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University of California, San Diego
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A NEW CONSTRUCT FOR CREATING CONDITIONAL KNOCK-OUTS IN MICE
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With conditional knockout mice, gene expression can be turned off at specific stages of development or in selected tissue types. Conventional Cre-lox technology requires two successive manipulations in mouse ES cells, which results in lowering of the effic...
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University of California, San Diego
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Artificial Bone from Sea Shells
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Summary of the Invention: The invention is a new method for creating synthetic bone for biomedical applications. The basis of the technology is derived from the hydro-thermal conversion of Calcite crystals (the structural basis of shells and marine bones) ...
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University of California, San Diego
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Genomic Predictors of Hypertension
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UCSD researchers have discovered new Single Nucleotide Polymorphisms (SNPs) in specific gene loci associated with autonomic dysfunction in human hypertension. End stage renal disease (ESRD) is prevalent in hypertensive African Americans. ESRD typically be...
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University of California, San Diego
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Higher Density for Magnetic Storage
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Description:
Rapid expansion of the Internet, the upcoming transition to HDTV, and other consumer electronics advances will soon create a need for greater storage capacity, greater storage density, and lower cost per bit stored - in other words ultra-h...
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University of California, San Diego
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HotPocketsTM:A Novel PMC Molding Process
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Summary of the Invention:
Provided here is a novel polymer matrix composite (PMC) manufacturing process for the fabrication of PMC based parts and structures.
Benefits of the system include:
low set-up / material costsease of set-up, e...
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University of California, San Diego
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Improving QoS in 802.11 Networks
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Summary of the Invention: With the increased use of 802.11 wireless technology and recent improvements made in 802.11's physical layer to support higher data rates, applications with real-time requirements, such as video and voice, are being widely used i...
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University of California, San Diego
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Novel Anxiolytic Target
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Background:
UCSD researchers have discovered that a deficiency in the expression of a certain sialyltransferase in mice alters fear responses which are normally processed by the hippocampus and the amygdala. These regions of the brain are involved in co...
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University of California, San Diego
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Novel Target for Methicillin Resistant Staph aureus (MRSA)
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Methicillin resistant Staph aureus (MRSA) have become increasingly unresponsive to first-line antibiotic therapy and have compromised the utility of methicillin and related antibiotics, cephalosporins, macrolides, quinolones, and beta-lactamase inhibit...
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University of California, San Diego
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WebCHARTS
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This is a browser-based software system which was designed by, and for use in, Emergency Medicine Departments. The system provides electronic documentation capabilities for maintaining up-to-date information on all patients seen and treated in the emergenc...
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University of California, San Diego
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“Smart Dust” – Porous Silicon Photonic Crystals
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SUMMARY: UCSD researchers have developed a new nanotechnology (“Smart Dust”) with state-of-the-art applications in almost every field of use, ranging from biological sensing and screening to communications technology.
The invention u...
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University of California, San Diego
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11q High Throughput Deletion Detection System
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Congenital heart disease is the most common birth defect, affecting almost 1% of the general population. While there is significant evidence for a genetic etiology for most congenital heart defects, to date few disease-specific genes have been identified. ...
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University of California, San Diego
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3D Visual Modeling with Wide View Images
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Description: Inventors at UCSD have invented a system to extract 3D geometrical structure of a scene and generate a novel view simultaneously at exactly the user's specified viewpoint. The invention also enables smooth virtual walkthroughs at a remote scen...
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University of California, San Diego
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A diagnostic method for Interstitial Cystitis
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Interstitial cystitis (IC) is a painful and under-diagnosed bladder condition thought to result from damage to the mucus lining the bladder wall. This breach in the protective lining, which is usually impermeable to urine components, allows these component...
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University of California, San Diego
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A Dynamic Bouncing Robot forFast Locomotion Over Difficult Terrain
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Given here is the locomotive means to enable a robot that can hop, at high rates of travel, to traverse very difficult terrain.
Present day robots use a variety of locomotive means (multiple sets of legs, tracks and wheels) to move about. All of the...
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University of California, San Diego
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A Macromolecular Carrier for Medical Imaging and Diagnostics
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Description: A UCSD researcher has developed a new macromolecular carrier having hundreds of leashes for readily attaching imaging agents and substrates. The attached substrate directs the carrier to specific tissues so that the attached imaging agent can ...
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University of California, San Diego
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A Mammalian Artificial Chromosome: Utilization For Gene Transfer
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BACKGROUND: Gene therapy holds the promise of correcting human pathologies related to the absence of an appropriate gene expression product. This therapy involves the introduction of a vector, containing the gene encoding the required expression product, i...
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University of California, San Diego
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A METHOD FOR CONTROLLING PLANT-PARASITIC NEMATODE INFECTIONS
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BACKGROUND: Nematode pests cause greater than $80 billion/year in crop damage worldwide. Currently, there is no good way to control endoparasitic nematodes (sedentary worms) on plants except the use of methyl bromide, a highly toxic compound banned by the ...
