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University of Southern California
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3D Continuous Multi-view Tracking for Activity and Behavior Monitoring of Drosophila Melanogaster
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The purpose of this research is to develop new methods that will make it possible to efficiently screen complex behavioral phenotypes in the fruit fly, Drosophila melanogaster. The behaviors of interest are those related to higher-order processing related to 'choice' (e.g. social interactions), which are difficult to screen and quantify by conventional methods. The basic strategy is to develop an ...
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University of Southern California
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A Contig Mapping Algorithm for Voice Separation
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VoSA, Voice Separation Analyzer, is a computer software program that separates voices in polyphonic music using basic principles of music perception. The application can separate musical voices (or parts) in MIDI files and evaluate the voice separation results. VoSA contains an implementation of the contig-mapping algorithm for voice separation. Algorithm outcomes are shown in the piano-roll view,...
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University of Southern California
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A DC to AC Converter for Light/Radiation
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The invention is a single compact device that produces tuneable bursts of radiation from the microwave to the ultraviolet range of the electromagnetic spectrum. Pulses are of high power, variable duration and may have arbitrary signal encoding....
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University of Southern California
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A Human-assisted System to Build 3-D Models from a Single Image
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This system allows the building of textured 3-D models of objects from a single image. The reconstruction algorithms use symmetry properties of the object to infer the 3-D structure under the guidance of a user who interactively provides high-level, qualitative information when needed....
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University of Southern California
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A Method for Carbonyl Olefinations with Titanocene Derivatives
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The invention is a practical and effective method for the conversion of some carbonyl compounds (aldehydes, ketones, esters, lactones, amides and lactams) to the corresponding olefinic derivatives (olefins, enol ethers, enamines). This process can be accomplished by reacting the carbonyl substrate with the appropriate dialkyl titanocene derivatives, which are readily available and reasonably stabl...
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University of Southern California
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A Method for Generating Amplified MRNA-CDNA Hybrids for Gene Silencing Analysis
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The present invention provides a fast, simple and specific method for generating amplified mRNA-cDNA hybrids whose quantity is high enough to be used in gene silencing transfection. The principle of this improved RNA-polymerase chain reaction method (Lin et.al. Nucleic Acid Res. 27: 4585-4589, 1999) relies upon the thermocycling steps of promoter-linked double-stranded cDNA synthesis and promoter-...
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University of Southern California
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A Method for Preventing Tooth Decay by Using Natural Polypeptides
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This invention comprises a simple formulation designed to prevent tooth decay when taken orally. The active ingredient is a natural substance normally found in the oral cavity. This invention takes advantage of the transient effect of the substance on the cariogenic species of bacteria. When administered orally in combination with table sugar (sucrose), the substance specifically inhibits the cari...
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University of California, Irvine
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A Micro-Fluidic Platform for Performing Gel Electrophoresis and Western Analysis
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The Researchers at the University of California are developing a miniaturized, integrated microfluidic device and method ("lab on a chip") that performs gel electrophoresis followed by Western analysis. The technology utilizes a novel design where a single channel serves multiple purposes, including (1) cooling, (2) staining, (3) detaining, (4) electro-blotting.The current invention provides multi...
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University of Southern California
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A Multi-Threshold Online Smoothing Technique for Variable Rate Multimedia Streams
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This technology is a novel online media transmission smoothing technique that adjusts multimedia traffic based on an end-to-end rate control mechanism in conjunction with an intelligent buffer management scheme. With this scheme, called Multi-Threshold Flow Control (MTFC), variable bit rate (VBR) streams are accommodated without a priori knowledge of the stream bit rate....
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University of Southern California
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A Novel Class of Molecules for Treatment of Cancer
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A novel series of compounds (SCs) with novel mechanisms of action as well as activity in a broad range of cancers. These SCs have remarkable anticancer activity against a panel of hormone receptor positive and negative cell lines. In vitro results demonstrate that SCs (25 analogs selected from a list of 900 compounds) are highly potent compounds effective in both hormone receptor positive and nega...
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University of Southern California
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A Power Efficient Image Convolution Engine for Field Programmable Gate Arrays
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The Moore's Law trend in performance of FPGAs has facilitated the use of 2-D filtering, as in image processing. However, this performance trend is also resulting in an exponential growth in power consumption. A USC/ISI researcher has developed several techniques to optimize an FPGA circuit design for power efficiency by considering the mapping to the FPGA micro-architecture, optimizing total switc...
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University of Southern California
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A System for the Identification of Genes, Mutations, and Drugs that Increase Cellular Resistance to Multiple Stresses, Toxins, and Diseases, and Extend Longevity in Eukaryotic Cells and Organisms
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The identification of the genes and drugs that increase the resistance of human cells to aging and insults, such as oxidative stress and DNA mutations, can lead to therapies that delay or prevent age-related diseases including cancer, Alzheimer's Disease, and Parkinson's Disease. Yeast cells, mutagenized by transposon insertion or other methods and maintained in the post-diauxic and stationary pha...
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University of Southern California
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Agents, Compositions, and Methods for Enhancing Neurological Function
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The present invention provides for therapeutic agents, compositions and treatment methods for neuro-enhancement in an individual who has undergone or is undergoing loss in neurological function due to neurological disease, neurological injury or age-related neurological decline or impairment....
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University of Southern California
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Alginate-Based Nanoparticles for Nucleic Acid Therapy
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This is a non-viral gene delivery system based on nanometer-sized particles (<100 nm) made from anionic polysaccharide-alginate. Erosion of the alginate nanoparticles contributes to osmotic swelling and disruption of endosomes, which frees the nucleic acids, thereby facilitating gene transfer. Tests with phagocytic and nonphagocytic cells have shown excellent nanoparticle entry to cells and hig...
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University of Southern California
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All-Optical Remote Location of High PMD Fiber Spans
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This technology is an all-optical technique for remotely determining the location and magnitude of high polarization mode dispersion (PMD) fiber spans using stimulated Brillouin scattering (SBS). SBS has been used as an all-optical sensor for environmental disturbances (i.e. temperature, strain and stress) in optical fibers. Since PMD is closely related to these changes, SBS can be used to monitor...
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University of Southern California
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Amelogenin Micro-ribbons as a Scaffold for Biomimetic Mineralization of Tooth Enamel
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This technology develops a stable amelogenin-based scaffold that can be used as a template for biomimetic mineralization of dental enamel. Nanospheres formed by the self-assembly of the dental enamel protein amelogenin spontaneously self-organize to generate birefringent micro-ribbons which serve as a framework for the oriented growth of apatite crystals....
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University of Southern California
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An User Preference Information Based Kernel for SVM Active Learning in Content-based Image Retrieval
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Content-based retrieval systems allow users to search for information in multimedia databases. Various mechanisms can be used for the search, including direct specification of object characteristics, query by example, etc. A very important tool in this context is user relevance feedback, which allows a user to provide to the system feedback on a set of objects retrieved. In its simplest form, the ...
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University of Southern California
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Anti H-2P Monoclonal Antibodies
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The basis of the allograft response lies in polymorphic cell surface determinants termed histocompatibility antigens. The strongest and most polymorphic of these transplantation antigens are encoded by the major histocompatibility complex (MHC). The products of the MHC have been shown to play central roles in the regulation of immune responsiveness.The inventors have produced and determined the sp...
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University of Southern California
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Antigen Specifically Expressed on the Surface Of B Cells and Hodgkin's Cells
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The invention relates to a new antigen, termed BLA-36, and associated monoclonal antibody, anti-BLA-36. The antigen is specifically expressed on the surface of Hodgkin's cells, Reed-Sternberg cells and B lymphocytes. BLA-36 is restricted to Hodgkin's cells and certain B cells and thus differs from all known leukocyte antigens. BLA-36 can be detected by immunologic methods even in B5 or formalin fi...
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University of Southern California
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Application of the GRP78 Promoter in Gene Therapy
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The patent concerns the use of a promoter subfragment from the rat grp78 gene which is inducible by glucose starvation, hypoxia and other stress conditions prevalent within the microenvironment of a solid tumor with deprived blood vessel supply. This promoter element will allow selective and high level expression of therapeutic genes in solid tumors. This promoter will also be useful to turn on ge...
