test: ( SearchWords LIKE '%University%' AND SearchWords LIKE '%of%' AND SearchWords LIKE '%California,%' AND SearchWords LIKE '%Irvine%' )
SELECT COUNT(*) FROM ipnavigate.Dockets AS d, ipnavigate.ResearchFirms AS rf WHERE d.ResearchFirmID=rf.ID AND ( ( SearchWords LIKE '%University%' AND SearchWords LIKE '%of%' AND SearchWords LIKE '%California,%' AND SearchWords LIKE '%Irvine%' ) ) ipNavigate - Search Results
ipNavigate - Innovation to Commercialization
ipNavigate Home About ipNavigate Contact ipNavigate Members Login
Search Tips
  Let Us do the Search For You!
 188 listing(s) found for University of California, Irvine
 University of California, Irvine 5-Alkoxypsoralens as Inhibitors of Potassium Channel Activity in Lymphocytes and Other Cells
  University of California, Irvine researchers in collaboration with researchers at the University of Kiel, Germany have synthesized a series of substituted 5-alkoxypsoralens. These 5-alkoxypsoralens block the Kv1.3 channel and suppress mitogen-stimulated human lymphocyte proliferation in the low nanomolar range. Unlike other Kv1.3 channel peptide and non-peptide inhibitors, these 5-alkoxypsoralens ...
 University of California, Irvine A Bio-Applique Containing Bacteria for Chrome-free Corrosion Protection of Metals
  University researchers have developed a new film composed of natural and/or engineered beneficial bacteria that are incorporated into single or multi-layer coatings to provide corrosion protection to metal surfaces to which these coatings are applied. The invention includes using protective bacteria to produce a biofilm that provides protective and "self-healing" properties to the coatings. Proper...
 University of California, Irvine A Broadband Amplifier with Huge Gain-bandwidth Product and Low Power Consumption
  University researchers have developed a design method by combining three-stage amplifier design to achieve a broadband amplifier with desirable gain, large bandwidth, low power consumption, low input/output reflection coefficients, low loss, and good reliability. Without a distributed amplifier, the invented broadband amplifier bandwidth of 1/2 of fT and/or approaching to fT can be achieved. There...
 University of California, Irvine A Device to Measure the Flow of Liquids Due to Pipe Leakage Via Measurements of Water Loss
  University researchers have developed a new test instrument to accurately quantify water loss at different water levels in discrete sections of pipe. This new instrument allows for new levels of: sensitivity (the exfiltration flow rates that can be detected are on the order of liters/hr.); specificity (the ability to vary the depth of water within the pipe allows for measurements of leakage at dif...
 University of California, Irvine A Diffusive Probe for Quantification of Optical Properties of Superficial Layers
  Researchers at the University of California have developed a fiber-based spectroscopic technique that can be used to quantify optical properties in superficial layers of tissue. In the past, quantitative characterization of superficial epithelial tissues such as skin and oral mucosa has been difficult due to the limiting assumptions in the models that are employed to describe light propagation in ...
 University of California, Irvine A General Constant Frequency Pulse-Width Modulator And Its Applications
  Therefore, there is a need for a pulse-width modulator which allows the system and circuit designer to implement a wide variety of constant-frequency control schemes without the need for special circuit components or specially designed circuits requiring extensive analysis and design.Researchers at the Power Electronics Laboratory at the University of California, Irvine, have developed a constant ...
 University of California, Irvine A High-Output Random Number Generator Based On Spontaneous Alpha-Decay
  This invention addresses the differences between an algorithmic random number generator (RNG) versus a physical RNG. The common problem with all algorithmic RNG’s is that their digital output is in fact far from random, no matter how sophisticated the underlying mathematical algorithm is. There exist severe fundamental restrictions on what can be done with this approach. The pro...
 University of California, Irvine A High-Output Random Number Generator based on Spontaneous Nuclear Decay
  This invention relates to a physical random number generator based on spontaneous nuclear decay. The novel design: (i) eliminates the need for a pure monoenergetic source of alpha-particles; (ii) accounts for every single decay event without any special precautions; (iii) is 100% external and internal noise and interference-proof; (iv) can be build with readily available, off-the-shelf components;...