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University of California, San Diego
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A Method for Inhibiting B Cell Maturation and Antibody Production
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UCSD researchers have identified a key activity required for the maturation of murine B cells and antibody production. This activity is also required for the formation of secondary lymphoid organs (i.e. spleen and lymph nodes). Genetic studies with deletio...
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University of California, San Diego
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A New Approach to Treating Atherosclerosis and Acute Inflammation.
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BACKGROUND: Atherosclerosis is a leading cause of illness and death in the United States , as well as many other developed countries, affecting over 60 million Americans. It can affect arteries of the brain, heart, kidneys and other vital organs along with...
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University of California, San Diego
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A NEW FAMILY OF ANTI-VIRAL AGENTS AND RELATED HIGH-THROUGHPUT SCREENS
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SUMMARY OF THE INVENTION: In search of small-molecule therapeutic agents that target the HIV-I Rev-Response Element (RRE), UCSD researchers have developed: (1) a high-throughput screen to assay the affinity and selectivity of drug candidates for the RRE; (...
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University of California, San Diego
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A new interactive method for the display of 2-D spatial data
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Description: A novel method for the display of 2-D spatial data has been devised. Methods for zooming data usually involve loss of data, either by removing the data from screen real-estate or by obscuring regions by zoomed windows. Methods for eliminating ...
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University of California, San Diego
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A Novel Approach to Reducing Thermal Skew Across High Speed Circuits
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Thermal stress is one of the greatest challenges for integration of high-performance electronic circuits and systems. Whether on a single-chip, multi-chip, stacked or board-level integration, thermal gradients and fluctuations cause mechanical, performance...
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University of California, San Diego
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A novel method of gene regulation.
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A novel method of gene regulation with broad possible applications has recently been described. This method takes advantage of a previously unrealized role for pseudogenes and involves increasing mRNA stability for a coding gene by expression of the homolo...
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University of California, San Diego
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A Novel Method to Detect and Inhibit Angiogenesis
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Researchers at the University of California, San Diego have discovered a novel method of detecting and inhibiting angiogenesis. In vivo experiments have shown that angiogenesis induced by a wide range of pro-angiogenic factors can be completely or signifi...
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University of California, San Diego
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A Simple Quantitative Method To Measure Cellular Secretion
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Background: Secretion is a central and important cellular function. Nevertheless, current methods for measuring cellular secretion are cumbersome and time consuming. Newly created growth factors, cytokines or extra-cellular matrix proteins all need to be c...
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University of California, San Diego
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Active Noise Control for Forced Air Cooling Systems
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Summary of the Invention:
The subject technology presents a novel approach to active noise control (ANC) using feed forward sound compensation. Unlike existing schemes, the subject invention takes into account the dynamic effects of sound propagation, ...
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University of California, San Diego
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Anticoagulants as a Therapeutic Approach for Multiple Sclerosis
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Multiple Sclerosis (MS) is a disease of the central nervous system associated with disruption in the blood-brain barrier. In MS, as well as in spinal cord injury and stroke, fibrin, derived from the blood protein fibrinogen, has been detected i...
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University of California, San Diego
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Arrays for Functional Genomics/High Throughput Phenotyping
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UCSD researchers have developed a method for assembling live biological cells using electrokinetic addressing for functional genomics studies. The method employs rapid, single cell arraying with real time fluorescence monitoring, in a non-well format and w...
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University of California, San Diego
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Article Comprising Universal Solders
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and Method for Fabricating Such Article
It is well known that low-melting-temperature solders, such as Pb-Sn, Sn-Ag, Au-Sn eutectic, do not wet and bond to the surfaces of oxides, nitrides, carbides, fluorides, diamond, and semiconductors. This is d...
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University of California, San Diego
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Automated Cell and Tissue Extraction and Solid Phase Capture Device
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An instrument has been developed that extracts proteins from cells or tissues, performs solid phase capture of the protein of interest and prepares the samples for quantitative analysis. This fully automated instrument can easily be adapted to isolate nucl...
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University of California, San Diego
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BACTERIAL TOXIN COMPLETELY SAFE TO HUMANS CAN TREAT WORM INFECTIONS
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Background: BT (Bacillus thurigensis) insecticidal protein toxins are
now widely used in crop protection as biocontrol agents for
agricultural nematode pests, replacing hazardous chemical pesticide
approaches. However, nematode infestations of ...
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University of California, San Diego
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Banking Human Stem Cells from a Novel Source
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BACKGROUND: Stem cells can be cryopreserved by existing methods for later retrieval and use. However, the range of available cells suitable for specific patients is relatively low, thus a large set of genetically different stem cells that can cov...
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University of California, San Diego
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Beam-Plasma Discharge Technology
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Researchers at the University of California at San Diego have developed a technology to produce a uniform and large area, low temperature plasma suitable for plasma chemistry, plasma processing, isotope separation, and numerous other applications.
...
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University of California, San Diego
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Benchmarks for Java (Version 1.1)
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Background: There are a host of Java compilers and interpreters in use. For this reason, there is a need to tell which compilers produce better code and which interpreters execute them faster.
Description: The software developed at UCSD is a small s...