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University of Southern California
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Augmented Virtual Environments (AVE) for Visualization and Fusion of Dynamic Imagery and 3D Models
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To provide an accurate and comprehensive picture of events in large areas such as urban neighborhoods, airports, or embassy complexes, a distributed multi-sensor network must be deployed. An operator or analyst is easily overwhelmed with the cognitive task of integrating these multiple sensor data streams into a comprehensive global view and understanding of the scene. Our work focuses on a novel ...
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University of Southern California
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Automatic Camera and Scene Recovery from Matched Points in Images
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Any 3-D point observed from different viewpoints and different cameras projects onto different image locations. Such 2-D image points, which correspond to one single 3-D point, are called matched points. Given at least 5 matched points, this technology automatically recovers the coordinates of the corresponding 3-D points, as well as the focal length, position and orientation of each camera....
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University of Southern California
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BioSIGHT
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This portfolio of technologies consists of interactive education modules that provide an inquiry-based pedagogical approach in a learning environment that incorporates 3-D computer animation and graphics, image rendering, audio, video, and text. Students can interact with content material, explore challenges, and perform inquiry-driven collaborative investigations, using an array of virtual labora...
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University of Southern California
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BioSIGHT
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This portfolio of technologies consists of interactive education modules that provide an inquiry-based pedagogical approach in a learning environment that incorporates 3-D computer animation and graphics, image rendering, audio, video, and text. Students can interact with content material, explore challenges, and perform inquiry-driven collaborative investigations, using an array of virtual labora...
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University of Southern California
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BioSIGHT
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This portfolio of technologies consists of interactive education modules that provide an inquiry-based pedagogical approach in a learning environment that incorporates 3-D computer animation and graphics, image rendering, audio, video, and text. Students can interact with content material, explore challenges, and perform inquiry-driven collaborative investigations, using an array of virtual labora...
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University of Southern California
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BioSIGHT
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This portfolio of technologies consists of interactive education modules that provide an inquiry-based pedagogical approach in a learning environment that incorporates 3-D computer animation and graphics, image rendering, audio, video, and text. Students can interact with content material, explore challenges, and perform inquiry-driven collaborative investigations, using an array of virtual labora...
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University of Southern California
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Case-Based Agent-Assisted Learning
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USC/ISI researchers have developed a series of software that provides intelligent tutoring online. These software include:Agent for Distance Education - Light Edition (Adele): (2853) As students solve problems online, the pedagogical agent, an animated character, called Adele, monitors each student's actions and provides advice, feedback, and guidance as necessary. Currently, Adele is the only ped...
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University of Southern California
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Case-Based Agent-Assisted Learning
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USC/ISI researchers have developed a series of software that provides intelligent tutoring online. These software include:Agent for Distance Education - Light Edition (Adele): (2853) As students solve problems online, the pedagogical agent, an animated character, called Adele, monitors each student's actions and provides advice, feedback, and guidance as necessary. Currently, Adele is the only ped...
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University of Southern California
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Case-Based Agent-Assisted Learning
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USC/ISI researchers have developed a series of software that provides intelligent tutoring online. These software include:Agent for Distance Education - Light Edition (Adele): (2853) As students solve problems online, the pedagogical agent, an animated character, called Adele, monitors each student's actions and provides advice, feedback, and guidance as necessary. Currently, Adele is the only ped...
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University of Southern California
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Case-Based Agent-Assisted Learning
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USC/ISI researchers have developed a series of software that provides intelligent tutoring online. These software include:Agent for Distance Education - Light Edition (Adele): (2853) As students solve problems online, the pedagogical agent, an animated character, called Adele, monitors each student's actions and provides advice, feedback, and guidance as necessary. Currently, Adele is the only ped...
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University of Southern California
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Case-Based Agent-Assisted Learning
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USC/ISI researchers have developed a series of software that provides intelligent tutoring online. These software include:Agent for Distance Education - Light Edition (Adele): (2853) As students solve problems online, the pedagogical agent, an animated character, called Adele, monitors each student's actions and provides advice, feedback, and guidance as necessary. Currently, Adele is the only ped...
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University of Southern California
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cDNA Sequence of Learning Induced Kinase
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The cDNA sequence coding for a CDC-2 related protein kinase, KKIAMRE, has been identified as a result of induced expression in the brain from an associative learning task in the rabbit. This is the first demonstration of a specific molecule that has been shown to be induced as a result of a learning procedure in any animal. The molecule identified by differential display PCR is a key player in a s...
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University of Southern California
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Chemical Sensing and Bio-Sensing Applications of Indium Oxide Nanowires
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This technology provides ultra sensitive chemical and biosensors based on indium oxide nanowires. Specifically these sensors can detect NO2 down to 5 ppb in air and NH3 down to 0.02% among many other potential targets such as CO, ethanol, hydrogen and ozone. In addition, we have demonstrated detection of low-density lipoprotein, a biochemical important for heart disease studies. This method can be...
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University of Southern California
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Chromate-Free Corrosion-Resistant Coatings for Galvanized Steel
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This is an environmentally friendly, chromate-free process for preventing corrosion of different types of galvanized steel. The technology provides a corrosion protection efficiency between 91 and 96%. Test results show that the method prevents white rust from forming on treated samples that are exposed to salt spray environments for 72 hours, thereby satisfying the industry standard for home appl...
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University of Southern California
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Code Cycle Modulation: Concept and Implementation
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Code Division Multiple Access (CDMA) technique has been widely used in wireless communication systems. The current trend towards an all-optical network requires increasingly sophisticated optical protocols to enable us to make best use of the available bandwidth on a fiber without undue implementation complexity. Optical CDMA (OCDMA) is one of these approaches. OCDMA networks have some very attrac...
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University of Southern California
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Communication Signal Receiver with Optimized Solution Capability
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Deterministic architecture and mapping of the solution of the maximum-likelihood sequence estimation (MLSE) of signals in the presence of inter-symbol interference and white Gaussian noise. The MLSE receiver is implemented in analog circuitry resulting in small-size and great power consumption efficiency. The processing includes a unique optimized solution capability, producing solution accuracy r...
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University of Southern California
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Compact Aerosol Concentrator for Use with Low Flow-Rate Continuous Aerosol Instrumentation
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This miniaturized versatile aerosol concentration enrichment system ("mini-VACES") is designed for particle mass spectrometer applications. With intake flows of 30 to 40 l/min, and concentrated aerosol flows of 1 to 2 l/min, the system is smaller, lighter, and more controllable than current VACES. In addition, it can be operated unattended for several days, allowing for continuous sampling often c...
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University of Southern California
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Composite Foam Made from Polymer Microspheres Reinforced by Long Fibers
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A new technological process was developed for the synthesis of fiber-reinforced foam to overcome the limitation of the use of long fibers in low-density reinforced foams. This approach does not have viscous flow and fiber arrangement limitations that are the inherent peculiarities of existing fiber-reinforced foam technology.This novel process for making foam is based on thermoplastic expandable h...
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University of Southern California
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Compositions and Methods for Preventing Adhesion Formation
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The invention is compositions and methods for prevention of adhesion formation by administration of an effective amount of peptide containing RGD, an amino acid sequence found in many extracellular matrix proteins which bind to integrins for a period of time sufficient to permit tissue repair. The RGD-containing peptide is further characterized by inhibition of platelet aggregation and the absence...
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University of Southern California
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Comprehensive Statistical Admission Control for Streaming Media Servers
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This technology embodies a novel statistical admission control algorithm named TRAC that is based on a mathematical three random variable (3RV) model to support both reading and writing of multiple variable bit rate media streams on current generation disk drives. It closely models a very comprehensive set of variable factors in continuous media streaming systems, such as VBR streams, multi-zoning...
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University of Southern California
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Computer-Based Amsler Grid Test for 3D Visual Field Testing
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We have developed a computerized test program that displays an Amsler grid at a pre-selected greyscale level and pre-selected angular resolution on a computer screen at a fixed distance. The patient, with the Troxler effect suppressed centrally, is able to mark the areas on the Amsler grid that are missing from his field of vision via touchscreen technology. The same procedure is then repeated at ...
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University of Southern California
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Contactless MEMS RF Switch
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This MEMS RF switch operates without any metal-to-metal or metal-to-dielectric contact, and offers the following performance specifications:Power isolation ratio of over 100.Capacitance ratio greater than 10.Voltage isolation ratio between ON/OFF of 11.Energy required to switch between ON and OFF is less than 10 nJ.Switching speed expected to be less than 10 msec under a critically damped conditio...