 University of California, Irvine A Key Pentacyclic Intermediate For The Preparation Of The Crambescidin/Ptilomycalic Family Of Guanidinium Alkaloids And Congeners
  The crambescidin/ptilomycalin A family are a class of guanidinium alkaloids purified from sponge extracts that have been shown to be pharmacologically important. Some members of this family are cytotoxic to bacteria, viruses, and fungi, while others inhibit key enzymes in the brain and muscles of animals. Researchers at the University of California, Irvine, have synthesized the key pentacyclic cor...
 University of California, Irvine A Laser System for the Generation of Pulses with Duration in the Pico-second Range and a Narrow Bandwidth
  UCI researchers have developed a laser system for the generation of pulses with duration in the picosecond range and a narrow bandwidth. The laser system produces pulses with a duration of about 25 ps. The radiation can be tuned between 410 nm and 2000nm. The bandwidth of the radiation is spectrally narrow, close to the theoretical limit (the Fourier limit). Technically this system is an optical p...
 University of California, Irvine A Method and Device for the Surgical Treatment of Adolescent Scoliosis Without Fusion
  Researchers at the University of CA have developed a method and apparatus for the surgical treatment of adolescent scoliosis without fusion. The apparatus is an expanding rod which produces a controlled force, slowly over time, under precise external control. It can be completely isolated under the skin. The rod is small, powerful, simple to manufacture, immune to accidental activation, and biolog...
 University of California, Irvine A Method For Detecting Interactions Between Protein, Encoded By cDNAs And Any Defined Molecular Target
  Researchers at the University of California, Irvine, have designed a sensitive, high-throughput strategy that can be performed manually or by automation for detecting interactions between proteins, encoded by CDNAs and any defined molecular target including other proteins, nucleic acids, protein nucleic acid complexes and drug/protein/nucleic acid complexes. The components of this process include ...
 University of California, Irvine A Micro-Fluidic Platform for Performing Gel Electrophoresis and Western Analysis
  The Researchers at the University of California are developing a miniaturized, integrated microfluidic device and method ("lab on a chip") that performs gel electrophoresis followed by Western analysis. The technology utilizes a novel design where a single channel serves multiple purposes, including (1) cooling, (2) staining, (3) detaining, (4) electro-blotting.The current invention provides multi...
 University of California, Irvine A Micro-Platform for Solubility Characterization of Induced Protein in Cells
  Researchers at the University of California are developing a miniaturized, integrated apparatus and method for incubating cells and performing solubility characterization of induced soluble protein in cells at regular, pre-programmed intervals. This invention provides an integrated, automated way to test cells for soluble protein content during incubation. The apparatus, which is small enough to f...
 University of California, Irvine A Micro-Platform for the Production of Plasmid Constructs, Cell Transformation, and Validation
  Researchers at the University of California are developing a micro-platfom device which miniaturizes and incorporates the gene expression optimization procedures on a lab-on-a-chip. Specifically, the technology integrates distinct laboratory steps onto a single automated platform that uses microliters of sample. These steps are the insertion of a PCR product into a plasmid (ligation reaction), the...
 University of California, Irvine A Microfluidic Device for Gel Electrophoresis with Integrated Thermal Cycling and Sample Elution
  University of California, Irvine researchers are developing a new microfluidic device and method for performing rapid thermal cycling on a small quantity of DNA sample for the purpose of performing PCR. This is followed by purification of the amplified DNA and then an optional step is available on this device to elute a specific band of purified DNA.Compared to currently known microfluidic devices...
 University of California, Irvine A Microfluidic Dynamic Vapor Control System
  University researchers have developed a small, integrated system to dynamically change the chemistry of a small drop by controlling the vapor. This system uses microfluidic vapor lines and on-board vapor reservoirs that can be actuated to produce vapor on demand. It also identifies storing the reagents or materials needed to generate the vapor on the same device for a convenient, disposable cartri...
 University of California, Irvine A New Burr Design
  University of California researchers have addressed these issues with a new burr design which discriminates between hard and soft tissues. As such no protective shield is necessary, it can be used closer to sensitive structures (such as the spinal durra), and powered endoscopic tools are much more possible. Because the burr is much safer near soft tissues, it can be used where there is not complet...
 University of California, Irvine A New Forward Converter with Natural Magnetizing reset and Interleaved Parallel-connection Features
  University researchers have developed a new forward converter, which combines two basic forward converter cells in such a way that the magnetizing reset and interleaved connection are realized naturally. The proposed converter has following features: each MOSFET is clamped at (Vinmax); no additional magnetizing reset circuit is necessary, which makes the circuit simple; the leakage energy and the ...