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University of California, San Diego
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Biosensor for nerve agents and pesticides
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UCSD researchers have developed a ligand sensing fluorescent enzyme assay for detection of
cumulative organophosphate pesticide and nerve agent exposure. The technology utilizes fluorescently labeled mutants of the acetylcholinesterase enzyme (AChE) th...
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University of California, San Diego
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Broad Spectrum Natural Protein Antibiotic
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UCSD researchers have discovered a potent antimicrobial protein with activity against bacteria, such as Staph. aureus, that are resistant to conventional antibiotics. The protein is naturally occurring in epithelial surfaces such as the skin, lung...
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University of California, San Diego
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CE-Combinatorial Extension
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Description: University inventors have implemented a new algorithm which builds an alignment between two protein structures. The algorithm involves a combinatorial extension (CE) of an alignment path defined by aligned fragment pairs (AFPs) rather than the...
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University of California, San Diego
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Cell Surface Dietary Marker in Cancer and Immune Disease
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Background
UCSD researchers have discovered that a non-human sialic acid molecule from red meat and milk is incorporated in human cells through dietary intake, and builds up in tumors. The compound, called Neu5Gc, is found on the surfaces of animal cell...
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University of California, San Diego
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CLINICAL TRIALS MANAGEMENT SYSTEM
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SUMMARY: UCSD researchers have developed software for the management of clinical trials (“CTMS”) in both single and multi-center research programs that provides a cost-effective, resource-sensitive, and easy-to-use alternative to cu...
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University of California, San Diego
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Combinatorial Transcription Control
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UCSD inventors have developed strategies and methods for exertion of combinatorial control on gene expression by integrating multiple transcription signals directly in the regulatory region without the need for additional genes and their expressio...
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University of California, San Diego
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Complex Optical Encoding of Porous Silicon Photonic Crystals
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Researchers at the University of California, San Diego, have invented a method of optically encoding porous silicon photonic crystals for use in high throughput screening and bioassays. The method allows for large libraries of unique particle types to ...
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University of California, San Diego
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Control Premature Seed-Pod Breakage In Crop Species
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Oil seed crops such as canola (Brassica) often break their seed-pods prematurely. This premature seed release can be a result of harvesting techniques or adverse weather conditions. Premature release can cause from 10-50% crop loss in canola, using current...
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University of California, San Diego
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DIAGNOSIS OF HNPCC
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SUMMARY: UCSD researches have discovered a new method to detect the defective gene responsible for most cases of hereditary nonpolyposis colon cancer (“HNPCC”). This method of diagnosis is far simpler and less cumbersome than existing metho...
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University of California, San Diego
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DIAGNOSTIC IMAGING OF LYMPH STRUCTURES
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Description: A UCSD researcher has developed a new method for identification of the first or sentinel lymph node that drains the tissue or organ, particularly those tissues associated with neoplastic or infectious diseases and disorders, and within the per...
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University of California, San Diego
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Diagnostic Markers for Kawasaki Disease
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Kawasaki disease (KD) is a childhood disease prevalent in Asian populations, especially Japan. Disease incidence is approximately 1/1000 for Asians, and 2/10,000 in Caucasian populations. One quarter of disease patients are susceptible to life—threat...
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University of California, San Diego
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Diagnostics for Diseases of Abnormal Protein Glycosylation
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Key Words: Diagnostic assays, carbohydrate-based disorders, peri-natal, post-natal
Invention: A UCSD researcher and a researcher at a sister institution have discovered a class of new analytes and methods using them, both directed to in vitro diagno...
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University of California, San Diego
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Digital Tickets
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Description: This is a novel Internet-based ticket delivery system that provides for secure instant ticket delivery for movies, sporting events, exhibits, and the like. In addition, the system has been utilized in two demonstration projects on campus to fu...
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University of California, San Diego
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DOMINANT-NEGATIVE KINASE ADENOVIRAL CONSTRUCT FOR ARTHRITIS
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SUMMARY OF THE INVENTION: UCSD researchers have discovered that gene therapy using agents that enhance apoptosis can suppress arthritis. This treatment decreases joint inflammation, cytokine production and metalloproteinase gene expression. Using gene-ther...
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University of California, San Diego
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Dynamically Optimal Optical Pulses
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Attempting communications with laser-driver current pulses which occur rapidly in succession, e.g., with randomly interleaved zero and one bits, results in a complex output pattern of light emission in which the bits cease to be decodable at the receiver.<...
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University of California, San Diego
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Enhanced Transfection Efficiency in the Presence of Serum.
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BACKGROUND: The presence of serum in the culture media of cells reduces the efficiency of lipid-mediated transfection. In most cell lines, lipid-mediated transfection requires serum-free media or serum depletion, even though these conditions are toxic to m...
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University of California, San Diego
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Enhancement of Gene Transfer Using a Viral Protein Preparation
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BACKGROUND: Lipids and liposomes are widely used for nucleic acid, protein and drug delivery into cells and several kits are commercially available, especially for DNA and RNA transfer. However, this non-selective lipid mediated transfection technology can...