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University of Southern California
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Continuous Micro- and Meso-Scale Preconcentrator for Trace Gas Analyzers
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This pre-concentrator is designed for continuous operation with mobile and distributed trace gas analyzers. Analysis predicts that it can increase micro/meso-scale trace gas concentrations by a factor of 10 per stage with no size filtration, and by a factor of 100 if complete size filtration is employed. A concentration factor as high as 1,000 could be achieved by reducing flow speed. Concentratio...
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University of Southern California
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Contour Crafting: A Novel Hybrid Rapid Prototyping Technique
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The invention concerns a new additive fabrication process that is useful for rapid prototyping and actual production of small to medium lot sizes of parts which may have complex geometries and large sizes....
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University of Southern California
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Crosslinked Siloxane Films Catalyzed by Water-Soluble Acids
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This is a process for preparing thin siloxane films and elastomers by crosslinking telechelic siloxane oligomers with multifunctional silanes. Common siloxane crosslinking procedures rely on tin or platinum catalysts, which may have toxic effects on their environment or affect the product's performance characteristics. The use of water-soluble phosphorous containing acids allows the catalyst to be...
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University of Southern California
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Cryptographic Systems Based on Crossed Inverse-Quasigroups
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This technology is a new commercial cryptographic system, which provides techniques for both public key cryptography and stream cipher cryptography based on non-associative algebraic structures (quasigroups) which possess the crossed-inverse property....
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University of Southern California
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Design of a Mini-Gene to Restore Tolerance in Multiple Sclerosis (MS)
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We have designed a gene encoding a mini-protein containing an encephalogenic epitope which can be secreted. The sequence of the mini-protein comprises of residues derived from a membrane-bound protein (which is not secreted) together with amino acids which direct the mini-protein to be secreted.When this gene is inserted into a retroviral vector and fibroblasts are transduced with this construct, ...
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University of Southern California
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Detection and Tracking of Moving Targets
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This technology is a software package, which detects and tracks moving objects from a video stream. The video stream processed can be taken from a moving platform, such as an airplane....
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University of Southern California
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Detection and Tracking of Moving Targets
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This technology is a software package, which detects and tracks moving objects from a video stream. The video stream processed can be taken from a moving platform, such as an airplane....
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University of Southern California
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Detection and Tracking of Moving Targets
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This technology is a software package, which detects and tracks moving objects from a video stream. The video stream processed can be taken from a moving platform, such as an airplane....
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University of Southern California
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Detection and Tracking of Moving Targets
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This technology is a software package, which detects and tracks moving objects from a video stream. The video stream processed can be taken from a moving platform, such as an airplane....
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University of Southern California
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Devices and Applications Based on Tunable Wave-Guiding Bragg Gratings with Nonlinear Group Delays
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USC researchers have developed a device - simple, tunable chromatic dispersion slope compensator capable of providing both inter- and intra-channel dispersion slope compensation for high-speed, reconfigurable WDM systems. The device is comprised of a novel, third-order chirped fiber Bragg grating (FBG). The FBG is fabricated such that the grating pitch varies along the grating length according to ...
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University of Southern California
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Digital Hormones
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This invention is a new method of using special signals called "digital hormones" to control distributed and self-reconfigurable systems such as metamorphic robots, embedded systems, or large software information management systems. This novel approach is inspired by the biological concept of hormones that support communication and control for billions of cells in complex biological systems. The k...
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University of Southern California
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Digitally Controlled Laser Via MEMS Deflectors
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This invention is a method for building arrays of MEMS mirrors that can act as optical cross connects. The invention will enable the switching of light from one fiber optic line to another in an all-optic signal system. The mirrors are driven digitally in response to a digital address word and each channel can be driven independently....
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University of Southern California
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Disintegrins: Effective Inhibitors of Complications Accompanying Wound Repair
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Events involved in wound healing are known to include alternations in integrin expression or functional activity and suggest that integrin modulation plays a central role in wound repair and inflammation. Recent studies have employed disintegrins as a novel therapeutic approach for complications accompanying wound repair. Disintegrins are effective agents for the treatment of complications accompa...
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University of Southern California
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Disposal of Waste CRT Glass Through the Manufacture of Concrete
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This invention encapsulates the lead from cathode ray tube (CRT) waste glass by using it to make concrete composite. CRTs, used in computer monitors and television sets, pose a disposal problem because of their lead content. Tests have shown that USC's method can prevent 99.99% of lead in CRT waste glass from leaching into its surroundings.USC's method replaces part of the sand in concrete composi...
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University of Southern California
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DNA Probe Synthesis on Chip on Demand by MEMS Ejector Array
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The invented idea is to use an array of the self-focusing acoustic transducers (SFATs) to eject DNA bases and synthesize DNA sequences. Two-dimensional array of the SFATs along with microchannels and four reservoirs (for the four DNA bases) are fabricated on a silicon chip in order to eject microdroplets of the four DNA bases (A, C, T, and G) in any desired sequence to any location on a glass chip...
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University of California, Berkeley
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DNA RECOMBINATION IN EUKARYOTIC CELLS BY THE BACTERIOPHAGE PHIC31 RECOMBINATION SYSTEM
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This invention provides methods for obtaining specific and stable integration of nucleic acids into eukaryotic cells. The method is an alternative to the widely used CRE-LOX method.The invention makes use of site-specific recombination systems that use prokaryotic recombinase polypeptides, such as the phiC31 recombinase, that can mediate recombination between the recombination sites, but not betwe...
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University of California, Berkeley
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DNA RECOMBINATION IN EUKARYOTIC CELLS BY THE BACTERIOPHAGE PHIC31 RECOMBINATION SYSTEM
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This invention provides methods for obtaining specific and stable integration of nucleic acids into eukaryotic cells. The method is an alternative to the widely used CRE-LOX method.The invention makes use of site-specific recombination systems that use prokaryotic recombinase polypeptides, such as the phiC31 recombinase, that can mediate recombination between the recombination sites, but not betwe...
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University of California, Berkeley
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DNA RECOMBINATION IN EUKARYOTIC CELLS BY THE BACTERIOPHAGE PHIC31 RECOMBINATION SYSTEM
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This invention provides methods for obtaining specific and stable integration of nucleic acids into eukaryotic cells. The method is an alternative to the widely used CRE-LOX method.The invention makes use of site-specific recombination systems that use prokaryotic recombinase polypeptides, such as the phiC31 recombinase, that can mediate recombination between the recombination sites, but not betwe...
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University of Southern California
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Dynamic Backlight Scaling for Power Minimization in a Backlit TFT-LCD
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USC's dynamic backlight scaling (DBS) technology is a set of techniques that reduce energy consumption of backlit liquid crystal displays (LCDs). The methods use pixel transformation and are designed to minimize image distortion. They can implement any piecewise linear grayscale spreading (transmittance) function by suitably adjusting the brightness and contrast of the displayed image. The approac...
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University of Southern California
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EGF-R Gene Polymorphism Predicts for Response to Chemotherapy
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EGF-R is a 170-kD transmembrane glycoprotein whose gene is located on the short arm of human chromosome 7p12. It is a member of the receptor protein tyrosine kinase family with several extracelluar growth factor ligands, including epidermal growth factor (EGF), and TGF-a. EGF-R are frequently over expressed in many types of human cancers, including CRC (colon and rectal cancers) and their over exp...
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University of Southern California
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Electrostatic Enhancement of Capture Efficiency of Metal Filters
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This invention is an attractive alternative to traditional technologies used for removal of fine and ultrafine particles from gas streams at high filtration velocities. It enhances the performance of stainless steel filters by using them as the collector plates in modified electrostatic precipitators....
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University of Southern California
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End1, A Potential Tumor Suppressor Gene in Endometrial Cancer
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End1, a novel gene underexpressed in endometrial and ovarian carcinomas, was isolated using differential display of human endometrial carcinomas and paired proliferative endometrion. The End1 was cDNA characterized. End1 full-length cDNA of 1728 bp potentially encodes a small 82 amino acid long protein. End1 deduced amino acid sequence contains a cAMP-/cGMP-dependent protein kinase, 3 protein kina...