 University of California, Irvine A New Polymerization Method For Polymethylene
  Researchers at the University of California have developed a new synthetic method for the manufacture of polymers that offers several distinct advantages over existing methods. The UC method consists of a unique polymerization reaction that:- Permits a high degree of monodispersity, - Enables the preparation of block copolymers, - Allows a broad variety of functional groups to be added to the chai...
 University of California, Irvine A New Process Of Adding Alkyl Groups To Organic Substrates Using TmI2(MeOCH2CH2OMe)3
  Researchers at the University of California, Irvine, have discovered a compound that allows a variety of important chemical transformations to be accomplished using cheaper materials and eliminates the use of some carcinogenic reagents in the currently used systems....
 University of California, Irvine A New Tandem-Affinity Tag for Two-Step Protein Purification under Fully Denaturing Conditions
  University of California, Irvine researchers have developed a novel tandem-affinity tag that is compatible with two-step purification under fully denaturing conditions such as 8 M urea or 6 M guanidinium. This novel tag serves as a biotinylation signal in vivo. Tagged proteins are efficiently biotinylated in vivo in both yeast and mammalian cells at a specific lysine residue present in the tag. Th...
 University of California, Irvine A Novel Method For Eliminating Mach Waves In Supersonic Jets
  A researcher at the University of California has devised a method for the elimination of Mach waves that does not suffer from the limitations seen in the currently available devices. Unlike the other less successful devices, this method minimizes Mach waves not by attempting to suppress or "muffle" them but, rather, by preventing their formation via alteration of the turbulent-eddy dynamics....
 University of California, Irvine A Polymeric Micro-Cantilever Resonator Array and Its Implications in Auditory Prostheses
  University of California, Irvine researchers have developed a polymeric micro-cantilever resonator array that mimics the biological front-end processing in the cochlea....
 University of California, Irvine A Reduction in Sumoylation of Cellular Proteins Reduces Polyglutamine Toxicity In Vivo in a Drosophila Fruit Fly Model of Huntington's Disease
  University of California researchers have found that Httex1p can be modified by either SUMO-1 or ubiquitin on common lysine residues; Httex1p is stabilized by SUMO-1 modification and co-localizes with SUMO-1 in vivo and in cell culture. Crossing a Drosophila model of HD with a reduced function smt3 (Drosophila SUMO) mutant results in suppression of lethality and neurodegeneration....
 University of California, Irvine A Soluble Type II TGF-ß Receptor To Suppress Pancreatic Cancer Growth
  To determine whether blocking TGFß actions would suppress pancreatic cancer cell growth in vivo, researchers at the University of California, Irvine expressed a soluble TßRII in COLO-357 human pancreatic cancer cells. COLO-357 cells express all three mammalian TGFß isoforms and are growth inhibited by TGFß in vitro. The results showed that COLO 3...
 University of California, Irvine A Technique to Make Carbon Nanotube Electrodes
  The present invention includes: 1) the use of carbon nanotubes as electrodes for dielectrophoretic trapping, 2) dielectrophoresis assisted assembly of nano-cuicuit made of macromolecules, and 3) electronically assisted chemical reaction for biological applications. More particularly, the present invention provides a specific dielectrophoresis system using carbon nanotubes as electrodes to pave the...
 University of California, Irvine Advanced Materials Processing
  University researchers have developed a method called In Situ Variable Equal Channel Angular Pressing (VECAP) - a system and method for producing ultra-fine grain and nanocrystalline materials with a desired gradient in microstructure. Conventional ECAP has involved the use of an extrusion die with a fixed angle that is typically in the range of 140 to 90 degrees. The present invention involves a ...
 University of California, Irvine Agrin Derived Antagonist and Agonist Polypeptides for the Treatment of CNS Disorders
  University of California, Irvine researchers have provided the first evidence for a specific agrin receptor in the brain and identified and developed polypeptides derived from agrin that fully retain agrin's biological activity. A second polypeptide derived from agrin was shown to act as an agrin antagonist....
 University of California, Irvine Amantadine Derivatives (Amantadine Analogues) for the Treatment of Hepatitis C Virus
  University of California, Irvine researchers have synthesized 1-amino adamantane and 1-boraadamantane derivatives that are structurally similar to amantadine. These derivatives were evaluated for an antiproliferative effect on CD81-enriched cell lines. Both 1-amino adamantane and 1-boraadamantane derivatives displayed a dose dependent antiproliferative effect on the CD81-enriched cells relative to...
