach lies in the precise control of the number of nucleation sites by placing the metal ions to be reduced at the active sites of enzymes that catalyze their reduction. Such nucleation control has been extremely difficult to achieve in typical soluti...
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Stanford University
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Expandable cage requiring minimum operating space
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A cage is located in the gap created by the removal of vertebrae and disks to support the compressible load before the gap is filled by the bone fusion. It should be easily expandable during surgery for the alignment of the spine. To adjust height in an existing expandable cage, a stick is inserted into the hole located in the middle ring of the cage and pulled to the right or left to rotate the r...
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University of California, Davis
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EYELID CLOSURE DEVICE
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Corneal exposure is a frequent source of morbidity in both in-patient and out-patientpopulations.Corneal exposure, with its attendant risk of corneal keratopathy, results from thetotal or partial loss of eyelid closure.Metabolic derangement, artificial respiration, immunologicdysfunction, impaired mental status, and facial injuries can all leave a patient vulnerable toophthalmologic complications...
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University of California, Irvine
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Fabrication Method for Polymer Thin Films
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University researchers have developed a method that allows for the synthesis of a wide variety of polymer thin films, the fabrication method of which can be combined with photolithography to create surface patterns. Thin film thickness is controlled from 1 nm to the submicron range. The method also supports the creation of "smart surfaces". It is applicable to most of the vinyl monomers, and block...
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University of Southern California
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Fabrication of Broadband Graded Transducer Using Piezoelectric Partial Composites
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Partial composite is a new type of piezoelectric material which can be easily manufactured. By using partial composites to make ultrasound transducers, it is much easier to obtain broad bandwidth. Broadband transducers satisfy the requirement of improved spatial resolution and offers the advantages of allowing better harmonic imaging. At the same time, the partial composite can be widely used in s...
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University of California, Los Angeles
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Free Text Medical Document Retrieval Via Phrase-based Vector Space Modeling
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Information retrieval are based VSM is based on a model whereby the document is a vector of index terms. Concepts have been proposed to replace word stems as the index terms to improve retrieval accuracy. However, past research revealed that such systems did not outperform stem-based systems. Knowledge sources should improve retrieval accuracy. But knowledge sources are based on word stems which ...
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University of California, Irvine
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Frequency-Amplitude-Modulation-Encoding (FAME) Strategies for Cochlear Implants and Audio Compression
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Frequency-Amplitude-Modulation-Encoding (FAME) strategies are developed by the researchers at the University of California, Irvine to improve the degree and quality of sound perception for the cochlear implant users. The same principle can be used to compress audio signals so that broad-band qualities can be achieved with narrow-band transmission channels. Broad-band audio signals are first divide...
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Stanford University
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Gas Sensor for Ammonia, Carbon Dioxide, and Water
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This invention uses a radiation source (such as a laser) to measure the presence of ammonia, carbon dioxide and water vapor; isolating the different absorption features from each other and enabling species-specific measurements without interference from primary bath gas constituents.Most applications for which measurements of trace ammonia concentration are pertinent include high background levels...
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University of California, Los Angeles
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Gesture-Driven User Interface for Medical Image Viewing
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Conventional medical imaging workstations employ standard user-interface paradigms for interaction, including menu bars, tool palettes, keyboard strokes and specialized hardware devices. Use of such tools is distracting to the user and disruptive to the image viewing process. ...
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Stanford University
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High Performance Prosthetic Foot
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The present invention includes features offering improvement over known foot prosthetics, particularly those used to handle foot amputations (e.g., Symes-type amputations). A functional prototype is available. ...
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University of California, Irvine
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Humidity And Temperature Sensor Device For The Determination Of Oxygen Consumption In Medical Applications
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An anesthesiologist at the University of California, Irvine, has invented a device which makes continuous, on-line and rapid measurements of gas temperature and humidity.This novel device is inexpensive to construct and operate, simple to calibrate and use, non-toxic, and stable. Unlike other present slower devices, this device has a response time adequate even for cyclical gas flows that occur du...