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University of Southern California
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Fabrication of Broadband Graded Transducer Using Piezoelectric Partial Composites
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Partial composite is a new type of piezoelectric material which can be easily manufactured. By using partial composites to make ultrasound transducers, it is much easier to obtain broad bandwidth. Broadband transducers satisfy the requirement of improved spatial resolution and offers the advantages of allowing better harmonic imaging. At the same time, the partial composite can be widely used in s...
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University of Southern California
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Fiber Optic Sensor for Classification of Burn Injuries
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This patented technology is a new process and fiber optic sensor system for the evaluation of burn injury, including measurement of burn depth.The system is composed of multiple lasers or light sources emitting in the ultraviolet, visible and near infrared range, optical detectors and a signal processing unit. With this system, physicians can objectively evaluate burn injured patients, determine t...
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University of Southern California
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Fuzzy Pseudorandom Number Generator
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The invention is a random number generator based on fuzzy rules. This system can generate frequency hopping sequences for a spread spectrum communication system that could be useful for wireless security applications....
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University of Southern California
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Generation of Human Regulatory T Cells by Bacterial Toxins for the Treatment of Inflammatory Disorders
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An adoptive immunotherapy using ex vivo-generated regulatory T cells may be used for the suppression of undesirable immune response. T cells are to be obtained from the patient's blood, the population of regulatory T cells will be enriched ex vivo and adoptively transferred back to the patient. The novel aspect of this technique is that it generates large numbers of type 1 regulatory T cells, whic...
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University of Southern California
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Globe-All: An Electronic Pan-Tilt-Zoom Camera Array
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This technology is a camera system that acts as a mobile pan-tilt-zoom camera, but performs all the functions electronically, rather than mechanically. The system consists of an array of CMOS cameras mounted in a fixed configuration that acquires a large field of view, with enough resolution to allow focusing on the desired region of interest.This system creates a two-dimensional mosaic of the obs...
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University of Southern California
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GST P1 Polymorphism Predicts for Survival in Patients with Metastatic Colorectal Cancer
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Glutathione transferases consist of a super-family of phase II metabolic enzymes that catalyze the conjugation of reduced glutathione. The detoxifying character of these reactions is responsible for the protection of cellular macromolecules from damage caused by carcinogenic and cytotoxic agents. GSTP1-1 has been shown to be widely expressed in human epithelial tissues and to be over-expressed in ...
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University of Southern California
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Heavy Metal Stabilization in Soils Using Biopolymers
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This technology makes use of biopolymers and crosslinking agents to stabilize lead and other heavy metals in soil. Screening protocols have been developed and demonstrated with several commercially available biopolymers. The method has been shown to reduce extractable lead concentrations by as much as 94% when soil samples are subjected to a modified TCLP solution having pH 4.2....
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University of Southern California
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High Speed Sense Amplifier
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This invention is a new CMOS sense-amplifier (SA) design implemented using Current-Source Evaluation (CSE) to improve the performance of SA flip-flop. The CSESA design consists of a current-mode core and a differential input stage, eliminates the clocked transistor from the evaluation phase, adopts a pre-discharge architecture and reduces the evaluation chain depth to one transistor. The removal o...
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University of Southern California
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HOWIE: A Visual Resources Database
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The HOWIE digital image database is designed to provide access to digitized images through a web browser interface. It is intended for instructional or research purposes. The database is fully searchable and users can save selected groups of images in folders for presentation. Images in the database are compressed with MrSid and allow for pan and zoom viewing in real time. The Database will be del...
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University of Southern California
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HYDRA High-Definition Live Streaming System
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The HYDRA HD live streaming technology is a suite of software components that provide low latency acquisition, transmission, and rendering of high resolution video. The live digital media data, for example MPEG-2 compressed high-definition video, is acquired from an HDV-capable camera via FireWire. The transport stream is extracted, packetized and transmitted over a commodity IP network. The optim...
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University of Southern California
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Ignition Enhancement of Internal Combustion Engines by
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This technology combines a lean-burn, natural-gas fueled internal combustion engine with a reactor that produces ignition-enhancing compounds. The in situ generation of these compounds eliminates the need for a secondary fuel, such as diesel. In tests, this technology significantly lowered ignition temperatures and allowed ignition at lower equivalence ratios....
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University of Southern California
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IMPACT: Interactive Media for Promoting Activity in Children
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This CD-ROM is an interactive cartoon drama that along the way teaches children the behavioral elements of incorporating greater amounts of physical activity into their lives. It was written and developed through collaboration between a team of writers and a team with expertise in health behavior so that the script is based on a theoretical underpinning that is designed to drive a change in every ...
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University of Southern California
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Implantable Microbolus Infusion Pump
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This is an implantable, fully self-contained pump allowing bolus drug infusion by remote-activation in small animals for use in research paradigms where drug administration is required in the conscious, behaving, non-tethered state....
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University of Southern California
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Improved Reed-Solomon Decoders
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Reed-Solomon (RS) error correcting codes have been used for many years to permit the correction of errors occurring during digital data transfers. A set of parity bytes are encoded from and then added to the data to be transmitted. After data transfer, data and parity bytes are compared in the decoding process that corrects data errors. A fixed number of errors can be corrected. RS coding has also...
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University of California, Berkeley
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Individual Earthquake Early Warning System
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Providing an emergency notification of an impending earthquake could significantly reduce harm to people and facilities. Even if the notification was just several seconds before the quake hit, that could be enough time for individuals to take cover, turn off gas-fueled devices, and/or shutdown electrical equipment. To rapidly detect earthquakes, extensive seismic networks have been established in ...
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University of California, Berkeley
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Individual Earthquake Early Warning System
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Providing an emergency notification of an impending earthquake could significantly reduce harm to people and facilities. Even if the notification was just several seconds before the quake hit, that could be enough time for individuals to take cover, turn off gas-fueled devices, and/or shutdown electrical equipment. To rapidly detect earthquakes, extensive seismic networks have been established in ...
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University of California, Berkeley
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Individual Earthquake Early Warning System
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Providing an emergency notification of an impending earthquake could significantly reduce harm to people and facilities. Even if the notification was just several seconds before the quake hit, that could be enough time for individuals to take cover, turn off gas-fueled devices, and/or shutdown electrical equipment. To rapidly detect earthquakes, extensive seismic networks have been established in ...
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University of Southern California
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Inhibitor of Apoptosis
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Strong evidence is accumulating that JNKs, the stress-kinase reported in our laboratory in 1995 (Mohit et al), plays a crucial role in responding to oxidant stress of Ab in Alzheimer's disease, and to hypoxia/ischemia. This kinase is especially important as it is expressed specifically in neurons.JNK may trigger cell death mechanisms of apoptosis via phosphorylation of c-Jun, a transcription facto...
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University of Southern California
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Intelligent Motion Surfaces
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The invention represents a surface comprising a dense array of motion devices that can be programmed to operate in conjunction to form an Intelligent Motion Surface (IMS). The area of the surface may be segmented under program control to apply a force vector to a part placed on it. The motion devices are micro-robots built in micro-electromechanical VLSI.An intelligent motion surface consisting of...
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University of Southern California
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Interactive Child Development Website
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The Virtual Child website is an interactive web site designed to illustrate facts, principles and theories of child development. It was developed to be used in conjunction with a chronologically organized course in child development at the college level. Students log on, become the "parent" of a child, and read up to 12 questions or events regarding their child at each of several successive points...
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University of Southern California
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Intraoperative Thermal Imaging for Tumor Demarcation
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Intraoperative Thermal Imaging (ITI) is a novel means for real-time identification of brain tumor margins during surgery. The technique distinguishes between brain tumor tissue and normal brain tissue based on differences in the heat each releases. The temperature differences are translated into visual images using color gradients....
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University of Southern California
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Layered Nanofabrication
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This technology offers a new rapid prototyping and fabrication process that operates at the nanoscale. The process is capable of producing 3-D solid nanoscale objects with very general geometries, while other known nanofabrication methods are limited to 2-D....
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University of Southern California
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LEA.135, a Cell-surface Glycoprotein, Associated with a Favorable Prognosis of Patients with Breast Cancer
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The invention relates to a new antigen, termed LEA.135, and associated monoclonal antibody, anti-LEA.135 antibody. The expression of the antigen is associated with a superior overall survival of patients with primary breast cancer. Furthermore, patients with histologically poorly differentiated or aneuploid tumors and LEA.135 positive cases showed an improved overall survival compared with those t...
