|
Stanford University
|
3D Bronchial Morphology Analysis Package
|
|
|
This integrated software package enables a user to perform registration, 3D localization and visualization and automated measurement and archiving of the bronchial morphology in serial volumetric CT scans.The software package consists of a Windows compatible front-end optimized to perform the bronchial analysis tasks in a multi-processor environment. It is integrated with a database to store patie...
|
 |
|
|
|
|
Stanford University
|
A Bipolar Magnet Configuration
|
|
|
Biplanar, symmetrical electromagnets for providing a homogeneous magnetic field. The magnets have coils disposed in two parallel planes. The coils in the two planes are identical. The radii and Ampere-turns of the coils are selected so that a magnetic field between the planes is homogeneous. One preferred embodiment has 6 coils, with 3 coils in each plane. Other embodiments have 8, 10, 12, or more...
|
|
|
|
|
|
|
University of California, Irvine
|
A Diffusive Probe for Quantification of Optical Properties of Superficial Layers
|
|
|
Researchers at the University of California have developed a fiber-based spectroscopic technique that can be used to quantify optical properties in superficial layers of tissue. In the past, quantitative characterization of superficial epithelial tissues such as skin and oral mucosa has been difficult due to the limiting assumptions in the models that are employed to describe light propagation in ...
|
|
|
|
|
|
|
Stanford University
|
A Live Cell Fluorescent Mitosis Biosensor
|
|
|
Professor Tobias Meyer, Joshua Jones, and Angie Hahn at Stanford have developed the first live cell biosensor-based fluorescent imaging strategy to quantitatively analyze the timing of the cell cycle phases, M, G1, S, and G2. The cell cycle is a tightly regulated cellular process and failure at critical checkpoints within often results in genetic instability and eventually, cancer. In high content...
|
|
|
|
|
|
|
University of California, San Diego
|
A Macromolecular Carrier for Medical Imaging and Diagnostics
|
|
|
Description: A UCSD researcher has developed a new macromolecular carrier having hundreds of leashes for readily attaching imaging agents and substrates. The attached substrate directs the carrier to specific tissues so that the attached imaging agent can ...
|
|
|
|
|
|
|
Stanford University
|
A Method and Apparatus for Performing Adaptive or Tunable Multi-Spectral Imaging
|
|
|
This invention introduces a method and system to detect a predefined object-of-interest irrespective of illumination by compensating for the unwanted effects of the ambient light. This novel method provides an adaptive imager, which reports only the required data versus existing methods that provide highly redundant information, rely on post-processing for detection of the object-of-interest and t...
|
|
|
|
|
|
|
Stanford University
|
A method for editing mesh structures at sub-element accuracy: Brain Imaging
|
|
|
This invention enables interactive editing of 3D surfaces, both smooth and irregular. It allows users to easily define sub-surfaces of a structure's surface. The user can then select, cut and manipulate sub-surfaces, or can project the extent of sub-surfaces onto 2D views of the structure, independent of the structure's representation. A software tool in JAVA has been developed and deployed in bre...
|
|
|
|
|
|
|
Stanford University
|
A Method for larger Field of View in CT
|
|
|
The present invention provides improved CT systems and methods that enjoy substantially increased FOV. The diameter of the in-plane FOV of CT systems according to the present invention can be larger than the in-plane extent of the detector (or source) array. Stanford scientists have created a method that provides CT systems with increased FOV without the expense and complication of larger detector...
|
|
|
|
|
|
|
Stanford University
|
A New Regime for Operating Capacitive Micromachined Ultrasonic Transducers
|
|
|
This invention is a novel operation regime for capacitive micromachined ultrasonic transducers (cMUTs). Its method allows the center of the membrane to be in constant contact with the substrate.Traditionally, cMUTs are operated at a bias voltage lower than the collapse voltage of their membrane. The method of this invention produces a higher electromechanical coupling efficiency than that of a cMU...
|
|
|
|
|
|
|
University of California, San Francisco
|
A NOVEL METHOD FOR MEASURING TISSUE PERFUSION (SF2005-067)
|
|
|
Measurements of tissue perfusion are critical forunderstanding physiological changes in the human body. For example,detection of abnormal perfusion may indicate pathological processesat an early stage, thereby preempting irreversible tissue damage.Perfusion measurements may also help to stage and predict diseaseprogression as well as monitor a patient’s response to treatment.
Current...
|
|
|
|
|
|
|
|
|
|
|
Stanford University
|
A Novel System of Image Guidance for Minimally Invasive Medical Interventions
|
|
|
5,000,000 people worldwide have Atrial Fibrillation with another 240,000 diagnosed every year. Catheter based ablation procedures offer a cure for this problem, with 7,500 performed last year alone. According to Frost and Sullivan, this two billion dollar market is predicted to experience 6-9% annual growth. More rapid growth is limited by poor efficacy (<70%), long procedure time (2-6 hrs), an...
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
University of California, San Francisco
|
A VISUAL TECHNIQUE FOR RADIOGUIDED SURGERY
|
|
|
Radioguidedsurgery allows surgeons to identify and resect tissues suspectedof metastatic involvement which are impossible to identify withother techniques. Researchers at UCSF have invented a device togreatly improve the surgeon's ability to locate the distributionof radiation emission with the anatomy of the patient by a uniquevisual technique. This invention can be applied to an intraoperativesi...
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
California Institute of Technology
|
Active pixel sensor array with multiresolution readout
|
|
|
An imaging device formed as a monolithic complementary metal oxide semiconductor integrated circuit in an industry standard complementary metal oxide semiconductor process, the integrated circuit including a focal plane array of pixel cells, each one of th...
|
|
|
|
|
|
|
California Institute of Technology
|
Active pixel sensor array with simple floating gate pixels
|
|
|
An imaging device formed as a monolithic complementary metal oxide semiconductor integrated circuit in an industry standard complementary metal oxide semiconductor process, the integrated circuit including a focal plane array of pixel cells, each one of th...
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
California Institute of Technology
|
Active pixel sensor with intra-pixel charge transfer
|
|
|
An imaging device formed as a monolithic complementary metal oxide semiconductor integrated circuit in an industry standard complementary metal oxide semiconductor process, the integrated circuit including a focal plane array of pixel cells, each one of th...
|
|
|
|
|
|
|
California Institute of Technology
|
Active pixel sensor with intra-pixel charge transfer
|
|
|
An imaging device formed as a monolithic complementary metal oxide semiconductor integrated circuit in an industry standard complementary metal oxide semiconductor process, the integrated circuit including a focal plane array of pixel cells, each one of th...
|
|
|
|
|
|
|
California Institute of Technology
|
Active pixel sensor with intra-pixel charge transfer
|
|
|
An imaging device formed as a monolithic complementary metal oxide semiconductor integrated circuit in an industry standard complementary metal oxide semiconductor process, the integrated circuit including a focal plane array of pixel cells, each one of th...
|
|
|
|
|
|
|
California Institute of Technology
|
Active pixel sensor with intra-pixel charge transfer
|
|
|
An imaging device formed as a monolithic complementary metal oxide semiconductor integrated circuit in an industry standard complementary metal oxide semiconductor process, the integrated circuit including a focal plane array of pixel cells, each one of th...
|
|
|
|
|
|
|
California Institute of Technology
|
Active pixel sensor with intra-pixel charge transfer
|
|
|
An imaging device formed as a monolithic complementary metal oxide semiconductor integrated circuit in an industry standard complementary metal oxide semiconductor process, the integrated circuit including a focal plane array of pixel cells, each one of th...
|
|
|
|
|
|
|
California Institute of Technology
|
Active pixel sensor with intra-pixel charge transfer
|
|
|
An imaging device formed as a monolithic complementary metal oxide semiconductor integrated circuit in an industry standard complementary metal oxide semiconductor process, the integrated circuit including a focal plane array of pixel cells, each one of th...
|
|
|
|
|
|
|
|
|
|
|
Stanford University
|
Adaptive Pixel for High Dynamic Range and Disturbance Detection and Correction
|
|
|
The invention describes a focal-plane array architecture for imaging very wide dynamic range scenes and the detection of sudden surges of illumination, e.g., due to pulsed laser. The proposed architecture comprises a per-pixel Analog Front End (AFE), a fine ADC stage, and a Digital Signal Processor/Controller (DSPC) stage. The AFE performs programmable gain amplification (PGA) and disturbance dete...