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University of California, San Diego
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Enhancement of Th2-dependent Anti-inflammatory Response
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SUMMARY: UCSD researchers have discovered elements of a signaling pathway that is invoked whenever T-cell receptors are intensely activated. Inhibition of these elements strongly augments the production of Th2 cytokines.
POTENTIAL COMMER...
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University of California, San Diego
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Ex vivo
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Preparation of Kidney Tissue
An invention developed by UCSD researchers provides for the characterized, sequential growth of kidney tissue ex vivo. Demonstrated, defined methods have been established for growing ureteric bud epithelium for branchin...
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University of California, San Diego
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Explosive Nanocrystalline Porous Silicon Device
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Researchers at the University of California, San Diego, have developed a solid state device fabricated from a high surface area porous silicon substrate and nitrate salts. On ignition, the material produces a very clean burning flame. Although ignition can...
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University of California, San Diego
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FADE and PADRE
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Description: University researchers have written powerful software for the molecular modeling of protein.
The Fast Atomic Density Evaluation (FADE) and Pairwise Atomic Density Reverse Engineering (PADRE) programs deduce molecular shape using the lo...
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University of California, San Diego
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Family Pairwise Search v1.0 Software
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Key Words: bioinformatics, software, biological sequence comparison.
Description: Family Pairwise Search (FPS) is a method for scoring a single biological sequence against a family of sequences. FPS compares pairs of sequences and then combines the ...
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University of California, San Diego
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FLINCH TEST MONITOR
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BACKGROUND: There are several methods currently employed to quantify the behavioral reaction induced by an insult to an animal, generally to a paw. These include (I) observing the numbers of flinches of the affected paw; (ii) measuring the time spent in di...
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University of California, San Diego
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Functional Ligand Display
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UCSD researchers have developed a novel screening method termed functional ligand display (FLD), in which phage or other displayed libraries can be selected not only for their ability to bind cell surface receptors, but also to produce a functional cellula...
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University of California, San Diego
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Gene Therapy for Usher Syndrome Type 1B
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SUMMARY: UCSD researchers have developed a gene therapy for preventing the blindness and correcting the deafness associated with Usher 1B Syndrome, an inherited recessive loss-of-function disorder caused by mutations in the myosin VIIa gene. These pati...
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University of California, San Diego
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GeoPlot Web Visualization Tool
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GeoPlot is a light-weight java applet which allows users to create a geographical image of a data set. The applet provides the user with many options to represent the data set. Basically, GeoPlot plots a set of nodes and a set of lines that connect...
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University of California, San Diego
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Heparan Sulfate Combination Therapy
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A UCSD faculty member has developed a novel therapeutic concept in which synthesis inhibitors of polysaccharides involved in a disease mechanism are used to alter the structure of the compound such that it no longer participated effectively in the disease ...
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University of California, San Diego
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HYPERECHO DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING
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SUMMARY: UCSD researchers have developed a hybrid method for analyzing diffusion data collected with magnetic resonance imaging (MRI). By using diffusion-weighted gradient pulses in conjunction with a hyperecho pulse sequence, researchers have been able to...
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University of California, San Diego
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Improved Materials for Lightweight Armor
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Lightweight armor materials have been developed that are damage tolerant and capable of defeating rifle-fired, armor-piercing rounds of ammunition. These materials are ideal for use as aircraft, watercraft and vehicle armor and have applications in both mi...
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University of California, San Diego
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IMPROVED MEDICAL DEVICE TO ASSIST BEDSIDE PRACTITIONERS WITH IV LINES
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SUMMARY: UCSD researchers have discovered a novel way to facilitate the handling of intravenous (IV) connectors in a clinical setting. This invention involves modifying an existing, simple medical device to allow practitioners to easily reconfigure...
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University of California, San Diego
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Improved Multilayer Vacuum Microtube Device
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and Method for Making Such device
Researchers at the University of California, San Diego, have invented a design and method of fabrication of a vacuum microtube device for cold-cathode microwave amplification. This MEMS design and practical fabricat...
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University of California, San Diego
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IMPROVED PERFUSION IMAGING USING MRI OR AS A STANDALONE PRODUCT
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BACKGROUND: Current arterial spin labeling techniques are problematic in that the life of the tracer is shorter then the time of delivery of the tagged blood to the target tissue by blood flow. The delivery time arises from variations in the distances and ...
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University of California, San Diego
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Improved, Real-time brain Computer Interface Systems
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Brain computer interface (BCI) systems allow the user to send information directly through the use of brain activity and offer a substitute for conventional computer interfaces such as the keyboard or mouse. This provides handicapped individuals a means of...
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University of California, San Diego
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Lead Compounds for the Development of Antimicrobials.
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Several novel alkaloids that act as inhibitors of the enzyme mycothiol S-conjugate amidase (MCA), a cellular detoxicant in Mycobacterium smegmatis, have been identified and isolated. Since MCA is also found in such pathogenic strains of actinomycetes as M....
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University of California, San Diego
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LOAD/UNLOAD SIMULATOR
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Description: This disk drive load/unload simulator allows the calculation of the air bearing spacing between a slider and a disk during start/stop when the tip of the suspension moves up or down on the load/unload ramp.
Keywords: disk drives, home...