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University of Southern California
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Lentiviral Vectors for Gene Transfer to Alveolar Epithelial Cells
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Alveolar epithelial cells (AEC) in the lower part of the lung are where gas exchange takes place, and to which gene therapy is desirable. These lentiviral vectors allow the introduction of genetic material to the AEC for the treatment of acute and chronic lung diseases. Additionally, genetic material can be introduced to the AEC for production of specific protein(s) to be secreted into the pulmona...
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University of Southern California
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Lossless Compression and Decompression of Dynamic Positron Emission Tomography Data
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We have developed a new approach to storing raw data collected from PET (positron emission tomography) scanners. The method applies information theoretic concepts in a novel way to reduce the size of the computer file necessary to store PET data without loss of information. The utility of this compression method is that PET data can be temporarily stored or archived using far less storage media (m...
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University of Southern California
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Low Cost 3-D Ultrasound System
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The objective of this device is to simplify the design and fabrication of a 2-D array transducer for a real-time three-dimensional ultrasound imaging system with only a small penalty in image quality compared to a fully sampled 2-D array. Due to these simplifications, system cost can also be dramatically reduced....
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University of Southern California
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Matrix Metalloproteinase Inhibitors to Prevent Toxicity From Cancer Chemotherapy
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Sinusoidal obstruction syndrome (SOS), previously known as hepatic venoocclusive disease, is a disease with a case fatality rate of 30-40%. In Western nations it occurs most commonly as a complication of bone marrow transplantation. In recent years, SOS has also been seen frequently in patients treated with Mylotarg (gemtuzamab ozogamicin, a monoclonal antibody plus toxin used in acute myeloid leu...
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University of Southern California
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Mechanical Battery
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This device converts mechanical energy into electrical energy without the use of torsion springs or gears found in conventional clockwork machines. A few turns of the device's input crank are expected provide more than 5 minutes of cell phone talk-time. When designed for use with portable electronics, its volume is less than 200 cm3. The design can be easily configured for electric vehicles or oth...
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University of Southern California
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Metallic Parts Fabrication using Selective Inhibition of Sintering (SIS)
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This technology is an extension of the original SIS process. With the additional steps, this invention is capable of building dense metallic parts of free form 3D geometry from metal power without the use of binder materials.To form a 3-D metal objects, there are five basic steps:Laying a thin powder layer,Powder layer compression,Application of sintering inhibitor,Creation of a boundary to contai...
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University of Southern California
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Method and Apparatus for Linear Light Source Reflectometry
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This invention is a method and apparatus to capture objects in a storage media but at the same time still retain the objects' light configuration. The technique is to estimate the spatially-varying reflectance properties of a surface based on its appearance during a single pass of a linear light source as illuminant, instead of a point light source. This device consists of several parts: the linea...
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University of Southern California
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Method and Composition for Treating Exocrine Gland Atrophy
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The invention represents a hormonal replacement therapy to improve lacrimal gland function that has been impaired by menopause or estrogen-based oral contraceptive use. Research indicates that there is an optimal level of the hormone prolactin. Clinical studies show that most menopausal women have too much. The main idea of this study is to administer a medication that adjust prolactin levels, suc...
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University of Southern California
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Method for Choosing Position System Geometries
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This technology determines optimal sensor placement (OSP) in wireless networks. It is especially suitable for indoor hyperbolic-positioning systems. The method minimizes uncertainty of the signal source location. Unlike many of the OSP methods, it has no prescribed restriction on the sensor alignments. The scheme is applied to any arbitrary area in 2-D and 3-D, and ensures complete coverage. The o...
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University of Southern California
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Method for Generating Multiple Virtual Microphone Signals for Multichannel Audio
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This invention is a method for generating multichannel sound from one- or two-channel venue recordings. A set of filters processes the signals from a pair of main microphones and synthesizes signals as though they were captured by microphones placed at various locations within the hall, while preserving the correct acoustical characteristics of the venue. This invention also provides a method for ...
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University of Southern California
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Method for Magnetic Resonance Excitation Field Non-uniformity Compensation
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This invention describes a new Magnetic Resonance Imaging (MRI) technique, which compensates for excitation field non-uniformity. It is based on measurements of the excitation field and can be used to perfectly correct for non-uniformity over regions of interest....
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University of Southern California
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Method of Making Avalanche Photodiode / Avalanche Photodiode with Floating Guard Ring
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The disclosed invention directs to a semiconductor material avalanche photodiode of a separate multiplication and absorption region heterostructure design (SAM-APD). The improved SAM-APD is characterized by a plurality of floating guard rings which are separated about a central region and doped in the opposite high concentration from that of the multiplication region in which they are positioned. ...
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University of Southern California
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Methods for Inhibiting Apoptosis DENN/MADD
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In human CNS tissue DENN/MADD has specific nuclear and nucleolar localization in neurons resulting from occurred hypoxic/ischemic stress. DENN/MADD is a death domain containing protein that interacts with JNK3. JNK signaling is implicated in neuronal cell death and DENN/MADD promotes activation of JNK in neuronal cultures. DENN/MADD co-localizes with JNK (active form) in the cytoplasm, which may p...
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University of Southern California
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Micromachined Mass Sensor
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This is a highly sensitive, resonant mass sensor that can operate in vapor and liquid environments. The technology uses a micromachined Film Bulk Acoustic Resonator (FBAR) to sense mass change through resonant frequency changes. By coating the surface of the FBAR with a thin film that selectively binds a specific material in vapor or liquid, a very sensitive and extremely small mass sensor is prod...
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University of Southern California
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MnSOD Gene Polymorphism Predicts for Increased Risk for Colorectal Carcinoma in Younger Patients
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Local recurrence for patients with rectal cancer is a significant medical issue. Patients with localized rectal cancer are treated with radiation therapy to reduce the risk for local recurrence. The standard therapy for locally advanced rectal cancer either pre or postoperative is 5-FU chemotherapy and radiation therapy. Depending on the pathological staging the risk for tumor recurrence is betwee...
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University of Southern California
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MnSOD Gene Polymorphism Predicts for Increased Risk of Colorectal Carcinoma in Younger Patients
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Cancer Risk is associated with genomic alterations in tumor suppressor genes and oncogenes, metabolic/oxidative enzymes and nutritive factors. Oxidative stress, resulting from the imbalance between pro- and antioxidant states, cause the damage of DNA, mitochondria, proteins and cell membranes. For MnSOD and MPO, two enzymes may influence the pool of free radicals in the cell, it has been demonstra...
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University of Southern California
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Modified Gelatin Cross-Linked with Silane for Biomedical Applications
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This technology makes use of collagen or gelatin material and a polymer to form a novel collagen-based biomaterial. The biomaterial can be processed into different forms, such as a solution, hydrogel, membrane/film, sponge, microsphere or tubing for different medical and tissue engineering applications....
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University of Southern California
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Monoamine Oxidase (MAO) A and B double Knock-out Mice
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Our invention generated mice colony which lack of Monoamine Oxidase (MAO) A and B activity, resulted in increased levels of neurotransmitters, serotonin, nerepinephrine, dopamine and phenylethylamines. These mice show small size from birth to about one month old. Also exhibit severe anxiety and disregulation of heartbeat....
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University of Southern California
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Movie Anti-Pirating System
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This invention describes a system for detecting someone in the audience pointing a video camera at the screen during a performance to record and pirate a movie....
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University of Southern California
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Multi-pipe, Multi-valve Reactor
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This invention is a design for a multi-tube reactor, which divides the reactor into separate small pipes and then reconnects them with valves. A heat exchanger jacket or coil was considered around each pipe. Capital cost may increase, but it will provide more efficient heat distribution. All pipes are connected to each other and to the central heat exchanger. Pressure drops may be minimized by fee...
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University of Southern California
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Multi-Split Ring Tester
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This invention is a new method for testing materials in a ring configuration. This method utilizes a mechanism, which can transfer the applied force into the radius pressure of the ring, thus measuring the tension in the ring. The relationships between the applied force and the pressure (ring stress) can be found by equilibrium condition of the system, and further by calibration using a ring with ...