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Stanford University
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Imaging of the Vasa Vasorum
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Chronic total occlusions (CTOs) have been described as "one of the last frontiers in angioplasty." Vascular imaging techniques used currently require contrast to flow through the area being imaged. Because contrast cannot flow through a total occlusion, it is difficult to image the area, and thus to intervene. This invention uses fluoroscopy of the vasa vasorum, a network of capillaries that perme...
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University of California, Davis
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IMMUNOASSAY ON A COMPACT DISC (CD): SUPPORT WITH INTERACTIVE DATA STORAGE
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There are significant obstacles to performing clinical or diagnostic immunoassays on large numbers of analytes given the expense, the waste of reagents (including clinical samples, e.g. patient blood), and the limits on the number of multianalytes that can be processed in a given protocol.Present techniques tend to be very costly and inefficient when a very large number of assays are required, suc...
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University of California, Berkeley
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Implantable Analyte Sensor
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Researchers at the University of California have developed an implantable analyte sensor fabricated using an improved porous membrane. A special property of the membrane is a defined pore size, which has a small size distribution (+/- 1%-5%) compared to the size distribution of standard membranes. These membranes can exclude interfering molecules, such as proteins, which could otherwise cause majo...
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University of California, Berkeley
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Implantable Analyte Sensor
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Researchers at the University of California have developed an implantable analyte sensor fabricated using an improved porous membrane. A special property of the membrane is a defined pore size, which has a small size distribution (+/- 1%-5%) compared to the size distribution of standard membranes. These membranes can exclude interfering molecules, such as proteins, which could otherwise cause majo...
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University of California, Berkeley
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Implantable Analyte Sensor
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Researchers at the University of California have developed an implantable analyte sensor fabricated using an improved porous membrane. A special property of the membrane is a defined pore size, which has a small size distribution (+/- 1%-5%) compared to the size distribution of standard membranes. These membranes can exclude interfering molecules, such as proteins, which could otherwise cause majo...
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Stanford University
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Improved abdominal aortic stent graft designs
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This invention provides a novel technology platform for improving endovascular fixation and seal during endoluminal repair of abdominal aortic aneurysms (AAA) of varying lengths and geometries. ...
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University of California, Berkeley
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Improved Process for Producing Nanoporous Membranes
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Researchers at the University of California, Berkeley have developed a method for the reliable and reproducible fabrication of porous membranes with pore size less than 50 nm.The process developed at Berkeley allows the incorporation of many different materials classes that could not be fabricated with previous thin film nanoporous membranes, as well as the use of structural materials other than s...
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University of California, Berkeley
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Improved Process for Producing Nanoporous Membranes
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Researchers at the University of California, Berkeley have developed a method for the reliable and reproducible fabrication of porous membranes with pore size less than 50 nm.The process developed at Berkeley allows the incorporation of many different materials classes that could not be fabricated with previous thin film nanoporous membranes, as well as the use of structural materials other than s...
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University of California, Berkeley
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Improved Process for Producing Nanoporous Membranes
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Researchers at the University of California, Berkeley have developed a method for the reliable and reproducible fabrication of porous membranes with pore size less than 50 nm.The process developed at Berkeley allows the incorporation of many different materials classes that could not be fabricated with previous thin film nanoporous membranes, as well as the use of structural materials other than s...
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Stanford University
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Improved Sampling in Volumetric CT
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Volumetric computed tomography (VCT) systems are conventionally operated by rotating the source and detector around a rotational axis (often called the zaxis), thereby obtaining image measurements from multiple angles. Many such systems have a single x-ray source that travels in a circular path as the system rotates. It is known that such systems suffer from cone-beam artifacts.To solve this sampl...
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Stanford University
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Improvements for Interfaces between Prosthesis Collars and Bone
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This invention attempts to improve the likelihood of a successful hip replacement.Approximately 125,000 hip replacements are performed in the United States each year. The number of hip replacements performed worldwide is difficult to determine; however, the frequency in certain countries, such as Sweden, is 130 procedures per 100,000 inhabitants- more than twice the rate of 60/100,000 performed in...