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University of California, San Diego
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Long-UV Excited Europium Aluminum Oxide Luminescent Powders
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The search for solid-state white light sources excited by near UV, and exhibiting high quantum efficiency, has eluded researchers. Currently, white-emitting LEDs use a GaN based blue-emitting phosphor which does not produce desirable white emission and is ...
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University of California, San Diego
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Magnetic Porous Silicon Photonic Crystals
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Porous silicon (PSi) is a particularly attractive material for biological and high-tech applications because of the ease with which the optical properties, pore size, and surface chemistry can be manipulated. The position, width and intensity of spectral r...
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University of California, San Diego
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Method and Apparatus for Body Modeling and Movement Analysis
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Description: Inventors at UCSD have invented a system for automatic acquisition of the human body model and tracking of its parameters using input from multiple synchronized video streams. The video frames are segmented and the 3D-voxel reconstructions of ...
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University of California, San Diego
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Method For 3D Cell Patterning Within Hydrogel Scaffolds
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UCSD researchers have developed a method of rapidly organizing a variety of cells within firm hydrogel slabs by utilizing electromagnetic fields. The embedded cells can be patterned, remain viable, and maintain differentiated function over long periods of ...
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University of California, San Diego
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Method for Automated Injection of drosophila Embryos
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In order to facilitate high-throughput biology, genomics and functional proteomics studies using drosophila melanogaster (Fruit Fly), UCSD researchers have devised a device for rapid, large-scale microinjection of large numbers of drosophila embryos with t...
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University of California, San Diego
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METHOD FOR FAST ATOMIC DENSITY EVALUATION
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Description: University researchers have invented a powerful method for the molecular modeling of proteins. This invention can rapidly calculate the distribution of atomic neighbors. A primary advantage of this atomic density method is its computationa...
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University of California, San Diego
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METHOD FOR GENERATING A PROGENITOR POPULATION FROM POSTNATAL HEARTS
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UCSD researchers have discovered a cardiac progenitor population which can be expanded and propagated in vitro. The undifferentiated cells express a characteristic subset of phenotypic markers, which allows the cells to be visualized and manipulate...
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University of California, San Diego
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Method for Predicting Protein Binding from Primary Structure Data
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An ambitious goal of proteomics is to elucidate the structure, interactions and functions of all proteins within cells and organisms. The expectation is that this will provide a fuller appreciation of cellular processes and networks at the protein level, u...
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University of California, San Diego
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Method for Rational Induction of Drought Resistance in Plants
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Suppression of an NMDA-like Receptor
BACKGROUND: A major influence on the successful harvest of nearly every type of crop is adequate rainfall or irrigation. Particularly at critical phases in crop life cycle, drought conditions can delay, d...
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University of California, San Diego
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Methods for Production of Sialic Acid Specific Antibodies
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All cells are covered with a dense and complex array of sugar chains. Sialic acids are a family of nine-carbon sugars that are typically present at the outermost units of these sugar chains. Being at this terminal position, sialic acids act as binding site...
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University of California, San Diego
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Microfabrication of Biodegradable Scaffolds by Micromolding
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UCSD researchers have developed a novel, low cost and versatile method for creating multi-layered biodegradable scaffolds using PLGA. The scaffolds can be rendered porous for use in a range of applications such as tissue arrays and drug-screening. To suppo...
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University of California, San Diego
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Micropatterning Polyethylene Oxide
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UCSD researchers have developed tools to control and study the microenvironment of cells in vitro by creating micropatterned non-adhesive domains on a variety of biomaterials using a simples, versatile method for micropatterning PEO. Using microfl...
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University of California, San Diego
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Molecular Biology Toolkit (MBT)
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Software Overview:
The Molecular Biology Toolkit (MBT) is a Java-based protein visualization and analysis system. The toolkit provides classes for efficiently loading, managing and manipulating protein structure and sequence data. The MBT also provides ...
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University of California, San Diego
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Molecular targets for Bipolar disorder
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Bipolar disorder (manic depression) is a serious mental condition, characterized by severe mood swings between depression and mania. While there is considerable evidence for a genetic component to this disease, its etiology is still poorly understood at th...
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University of California, San Diego
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MONITOR RESISTANCE TO BT TOXINS IN THE FIELD
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BACKGROUND: Bacillus thuringiensis (Bt) insecticidal protein toxins are now widely used in crop protection as biocontrol agents for agricultural nematode pests, replacing hazardous chemical pesticide approaches. The crystal protein toxins are expressed in ...
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University of California, San Diego
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Mouse Model for Macular Degeneration
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Problem : Good animal models are needed in order to test the efficacy of potential therapies for the devastating eye diseases, Stargardt's and Age-related macular degeneration.
Solution Provided by Technology : UCSD and the University of Utah have ...
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University of California, San Diego
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Multi-Potent Central Nervous System (CNS) Stem Cells
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Background: Prior to the discoveries of UCSD researchers, CNS stem cells had been isolated that gave rise to neurons or glia in response to trophic factors and upon implantation into the fetal, newborn or adult brain. Differentiation into cells derived fro...