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University of Southern California
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Murine Monoclonal Antibody 58-15 (IgM)
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Murine monoclonal antibody 58-15 (IgM) identifies a nuclear antigen expressed in actively dividing human cells. The purpose of the antibody is to identify and quantify proliferating cells in a tissue or cell population. This antibody can be used for two types of research and diagnostic applications: flow cytometry and histopathology....
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University of Southern California
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MuSA.RT- Music on the Spiral Array. Real Time
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This technology is an interactive environment for content-based music visualization, to help listeners understand and literally "see" the structure of music.MIDI output from a live performance is mapped to the Spiral Array model. Algorithms based on the Spiral Array are used to compute pitch structures such as spelling, chords, and keys. The pitch structures are highlighted visually in the display...
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University of Southern California
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Nanosecond Pulse Generator for Cell Electro-manipulation
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Pulse generator for nanosecond-length pulses with intense electric fields.Output in unipolar mode >1 kilovolt (kV), 3.5 nanosecond (nsec), into 50 ohms.Output in bipolar mode +/- 500V, 3.5 nsec, into 50 ohms.Applies pulses to biological cells, and induces biological effects within the cells. Observed effects include intracellular calcium bursts, and induction of apoptosis....
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University of Southern California
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Narratoria, An Authoring Suite and Software Development Kit for Digital Interactive Narrative
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The Narratoria application provides the capabilities for novices and non experts of real-time, 3-dimensional computer graphics to create interactive movies and movie pre-visualization using game engines. All of this is available within one software application framework. Using a computer game as a 3-dimensional output device, digital movies can be created with little to no knowledge of game engine...
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University of Southern California
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NetCheque®: A Network Payment System
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Secure methods of payment are needed before we will be widespread commercial use of the Internet. Recently proposed and implemented payment methods follow one of three models: electronic currency, credit-debit, and secure credit card transactions. Such payment services have different strengths and weaknesses with respect to the requirements of security, reliability, scalability, anonymity, accepta...
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University of Southern California
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Noisy-Channel-Based Method for Question Answering
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USC/ISI researchers have developed a probabilistic noisy channel model for question answering. This core QA system is a pipeline of only two modules: 1) An IR engine that retrieves a set of M documents/ N sentences that may contain answers to a given question Q. 2) An answer identifier / ranker module that given a question Q and a sentence S identifies a sub-string of S that is likely to be an ans...
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University of Southern California
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Novel Estrogen Receptors
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It has been shown that members of the estrogen receptor (ER) superfamily have multiple subtypes and isoforms specifically expressed in different tissue and cell type. ER-like mRNA distinct from wild-type ER mRNA has been identified in many known ER positive tissues and cells lines. These isoforms have been mostly derived from alternative splicing of ER mRNA's. This technology describes the identif...
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University of Southern California
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OmniGrasp- A Full Hand Haptics Grasp System
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OmniGrasp is a full-hand haptics grasp system with an unprecedented performance in providing realistic feeling of grasp, applicable to all finger segments (phalanges) and palm. Commercially available state-of-the-art products apply pressure to finger tips only....
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University of Southern California
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Optical Dispersion Monitoring Based on Vestige Side Band Optical Filtering
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This technology proposes a new technique for monitoring chromatic dispersion and polarization-mode dispersion (PMD) in high-bit-rate optical fiber communications systems.This method implements vestige side band (VSB) filtering for monitoring dispersion. Chromatic dispersion (CD) is monitored from measuring the relative group delay between the upper and lower VSB signals. In our modeling, the trans...
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University of Southern California
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PEO Based Hydrogels Subject to Controlled Degradation
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This technology describes crosslinked polyethylene oxide (PEO) hydrogels that are formed under synthetically convenient conditions in a one-pot reaction. The PEO networks absorb large amounts of water to give hydrogels. The hydrogels are soft and transparent and are either indefinitely stable in aqueous media or degrade spontaneously at rates that can be controlled by the choice of synthesis condi...
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University of Southern California
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Perfluorocarbon-Soluble Surfactants
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This invention is a method of synthesizing fluorosurfactants that are highly soluble in perfluorocarbon (PFC). The surfactants can be used to facilitate the formation of water-in-PFC microemulsion systems, which can confine a drug or gene within nanoparticles dispersed in the continuous PFC phase....
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University of Southern California
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Peroxynitrite: A Mediator of the Toxicity of Activated Microglia
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The amyloid ß-peptide (Aß) promotes the activation of microglia and the generation of cytokines and oxygen species, including nitric oxide (NO) and tumor necrosis factor a (TNF-a), which can be either neurotoxic or neuroprotective. We show that cell death in co-cultures of microglia-neurons activated by lipopolysaccharide (LPS) or Aß1-42 is caused by short-lived diffusible molecu...
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University of Southern California
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Personal Scent Release Necklace and Cartridges
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ICT and AnthroTronix, Inc. have developed a personal scent necklace (worn as a lightweight collar) for virtual reality simulation. It is designed to work with and enhance a multi-sensory virtual reality environment, providing appropriate smells that relate to the environment. The necklace can currently contain 4 scent cartridges. Computer instructions control the scent release in response to the v...
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University of Southern California
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PET Scanning Analysis Software
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We have developed a new computational method for reconstruction of images from positron emission tomography (PET) data. This approach combines accurate physical and statistical models for the data with rapidly convergent algorithms to reconstruction images of the spatial distribution of pharmaceuticals labeled with positron-emitting radioisotopes. The process we describe includes efficient and acc...
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University of Southern California
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PET Scanning Analysis Software
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We have developed a new computational method for reconstruction of images from positron emission tomography (PET) data. This approach combines accurate physical and statistical models for the data with rapidly convergent algorithms to reconstruction images of the spatial distribution of pharmaceuticals labeled with positron-emitting radioisotopes. The process we describe includes efficient and acc...
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University of Southern California
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PET Scanning Analysis Software
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We have developed a new computational method for reconstruction of images from positron emission tomography (PET) data. This approach combines accurate physical and statistical models for the data with rapidly convergent algorithms to reconstruction images of the spatial distribution of pharmaceuticals labeled with positron-emitting radioisotopes. The process we describe includes efficient and acc...
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University of Southern California
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PET Scanning Analysis Software
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We have developed a new computational method for reconstruction of images from positron emission tomography (PET) data. This approach combines accurate physical and statistical models for the data with rapidly convergent algorithms to reconstruction images of the spatial distribution of pharmaceuticals labeled with positron-emitting radioisotopes. The process we describe includes efficient and acc...
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University of Southern California
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Polarization Mode Dispersion Emulator
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USC researchers have developed a PMD emulator method. It includes a plurality of birefringent wave-guiding sections to transmit light and a plurality of variable polarization-changing connectors to connect the wave-guiding sections. PMD dispersion in an actual fiber can be emulated by transmitting a beam through the wave-guiding sections and the connectors. The connectors can be adjusted to produc...
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University of Southern California
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Polymer Micro-Resonator Strain Sensor
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This is a new class of fiber-based polymer micro-resonator strain sensor. The principle of operation is based on distorting a flexible micro-ring, which shifts the device's resonant wavelength. Test results have been in good agreement with calculated predictions. The design concept can be expanded to real-time temperature, vibration, and load sensing. With the use of a selective polymer coating, t...
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University of Southern California
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Preparation and Use of
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This invention is a new method for converting a-diazomethylenephosphonate and bisphosphonate esters into carbonylphosphonates and bisphosphonates. The technique could be used to prepare any bisphosphonate possessing a particular utility or desirable property requiring introduction of a specific "R" group. The technology provides a versatile pathway to new a-substituted bisphosphonate derivates and...
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University of Southern California
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Process for Converting Methane Directly to Acetic Acid
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This is a direct, selective conversion of methane to acetic acid, catalyzed by palladium. Both carbons of acetic acid are derived directly from two methane molecules in a single reaction system at 180° C. The invention provides advantages over conventional methods, which use a three-step, capital- and energy-intensive process.This technology is one part of a USC research program focused on con...
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University of Southern California
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Process for the Recovery of Chlorine from Waste HCl
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The invention is a new, improved process for the recovery of chlorine from waste HCl which uses two fluidized beds of catalyst to achieve 100% recovery of chlorine values under highly economic conditions....