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Stanford University
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Increasing Bone Fracture Resistance
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Osteoporosis affects 25 million Americans and leads to 1.5 million fractures in the US each year. This includes 200,000 wrist fractures and 300,000 hip fractures which occur primarily as a result of a fall. The annual cost to society related to hip fractures alone exceeds $10 billion. Reducing the number of hip fractures by 1% would save $100 million each year.We have developed a novel approach fo...
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University of Southern California
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Intelligent Motion Surfaces
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The invention represents a surface comprising a dense array of motion devices that can be programmed to operate in conjunction to form an Intelligent Motion Surface (IMS). The area of the surface may be segmented under program control to apply a force vector to a part placed on it. The motion devices are micro-robots built in micro-electromechanical VLSI.An intelligent motion surface consisting of...
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Stanford University
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Interactive Reporting of Postprocessed Radiological Images and Measurements
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Current imaging modalities including CAT scans and MRI scans produce thousands of images per scan. To allow for faster and more accurate interpretation, a variety of post-processed images are produced that depict the anatomy in three dimensions. Many measurements are also made at clinically significant anatomic points. Currently, these images are viewed separately in the clinical picture archiving...
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Stanford University
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Interventional Nuclear Diagnostic Device
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Atheroma alter the expression of receptors in the endothelium. Identifying specific receptors that are upregulated in unstable plaque has been accomplished using autoradiography following either incubation of the specimen or intravenous administration of an appropriate ligand in-vivo prior to sacrifice of the animal and harvesting the vessels. The autoradiographic film is primarily exposed by char...
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Stanford University
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Laparoscopic Renal Hypothermia
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The purpose of the device is to lower the core temperature of the kidney during laparoscopic surgery. The kidney is the body's blood filter. Therefore the kidney is always filled with blood, making kidney surgery difficult to perform. Any incision into the kidney tends to cause large amounts of bleeding.To prevent bleeding while operating on the kidney, doctors clamp the renal artery, which suppli...
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University of California, Irvine
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Laser Based Quantitative Optical Analyzer For Turbid Media
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New Instrumentation has recently been developed by researchers at the University of California that can be used to determine distinct optical properties of turbid media in-situ. The new method utilizes frequency domain photon migration (FDPM) as a non-invasive diagnostic technique. Measurements are performed by launching modified laser light into a scattering medium. Optical property variations wi...
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Stanford University
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Laser Enhanced Hygienic Care Products
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Stanford University is searching for a licensee to commercialize a new generation of inventions for unique laser enhanced personal care products that will provide consumers with improved hygienic results and healing effects using the photo effect of low level laser technology to treat biological composition.This revolutionary technology has significant advantages with applications ranging from ora...
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University of California, Berkeley
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Low Cost Methods for Forming Hollow Out-of-Plane Microneedles
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There is growing interest in using arrays of hollow microneedles to implement minimally invasive, low-cost, highly integrated systems for delivering drugs to, or sampling fluids from humans. However most existing methods for fabricating microneedles are cost prohibitive and/or have design limitations. For example, existing fabrication concepts for hollow in-plane microneedles can only arrange the ...
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University of California, Berkeley
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Low Cost Methods for Forming Hollow Out-of-Plane Microneedles
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There is growing interest in using arrays of hollow microneedles to implement minimally invasive, low-cost, highly integrated systems for delivering drugs to, or sampling fluids from humans. However most existing methods for fabricating microneedles are cost prohibitive and/or have design limitations. For example, existing fabrication concepts for hollow in-plane microneedles can only arrange the ...
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University of California, Berkeley
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Low Cost Methods for Forming Hollow Out-of-Plane Microneedles
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There is growing interest in using arrays of hollow microneedles to implement minimally invasive, low-cost, highly integrated systems for delivering drugs to, or sampling fluids from humans. However most existing methods for fabricating microneedles are cost prohibitive and/or have design limitations. For example, existing fabrication concepts for hollow in-plane microneedles can only arrange the ...