 University of California, Irvine An Antibody-based Method for Reducing Ocular Inflammation Which Can Aid in Corneal Transplantation
  HSV keratinitis is characterized, in part, by scarring of the eye as a result of HSV reactivation. To date, corneal transplantation is the standard treatment method. A significant obstacle preventing successful corneal transplantation is inflammation that occurs within the eye (ocular inflammation). Researchers at University of California, Irvine and the University of Oklahoma have identified an a...
 University of California, Irvine An Expandable Cage Intended For Use In Performing Lumbar Interbody Spinal Fusions From Posterior
  A Researcher at the University of California, Irvine, has designed a folding cage that can be placed from the posterior, is small enough to slip past the nerve roots and can then expand three to five times its original height. The unique geometry and construction of the compressed cage allows for flexibility in the application procedure and enhanced strength in its expanded form....
 University of California, Irvine An Improved Clamp for Performing Circumcisions on Newborn Boys
  University of California, Irvine researchers have recently developed a new clamp that is safer than the Mogen clamp and easier to use than the Gomco clamp. This newly developed clamp is pre-assembled and can include an integrated cutting blade, eliminating the need for a scalpel....
 University of California, Irvine Anti-Microbial Peptide And Methods Of Use
  Researchers at the University of California, Irvine (UCI) have developed a platform technology for a new class of antimicrobials that have broad spectrum activities against bacteria, fungi, viruses and protozoa. These compounds, termed "defensins," are microbicidal peptides that show promise as systemic ad topical antimicrobials, antisepsis agents, disinfectants, preservatives, and adjuvants. An a...
 University of California, Irvine Antibiotic Cryptdin Peptides And Methods Of Their Use
  Researchers at the University of California have recently characterized and purified five intestinal defensins of epithelial origin and demonstrated their antibacterial activity. The discovery of intestinal defensins is important for a number of reasons. First, whereas leukocyte-derived defensins function primarily intracellularly, this discovery suggests that intestinal defensins function in the ...
 University of California, Irvine Applications of Photonic Crystals with Degenerate Spectral Band Edge
  University researchers have developed a photonic crystal with specially designed geometry and composition capable of slowing down electromagnetic pulses, thereby enhancing the physical characteristics of non-linear and other active electromagnetic materials, as well as enhancing and reducing sizes of various electromagnetic devices....
 University of California, Irvine Architectural Enhancements and Code Transformations for Energy Reduction via Processor and Energy Free Time Aggregation
  University researchers have developed architectural enhancements and code transformations for modern programmable processor systems for energy reduction.The architectural enhancements and the code transformations enable the aggregation of processor free time. The processor can be switched to low-power mode during its aggregated period of inactivity, and thus reduce the energy consumption. This inv...
 University of California, Irvine Assay For And Treatment Of Autoimmune Disease
  The invention is directed to prognosis, diagnosis and treatment of autoimmune diseases, including SLE (systemic lupus erythematosus), type-1 diabetes, experimental allergic encephalomyelitis (EAE) and other, which demonstrate uniquely the presence abnormal double-negative (CD4- and CD8-) T cells expressing large numbers of type 1 K+ ion channels. Such channel expression parallels the ability to in...
 University of California, Irvine Assay, Methods And Products Based On N K+ Channel Expression
  This disclosure relates to the n K.sup.+ channel expression product of the MK3 gene or a functionally bioactive equivalent thereof and its uses, particulary in combination with identifying immune responses and materials modulating or blocking same....
 University of California, Irvine Automated, Programmable, High Throughput, Multiplexed Assay System for Cellular and Biological Assays
  Researchers at the University of California have developed a method and apparatus for performing automated, programmable, high-throughput analysis of adherent cells. It uses microscopic structures (cell pallets) patterned in such a manner so that adherent cells can plate against them. These structures are designed to provide a portable scaffolding for one or more adherent cells to be stored or car...
 University of California, Irvine Automatic Detection and Diagnostics of Diabetic Retinopathy
  UC researchers have developed a tool to aid in the automated detection of diabetic retinopathy. This novel system provides for blood vessel detection in a clutter (abnormality) environment and allows for efficient recognition of low-contrast minor blood vessels. A computer algorithm using adaptive thresholding and the localized Radon transform detects the normal vascular network from a retinal ima...