|
|
|
|
|
|
|
Stanford University
|
Addressing CMUT Arrays
|
|
|
Capacitive micromachined ultrasound transducers (CMUT) have recently emerged as a viable alternative to traditional piezoelectric transducers. Conventionally, a CMUT array is fabricated on the front side of a silicon substrate. However, conventional arrangements of the CMUT arrays make inefficient use of the surface area on the front side of the silicon substrate, and require long routing lines to...
|
|
|
|
|
|
|
California Institute of Technology
|
Advanced x-ray imaging spectrometer
|
|
|
An x-ray spectrometer that also provides images of an x-ray source. Coded aperture imaging techniques are used to provide high resolution images. Imaging position-sensitive x-ray sensors with good energy resolution are utilized to provide excellent spectro...
|
|
|
|
|
|
|
University of California, Los Angeles
|
Algorithmic Method for NIR Image Reconstruction
|
|
|
A new algorithm is available that effectively enables the non-invasive imaging of human tissue using near infrared (NIR) light. This algorithm enables the reconstruction of position-dependent optical absorption coefficients in the NIR region (700-800nm). It provides the basis for a new method of NIR image reconstruction and the development of commercially successful NIR scanner systems with impr...
|
|
|
|
|
|
|
Stanford University
|
Alignment of Nanotubes by Beam of Particles
|
|
|
This is a method to align carbon nanotubes and other similar thin nanostructures in a desired direction using a beam of particles. The nanostructures are aligned towards the source of the beam, which is used to determine the direction of alignment precisely. The major impact of this method will be in applications where nanotubes and similar nanostructures of a precise alignment are needed. Scannin...
|
|
|
|
|
|
|
University of California, Berkeley
|
An Automated System For Three-Dimensional Histological Imaging
|
|
|
Researchers at the University of California, Berkeley have developed an automated three-dimensional imaging system that provides an efficient, high-resolution method of creating complete volumetric reconstructions of biological tissues containing histological information in the form of fluorochrome labels.Alternatively, samples may be individually processed by the automated system using a histolog...
|
|
|
|
|
|
|
University of California, Berkeley
|
An Automated System For Three-Dimensional Histological Imaging
|
|
|
Researchers at the University of California, Berkeley have developed an automated three-dimensional imaging system that provides an efficient, high-resolution method of creating complete volumetric reconstructions of biological tissues containing histological information in the form of fluorochrome labels.Alternatively, samples may be individually processed by the automated system using a histolog...
|
|
|
|
|
|
|
University of California, Berkeley
|
An Automated System For Three-Dimensional Histological Imaging
|
|
|
Researchers at the University of California, Berkeley have developed an automated three-dimensional imaging system that provides an efficient, high-resolution method of creating complete volumetric reconstructions of biological tissues containing histological information in the form of fluorochrome labels.Alternatively, samples may be individually processed by the automated system using a histolog...
|
|
|
|
|
|
|
University of California, Berkeley
|
An Automated System For Three-Dimensional Histological Imaging
|
|
|
Researchers at the University of California, Berkeley have developed an automated three-dimensional imaging system that provides an efficient, high-resolution method of creating complete volumetric reconstructions of biological tissues containing histological information in the form of fluorochrome labels.Alternatively, samples may be individually processed by the automated system using a histolog...
|
|
|
|
|
|
|
University of California, Berkeley
|
An Automated System For Three-Dimensional Histological Imaging
|
|
|
Researchers at the University of California, Berkeley have developed an automated three-dimensional imaging system that provides an efficient, high-resolution method of creating complete volumetric reconstructions of biological tissues containing histological information in the form of fluorochrome labels.Alternatively, samples may be individually processed by the automated system using a histolog...
|
|
|
|
|
|
|
University of California, Berkeley
|
An Automated System For Three-Dimensional Histological Imaging
|
|
|
Researchers at the University of California, Berkeley have developed an automated three-dimensional imaging system that provides an efficient, high-resolution method of creating complete volumetric reconstructions of biological tissues containing histological information in the form of fluorochrome labels.Alternatively, samples may be individually processed by the automated system using a histolog...
|
|
|
|
|
|
|
Stanford University
|
An Integrated Bioluminescent Detection System for Biological Applications
|
|
|
Future biological studies will require very high throughput and integration of different systems. However, current biological assays are highly repetitive, labor intensive and require tiny volume samples prepared. Current detection methods employ CCD (Charged-Coupled Device) - based imaging systems that are bulky, expensive and slow. This novel invention integrates the assay, detection and analysi...
|
|
|
|
|
|
|
University of California, Los Angeles
|
Animal Imaging Chamber for Reproducible Positioning in Repetitive and Cross-platform Imaging
|
|
|
Magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), single-photon emission computed tomography (SPECT), and optical imaging have become useful and standard tools for researchers to non-invasively monitor physiological, anatomical, and molecular events in living animals. In vivo imaging provides important information into disease development, therapeutic...
|
|
|
|
|
|
|
University of California, Los Angeles
|
Anti-Sense Oligonucleotide Targeted Prophylactic and Chemotherapeutic Agent Against Mycobacterium Tuberculosis
|
|
|
As Mycobacterium tuberculosis develops resistance to conventional antibiotics used to treat disease, new strategies of prevention and therapy are needed.Previously it was not known that antisense oligonucleotides directed against mRNA of genes encoding M. tuberculosis proteins could be used therapeutically or prophylactically. Researchers at UCLA have demonstrated that several different antisens...
|
|
|
|
|
|
|
California Institute of Technology
|
Aperture coded camera for three dimensional imaging
|
|
|
A three-dimensional imaging system uses apertures through which images are projected. The image through each aperture is obtained by a different camera element. The camera elements can be totally physically separate, multiple receiving parts of a single ca...
|
|
|
|
|
|
|
|
|
|
|
Stanford University
|
Application of Nano Carbons and Nano Carbon Tubes to Create Intravascular Devices
|
|
|
This invention provides applications for the use of nano carbon architectures, such as carbon nanotubes, as backbone structures for intravascular prothesis. These applications include the implantation of carbon nanotubes for the support, replacement, or bypass of compromised vascular tissues. In addition, this invention describes the use nanotubes as delivery vehicles for biological and non biolog...
|
|
|
|
|
|
|
Stanford University
|
Asymmetric Minimum-Cost MRI Magnet
|
|
|
A homogeneous field electromagnet having at least two coils in each of two regions. One region has a smaller inner radius than the other region so that the magnet is asymmetrical. The magnet has coils with a smaller radius on one side compared to the other side. This provides the benefit of allowing the magnet to be shorter for a given field of view size (compared to a uniform-radius cylindrical m...
|
|
|
|
|
|
|
|
|
|
|
University of California, Los Angeles
|
Automated Intelligent Image Slice Selector
|
|
|
Advances in imaging, particularly in magnetic resonance imaging (MRI), during the past two decades have provided an unparalleled view into human anatomy and function and the understanding of the disease state. At the same time, however, a massive amount of data created by this technology has resulted in "information overload" for physicians to view these studies. There are in principle several pr...
|
|
|
|
|
|
|
University of California, Los Angeles
|
Automated Intelligent Image Slice Selector
|
|
|
Advances in imaging, particularly in magnetic resonance imaging (MRI), during the past two decades have provided an unparalleled view into human anatomy and function and the understanding of the disease state. At the same time, however, a massive amount of data created by this technology has resulted in "information overload" for physicians to view these studies. There are in principle several pr...
|
|
|
|
|
|
|
University of California, Irvine
|
Automated, Programmable, High Throughput, Multiplexed Assay System for Cellular and Biological Assays
|
|
|
Researchers at the University of California have developed a method and apparatus for performing automated, programmable, high-throughput analysis of adherent cells. It uses microscopic structures (cell pallets) patterned in such a manner so that adherent cells can plate against them. These structures are designed to provide a portable scaffolding for one or more adherent cells to be stored or car...
|
|
|
|
|
|
|
University of California, Berkeley
|
Axial Light-Force Sensor
|
|
|
Commercially available optical tweezers can move objects using laser light, but they are generally not used to measure forces exerted on those objects, since accurate force calibration is difficult. Research in the field of optical trapping has led to the development of optical tweezers that measure forces (transverse to optic axis) by changes in light-momentum. Force calibration is greatly simpli...