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University of California, Berkeley
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Low Cost Methods for Forming Hollow Out-of-Plane Microneedles
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There is growing interest in using arrays of hollow microneedles to implement minimally invasive, low-cost, highly integrated systems for delivering drugs to, or sampling fluids from humans. However most existing methods for fabricating microneedles are cost prohibitive and/or have design limitations. For example, existing fabrication concepts for hollow in-plane microneedles can only arrange the ...
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University of California, Berkeley
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Low Cost Methods for Forming Hollow Out-of-Plane Microneedles
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There is growing interest in using arrays of hollow microneedles to implement minimally invasive, low-cost, highly integrated systems for delivering drugs to, or sampling fluids from humans. However most existing methods for fabricating microneedles are cost prohibitive and/or have design limitations. For example, existing fabrication concepts for hollow in-plane microneedles can only arrange the ...
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Stanford University
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LUCY, a 3D Anatomic Model of the Human Female Pelvis
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This invention consists of a biofidelic 3D model of the human female pelvis for subsequent use in a surgical simulation training device. Essentially, a total of 95 (2mm thin) sections of the pelvis portion (hip to upper-thigh) was photographed and then converted to digital format, resulting in a 3D model called LUCY. The deployment of surgical simulation models such as LUCY may facilitate the tech...
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Stanford University
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Means for Detection and Monitoring Cardiac Dysfunction
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Acute myocardial infarction, in which an artery feeding the heart suddenly becomes blocked, can be successfully treated if therapy is initiated early. Treatment within the first 70 minutes has been associated with an 86% decrease in in-hospital mortality for these patients. Unfortunately, patients usually delay getting to the hospital because they do not believe the symptoms warrant emergency care...
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Stanford University
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Medical CAD / Vascular: Automated Measurement of Diameters and Volumes of Abdominal Aortic Aneurysms
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Patients with Abdominal Aortic Aneurysms (AAAs) usually have multiple serial CAT scans to evaluate the size of the bulging aorta prior to surgery, and also to follow patients after surgery to ensure that the aneurysm is shrinking. The volume of the aneurysm includes the flow lumen, which enhances brightly in contrast CAT scans, and also the surrounding thrombus (clotted blood) in and around the wa...
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Stanford University
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Medical CAD / Vascular: Automated Quantification of Arterial Calcification in CT Studies
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Abnormal (dystrophic) calcification has been shown to commonly be seen in CT scans of vessels in regions of atherosclerosis. The extent of calcification has been shown to correlate with the severity of atherosclerosis, and also predicts the risk of heart attacks and other vascular diseases. However, current methods of quantifying calcium in vessels are manual and time consuming, and have been show...
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Stanford University
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Medical CAD / Vascular: Bone Removal in CT using Automated Targeted Morphological Separation
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Bone removal is a necessary pre-processing step before the generation of more complex post-processed images, such as Whole Volume Maximum Intensity Projection (Whole Volume MIP). This is because bone obscures vascular anatomy and reduces the apparent extent of vascular calcification and atherosclerosis. In projections where the bone does not obscure anatomy, the bone decreases the contrast in an i...
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Stanford University
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Medical CAD / Vascular: Quantifying the Infrarenal Aorta and Iliac Arteries
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The aortic wall is usually very smooth and circular. In disease states like atherosclerosis, the wall becomes irregular early in the course of the disease. Our system automatically detects and quantifies the amount of irregularity in the aortic wall in CT scans as an index of the level of atherosclerosis. This capability can be used to determine the distribution and severity of atherosclerosis in ...
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Stanford University
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Medical CAD Vascular: Automated Measurement of Aortic and Aortilliac Angulation
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Patients with vascular disease are usually imaged using Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) to evaluate the level of angulation of the vessels prior to reparative surgery. Currently, manual measurement of angulation takes about 5-10 minutes per scan and suffers from high inter-user and intra-user variability. Manual observers have difficulty integrating the large amount of...