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University of California, San Diego
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Murine Cell lines for studing innate immunity and myeloid progenitors
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BACKGROUND Macrophages and neutrophils orchestrate the inflammatory response, communicating with each other and with T and B cells to induce cell activation and cell proliferation, to recruit more inflammatory cells, to kill the invader, to protect the su...
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University of California, San Diego
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MUSCLE FATIGUE CONTROLLER
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Description:
Neuromuscular electrical stimulation (NMES) offers numerous benefits in physical therapy and is widely used today to maintain or increase muscle strength. The most efficient use of NMES requires continual feedback to adjust the electrical ...
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University of California, San Diego
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Nanoporous Silicon Bioreactor
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UCSD researchers have developed a silicon-based bioreactor. Initial studies have been done with primary hepatocytes from rat, stabilized in cell-sized pores of porous silicon. Physiological and biochemical activities of the cells were quantitatively evalua...
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University of California, San Diego
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Narrowly Filtered On-Off Keying Modulation in Communication Links
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Summary of the Invention: The invention extends the dispersion limited reach of fiber optic cable to at least 500 km relying on simple OOK signaling, requiring no additional complexity in the transmitter such as additional amplitude or phase modulators. In...
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University of California, San Diego
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NEW CATALYTIC METHOD FOR SYNTHESIZING POLYMETALLOLES
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SUMMARY: UCSD researchers have developed a new method to synthesize polymetalloles. This method represents a vast improvement over current methods of synthesis, such as Wurtz-coupling polycondensation, because:
Yields are very high: 80-90% with only...
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University of California, San Diego
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New Global Motion Algorithm
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Description:
UCSD inventors has come up with a global motion estimation technique for affine motion vectors with the following benefits
1. Requires less computational overhead
2. Relies on the easy-to-compute FFT
3. Highly parallelizabl...
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University of California, San Diego
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NEW METHOD FOR ANALYZING MRI DIFFUSION DATA
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SUMMARY: UCSD researchers have developed a novel method for analyzing diffusion data collected with magnetic resonance imaging (MRI). It represents a substantial improvement over existing diffusion analyses, without the inherent errors. This method allows ...
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University of California, San Diego
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New Technology for Functional Genomics
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A new method has been developed that will allow functional genomics questions to be addressed under a variety of physiological conditions. The method allows selective enrichment of functional DNA elements, such as promoters/enhancers, replication origins a...
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University of California, San Diego
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New Tensioning System for Portable Racquet Stringers
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Summary of the Invention:
Currently marketed tennis racquet stringing machines utilize a drop-weight lever arm to create tension in the string during the stringing process (as seen in this example);
The drawback of this drop-weig...
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University of California, San Diego
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New Transistor Structure for More Efficient Cell Phone Power Amplifiers
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Summary
GaAs heterojunction bipolar transistors (HBTs) are in widespread use for power amplifiers in cell phone handsets. The efficiency of these amplifiers is a critical system parameter that influences the battery life for the handset. The efficie...
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University of California, San Diego
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New Treatment for Sepsis.
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Septic shock occurs from an overwhelming bacterial infection and is characterized by severe hypotension with low blood flow. It is the 13th leading cause of death in the United States with a mortality rate of 30%-50% due to the lack of effective treatments...
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University of California, San Diego
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NOVEL AMIDE-BASED PROTECTING GROUPS FOR THE SYNTHESIS OF COMPLEX MOLECULES
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SUMMARY OF THE INVENTION: UCSD researchers have developed a novel amide-based protecting group that can be cleaved under a prescribed set of acidic conditions, ranging from highly acidic to very mildly acidic. In doing so, we have developed a tunable famil...
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University of California, San Diego
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Novel Animal Model and Screening System for Anti-Psychotic Drugs
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BACKGROUND: Development of anti-psychotic drugs has been handicapped by the lack of a validated animal model for screening and efficacy assessment. There is not good correspondence between known drug mechanisms of CNS action and anti-psychotic efficacy in ...
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University of California, San Diego
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Novel Gene Target for the Treatment of Cardiac Arrhythmia
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Cardiac arrhythmias are a leading cause of morbidity and mortality in developed nations. UCSD researchers have discovered the function of a gene which modulates transient outward potassium current in the heart. Knock-out mice lacking this gene exhibited a ...
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University of California, San Diego
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NOVEL MOTION ESTIMATION TECHNIQUE
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Description:
UCSD inventors has come up with a novel motion estimation technique with applications in the following (and more)
Frame Rate Conversion - for example NTSC to HDTV video rate conversion.Compression - for example in MPEG2, MPEG4, H...
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University of California, San Diego
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NOVEL SCREENING METHOD FOR DRUGS THAT MODULATE TRANSCRIPTION.
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BACKGROUND: Certain disease states in man have their origin in aberrant gene function. Drugs which can obviate such aberrant gene function by targeting the appropriate protein interactions would be of obvious value. Two known mediators of gene expression a...
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University of California, San Diego
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Novel Single Nucleotide Polymorphisms (SNPs) Associated with Hypertension
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UCSD researchers have discovered over one hundred and fifty (150) new Single Nucleotide Polymorphisms (SNPs) in specific gene loci associated with autonomic dysfunction in human hypertension. Over one third of these SNPs have a minor allelic frequency >...