|
|
|
|
|
|
|
University of California, Berkeley
|
Axial Light-Force Sensor
|
|
|
Commercially available optical tweezers can move objects using laser light, but they are generally not used to measure forces exerted on those objects, since accurate force calibration is difficult. Research in the field of optical trapping has led to the development of optical tweezers that measure forces (transverse to optic axis) by changes in light-momentum. Force calibration is greatly simpli...
|
|
|
|
|
|
|
University of California, Berkeley
|
Axial Light-Force Sensor
|
|
|
Commercially available optical tweezers can move objects using laser light, but they are generally not used to measure forces exerted on those objects, since accurate force calibration is difficult. Research in the field of optical trapping has led to the development of optical tweezers that measure forces (transverse to optic axis) by changes in light-momentum. Force calibration is greatly simpli...
|
|
|
|
|
|
|
University of California, Berkeley
|
Axial Light-Force Sensor
|
|
|
Commercially available optical tweezers can move objects using laser light, but they are generally not used to measure forces exerted on those objects, since accurate force calibration is difficult. Research in the field of optical trapping has led to the development of optical tweezers that measure forces (transverse to optic axis) by changes in light-momentum. Force calibration is greatly simpli...
|
|
|
|
|
|
|
University of California, Berkeley
|
Axial Light-Force Sensor
|
|
|
Commercially available optical tweezers can move objects using laser light, but they are generally not used to measure forces exerted on those objects, since accurate force calibration is difficult. Research in the field of optical trapping has led to the development of optical tweezers that measure forces (transverse to optic axis) by changes in light-momentum. Force calibration is greatly simpli...
|
|
|
|
|
|
|
University of California, Berkeley
|
Axial Light-Force Sensor
|
|
|
Commercially available optical tweezers can move objects using laser light, but they are generally not used to measure forces exerted on those objects, since accurate force calibration is difficult. Research in the field of optical trapping has led to the development of optical tweezers that measure forces (transverse to optic axis) by changes in light-momentum. Force calibration is greatly simpli...
|
|
|
|
|
|
|
University of California, Berkeley
|
Axial Light-Force Sensor
|
|
|
Commercially available optical tweezers can move objects using laser light, but they are generally not used to measure forces exerted on those objects, since accurate force calibration is difficult. Research in the field of optical trapping has led to the development of optical tweezers that measure forces (transverse to optic axis) by changes in light-momentum. Force calibration is greatly simpli...
|
|
|
|
|
|
|
University of California, Berkeley
|
Axial Light-Force Sensor
|
|
|
Commercially available optical tweezers can move objects using laser light, but they are generally not used to measure forces exerted on those objects, since accurate force calibration is difficult. Research in the field of optical trapping has led to the development of optical tweezers that measure forces (transverse to optic axis) by changes in light-momentum. Force calibration is greatly simpli...
|
|
|
|
|
|
|
University of California, Davis
|
BIFUNCTIONAL CHELATORS FOR RADIODIAGNOSIS/ THERAPY AND METHOD FOR THEIR EFFICIENT RADIOLABELING
|
|
|
BACKGROUND: Bifunctional chelating agents (BCAs) containreactive groups capable of both attaching to monoclonal antibodies(mAbs) and chelating metallic radioisotopes.SuchmAb-BCA-radioisotope complexes are used to detect cancer cells andto target cancer cells for therapeutic purposes. Although the mAbsare specific to cancer cells, the mAb-BCA-radioisotope complexescan also bind to non-cancer cell...
|
|
|
|
|
|
|
University of California, Berkeley
|
Biocompatible Nanostructures for Ultrasensitive Biomolecular Sensors and Cellular Imaging
|
|
|
A variety of nanostructures have been developed for use in biomolecular detection. The nanosphere is the most widely used structure because of unique, highly desirable properties that make it a superior detection platform for life science research, in vitro diagnostic testing, and in vivo imaging. Other structures such as nanotips, nanorings, and nanocups have also been demonstrated for use in hig...
|
|
|
|
|
|
|
University of California, Berkeley
|
Biocompatible Nanostructures for Ultrasensitive Biomolecular Sensors and Cellular Imaging
|
|
|
A variety of nanostructures have been developed for use in biomolecular detection. The nanosphere is the most widely used structure because of unique, highly desirable properties that make it a superior detection platform for life science research, in vitro diagnostic testing, and in vivo imaging. Other structures such as nanotips, nanorings, and nanocups have also been demonstrated for use in hig...
|
|
|
|
|
|
|
University of California, Berkeley
|
Biocompatible Nanostructures for Ultrasensitive Biomolecular Sensors and Cellular Imaging
|
|
|
A variety of nanostructures have been developed for use in biomolecular detection. The nanosphere is the most widely used structure because of unique, highly desirable properties that make it a superior detection platform for life science research, in vitro diagnostic testing, and in vivo imaging. Other structures such as nanotips, nanorings, and nanocups have also been demonstrated for use in hig...
|
|
|
|
|
|
|
University of California, Berkeley
|
Biocompatible Nanostructures for Ultrasensitive Biomolecular Sensors and Cellular Imaging
|
|
|
A variety of nanostructures have been developed for use in biomolecular detection. The nanosphere is the most widely used structure because of unique, highly desirable properties that make it a superior detection platform for life science research, in vitro diagnostic testing, and in vivo imaging. Other structures such as nanotips, nanorings, and nanocups have also been demonstrated for use in hig...
|
|
|
|
|
|
|
University of California, Berkeley
|
Biocompatible Nanostructures for Ultrasensitive Biomolecular Sensors and Cellular Imaging
|
|
|
A variety of nanostructures have been developed for use in biomolecular detection. The nanosphere is the most widely used structure because of unique, highly desirable properties that make it a superior detection platform for life science research, in vitro diagnostic testing, and in vivo imaging. Other structures such as nanotips, nanorings, and nanocups have also been demonstrated for use in hig...
|
|
|
|
|
|
|
University of California, Berkeley
|
Biocompatible Nanostructures for Ultrasensitive Biomolecular Sensors and Cellular Imaging
|
|
|
A variety of nanostructures have been developed for use in biomolecular detection. The nanosphere is the most widely used structure because of unique, highly desirable properties that make it a superior detection platform for life science research, in vitro diagnostic testing, and in vivo imaging. Other structures such as nanotips, nanorings, and nanocups have also been demonstrated for use in hig...
|
|
|
|
|
|
|
University of California, Berkeley
|
Biocompatible Nanostructures for Ultrasensitive Biomolecular Sensors and Cellular Imaging
|
|
|
A variety of nanostructures have been developed for use in biomolecular detection. The nanosphere is the most widely used structure because of unique, highly desirable properties that make it a superior detection platform for life science research, in vitro diagnostic testing, and in vivo imaging. Other structures such as nanotips, nanorings, and nanocups have also been demonstrated for use in hig...
|
|
|
|
|
|
|
University of California, Berkeley
|
Biomimetically Inspired Artificial Compound Eyes
|
|
|
Compound eyes in nature have been one of the most studied and intriguing topics in physiological optics due to their unique optical scheme for imaging. Hundreds to ten thousands of integrated optical units called ommatidia are spherically arranged along a curvilinear surface and point in different directions. Each ommatidium collects light within a small angular acceptance and collectively they co...
|
|
|
|
|
|
|
University of California, Berkeley
|
Biomimetically Inspired Artificial Compound Eyes
|
|
|
Compound eyes in nature have been one of the most studied and intriguing topics in physiological optics due to their unique optical scheme for imaging. Hundreds to ten thousands of integrated optical units called ommatidia are spherically arranged along a curvilinear surface and point in different directions. Each ommatidium collects light within a small angular acceptance and collectively they co...
|
|
|
|
|
|
|
University of California, Berkeley
|
Biomimetically Inspired Artificial Compound Eyes
|
|
|
Compound eyes in nature have been one of the most studied and intriguing topics in physiological optics due to their unique optical scheme for imaging. Hundreds to ten thousands of integrated optical units called ommatidia are spherically arranged along a curvilinear surface and point in different directions. Each ommatidium collects light within a small angular acceptance and collectively they co...