 University of California, Irvine Batch-Fabricated, Micromachined Oven and Hot Plate System
  University researchers have developed a method of design and manufacture of miniature and microscale ovens and hot plates ("micro-ovens") that are compatible with standard batch process, microfabrication techniques. The temperature controlled microsystems may be precision controlled using simple circuitry, and are capable of producing very fast temperature ramp rates. High aspect ratio micromachin...
 University of California, Irvine Bioactive Fluorescent Derivatives Of The Alzheimer Amyloid A-Beta Peptide
  Investigators at the University of California, Irvine, have identified and prepared novel fluorescent derivatives of the amyloid A-Beta peptide. It contains features that utilize specific amino acid substitutions at many different positions along the peptide chain. These yield modified peptides with unique sulfhydryl chemical reactivity that is used for making covalent fluorescent derivatives. Thi...
 University of California, Irvine Borna Disease Viral Sequences, Diagnostices And Therapeutics For Nervous System Diseases
  Researchers at the University of California, Irvine, have elucidated the genomic sequence of the BD virus and created an ELISA test for the detection of BD antibodies and consequent diagnosis of the disease (or ruling out of BD infection). Moreover, the researchers have also isolated a glycoprotein that mediates the attachment of the BD virus to host cells. This protein can be used as a potential ...
 University of California, Irvine Broadband Absorption Spectroscopy In Turbid Media By Combining Frequency-Domain And Steady State Methods
  Reflectance spectroscopy is a technique for characterizing turbid media that has become widely used in medical diagnostics. The University has developed a technique for measuring broadband near-infrared absorption spectra of turbid media that uses a combination of frquency-domain (FD) and steady-state (SS) reflectance methods. Most of the wavelength coverage is provided by a white-light SS measure...
 University of California, Irvine Broadband Distributed-Mass Micromachined Gyroscope
  University researchers have invented a distributed-mass micromachined gyroscope which minimizes quadrature error, eliminates effects of directional residual stresses, and completely decouples the drive and sense modes. The device has multiple drive-mode oscillators, distributed symmetrically around the center of a supporting frame. The multi-directional linear drive-mode and the rotational sense-m...
 University of California, Irvine C-MEMS Technology for Ni Nanowire Formation
  University researchers have developed a method for two and even three level C-MEMS processes to fabricate low resistance contacts to C-MEMS features and to make very high aspect ration structures (> 40). In the present case, researchers used the more familiar Ti/Au combination as contact material; the Au layer melted and changed to a multitude of Au balls at the high pyrolysis temperature, dist...
 University of California, Irvine Cell Encapsulation on a Microfluidic Platform
  Univeristy of California researchers have developed a novel microfluidic platform for encapsulation of cells in droplets. Cells can be loaded at low or high densities to achieve droplets of 1-5 cells or up to 20-50 cells. Droplet size can be manipulated by channel geometries and flow rates.In contrast with prior batch techniques, this device allows for a smaller minimum droplet size of 100 Â...
 University of California, Irvine Cell-Permeable Enzyme Activation Reporter (PTD-Modified Reporters)
  UC researchers have developed an efficient method to deliver biologically active proteins into intact cells. The invention uses a peptide chemically conjugated to a reporter (substrate peptide and fluorescent tag) to effect transport of cell-impermeable molecules across cellular membranes. The peptide is either a peptide transduction domain (PTD) or a cell-penetrating peptide (CPP). The molecule i...
 University of California, Irvine Combination of HRE and SP1/SP3 Binding Sites for Gene Therapy in Hypoxic Tumors
  University of California, Irvine researchers have found that the CA9 promoter includes a Hypoxia Related Element (HRE). This HRE binding site on CA9 along with SP1 and/or SP3 binding sites are necessary for induction of CAIX transcription under hypoxic conditions....
 University of California, Irvine Composite Transistors for Compensation of HBT Self-heating Effect and Enhancement of HBT Linearity
  University researchers have designed a composite transistor that solves this problem with a conventional processing technology, without sacrificing too much power gain or chip area. The compensation mechanism of self-heating effect in active HBT is based on the concept of negative feedback in control theory. After the compensation, the DC performance of forward output is much better than before.Th...