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University of Southern California
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Production of Alkenes
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Ethane and chlorine are premixed in a 1:1 mole ratio and allowed to react adiabatically producing in excess of 90% conversion of ethane to C2H4, some vinyl chloride and HCl. No Cl2 is left. The process is exothermic....
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University of Southern California
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Progressive Triangle Mesh Compression for Lossless Transmission
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This technology is a new method for lossless transmission of 3D meshes. It is a fully progressive encoding approach for compression of arbitrary triangle meshes with a very fine granularity. The bit rate is approximately equivalent to the most powerful single-rate encoders....
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University of Southern California
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PROPOLYNE: Data Storage and Query Evaluation
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PROPOLYNE is a data storage and query evaluation technology designed to deliver fast, exact, progressive and approximate answers to analytical queries on real-time databases. It supports a wide range of aggregate queries, from standard COUNT and SUM queries to sophisticated analysis using multivariate regression and principle component analysis. PROPOLYNE can be integrated with existing systems to...
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University of Southern California
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Quantitative Histochemistry
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Computer-assisted imaging of histochemical preparations permits an objective measure of the staining expressed as optical density units or gray scale units. However, computerized cytometry does not provide information about the actual amount per cell of the cellular component that is identified. The current invention discloses a method and compositions to quantitate proteins, nucleic acids or othe...
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University of Southern California
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Reconstitution of IKB Kinase Complex in Yeast and Methods of Using Same
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IkB kinase (IKK) is a large enzyme complex consisting of three subunits, a, b, and g. This enzyme is the key regulator of NF-kB and thus it plays an important role in regulating inflammation and apoptosis. This invention relates to reconstituting human IkB kinase in yeast and using the expressed kinase.In addition, we have co-expressed IKKbg along with its substrate, IkBa in yeast, and the substra...
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University of Southern California
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Regulation of Gene Expression by Protein Methylation
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Dr. Stallcup's laboratory has discovered a new mechanism that contributes to the regulation of gene transcription: protein methylation. The nuclear hormone receptors are proteins that activate transcription of specific target genes in response to their hormones. The family includes the receptors for all steroid hormones, thyroid hormone, retinoic acid (vitamin A), and vitamin D, among others. The ...
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University of Southern California
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RT Simulator-Simulation Software for 3D Radiation Therapy Treatment Planning
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RT Simulator is an advanced "radiological physics simulator". It uses CT or MR imaging data to create digital radiographs and to build 3D anatomic models. Anatomy can be rendered as lines, voxels or triangulated surfaces. CT image data can be applied as textures. Extensive transparency effects are supported. It was specifically designed for teaching and simulating all forms of radiological imaging...
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University of Southern California
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Saturable Absorber Q-Switches for 2
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USC researchers have designed a novel saturable absorber Q-switch (SAQS) for the 2 m (micron) solid state laser. Tunability and access to mid-infrared wavelengths can be obtained by utilizing the lasers as drivers for optical parametric oscillators (OPO)....
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University of Southern California
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SCADDAR: An Efficient Randomized Technique to Reorganize Continuous Media Blocks
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This technology is a new scalable storage architecture called SCADDAR (SCAling Disks for Data Arranged Randomly.) SCADDAR uses a pseudo-random placement technique to place data across a set of disks in order to achieve load balancing. The random locations can always be regenerated using a standard pseudo-random number generator and the same seed value. This approach efficiently redistributes only ...
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University of Southern California
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Sealing of Anodized Aluminum with Cerium Salts
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This invention provides a chromate- and nickel-free alternative for sealing anodized aluminum alloys. The seal produced with this technology has been shown to meet standard corrosion-resistance requirements and provide good paint adhesion. The invention makes use of rare earth metal salts (REMS) which do not present the health and environmental hazards of the highly toxic chromates presently emplo...
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University of Southern California
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Selective Cancellation of Audio Signals in Multiple Listener Environments
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This invention is a method for performing automatic selective audio signal cancellation through a Digital Signal Processing filter. The filter provides a region of silence, where there is no audio signal, without significantly affecting the audio signal in another region in any environment (e.g., rooms, cars, etc.). The method obtains a filter by: (i) measuring the room acoustical responses at mul...
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University of Southern California
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Self-directed Learning Internet Module (SLIM / SLIM-ES3)
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Self-directed Learning Internet Module - Every Solder a Sensor Simulation (SLIM-ES3) is a web-delivered, web-enabled cognitive Combat Patrol training tool for U.S. ground forces. The application enables users to practice and enhance their competency in Active Surveillance and Threat Indicator Identification....
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University of Southern California
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Simplified Chemical Battery
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This device employs common, inexpensive, and non-hazardous materials to create electricity through a chemical reaction. The present lab bench design has approximate dimensions of 4" x 3" x 0.75", produces roughly 180 mA and 22.5 V, and is intended for use as a disposable quick-charge device for cell phones and other consumer electronics. Its cost could be as low as $3. A one-minute charge from the...
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University of Southern California
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Simultaneous Multiple Location Equalization for Audio Signals in Multimedia Environments
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This invention is a method for performing automatic multi-channel room acoustic equalization through a Digital Signal Processing filter. The equalization is performed simultaneously for multiple listeners in any environment (e.g., rooms, automobiles, theatres, etc.) The method obtains a filter by: (i) measuring the room acoustical responses at multiple seating positions, and (ii) applying the meas...
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University of Southern California
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Size Enlargement of Male Genitalia
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The technology is a physiological secreted molecule that can be used to enlarge the size of male genitalia. The product is a secreted protein. In male mouse models, the size of the genitalia is visually noticeable compared to a control group....
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University of Southern California
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SPACEMAT: A Real-time User Tracking Apparatus
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The SPACEMAT is a non-intrusive human-computer interface that tracks the position of a moving user in real-time. It consists of an array of miniature sensors (or switches) connected together within a given area, and with a given density. The wires drawn out of the grid of switches/sensors are connected to an electronic circuit that interfaces with a personal computer running the supporting softwar...
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University of Southern California
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Spectrally-efficient L-C band EDFA
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This invention is a technique for widening the effective bandwidth of an Erbium-doped fiber amplifier (EDFA). This is achieved by using sampled fiber Bragg gratings for L and C band splitting configured in a way, which completely avoids wavelength dead zone in the structure of L-C band....
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University of Southern California
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State-Space Method for Immersive Audio Synthesis and Rendering
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This technology is a new method for synthesizing and rendering 3-D (spatial) sound. Previous methods have relied on measurements of a few discrete points around the listener and interpolation to render sound at other locations. Interpolation can cause large errors in the Head-Related Transfer Functions that are synthesized. Furthermore, previous methods use look-up tables and can only synthesize o...
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University of Southern California
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Steady State Free Precession MRI with Significantly Increased Signal Bandwidth
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This invention describes a new Magnetic Resonance Imaging (MRI) technique and pulse sequence based on Steady-State Free Precession (SSFP), which overcomes the bandwidth limitations of conventional techniques. It achieves a resonance frequency bandwidth up to 100% wider than conventional SSFP MRI....
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University of Southern California
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Subsurface Soil Contaminant Remediation System
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This technology confines contaminants within soil or other porous media. The system has been demonstrated in a laboratory pressurized pumping flow system. Test data showed that the system performed well by encapsulating contaminants to minimize their leaching by 98% over untreated soil. This in turn decreased permeability of soil matrix....
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University of Southern California
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Synthesis of Human-Like Laughter
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This technology is a method to synthesize laughter for text-to-speech synthesizers (TTS) and computer generated avatars. It is based on the equations that govern the simple harmonic motion of a mass attached to a spring....
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University of Southern California
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System for Remote Control Loading of Sample on to a Liquid Chromatography Injection Valve
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The system implements the controlled transfer of a test solution from its container to the loading loop of a standard chromatography injection valve. In its basic concept the device consists of a manually operated control module and accessories that include an air-bubble sensor, solenoid valves and appropriate power sources....
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University of Southern California
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System for Subnet Relocation
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ISI / USC Researchers have developed a system for dynamically relocating Internet subnets. This system can securely relocate portions of a network to a location remote from the original network via an automation process for configuration and management, using a graphical interface and multipoint control channel to manage overlay deployment at the IP layer. An anchor site can provide a delegated IP...