|
|
|
|
|
|
|
University of California, Berkeley
|
Biomimetically Inspired Artificial Compound Eyes
|
|
|
Compound eyes in nature have been one of the most studied and intriguing topics in physiological optics due to their unique optical scheme for imaging. Hundreds to ten thousands of integrated optical units called ommatidia are spherically arranged along a curvilinear surface and point in different directions. Each ommatidium collects light within a small angular acceptance and collectively they co...
|
|
|
|
|
|
|
University of California, Berkeley
|
Biomimetically Inspired Artificial Compound Eyes
|
|
|
Compound eyes in nature have been one of the most studied and intriguing topics in physiological optics due to their unique optical scheme for imaging. Hundreds to ten thousands of integrated optical units called ommatidia are spherically arranged along a curvilinear surface and point in different directions. Each ommatidium collects light within a small angular acceptance and collectively they co...
|
|
|
|
|
|
|
University of California, Berkeley
|
Biomimetically Inspired Artificial Compound Eyes
|
|
|
Compound eyes in nature have been one of the most studied and intriguing topics in physiological optics due to their unique optical scheme for imaging. Hundreds to ten thousands of integrated optical units called ommatidia are spherically arranged along a curvilinear surface and point in different directions. Each ommatidium collects light within a small angular acceptance and collectively they co...
|
|
|
|
|
|
|
University of California, Berkeley
|
Broad Bandwidth and Highly Reflective Gratings
|
|
|
Broadband mirrors with very high reflectivity are essential for applications such as telecommunications, surveillance, sensors and imaging. Among the various conventional mirror designs, metal mirrors have larger reflection bandwidths but lower reflectivities; as a result they are not suitable for fabricating transmission-type optical devices such as etalon filters. Dielectric distributed Bragg re...
|
|
|
|
|
|
|
University of California, Berkeley
|
Broad Bandwidth and Highly Reflective Gratings
|
|
|
Broadband mirrors with very high reflectivity are essential for applications such as telecommunications, surveillance, sensors and imaging. Among the various conventional mirror designs, metal mirrors have larger reflection bandwidths but lower reflectivities; as a result they are not suitable for fabricating transmission-type optical devices such as etalon filters. Dielectric distributed Bragg re...
|
|
|
|
|
|
|
University of California, Berkeley
|
Broad Bandwidth and Highly Reflective Gratings
|
|
|
Broadband mirrors with very high reflectivity are essential for applications such as telecommunications, surveillance, sensors and imaging. Among the various conventional mirror designs, metal mirrors have larger reflection bandwidths but lower reflectivities; as a result they are not suitable for fabricating transmission-type optical devices such as etalon filters. Dielectric distributed Bragg re...
|
|
|
|
|
|
|
University of California, Berkeley
|
Broad Bandwidth and Highly Reflective Gratings
|
|
|
Broadband mirrors with very high reflectivity are essential for applications such as telecommunications, surveillance, sensors and imaging. Among the various conventional mirror designs, metal mirrors have larger reflection bandwidths but lower reflectivities; as a result they are not suitable for fabricating transmission-type optical devices such as etalon filters. Dielectric distributed Bragg re...
|
|
|
|
|
|
|
University of California, Berkeley
|
Broad Bandwidth and Highly Reflective Gratings
|
|
|
Broadband mirrors with very high reflectivity are essential for applications such as telecommunications, surveillance, sensors and imaging. Among the various conventional mirror designs, metal mirrors have larger reflection bandwidths but lower reflectivities; as a result they are not suitable for fabricating transmission-type optical devices such as etalon filters. Dielectric distributed Bragg re...
|
|
|
|
|
|
|
University of California, Berkeley
|
Broad Bandwidth and Highly Reflective Gratings
|
|
|
Broadband mirrors with very high reflectivity are essential for applications such as telecommunications, surveillance, sensors and imaging. Among the various conventional mirror designs, metal mirrors have larger reflection bandwidths but lower reflectivities; as a result they are not suitable for fabricating transmission-type optical devices such as etalon filters. Dielectric distributed Bragg re...
|
|
|
|
|
|
|
University of California, Irvine
|
Broadband Absorption Spectroscopy In Turbid Media By Combining Frequency-Domain And Steady State Methods
|
|
|
Reflectance spectroscopy is a technique for characterizing turbid media that has become widely used in medical diagnostics. The University has developed a technique for measuring broadband near-infrared absorption spectra of turbid media that uses a combination of frquency-domain (FD) and steady-state (SS) reflectance methods. Most of the wavelength coverage is provided by a white-light SS measure...
|
|
|
|
|
|
|
Stanford University
|
Bronchoscopic Anesthesia Device
|
|
|
Bronchoscopy is a procedure performed to capture images of the bronchus. These images allow for visualization of inflammation and unusual tissue growth in the trachea.This device addresses a common problem with performing bronchoscopy, which is the patient's natural reaction of coughing caused by stimulation of the tracheal tract. Coughing also causes the bronchoscope to need to be removed and len...
|
|
|
|
|
|
|
California Institute of Technology
|
Bubble imaging technology
|
|
|
A method and apparatus for producing an image defined by fluid bubbles in a medium fluid. Alphanumeric digits and/or graphic images in a fluid medium are formed by injecting into the fluid medium a multitude of fluid bubbles having a density different than...
|
|
|
|
|
|
|
Stanford University
|
Capillary for Optical Imaging
|
|
|
This invention introduces a novel capillary that is implanted into an animals body to serve as an imaging guide. An endoscope inserted into the capillary can be used to image deep tissue structures in living animals. Because the capillary remains fixed in place, the endoscope can probe the same location of the animal's body on repeating imaging sessions. This will provide the capability of imaging...
|
|
|
|
|
|
|
|
|
|
|
Stanford University
|
Catalyzing the Transient Response
|
|
|
A steady-state condition for tipped nuclear spins is accelerated or catalyzed by first determining magnetization magnitude of the steady state and the scaling magnetization along one axis (Mz) to at least approximate the determined magnetization magnitude. Then the scaled magnetization is rotated to coincide with a real-valued eigenvector extension of the tipped steady-state magnetization. Any err...
|
|
|
|
|
|
|
Stanford University
|
Catheter-Based Three-Dimensional Ultrasonic Imaging
|
|
|
This invention is a significantly improved system of methods and devices for obtaining three-dimensional images of an internal body site. The nature of the devices allows for radially wide three-dimensional images to be obtained in real time from a device that has a low profile during introduction to the body site of interest. ...
|
|
|
|
|
|
|
California Institute of Technology
|
CCD imaging sensor with flashed backside metal film
|
|
|
A backside illuminated CCD imaging sensor for reading out image charges from wells of the array of pixels is significantly improved for blue, UV, far UV and low energy x-ray wavelengths (1-5000.ANG.) by so overthinning the backside as to place the depletio...
|
|
|
|
|
|
|
California Institute of Technology
|
CCD imaging sensors
|
|
|
A method for promoting quantum efficiency (QE) of a CCD imaging sensor for UV, far UV and low energy x-ray wavelengths by overthinning the back side beyond the interface between the substrate and the photosensitive semiconductor material, and flooding the ...
|
|
|
|
|
|
|
University of California, Davis
|
Cell-Growth-On-Bead Assay
|
|
|
A novel “cell-growth-on-bead� assay for screening epithelial cells that attach and proliferate on beads conjugated with specific compounds such as peptides has been developed by scientists at the University of California, Davis.This assay has been shown to exhibit high sensitivity and specificity in the following applications:
Screening compound-bead librarie...
|
|
|
|
|
|
|
California Institute of Technology
|
Center of mass detection via an active pixel sensor
|
|
|
An imaging system for identifying the location of the center of mass ("COM") in an image. In one aspect, an imaging system includes a plurality of photosensitive elements arranged in a matrix. A center of mass circuit coupled to the photosensitive elements...
|
|
|
|
|
|
|
Stanford University
|
Characterization and Correction of Spatial Gradient Field Nonuniformities
|
|
|
This invention is a novel method to characterize and correct for spatial gradient field non-uniformities in diffusion imaging with a special focus on diffusion tensor imaging. It can also be applied to fiber tracking, high-angular resolution diffusion imaging, and diffusion spectrum imaging. ...
|
|
|
|
|
|
|
Stanford University
|
Chronically Implantable Optical Imaging System
|
|
|
The implantable imaging system allows a minimally invasive imaging of brain neuronal activities through optical imaging of the brain for use in animal models for drug discovery as well as in humans for studies of disease progression and prosthetic limb control. This semiconductor based optical imaging array can be as small as few mm in size allowing studies of free behaving small animals like mice...
|
|
|
|
|
|
|
University of California, Los Angeles
|
Clinical Tool for Determining Anti-Aggregation Activity of Alzheimer's Therapeutics
|
|
|
Currently, there are more than twenty therapeutic agents in development for Alzheimer's disease. The tool to measure the therapeutic effectiveness of these agents, however, remains to be the standard memory test that measures memory loss, a late-stage symptom reflective of irreversible neuronal cell death. A more informative clinical tool is therefore needed to monitor the effect of therapy on di...
|
|
|
|
|
|
|
California Institute of Technology
|
CMOS active pixel sensor type imaging system on a chip
|
|
|
A single chip camera which includes an intergrated image acquisition portion and control portion and which has double sampling/noise reduction capabilities thereon. Part of the intergrated structure reduces the noise that is picked up during imaging....