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Stanford University
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Medical CAD: Method for Reducing False Positives in Medical Imaging
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In the United States, lung cancer and colon cancer are the first and second leading cancer killers, respectively. Early detection of colonic polyps and lung nodules, the precursors to these diseases, has been shown to improve survival. Therefore, early detection of precancerous growths has become important so that they can be removed before evolving into a frank malignancy. In order to alert the r...
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Stanford University
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Medical CAD: Osteoarthritis - Breakthrough in Detection & Monitoring using Functional Medical Imaging
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The solution presented offers a computer-assisted cartilage loss measurement capability as an aid to detecting and monitoring Osteoarthritis. The method provides a consistent, reproducible screening platform for tracking longitudinal changes, and hence provides a useful aid to tracking deasease development and treatment. The solution also provides a method for determining the rate of cartilage los...
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Stanford University
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Medical Diagnostic Ultrasound System and Method for Flow Analysis
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This invention is a technique for automatic analysis of 4D ultrasound data of the carotid artery. The invention uses an ultrasound scanner fitted with a special probe. Stenosis categories are computed automatically based on cross-sectional areas and examination time is approximately 1/4 of that required for conventional methods. This is a simple and rapid technique with promising results in early ...
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University of California, Berkeley
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MEMS Microbial Fuel Cells Powered by Glucose
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The application of MEMS technology to implantable biomedical devices has great potential to decrease the size and costs of these implantable systems. However lithium batteries -- the common power source for these medical devices -- are not well-suited to MEMS-based systems as the batteries are relatively expensive and bulky.To achieve the full potential of MEMS-based implantable biomedical devices...
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University of California, Berkeley
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MEMS Microbial Fuel Cells Powered by Glucose
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The application of MEMS technology to implantable biomedical devices has great potential to decrease the size and costs of these implantable systems. However lithium batteries -- the common power source for these medical devices -- are not well-suited to MEMS-based systems as the batteries are relatively expensive and bulky.To achieve the full potential of MEMS-based implantable biomedical devices...
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University of California, Berkeley
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MEMS Microbial Fuel Cells Powered by Glucose
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The application of MEMS technology to implantable biomedical devices has great potential to decrease the size and costs of these implantable systems. However lithium batteries -- the common power source for these medical devices -- are not well-suited to MEMS-based systems as the batteries are relatively expensive and bulky.To achieve the full potential of MEMS-based implantable biomedical devices...
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University of California, Berkeley
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MEMS Microbial Fuel Cells Powered by Glucose
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The application of MEMS technology to implantable biomedical devices has great potential to decrease the size and costs of these implantable systems. However lithium batteries -- the common power source for these medical devices -- are not well-suited to MEMS-based systems as the batteries are relatively expensive and bulky.To achieve the full potential of MEMS-based implantable biomedical devices...
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University of California, Berkeley
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MEMS-Based Glucose Monitoring System
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Diabetes is a huge healthcare problem, and in particular the inability of diabetics to continuously monitor their glucose levels causes some of the most severe complications for this condition due to undetected hypoglycemic or hyperglycemic events. The traditional fingerstick test is an invasive, painful and inconvenient method of measuring glucose levels, and it often fails to detect rapidly fluc...
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University of California, Berkeley
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MEMS-Based Glucose Monitoring System
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Diabetes is a huge healthcare problem, and in particular the inability of diabetics to continuously monitor their glucose levels causes some of the most severe complications for this condition due to undetected hypoglycemic or hyperglycemic events. The traditional fingerstick test is an invasive, painful and inconvenient method of measuring glucose levels, and it often fails to detect rapidly fluc...
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University of California, Berkeley
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MEMS-Based Glucose Monitoring System
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Diabetes is a huge healthcare problem, and in particular the inability of diabetics to continuously monitor their glucose levels causes some of the most severe complications for this condition due to undetected hypoglycemic or hyperglycemic events. The traditional fingerstick test is an invasive, painful and inconvenient method of measuring glucose levels, and it often fails to detect rapidly fluc...