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University of California, San Diego
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Novel, validated target for type II Diabetes drug inhibitors
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Problem:
Insulin regulates glucose uptake into fat and muscle cells through glucose transporters (GLUT4) which are translocated from an intracellular membrane storage pool to the plasma membrane. A Type II diabetic either does not produce enough insuli...
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University of California, San Diego
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Nutrition Link Web Site
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This is a uniquely designed web site and educational program addressing proper nutrition that dove-tails into the 4th and 5th Grade school curriculum. The web site (ucsdnutritionlink.org) includes a calendar, jokes, lessons, fitness, facts, cr...
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University of California, San Diego
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Oligonucleotides for the Treatment of Cancer and Autoimmune Diseases
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SUMMARY: UCSD researchers have discovered new synthetic oligodeoxynucleotides (15-mers) useful in treating cancer and certain autoimmune diseases. These compounds induce apoptosis in chronic lymphocytic leukemia cells but actually stimulate normal huma...
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University of California, San Diego
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OPEN MMS
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Description:
Researchers at UCSD have produced bioinformatics middleware for working with protein and nucleic acid macromolecular structure data stored in the new standard mmCIF format now being supported by the Protein Data Bank. The software will ...
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University of California, San Diego
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Optically Encoded Nanoparticles
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Researches at the University of California at San Diego have invented an optical encoding method for encoding micron-sized nanoporous semiconductor, conductor, or dielectric particles to be used in biological and / or chemical screening, sensing,or identif...
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University of California, San Diego
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Optimizing Expression of Recombinant Protein in Mammalian Cells
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Background: For the biotech industry, many therapeutic proteins, such as erythropoietin (EPO) and tissue plasminogen activator (tPA), have to be produced in mammalian cells despite relatively low yields and high cost to achieve the posttranslational proces...
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University of California, San Diego
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OVERCOME THE b-AMYLOID BLOCK IN ALZHEIMER'S
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An important brain receptor, nicotinic acetylcholine receptor (a7nAChR) is inhibited by the b-amyloid peptide produced in Alzheimer's disease. UCSD investigators have found a novel approach to overcome the neural blockade caused by b-amyloid by modulating ...
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University of California, San Diego
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PHOSPHATASES THAT REGULATE GENE TRANSCRIPTION
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UCSD researchers have determined a novel activity for a family of small c-terminal domain phosphatases (SCP) in regulating gene transcription by preferentially dephosphorylating ser5 of RNA polymerase II. The UCSD researchers have developed methods for upr...
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University of California, San Diego
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POROUS PHOTONIC CRYSTALS FOR INTRAOCULAR DRUG DELIVERY
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Problem: The treatment of eye diseases such as Age-related Macular Degeneration, Diabetic Retinopathy, Uveitis and others, has been very problematic. The largest barrier to effective treatment is the difficulty of delivering the appropriate concentration o...
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University of California, San Diego
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Portable Hand Held Alveolar Oxygen and Carbon Dioxide Meter
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This invention is a portable alveolar oxygen and carbon dioxide meter, which shows the concentration or partial pressures of oxygen and /or carbon dioxide in the alveolar gas in the depths of the lung. It is the first portable oxygen meter, and would comp...
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University of California, San Diego
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RAPID DETECTION OF EXPLOSIVES
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SUMMARY: UCSD researchers have developed a simple, fast, and inexpensive sensor to detect trace amounts of explosives. A silicon polymer has been made into a nanowire, 2000 times thinner than a human hair, that detects compounds such as picric acid, nitrob...
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University of California, San Diego
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Regulating genes in the COX-2 pathway for colon cancer
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Colon cancer is the second leading cause of cancer deaths in the US and is the third most common cancer worldwide. The National Cancer Institute estimates 147,500 new cases and over 57,000 deaths in the United States in 2003, with a greater incidence i...
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University of California, San Diego
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REPORTERS FOR THE "ALTERNATIVE" NF-kB PATHWAY
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SUMMARY: A second major NF-kB pathway has been described, which is important for the maturation of B cells and the development of secondary lymphoid organs. In order to identify agents that specifically affect this pathway, and not the classical NF-kB casc...
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University of California, San Diego
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RESTORATION OF SYMMETRIC CORNEAL THICKNESS
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A class of corneal diseases causing refractive errors of the eye, corneal ectasia, results in severe irregular astigmatism and vision that is not corrected by spectacles. The underlying cause is a bulging of the cornea which is thought to result from asymm...
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University of California, San Diego
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Secure Internet-based Behavior Modification
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Description:
The invention is a new technique for people to engage in behavior modification (smoking cessation, dieting, etc.) or explore mutual interests in a secure fashion via the Internet. A working prototype exists and is showing e...
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University of California, San Diego
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Self-Assembling, Self-Orienting Photonic Crystals of Porous Silicon
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There are presently many examples of 1-,2-,and 3-dimensional objects constructed using so-called self-assembly reactions. For example, covalent bonds formed between alkanethiols and gold substrates have been used to pattern surfaces; or hydrogen bo...