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Stanford University
|
CMOS Image Sensor with Self Reset Pixel Architecture
|
|
|
By integrating image detection and processing on a single chip, CMOS sensors provide a great advantage over CCD sensors. However, as technology scales, the CMOS sensor's dynamic range and signal-to-noise ratio (SNR) decrease dramatically. The CMOS image sensor overcomes this effect by utilizing self-reset pixel architecture, in which pixels reset when their collected charge reaches well capacity. ...
|
|
|
|
|
|
|
|
|
|
|
Stanford University
|
CMOS Video Sensor System with Improved SNR under Low Illumination
|
|
|
Video sensors currently suffer from poor quality under low illumination, because the collected photocharge is small relative to system noise, resulting in low signal-to-noise ratio (SNR). Such systems further reduce image quality by performing "global reset"-the reset of all pixels at the beginning of each video frame-an action necessary to prevent pixel saturation. The CMOS video sensor system el...
|
|
|
|
|
|
|
Stanford University
|
CMUTS with Higher Mechanical Sensitivity
|
|
|
One aspect of this invention is a capacitive micromachined ultrasonic transducer with improved mechanical sensitivity. The invention pertains to elements of a 1-D or a 2-D array of cMUTs for high-resolution ultrasonic imaging and transduction. ...
|
|
|
|
|
|
|
University of California, Los Angeles
|
Collision Avoidance System
|
|
|
The problem of safely coordinating the motion of several agents has received a great deal of attention, both in robotics and for other applications. Most of the existing techniques require a central authority and/or can only be proven safe for a small number of agents. When looking at Air Traffic Control and other applications, the need for a decentralized system that is scalable to many agents i...
|
|
|
|
|
|
|
University of California, Irvine
|
Data Compression Of Time-Varying Images
|
|
|
Researchers at the University of California have developed a method of time-varying image compression which provides compression ratios of several hundred. Unlike spatial compression techniques, information on the pixel intensity values are only transmitted for intermittent frames. Between the intermittent frames, the invention compresses the image motion rather than the spatial pixel intensity di...
|
|
|
|
|
|
|
|
|
|
|
University of California, Irvine
|
Depth Profiling of the Skin Structure In Vivo
|
|
|
University researchers have developed a photoacoustic probe contained within a handpiece for use in contact with the skin. The laser pulses generate acoustic waves at the subsurface absorption sites. It is believed that no known use of photoacoustics has been used for this purpose in the past. Previous probes of skin structure include biopsy and histology, and optical and ultrasound measurements. ...
|
|
|
|
|
|
|
Stanford University
|
Design of Image Sensor Pixel in Dual Gate Oxide Deep Sub-Micron CMOS Process
|
|
|
Decreasing the size of CMOS image sensors lowers the cost of manufacturing and raises the spatial resolution of the images. However, the downscaling of CMOS circuits dramatically increases the leakage current and decreases dynamic range. This invention provides a design for a CMOS image sensor that reduces these undesirable effects by combining the use of both thin and thick gate oxide transistors...
|
|
|
|
|
|
|
University of California, Berkeley
|
DETECTION OF HOMOLOGOUS RECOMBINATION EVENTS BY ACTIVATION OF A CHIMERIC REPORTER GENE
|
|
|
Researchers at UC Berkeley have developed a method to simplify identification of meiotic unequal crossing-over of genes in a tandem array or from a multiple transgenic insertion . A synthetic RBCSB gene cluster was produced with a silent RBCS1B::LUC chimeric gene fusion, lacking all 5 transcription and translation signals, followed by RBCS2B and RBC3B genomic DNA. Expression of luciferase activity...
|
|
|
|
|
|
|
University of California, Davis
|
DETERMINATION OF GLOMERULAR FILTRATION RATE USING MAGNETIC RESONANCE IMAGING TECHNOLOGY
|
|
|
DESCRIPTION: Magnetic resonance imaging (MRI) has revolutionizedmedical technology by providing detailed images of human anatomyand offers the possibility of human physiologic assessments. However, the expansion of this technology into areas of biochemicaland physiological assessments has yet to be realized.With regards to renal diseases, MRI has not been widely usedbecause MRI assessments are p...
|
|
|
|
|
|
|
|
|
|
|
University of California, San Diego
|
DIAGNOSTIC IMAGING OF LYMPH STRUCTURES
|
|
|
Description: A UCSD researcher has developed a new method for identification of the first or sentinel lymph node that drains the tissue or organ, particularly those tissues associated with neoplastic or infectious diseases and disorders, and within the per...
|
|
|
|
|
|
|
University of California, Irvine
|
Diagnostic Method And Apparatus For Monitoring Thermal Mediated Laser Surgery In Situ
|
|
|
Researchers at the University of California have developed a method and apparatus to form two-dimensional tomographic images of optical birefringence in turbid biological tissue in situ. The method is based upon optical coherence tomography. The researchers have demonstrated the utility of this technique in monitoring laser surgery using bovine tendon tissues....
|
|
|
|
|
|
|
University of California, Davis
|
DIAGNOSTIC METHOD AND APPARATUS FOR MONITORING THERMAL-MEDIATED LASER SURGERY IN SITU
|
|
|
BACKGROUND: Birefringence spectra of tissue can provide physicians with detailedstructural images of turbid tissues, such as tendon tissue.Although methods exist to image thebirefringence of excised tissue specimens, these techniques require surgical remove of thespecimen and are limited by processing artifacts. DESCRIPTION: Researchers at the University of California have developed a method anda...
|
|
|
|
|
|
|
University of California, Irvine
|
Differential Diagnosis of Oral Pathologies
|
|
|
By analyzing certain specific characteristics of these and other oral pathologies, the University has developed a novel approach that provides non-invasive diagnosis and monitoring of the pathologies, thus avoiding the need for traumatic surgical biopsies, while allowing for earlier detection and optimization of treatments....
|
|
|
|
|
|
|
University of California, Los Angeles
|
Distributed Utility Optimization with Constrained Information and Communication
|
|
|
Structural biology at the molecular level is critical to the understanding of protein function, but determining protein structure can be a labor- and time-intensive procedure. While the "gold standard" for structure determination is x-ray crystallography, many protein molecules, particularly integral membrane proteins, are extremely difficult to crystallize. Indeed, most integral membrane protein...
|
|
|
|
|
|
|
Stanford University
|
Dual-Axis Confocal Microscope Having Improved Performance For Thick Samples
|
|
|
This invention provides a fiber optic coupled optical head for a dual axis confocal scanning microscope that can be miniaturized for clinical in-vivo imaging. This design allows high resolution and high speed imaging with an increased working distance that is advantageous for samples with significant thickness.The optical head comprises parts that provide multiple collimated input beams of differe...
|
|
|
|
|
|
|
University of California, Irvine
|
Early detection of Dental Caries Using Optical Coherence Tomography (OCT)
|
|
|
Researchers at the University of California, Irvine are investigating the use of Optical Coherence Tomography (OCT) as an in vivo, non-invasive modality for the diagnosis, preventive treatment, and therapy in patients with high caries risk, large numbers of poorly accessible restorations, or developmental abnormalities. The method involves scanning for dental caries with high-resolution real-time ...