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University of Southern California
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Targeting Drugs to Hepatocytes in the Liver
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The invention is a new process of targeting drugs to hepatocytes, the major cells in the liver, using phospholipid vesicles or liposomes. These vesicles are capable of entrapping and carrying pharmacologically active agents, including factors regulating gene expression....
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University of Southern California
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The Automated Laser System for Graffiti Removal
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This is a portable laser-based system that can rapidly and effectively remove unwanted paint from a variety of surfaces. It is intended to safely remove graffiti and other paint from concrete and brick, metal, wood and from highway signs, without causing unacceptable damage to their usefulness....
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University of Southern California
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Three Dimensional Interaction with Autostereoscopic Displays
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Our technology is a system that enables a user to interact with a computer in three-dimensions. In operation, our tracking system tracks a stylus held by the user. A computer interprets movements of this stylus. These interpretations result in the creation and modification of a virtual scene in the computer. This virtual scene is converted to desired autostereoscopic display format and the virtual...
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University of Southern California
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Tooth Enamel Inspired Materials for Dental and Biomedical Applications
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The invention provides novel dental enamel inspired materials for biomedical and dental applications. We apply chemical processes to prepare a material composed of apatite-like calcium phosphate complexes in the presence of tooth enamel protein, amelogenin. The presence of amelogenin promotes the formation of calcium phosphate crystals mimicking the in vivo enamel apatite crystals....
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University of Southern California
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Tracking Objects and Cameras from Video Imagery
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This portfolio of technologies improves camera pose tracking within an augmented reality system. The portfolio includes feature tracking capabilities, autocalibration methodologies, and improved camera estimation algorithms. It is composed of the following technologies:(2914) Feature Tracking Software: This software package detects and tracks natural features in video image sequences by automatica...
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University of Southern California
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Tracking Objects and Cameras from Video Imagery
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This portfolio of technologies improves camera pose tracking within an augmented reality system. The portfolio includes feature tracking capabilities, autocalibration methodologies, and improved camera estimation algorithms. It is composed of the following technologies:(2914) Feature Tracking Software: This software package detects and tracks natural features in video image sequences by automatica...
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University of Southern California
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Tracking Objects and Cameras from Video Imagery
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This portfolio of technologies improves camera pose tracking within an augmented reality system. The portfolio includes feature tracking capabilities, autocalibration methodologies, and improved camera estimation algorithms. It is composed of the following technologies:(2914) Feature Tracking Software: This software package detects and tracks natural features in video image sequences by automatica...
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University of Southern California
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Tracking Objects and Cameras from Video Imagery
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This portfolio of technologies improves camera pose tracking within an augmented reality system. The portfolio includes feature tracking capabilities, autocalibration methodologies, and improved camera estimation algorithms. It is composed of the following technologies:(2914) Feature Tracking Software: This software package detects and tracks natural features in video image sequences by automatica...
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University of Southern California
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Training Tree Transducers
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USC/ISI researchers have developed a training algorithm motivated by the use of tree transducers for natural language and have addressed the training problem for probabilistic tree-to-tree and tree-to-string transducers. This training algorithm is a generalization of forward-backward EM (Estimation-Maximization) training for finite-state string transducers, which is in turn a generalization of the...
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University of Southern California
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Transient Pressure Driven Micromechanical Devices
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These devices use an energy pulse in a gas-filled microvolume to produce a transient pressure wave which moves a flexible diaphragm. For devices around 100 micrometers, the power to weight ratio and forces produced are several orders of magnitude greater than can be produced by comparably sized electrostatic devices. For devices around 1 micrometer, reaction time is about 1 nanosecond for a 1 pico...
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University of Southern California
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Transmitter Location Identification in a Multipath Environment
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This technology increases the accuracy of locating signal transmitters in advanced wireless communication systems by reducing non-line-of-sight (NLOS) error. The method uses an algorithm to omit reflected signals, thereby improving the precision in source localization. Another algorithm finds the source position by using located reflectors, when there are no (or not enough) LOS signals. The method...
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University of Southern California
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Treatment of AIDS-Associated Neuropathy
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Opthamologic problems are common in patients with acquired immunodeficiency syndrome (AIDS). With newer developments in AIDS treatment (such as protease inhibitors), patients are living longer but most are now deteriorating from neurologic symptoms, especially AIDS dementia or encephalopathy. Another manifestation of CNS AIDS is an AIDS-associated optic neuropathy. This technology is a method of t...
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University of Southern California
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Trusted Email (TE) and Full Address Verification Service (FAVS)
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Trusted Email (TE) and the Full Address Verification Service (FAVS) form an integrated solution for preventing fraudulent credit card transactions. This system is designed particularly for E commerce transactions involving "soft products" where there are no physical shipments involved; examples include the delivery of multimedia, software calling cards, and online games....
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University of Southern California
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TS Gene Polymorphism Predicts Intratumoral Gene Expression
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Recently our group demonstrated a significant association between this TS polymorphism and the mRNA expression level of TS. Further we found, that this polymorphism predicts for response and survival of patients with colorectal cancer treated with 5-Fluorouracil. Thus this polymorphic region appears to be functional and may modulate TS gene expression. Ulrich et al. recently discovered a common po...
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University of Southern California
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TS Polymorphism Predicts TS Gene Expression in Normal Tissue and in the Tumor
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Cancer chemotherapy is limited by significant inter-individual variations in responses and toxicities. Such variation are often due to genetic alterations in a drug metabolizing enzyme or receptor expression. Pharmacogenetic screening prior to anticancer drug administration may lead to identification of specific populations predisposes to drug toxicity or poor drug response. We have found that the...
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University of Southern California
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Tunable Optical Fiber Dispersion Slope Compensator
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This invention presents a new dispersion slope compensation technique for broadband high-speed long-distance systems. This technology solves the capacity constraint problem of network expansion by providing the need for the compensation of fiber dispersion slope. Because the optical path can vary in reconfigurable networks, tunable compensation can be obtained by stretching the grating to increase...
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University of Southern California
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Ultrasonic Propulsion
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This propulsion system uses high-intensity acoustic waves to produce a thrust force in liquid, such as water, petroleum products, or blood. It is based on a self-focusing acoustic transducer operating at about 10 MHz, and focuses acoustic waves through constructive wave interference. Thrust magnitude and direction can be controlled in analog fashion by adjusting applied input power, or digitally, ...
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University of Southern California
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Unwrapping Phase Information in Interferometry Imagery
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This is a unique method developed to process the data produced by radar interferometry. It is a non-iterative scheme which can be used to produce a coherent three dimensional digital elevation map....
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University of Southern California
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Updated Version of the Tensor Voting Software
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The Updated Version of the Tensor Voting Software is a software suite for the inference of surfaces, curves and junctions from noisy, incomplete, unorganized point clouds....
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University of Southern California
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Use of Delaunay Triangulation to Report and Optimize Interstitial Radiation Therapy
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The coordinates of the radioactive sources of an interstitial implant may be considered as a set of points, which define the implanted volume. Delaunay triangulation of these points will create a set of tetrahedra, or a set of triangles in the case of a single plane implant, with little or no manual intervention. The geometric centers of these tetrahadra define a new set of points of manageable si...
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University of Southern California
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Valence-Driven Connectivity Encoding for 3D Meshes
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This technology is a new technique for lossless compression of triangle mesh connectivity using valence-driven, single-resolution encoding. This method uses an adaptive conquest over the mesh to transform the mesh into a sequence of valences and few additional codes. This sequence is then processed by an adaptive arithmetic encoder, which will use the low dispersion present in these valences to co...
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University of Southern California
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Virtual Reality Attention Process Assessment and Training System
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This invention concerns a virtual reality (VR)-based system for assessing the attention process. The system utilizes the commercially available virtual reality hardware, such as a headmounted display and headphones. The system is powered by a Silicon Graphics Onyx workstation. The invention consists of software that allows the VR system to be used to test attention deficits. For example, a subject...
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University of Southern California
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Virtual Reality Spatial Skill Assessment System
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This invention concerns a virtual reality (VR)-based system for testing spatial skills. The system utilizes the commercially available ImmersaDesk virtual drafting device from Pyramid Systems. The ImmersaDesk includes a large screen, stereo glasses, and head and hand tracking capability. It creates a semi-immersive VR environment. The system is powered by a Silicon Graphics Onyx workstation. The i...
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