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University of California, San Diego
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SOMATOSTATIN ANALOGUES THAT INHIBIT GROWTH HORMONE and INSULIN RELEASE
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SUMMARY: UCSD researches have synthesized several somatostatin analogues with specific activity at 2 of the 5 somatostatin receptor subtypes. These receptors are hsst2, which is involved in diabetic retinopathy, pain sensation, insulin and glucagon release...
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University of California, San Diego
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Splicing Graph Genome Assembler Software Modules
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Description: This approach abandons the classical overlap - layout - consensus approach in favor of a new Eulerian splicing graph approach that, for the first time, resolves the problem of repeats in fragment assembly. The splicing graph approach, in contr...
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University of California, San Diego
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SQUID
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Description: University researchers have written a high-performance proxy caching server for web clients, supporting FTP, gopher, and HTTP data objects. Using a single, non-blocking, I/O-driven process, Squid is able to handle all requests.
For more...
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University of California, San Diego
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Synthetic Fusion-Peptide Vaccine for Cancer and Viral Infection
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Problem:Cytotoxic T lymphocytes (CTL) are among the most direct and effective elements of the immune system against cancer cells and virus-infected cells. The malignant cells expressing the appropriate associated antigens can be effectively recognized and ...
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University of California, San Diego
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System and Methods for Knowledge-Guided Information Integration
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Description: University researchers have a novel technique to perform information mediation across heterogeneous sources even when the sources are hard to integrate. This is accomplished by a novel mediator architecture that allows information sources to b...
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University of California, San Diego
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Tacky Dot® Technologies
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Description: As part of the Tacky Dot® donation, the University is offering for commercialization technologies related to improved photo-imageable solder delivery allowing for 3-5 micron diameter solder balls, cleanup of excess particles from an array ...
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University of California, San Diego
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Telephony: A System for the Bi-directional Sharing of Phone Lines
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Summary of the Invention:
The subject technology presents a telecommunications system employing peer-to-peer and centralized server networking to enable POTS/PBX/PSTN phone lines, collectively PCP, to be accessed via the Internet by remote authorized u...
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University of California, San Diego
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The Equalizer : DNA Array Analysis Software for Data Normalization
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The Equalizer is a custom application which uses rank-order similarity in gene expression intensity to construct non-linear equalization vectors which are then used to linerize the data matrix to a consistent slope of 1. In addition, The Equalizer rational...
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University of California, San Diego
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Tissue Oxygen Distribution by Pulse Oximetry
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Current pulse oximetry technology yields information that represents the average amount of oxygen saturation in the blood for all blood vessels, arterioles, capillaries and venules. This method does not differentiate between arterioles and the rest of the ...
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University of California, San Diego
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TRANSPORT MOLECULES FROM DENDRITIC OLIGO-GUANIDINES
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SUMMARY: UCSD researchers have developed novel non-peptoid transport molecules that, when coupled to a "cargo" such as an antibiotic or a fluorophore, facilitate the crossing of the cargo across cell membranes into the cytoplasm. A key featur...
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University of California, San Diego
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TRANSPORT PEPTIDES TO ENHANCE IRON ABSORPTION
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SUMMARY: UCSD researchers have developed a molecule that enhances the transport of supplemented iron into cells. They have synthesized a peptide that chelates iron, and then safely delivers it to specialized intestinal cells for efficient absorption by...
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University of California, San Diego
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Uniaxial strain device
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Problem : Cells are subjected to physiological mechanical strains resulting in intracellular signaling, gene expression, protein synthesis, along with changes in cell shape, proliferation and apoptosis. The types of strain depend on the tissue. The cardiac...
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University of California, San Diego
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Use of Calcium Binding Proteins to Improve Cardiac Contractile Function
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The current treatment of heart failure is often heart transplantation. UCSD researchers have developed an alternative treatment for heart failure by regulating cytostolic calcium fluxes, in order to improve contractile function. Calcium regulation is achie...
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University of California, San Diego
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Use of Steady State Oxygen Gradients to Modulate Cell Functions
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UCSD researchers have developed a perfusion bioreactor system with a directional oxygen gradient, and a method to determine the effect of oxygen gradients on cellular functions. Cellular components exhibit different functional characteristics based on the ...
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University of California, San Diego
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Video Walkie-Talkie
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Description:
UCSD inventors has come up with a low-complexity video compression engine, suitable for next generation interactive mobile phones. Using this invention it is possible to transmit video sequences for video conferencing on a wireless cha...
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University of California, San Diego
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Web Server with Differentiated Quality of Service
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Description:
University researchers have invented a method for providing different levels of quality of service (QoS) at the level of the web server. This allows for the follow benefits:
1) Allows for higher quality of service to paying custo...
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University of California, San Diego
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WHOLE-PROTEOME INTERACTION MINING
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SUMMARY: UCSD researchers have developed a novel algorithm for the prediction of the positive interactions of proteins with other proteins, nucleic acids, small molecules and biopolymers. The system is first trained to recognize patterns that characterize ...
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