|
|
|
|
|
|
|
University of California, Berkeley
|
Efficient On-Chip Sample Preparation
|
|
|
In conventional chemical and biological analysis the most time consuming and expensive steps involve sample preparation. Preparation of biological samples for on-chip analysis requires extraction of intracellular biomolecules, accomplished by various methods of cell lysis. Depending on the type of analysis to be performed, lysing may be done with detergents, thermal cycling, or irreversible electr...
|
|
|
|
|
|
|
University of California, Berkeley
|
Efficient On-Chip Sample Preparation
|
|
|
In conventional chemical and biological analysis the most time consuming and expensive steps involve sample preparation. Preparation of biological samples for on-chip analysis requires extraction of intracellular biomolecules, accomplished by various methods of cell lysis. Depending on the type of analysis to be performed, lysing may be done with detergents, thermal cycling, or irreversible electr...
|
|
|
|
|
|
|
University of California, Berkeley
|
Efficient On-Chip Sample Preparation
|
|
|
In conventional chemical and biological analysis the most time consuming and expensive steps involve sample preparation. Preparation of biological samples for on-chip analysis requires extraction of intracellular biomolecules, accomplished by various methods of cell lysis. Depending on the type of analysis to be performed, lysing may be done with detergents, thermal cycling, or irreversible electr...
|
|
|
|
|
|
|
University of California, Berkeley
|
Efficient On-Chip Sample Preparation
|
|
|
In conventional chemical and biological analysis the most time consuming and expensive steps involve sample preparation. Preparation of biological samples for on-chip analysis requires extraction of intracellular biomolecules, accomplished by various methods of cell lysis. Depending on the type of analysis to be performed, lysing may be done with detergents, thermal cycling, or irreversible electr...
|
|
|
|
|
|
|
University of California, Berkeley
|
Efficient On-Chip Sample Preparation
|
|
|
In conventional chemical and biological analysis the most time consuming and expensive steps involve sample preparation. Preparation of biological samples for on-chip analysis requires extraction of intracellular biomolecules, accomplished by various methods of cell lysis. Depending on the type of analysis to be performed, lysing may be done with detergents, thermal cycling, or irreversible electr...
|
|
|
|
|
|
|
University of California, Berkeley
|
Efficient On-Chip Sample Preparation
|
|
|
In conventional chemical and biological analysis the most time consuming and expensive steps involve sample preparation. Preparation of biological samples for on-chip analysis requires extraction of intracellular biomolecules, accomplished by various methods of cell lysis. Depending on the type of analysis to be performed, lysing may be done with detergents, thermal cycling, or irreversible electr...
|
|
|
|
|
|
|
Stanford University
|
Electrode Probes for Interventional MRI
|
|
|
In MRI, it is generally thought that a tuned receiver coil is needed to detect an MRI signal. This invention provides a method of using electrodes implanted in the tissue and impedance matched to the preamplifier to detect MRI signals. The tissue between the electrodes forms a parallel resistor capacitor that effectively closes the loop formed by the electrodes and feedwires. The sensitivity is de...
|
|
|
|
|
|
|
Stanford University
|
Electronically Scanned Acoustic Microscope
|
|
|
Acoustic microscopy has been an active area of research and commercial development over the past three decades. The purpose of acoustic microscopy is to obtain subsurface planar images of a material. Applications have ranged from non-destructive evaluation of manufactured parts to biological imaging. Researchers at Stanford have devised a method for scanning acoustic microscopy (SAM) that employs ...
|
|
|
|
|
|
|
University of California, Berkeley
|
Electrostatic Microactuator for Phase Micromirror Arrays
|
|
|
Micromirror arrays represent a huge market opportunity in a variety of sectors from optical displays, scanners and communication switches, to maskless lithography and optical spectroscopy. In the conventional design of these arrays, mirrors are mounted on tiltable cantilevers. However, in high frequency and analog applications a phased-mirror approach would be more useful. In this design, mirrors ...
|
|
|
|
|
|
|
University of California, Berkeley
|
Electrostatic Microactuator for Phase Micromirror Arrays
|
|
|
Micromirror arrays represent a huge market opportunity in a variety of sectors from optical displays, scanners and communication switches, to maskless lithography and optical spectroscopy. In the conventional design of these arrays, mirrors are mounted on tiltable cantilevers. However, in high frequency and analog applications a phased-mirror approach would be more useful. In this design, mirrors ...
|
|
|
|
|
|
|
University of California, Berkeley
|
Electrostatic Microactuator for Phase Micromirror Arrays
|
|
|
Micromirror arrays represent a huge market opportunity in a variety of sectors from optical displays, scanners and communication switches, to maskless lithography and optical spectroscopy. In the conventional design of these arrays, mirrors are mounted on tiltable cantilevers. However, in high frequency and analog applications a phased-mirror approach would be more useful. In this design, mirrors ...
|
|
|
|
|
|
|
University of California, Berkeley
|
Electrostatic Microactuator for Phase Micromirror Arrays
|
|
|
Micromirror arrays represent a huge market opportunity in a variety of sectors from optical displays, scanners and communication switches, to maskless lithography and optical spectroscopy. In the conventional design of these arrays, mirrors are mounted on tiltable cantilevers. However, in high frequency and analog applications a phased-mirror approach would be more useful. In this design, mirrors ...
|
|
|
|
|
|
|
University of California, Berkeley
|
Electrostatic Microactuator for Phase Micromirror Arrays
|
|
|
Micromirror arrays represent a huge market opportunity in a variety of sectors from optical displays, scanners and communication switches, to maskless lithography and optical spectroscopy. In the conventional design of these arrays, mirrors are mounted on tiltable cantilevers. However, in high frequency and analog applications a phased-mirror approach would be more useful. In this design, mirrors ...
|
|
|
|
|
|
|
University of California, Berkeley
|
Electrostatic Microactuator for Phase Micromirror Arrays
|
|
|
Micromirror arrays represent a huge market opportunity in a variety of sectors from optical displays, scanners and communication switches, to maskless lithography and optical spectroscopy. In the conventional design of these arrays, mirrors are mounted on tiltable cantilevers. However, in high frequency and analog applications a phased-mirror approach would be more useful. In this design, mirrors ...
|
|
|
|
|
|
|
University of California, Berkeley
|
Electrostatic Microactuator for Phase Micromirror Arrays
|
|
|
Micromirror arrays represent a huge market opportunity in a variety of sectors from optical displays, scanners and communication switches, to maskless lithography and optical spectroscopy. In the conventional design of these arrays, mirrors are mounted on tiltable cantilevers. However, in high frequency and analog applications a phased-mirror approach would be more useful. In this design, mirrors ...
|
|
|
|
|
|
|
Stanford University
|
Endoscopic Targeting Method and System
|
|
|
The invention provides a system for enhancing the ability of a surgeon to access a target site within a patient. The system includes a data file containing volumetric scan data of a region of the patient that includes the target site, a display device, and a movable imagining tool for producing on the display device, an image of visible patient structure seen by the tool. A computer in the system ...
|
|
|
|
|
|
|
Stanford University
|
Endothelial Cell Specific Markers
|
|
|
The vascular endothelium serves as the boundary between the systemic circulation and soft tissues and is involved in a number of pathological conditions. Angiogenesis, the formation of new blood vessels from existing vasculature, is initiated by endothelial cells and is a trademark of a number of these conditions including cardiovascular ischemia, inflammatory diseases, and cancers. In order to de...
|
|
|
|
|
|
|
Stanford University
|
Error-Minimizing Noise-Reduction System
|
|
|
A system to improve the signal to noise ratio derived from a plurality of measurements. Especially for material-selective x-ray and magnetic resonance cross-sectional and projection images.The issued patent for this technology,US4,827,528, can be viewed at: Error-minimizing noise-reduction system...
|
|
|
|
|
|
|
|
|
|
|
California Institute of Technology
|
Fabricating a hybrid imaging device
|
|
|
A hybrid detector or imager includes two substrates fabricated under incompatible processes. An array of detectors, such as charged-coupled devices, are formed on the first substrate using a CCD fabrication process, such as a buried channel or peristaltic ...
|
|
|
|
|
|
|
California Institute of Technology
|
Fabricating a hybrid imaging device
|
|
|
A hybrid detector or imager includes two substrates fabricated under incompatible processes. An array of detectors, such as charged-coupled devices, are formed on the first substrate using a CCD fabrication process, such as a buried channel or peristaltic ...
|
|
|
|
|
|
|
California Institute of Technology
|
Fabricating a hybrid imaging device having non-destructive sense nodes
|
|
|
A hybrid detector or imager includes two substrates fabricated under incompatible processes. An array of detectors, such as charged-coupled devices, are formed on the first substrate using a CCD fabrication process, such as a buried channel or peristaltic ...
|
|
|
|
|
|
|
University of Southern California
|
Fabrication of Broadband Graded Transducer Using Piezoelectric Partial Composites
|
|
|
Partial composite is a new type of piezoelectric material which can be easily manufactured. By using partial composites to make ultrasound transducers, it is much easier to obtain broad bandwidth. Broadband transducers satisfy the requirement of improved spatial resolution and offers the advantages of allowing better harmonic imaging. At the same time, the partial composite can be widely used in s...