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University of California, Berkeley
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MEMS-Based Glucose Monitoring System
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Diabetes is a huge healthcare problem, and in particular the inability of diabetics to continuously monitor their glucose levels causes some of the most severe complications for this condition due to undetected hypoglycemic or hyperglycemic events. The traditional fingerstick test is an invasive, painful and inconvenient method of measuring glucose levels, and it often fails to detect rapidly fluc...
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University of California, Irvine
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Method and Apparatus for Spatially Modulated Fluorescence Imaging and Tomography
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University of California researchers have developed a method and apparatus which can provide simultaneous surface and sub-surface mapping of media structure, function and composition. The method disclosed herein allows: Wide field imaging; Subsurface imaging/tomography (depth sensitivity to be assessed as a function of source spatial frequency, wavelength selection and/or amplitude modulation); Sp...
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Stanford University
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Method and Apparatus for Tracking a Medical Instrument Based on Image Registration
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This invention is an apparatus, method and system for tracking a medical instrument in three-dimensional (3-D) space based on diagnostic scan data and intra-operative stereo images. The invention has particular application in tracking instruments, both flexible and rigid, as they are moved inside a patient's body. The invention also relates to an algorithm that registers preoperative 3-D diagnosti...
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Stanford University
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Method and Apparatus for Transforming View Orientations in Image Guided Surgery
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This invention relates to systems, devices and methods for performing transformations between a view orientation in a virtual space and a view orientation with respect to a target site in a patient's body where surgery is being performed. One can transform between a view orientation (a) with respect to a virtual point external to a patient; (b) with respect to an axis along which the virtual point...
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University of California, Irvine
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Method and Apparatus of Using 3D Conductive Structures in Dielectrophoretic Separation Applications
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Researchers at the University of California, Irvine have developed novel 3D dielectrophoretic designs for high efficiency separation and have demonstrated such a system for filtration of submicron contaminants from lubricants. The system also allows for online monitoring of contaminant levels. The novel high throughput electrode designs could be used for other applications were separation, filtrat...
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University of California, Los Angeles
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Method and Device for Treating Intracranial Vascular Aneurysms
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Strokes are the most common life-threatening neurological disease, and are the third leading cause of death in developed countries after heart disease and cancer. Approximately 6-8 percent of all strokes results from non-traumatic subarachnoid hemorrhage, a condition where blood leaks from the cerebral vasculature into the subarachnoid space. About 8 percent of subarachnoid hemorrhages result fr...
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Stanford University
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Method for Calibration of X-ray Detectors
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The purpose of this invention is to calibrate x-ray detectors in a reproducible way during operation. The technology addresses how to provide a calibration object that can be used to characterize the distortion during normal operation, but does not produce significant artifact in the x-ray images when distortion characterization is not underway. The device allows x-ray detectors to acquire images ...
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Stanford University
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Method for the real-time therapeutic dosimetry based on dynamic response of the treated tissue
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Laser treatment of the retina is one of the most common applications of lasers in medicine. In many cases the laser-induced effects on the retina are not directly observable and are done in the absence of real-time feedback from the treated tissue. Stanford scientists have developed an apparatus that can allow for live observation of the treatment-induced effects in tissue during laser therapy, in...
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Stanford University
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Method of beam orientation selection for intensity modulated radiation therapy (IMRT)
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In IMRT, selection of incident beam orientations is often determined by a trial-and-error search. The conventional beam's-eye-view (BEV) tool becomes less helpful in IMRT because it is frequently required that beams go through organs at risk (OARs) in order to achieve a compromise between the dosimetric objectives of the target and the OARs. We propose a pseudo-BEV (PBEV) technique to assist the s...