 University of California, Irvine Composition And Method For Treating Inflammation
  University of California researchers have found two cytokines (proteins that interact with immune cells) which inhibit neutrophil migration. They have invented formulations containing mixtures of both cytokines with pharmaceutical carriers. In animal studies, their formulations have proven to be as effective as the most powerful existing immunosuppressives in controlling acute inflammation. One fo...
 University of California, Irvine Compositions and Methods for Treating Obesity
  University of California, Irvine researchers have discovered a new class of synthetic compounds that modulate cannabinoid receptors. These compounds directly down-regulate cannabinoid neurotransmission in the central nervous system....
 University of California, Irvine Corneal Transplantation
  Researchers at the University of California, Irvine, have developed a method using an automated microkeratome to provide an essential means of harvesting stem cell tissue of reproducible dimensions. This method is far more consistent than the current manual method for stem cell harvesting. By providing consistency to the procedure, the operation could be based out of hospitals, surgical centers or...
 University of California, Irvine Data Compression Of Time-Varying Images
  Researchers at the University of California have developed a method of time-varying image compression which provides compression ratios of several hundred. Unlike spatial compression techniques, information on the pixel intensity values are only transmitted for intermittent frames. Between the intermittent frames, the invention compresses the image motion rather than the spatial pixel intensity di...
 University of California, Irvine Defensin Peptide Compositions And Methods For Their Use
  Researchers at the University of California, Irvine (UCI) have developed a platform technology for a new class of antimicrobials that have broad spectrum activities against bacteria, fungi, viruses and protozoa. These compounds, termed "defensins," are microbicidal peptides that show promise as systemic ad topical antimicrobials, antisepsis agents, disinfectants, preservatives, and adjuvants. An a...
 University of California, Irvine Depth Profiling of the Skin Structure In Vivo
  University researchers have developed a photoacoustic probe contained within a handpiece for use in contact with the skin. The laser pulses generate acoustic waves at the subsurface absorption sites. It is believed that no known use of photoacoustics has been used for this purpose in the past. Previous probes of skin structure include biopsy and histology, and optical and ultrasound measurements. ...
 University of California, Irvine Design Of Primer Pairs And Usage In PCR For Virus Detection
  Researchers at the University of California, Irvine have designed primer pairs to detect all important human respiratory viruses. Comparison with primer pairs from other researchers has demonstrated that the new primer pairs are more sensitive and efficient. These primer pairs can be used for a single or a multiplex PCR and are important for use with pathogen chips....
 University of California, Irvine Development of Diagnostics and Therapeutics for Cornelia de Lange Syndrome
  The product of the NIPBL gene is a global regulator of DNA interactions that control the expression of many classes of genes. It is believed that the abnormalities of CdLS arise because levels and sites of expression of many genes change when NIPBL levels are low. University of California, Irvine researchers have developed a mouse model of CdLS, based on heterozygous mutation of the NIPBL gene, an...
 University of California, Irvine Device for Controlling and Limiting Thermal Injury to Tissue During Thermal procedures
  University researchers have developed a new device that reduces or eliminates full thickness injury....
 University of California, Irvine Diagnostic Method And Apparatus For Monitoring Thermal Mediated Laser Surgery In Situ
  Researchers at the University of California have developed a method and apparatus to form two-dimensional tomographic images of optical birefringence in turbid biological tissue in situ. The method is based upon optical coherence tomography. The researchers have demonstrated the utility of this technique in monitoring laser surgery using bovine tendon tissues....
 University of California, Irvine Differential Diagnosis of Oral Pathologies
  By analyzing certain specific characteristics of these and other oral pathologies, the University has developed a novel approach that provides non-invasive diagnosis and monitoring of the pathologies, thus avoiding the need for traumatic surgical biopsies, while allowing for earlier detection and optimization of treatments....
 University of California, Irvine DRD4 To Clarify Diagnosis ADHD
  University of California, Irvine researchers have done molecular genetic work on the Dopamine Receptor D4 (DRD4). Their work suggests that the DRD4 7R "risk allele" may produce a genocopy of the disorder (ADHD), which is a partial syndrome with behavioral excesses but not cognitive deficits. The true syndrome may be due to minimal brain damage (MBD) as a consequence of fetal distress that results ...