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Stanford University
|
Feedback-Controlled Stagnation Point Device
|
|
|
The feedback-controlled stagnation point device provides researchers with a simple tool for indefinite observation time of samples on the microscale. The device, when coupled with an imaging system, allows one to study the behavior of an object (DNA molecule, vesicle, micelle, macromolecule, cell, nucleic acid/protein complex, or any general particle) for extremely long times, during which the env...
|
|
|
|
|
|
|
Stanford University
|
Fluorophores for Biological Imaging
|
|
|
Studying the activity of a single molecule within a biological system allows us to understand complex biological processes from a distance. Researchers at Stanford and Kent State have discovered a new, broad class of molecules that can be used to fluorescently label molecules of interest in vitro and in vivo. These fluorophores, consisting of an amine donor and a dicyanodihydrofuran (DCDHF), allow...
|
|
|
|
|
|
|
University of California, Los Angeles
|
Gesture-Driven User Interface for Medical Image Viewing
|
|
|
Conventional medical imaging workstations employ standard user-interface paradigms for interaction, including menu bars, tool palettes, keyboard strokes and specialized hardware devices. Use of such tools is distracting to the user and disruptive to the image viewing process. ...
|
|
|
|
|
|
|
University of California, Davis
|
GLUCOSE EMULATING RADIOPHARMACEUTICAL FOR CONVENTIONAL GAMMA CAMERA IMAGING
|
|
|
Glucose transport protein is present on every living cell'smembrane, and its concentration is up- and down-regulated with thecell's need for glucose. Thus a tracer of this transport protein isa tracer of glucose metabolism itself.Studies with radioactivefluordeoxyglucose, a glucose tracer in positron emission tomography(PET), show a unique utility for the diagnosis of most cancers, forindicating...
|
|
|
|
|
|
|
Stanford University
|
Gravitational Reference Sensor
|
|
|
Dr. Ke-Xun Sun and Professor Byer at Stanford University have developed an all reflective grating based Gravitational Reference Sensor (GRS). This invention provides a method with higher precision distance measurement and timing compared to existing capacitive sensing method. The implementation of grating as beam splitter results in reducing the background signal and consequently increasing the pr...
|
|
|
|
|
|
|
Stanford University
|
Harmonic Force Microscopy using Flexural Resonance
|
|
|
Harmonic cantilevers provide new contrast mechanism for imaging and characterizing surfaces on the nanoscale. When a harmonic cantilever is used as a replacement for a regular cantilever in tapping-mode Atomic Force Microscopy, energy is efficiently transferred from the fundamental vibration mode to a specific higher order mode of the harmonic cantilever. The vibrations of the higher mode, which c...
|
|
|
|
|
|
|
Stanford University
|
High Order Shimming Using Regularization Methods
|
|
|
This invention is a method of high order shimming in MRI which is robust to arbitrary regions of interest. For example, high order shimming has provided substantial benefit for MRI of the brain. ...
|
|
|
|
|
|
|
University of California, Irvine
|
High Resolution Optical Coherence Tomography Over a Greater Depth Range Using an Axicon Lens
|
|
|
Researchers at the University of CA have developed a scanning OCT system to overcome these limitations. The invention incorporates an axicon lens into the sample arm of the interferometer. Using this axicon lens, 10um or better lateral resolution is maintained over a focusing depth of at least 6 mm. Thus high lateral resolution is simultaneously achieved with a greater depth of focus. The technolo...
|
|
|
|
|
|
|
California Institute of Technology
|
High speed infrared imaging system and method
|
|
|
A system and method for radiation detection with an increased frame rate. A semi-parallel processing configuration is used to process a row or column of pixels in a focal-plane array in parallel to achieve a processing rate up to and greater than 1 million...
|
|
|
|
|
|
|
Stanford University
|
High Speed Videography
|
|
|
An improved technique for capturing and processing video of dynamic scenes using a collection of precisely timed video cameras. This system uses multiple synchronized image sensors with precise time delays to capture high-speed video. If the cameras are closely packed together, the system can be used as a continuously streaming high-speed camera. If the cameras are spread further apart, the system...
|
|
|
|
|
|
|
Stanford University
|
Holographic Data Storage Inventions
|
|
|
These are several related Holographic Data Storage issued patents that are available for licensing:US 4,988,153 - This invention provides a method for angularly multiplexing multiple images in a holographic storage media without the need for bulky, complex or costly optical components. The system utilizes an integrated, two-dimensional array of surface emitting lasers for holographic readout. Indi...
|
|
|
|
|
|
|
California Institute of Technology
|
Holographic imaging spectrometer
|
|
|
A holographic imaging spectrometer, apparatus, and/or method enables the projection of a two-dimensional (2D) slice (having spectral information) of a four-dimensional (4D) probing object. A 4D probing source object is illuminated to emit an optical field....
|
|
|
|
|
|
|
Stanford University
|
Homogeneous Electromagnet for Prepolarized MRI
|
|
|
Method of making Optimized electromagnets. The electromagnets have at least three coaxial coils and can be symmetric or asymmetric. The coils can be circular or elliptical. The electromagnets have a coil region in which the coils are located. The coil region can have a bore of any rotationally symmetric shape or any elliptical shape. The coil region is shaped to allow an object to access a predete...
|
|
|
|
|
|
|
University of California, Davis
|
HYBRID ANTI-SCATTER GRID/DETECTOR FOR X-RAY IMAGING
|
|
|
DESCRIPTION: X-ray detection is typically a two-step process.Anx-ray scintillation screen absorbs x-rays and emits visible light,and then a light sensitive receptor records the light image.Theanti-scatter grid is a separate component in the imaging chain thatis positioned between the object being imaged and the x-raydetector in order to reduce the amount of scattered radiationreaching the detect...
|
|
|
|
|
|
|
University of California, Berkeley
|
Hybridoma BP102 Producing Monoclonal Antibodies Specific for Axons of the Drosophila Central Nervous System
|
|
|
This invention relates to the development of monoclonal antibodies that enable the detection of defects in neural development in Drosophila. The antibody shows strong specificity for axons with no staining of neuron cell bodies, the PNS, or other embryo tissues. Specificity is retained after glutaraldehyde treatment but is lost with periodate, indicating that the antibody likely recognizes a carbo...
|
|
|
|
|
|
|
University of California, San Diego
|
HYPERECHO DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING
|
|
|
SUMMARY: UCSD researchers have developed a hybrid method for analyzing diffusion data collected with magnetic resonance imaging (MRI). By using diffusion-weighted gradient pulses in conjunction with a hyperecho pulse sequence, researchers have been able to...