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University of California, Berkeley
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Method of Forming Microneedles and other Micron-Scale Transdermal Probes
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The biomedical industry seeks to replace stainless steel hypodermic injection needles with needles that have smaller diameters and sharper tips, to minimize pain and tissue damage. Also desirable in an improved needle is added functionality, such as the capability of providing integrated electronics for chemical concentration monitoring, cell stimulation, and the control of fluid flow such as thro...
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University of California, Berkeley
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Method of Forming Microneedles and other Micron-Scale Transdermal Probes
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The biomedical industry seeks to replace stainless steel hypodermic injection needles with needles that have smaller diameters and sharper tips, to minimize pain and tissue damage. Also desirable in an improved needle is added functionality, such as the capability of providing integrated electronics for chemical concentration monitoring, cell stimulation, and the control of fluid flow such as thro...
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University of California, Berkeley
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Method of Using Hollow Out-Of-Plane Microneedles for Interfacing with Bodily Fluids in Mammalian Skin
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The emerging plethora of miniaturized body monitoring and drug delivery systems largely rely on integrated microneedles to penetrate skin. However, in contrast to conventional hypodermic needles, extremely sharp small needles are problematic in that they are expensive to fabricate, and subject to breakage when used. Moreover, these microneedles are often implemented as arrays, and consequently the...
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University of California, Berkeley
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Method of Using Hollow Out-Of-Plane Microneedles for Interfacing with Bodily Fluids in Mammalian Skin
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The emerging plethora of miniaturized body monitoring and drug delivery systems largely rely on integrated microneedles to penetrate skin. However, in contrast to conventional hypodermic needles, extremely sharp small needles are problematic in that they are expensive to fabricate, and subject to breakage when used. Moreover, these microneedles are often implemented as arrays, and consequently the...
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University of California, Berkeley
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Method of Using Hollow Out-Of-Plane Microneedles for Interfacing with Bodily Fluids in Mammalian Skin
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The emerging plethora of miniaturized body monitoring and drug delivery systems largely rely on integrated microneedles to penetrate skin. However, in contrast to conventional hypodermic needles, extremely sharp small needles are problematic in that they are expensive to fabricate, and subject to breakage when used. Moreover, these microneedles are often implemented as arrays, and consequently the...
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University of California, Berkeley
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Method of Using Hollow Out-Of-Plane Microneedles for Interfacing with Bodily Fluids in Mammalian Skin
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The emerging plethora of miniaturized body monitoring and drug delivery systems largely rely on integrated microneedles to penetrate skin. However, in contrast to conventional hypodermic needles, extremely sharp small needles are problematic in that they are expensive to fabricate, and subject to breakage when used. Moreover, these microneedles are often implemented as arrays, and consequently the...
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University of California, Irvine
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Method to Measure Microfluidic Flow Based on Electrical Admittance
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Researchers at the University of California have developed a method for measuring the flow rate of a conducting fluid in a microchannel that is simple in design and can be integrated to most of the microfluidic platforms. This flow sensor has a high signal-to-noise ratio, can measure of a wide range of liquids (including biochemical buffers and solutions containing biomolecules such as DNA and cel...
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Stanford University
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Methods and Apparatus for Spine Support
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The invention is a device/system that provides musculoskeletal stabilization to address many of the causes of back pain.The invention focuses on lower lumbar spine stabilization.The inventors have developed an implantable, motion-preserving instrument. The device addresses two unique pathologies, degenerative disc disease and disc herniation, both of which possess existing DRG and ICD9 codes for r...
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Stanford University
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Methods and Apparatuses for Maintaining a Trajectory in Sterotaxi for Tracking a Target Inside a Body
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This invention is an improvement on current image-guided, robotic-assisted surgical techniques. It comprises of an apparatus and method for adjusting the orientation of a surgical viewing instrument as the position of the instrument is changed by a user. The apparatus and method may be used to view a patient target site and any intervening tissue from outside the body. The instrument is attached t...
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University of California, Irvine
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Methods for Assessing the Condition of Bone In-Vivo Using Non-Ionizing Radiation
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University of California researchers have developed an optical method to characterize bone tissue viability. The optical properties of bone are strongly influenced by composition, structure and physiology. Disease alters these bone characteristics, and thus bone optical properties are parameters that gauge bone disease progression. The method involves 1) the use of non-ionizing radiation including...
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University of California, Irvine
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Methods for Assessing the Temperature of Deep Tissue in vivo Using Non-ionizing Radiation
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Researchers at the University of California, Irvine have invented a novel method to measure deep tissue temperatures non-invasively. It uses a non-invasive method for quantifying absorption and scattering values of tissue over a broad wavelength range (600 to 2500 nm). Using this method to give an absolute measure of the tissue absorption, it is possible to determine the concentrations of chromoph...
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University of California, Berkeley
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Microfabricated Microneedles
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An IC-processed microneedle including an interface region and shaft. A shell defines an enclosed channel to form the shaft. The shaft has ports to permit fluid movement therethrough. Microheaters, microdetectors and additional devices may also be fabricated on the microneedle. The small diameter minimizes trauma to the patient yet retains sufficient strength to effectively penetrate biological tis...
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University of California, Berkeley
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Microfabricated Microneedles
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An IC-processed microneedle including an interface region and shaft. A shell defines an enclosed channel to form the shaft. The shaft has ports to permit fluid movement therethrough. Microheaters, microdetectors and additional devices may also be fabricated on the microneedle. The small diameter minimizes trauma to the patient yet retains sufficient strength to effectively penetrate biological tis...
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University of California, Irvine
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Microscope Immersion Fluid Applicator
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Researchers at the University of California, Irvine have designed a simple device to deliver immersion fluid (oil, water, glycerin, etc.) onto the specimen without removing the specimen from the microscope stage. Many microscope manufacturers have developed microscopes designed so that each objective in the turret can be rotated into place with high repeatability of alignment so that the specimen ...
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Stanford University
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Minimally invasive lumbar fusion device
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Currently, no facet joint fusion device exists except translaminar facet joint screws, which are ineffective as stand-alone devices and entail a higher degree of risk of neurologic injury. This invention is a spinal implant that serves as a facet joint fusion device. Additionally, it may operate as a router to remove articular cartilage of facet joints in preparation for fusion....
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Stanford University
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Minimum Power or Minimum-cost MRI Gradient Coils
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A very flexible method for designing electromagnets which produce an arbitrary magnetic field. The conductors of the magnet can be constrained to an arbitrary surface or volume. The method provides the lowest power (or shortest wire-length) design given constraints on the desired magnetic field and constraints on where the coils can be located with respect to the desired magnetic field. The method...
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Stanford University
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Molecular-Transfer Lithography
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This invention introduces a new low cost contact based lithography method that provides high resolution capability and addresses the particulate contamination issues in the lithography that affect the subsequent processing steps such as etching process. The lithography is performed by adding an intermediate buffer process and tool to the conventional infrastructure of mask making and exposure tech...
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Stanford University
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Monitoring of Cardiac Dysfunction
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Acute myocardial infarction, in which an artery feeding the heart suddenly becomes blocked, can be successfully treated if therapy is initiated early. Treatment within the first 70 minutes has been associated with an 86% decrease in in-hospital mortality for these patients. Unfortunately, patients usually delay getting to the hospital because they do not believe the symptoms warrant emergency care...
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Stanford University
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Morphometric Measurement Tool
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This invention uses a morphometric model to provide a rapid, accurate, and reproducible method for predicting whether patients have Obstructive Sleep Apnea Syndrome (OSAS). The morphometric model combines measurements of the oral cavity with body mass index and neck circumference and may be clinically useful as a screening tool for OSAS. ...
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Stanford University
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MRI with Table Motion and Coil Array
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In a magnetic resonance imaging system, an extended field of view through an object is realized with a magnet having a smaller homogeneous field of view by translating the object through the homogeneous field while exciting nuclear spins within the object and detecting MRI signals with a plurality of coils which translate through the homogeneous field with the object. In a preferred embodiment, th...
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