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Stanford University
|
Imaging of Protease Activity in Live Cells Using Activity Based Probes
|
|
|
Proteases play fundamental roles in the control of both normal and disease processes. Alterations in protease expression and activity patterns underlie many human pathological processes, including cancer, arthritis, osteoporosis, atherosclerosis and neurodegenerative disorders. Thus, a detailed understanding of how, when and where a particular protease functions in a complex cellular environment i...
|
|
|
|
|
|
|
Stanford University
|
Imaging of the Vasa Vasorum
|
|
|
Chronic total occlusions (CTOs) have been described as "one of the last frontiers in angioplasty." Vascular imaging techniques used currently require contrast to flow through the area being imaged. Because contrast cannot flow through a total occlusion, it is difficult to image the area, and thus to intervene. This invention uses fluoroscopy of the vasa vasorum, a network of capillaries that perme...
|
|
|
|
|
|
|
Jet Propulsion Laboratory
|
Imaging spectrometer/camera having convex grating
|
|
|
An imaging spectrometer has fore-optics coupled to a spectral resolving system with an entrance slit extending in a first direction at an imaging location of the fore-optics for receiving the image, a convex diffraction grating for separating the image int...
|
|
|
|
|
|
|
|
|
|
|
University of Southern California
|
Implantable Microbolus Infusion Pump
|
|
|
This is an implantable, fully self-contained pump allowing bolus drug infusion by remote-activation in small animals for use in research paradigms where drug administration is required in the conscious, behaving, non-tethered state....
|
|
|
|
|
|
|
University of California, San Diego
|
IMPROVED PERFUSION IMAGING USING MRI OR AS A STANDALONE PRODUCT
|
|
|
BACKGROUND: Current arterial spin labeling techniques are problematic in that the life of the tracer is shorter then the time of delivery of the tagged blood to the target tissue by blood flow. The delivery time arises from variations in the distances and ...
|
|
|
|
|
|
|
Stanford University
|
Improved Sampling in Volumetric CT
|
|
|
Volumetric computed tomography (VCT) systems are conventionally operated by rotating the source and detector around a rotational axis (often called the zaxis), thereby obtaining image measurements from multiple angles. Many such systems have a single x-ray source that travels in a circular path as the system rotates. It is known that such systems suffer from cone-beam artifacts.To solve this sampl...
|
|
|
|
|
|
|
University of California, Davis
|
IMPROVED ULTRASOUND COLOR-FLOW IMAGING FOR VASCULAR ARCHITECTURE AND TUMOR ASSESSMENT
|
|
|
DESCRIPTION: Diagnostic ultrasound techniques are of growingimportance in medicine because they are non-invasive, non-ionizing,and inexpensive compared to other sensing and imaging methods. However, ultrasound methods are currently limited by inadequateresolution and sensitivity.In particular, the promise ofcolor-flow imaging that provides spatial velocity estimates forblood flow has yet to be f...
|
|
|
|
|
|
|
University of California, Irvine
|
In Situ Microthermometry For Biological Systems
|
|
|
Researchers at the University of California have developed a microparticle biosensor that converts thermal energy into light in a very temperature-sensitive manner for use in an optical microthermometry system. It is the first non-invasive optical system for measuring temperature in situ and for mapping temperature in living organisms. The UC microthermometry system has a spatial resolution on the...
|
|
|
|
|
|
|
University of California, San Francisco
|
INCLINOMETERS FOR RADIOGRAPHICIMAGING
|
|
|
BACKGROUND:
Accurate interpretation of radiographic imaging studiesrequires knowledge of the patient’s angle of inclination at the timeof image exposure. Conventional X-ray studies are presented in a two-dimensionalformat, effectively flattening the imaged body part or organ. The methodscurrently used for measuring the angle of inclination are crude and inconsistent,detecting only if ...
|
|
|
|
|
|
|
Stanford University
|
Integrated Array of Image Sensors
|
|
|
The active imaging method (AIM) makes it possible to measure images from a controlled light source even in the presence of uncontrolled, stray ambient light. The method consists of an emitter, which emits temporally modulated light onto the scene or object, and a detector, which measures the reflected light. From the detected light, a processing means, such as a simple filter, distinguishes the re...
|
|
|
|
|
|
|
Stanford University
|
Integrated Color Pixel (ICP)
|
|
|
Current color sensor pixels utilize a two-stage process of designing an image sensor and a separate color filter, which is added after the semiconductor manufacturing process. The integrated color pixel (ICP) provides a method for bypassing this two stage process. The ICP utilizes spatial arrangements of metal wires between the lens and the photodetector to create a color filter integrated in the ...
|
|
|
|
|
|
|
California Institute of Technology
|
Integrated infrared and visible image sensors
|
|
|
Semiconductor imaging devices integrating an array of visible detectors and another array of infrared detectors into a single module to simultaneously detect both the visible and infrared radiation of an input image. The visible detectors and the infrared ...
|
|
|
|
|
|
|
University of California, Davis
|
Integrated PET-MRI Scanner for Simultaneous Imaging
|
|
|
University of California, Davis researchers have developed new devices and methods for acquiring simultaneous magnetic resonance imaging (MRI) and positron emission tomography (PET) images from patients.Currently, no combined PET and MRI scanners exist. PET is a powerful imaging modality that uses isotopes attached to specific molecules to provide exceptionally sensitive assays of a wide range of ...
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Stanford University
|
Interactive Reporting of Postprocessed Radiological Images and Measurements
|
|
|
Current imaging modalities including CAT scans and MRI scans produce thousands of images per scan. To allow for faster and more accurate interpretation, a variety of post-processed images are produced that depict the anatomy in three dimensions. Many measurements are also made at clinically significant anatomic points. Currently, these images are viewed separately in the clinical picture archiving...
|
|
|
|
|
|
|
California Institute of Technology
|
Interferometric system for precision imaging of vibrating structures
|
|
|
An optical profiler is modified in a way which allows it to image a MEMS device at various points during the movement of the MEMS device. The light source is synchronized with a desired movement of the MEMS device. The light source produces pulse at each s...
|
|
|
|
|
|
|
Stanford University
|
Interpolation Filter for Subarray Image Reconstruction
|
|
|
This invention is a novel method and apparatus for coherent array image formation and restoration. The invention is especially useful when there are fewer front-end electronic channels than the number of transducer elements in an array. The invention is applicable for both 2D and 3D imaging using either 1D or 2D linear arrays, respectively. The system reduces the frame rate by less than a factor o...
|
|
|
|
|
|
|
Stanford University
|
Interventional Nuclear Diagnostic Device
|
|
|
Atheroma alter the expression of receptors in the endothelium. Identifying specific receptors that are upregulated in unstable plaque has been accomplished using autoradiography following either incubation of the specimen or intravenous administration of an appropriate ligand in-vivo prior to sacrifice of the animal and harvesting the vessels. The autoradiographic film is primarily exposed by char...
|
|
|
|
|
|
|
University of Southern California
|
Intraoperative Thermal Imaging for Tumor Demarcation
|
|
|
Intraoperative Thermal Imaging (ITI) is a novel means for real-time identification of brain tumor margins during surgery. The technique distinguishes between brain tumor tissue and normal brain tissue based on differences in the heat each releases. The temperature differences are translated into visual images using color gradients....
|
|
|
|
|
|
|
University of California, Davis
|
Ligands for Alpha-4-Beta-1 Integrin
|
|
|
Highly potent ligands for activated alpha-4 beta-1 integrin have been identified by University of California, Davis researchers. These ligands can potentially be used as targeting agents for cancer as well as anti-inflammatory agents for autoimmune diseases. Notable applications of these alpha-4 beta-1 ligands include:
Targeting therapy for imaging of cancers including lymphoid malignancies...
|
|
|
|
|
|
|
Stanford University
|
Linear Combination Steady-State Free Precision MRI
|
|
|
A fast, spectrally-selective steady-state free precession (SSFP) imaging method is presented. Combining k-space data from SSFP sequences with certain phase schedules of radiofrequency excitation pulses permits manipulation of the spectral selectivity of the image. For example, lipid and water can be rapidly resolved. The contrast of each image depends on both T1 and T2, and the relative contributi...
|
|
|
|
|
|
|
|
|
|
|
University of Southern California
|
Lossless Compression and Decompression of Dynamic Positron Emission Tomography Data
|
|
|
We have developed a new approach to storing raw data collected from PET (positron emission tomography) scanners. The method applies information theoretic concepts in a novel way to reduce the size of the computer file necessary to store PET data without loss of information. The utility of this compression method is that PET data can be temporarily stored or archived using far less storage media (m...
|
|
|
|
|
|
|
University of Southern California
|
Low Cost 3-D Ultrasound System
|
|
|
The objective of this device is to simplify the design and fabrication of a 2-D array transducer for a real-time three-dimensional ultrasound imaging system with only a small penalty in image quality compared to a fully sampled 2-D array. Due to these simplifications, system cost can also be dramatically reduced....
|
|
|
|
|
|
|
|
|
|
|
|