 University of California, Irvine Droplet Stream Generation Method
  University researchers have developed a method which produces a droplet stream whose break-up distance is less variant than current methods, by minimizing or eliminating the standing wave and thus requiring less perturbation amplitude to result. This new process also requires less power to implement....
 University of California, Irvine Early detection of Dental Caries Using Optical Coherence Tomography (OCT)
  Researchers at the University of California, Irvine are investigating the use of Optical Coherence Tomography (OCT) as an in vivo, non-invasive modality for the diagnosis, preventive treatment, and therapy in patients with high caries risk, large numbers of poorly accessible restorations, or developmental abnormalities. The method involves scanning for dental caries with high-resolution real-time ...
 University of California, Irvine Efficient Transaction Based Modeling with Cycle Count Accurate at Transaction Boundary (CCATB) Models
  University researchers have developed an abstraction for modeling system designs called CCATB (which stands for Cycle Count Accurate at Transaction Boundaries). Traditionally, systems have been captured with cycle accurate (CA) models for design space exploration which are too time consuming to create and also to simulate. Transaction level models (TLM) are very high abstraction models of the syst...
 University of California, Irvine Enhancement Of Host Defense Via Receptor(s) For C1q
  Researchers of the University of California, Irvine, have discovered and sequenced a novel receptor molecule which can be used to develop agonists that will promote the initial host response of limiting or abrogating infection or trauma by pathogens or other detrimental material without the generation of extracellular toxic O2. This structural information will be used to design a specific and effe...
 University of California, Irvine Environmentally-Sensitive Reconfigurable Antenna
  University researchers have developed an antenna system that changes the nature of its transmission and reception of electromagnetic radiation based on local environmental conditions. It may use this feature to transmit local environmental information by wireless means without the need for power.The sensor system described in this invention requires no power, but may be interrogated remotely by wi...
 University of California, Irvine Fabrication Method for Polymer Thin Films
  University researchers have developed a method that allows for the synthesis of a wide variety of polymer thin films, the fabrication method of which can be combined with photolithography to create surface patterns. Thin film thickness is controlled from 1 nm to the submicron range. The method also supports the creation of "smart surfaces". It is applicable to most of the vinyl monomers, and block...
 University of California, Irvine Fabrication of C-PPy Microarrays for Li Microbattery
  University researchers have developed a completed battery structure with posts of C-MEMS (doped with Li) for anodes and dodecylbenzenesulfonate-doped poly(pyrrole) (PPYDBS) for cathodes. Researchers chose high molecular weight anion-doped PPY because of it's low specific weight, good chemical stability and good specific capacity, but most importantly because PPY can be electrochemically deposited ...
 University of California, Irvine FDA-Approved Topically Applied Chemical Compounds for Optical Clearing of Skin to Improve Diagnostics and Laser Therapeutic Applications
  University of California, Irvine researchers have developed a method to reduce the scattering inside the skin and improve the optical clearance. Food and Drug Administration (FDA) approved compounds are applied topically to the human skin for the purpose of reducing light scattering prior to performing light-based diagnostic and therapeutic procedures. The application of such clearing agents impro...
 University of California, Irvine Frequency-Amplitude-Modulation-Encoding (FAME) Strategies for Cochlear Implants and Audio Compression
  Frequency-Amplitude-Modulation-Encoding (FAME) strategies are developed by the researchers at the University of California, Irvine to improve the degree and quality of sound perception for the cochlear implant users. The same principle can be used to compress audio signals so that broad-band qualities can be achieved with narrow-band transmission channels. Broad-band audio signals are first divide...
 University of California, Irvine Fuel Cell System for Aircraft Propulsion
  University researchers have developed a means of providing propulsive power for an aircraft without the need for heavy electric propulsion motors and without the limitations of the propeller. It utilizes a high temperature fuel cell instead of or in conjunction with internal combustion to provide higher fuel efficiencies and lower exhaust emissions. High temperature fuel cells allow the usage of a...
 University of California, Irvine Gyrotropic Phontonic Crystals And Their Applications In Microwave Technology
  By proper spatial arrangement of magnetic and dielectric components, one can construct a magnetic photonic crystal with strong spectral asymmetry (nonreciprocity). The spatial asymmetry, in turn, results in a number of interesting phenomena, in particular, one-way transparency when the magnetic photonic crystal, being perfectly transparant for a Bloch wave of frequency omega, "freezes" the radiati...
 University of California, Irvine Her2/neu Vaccine Protects Against Tumor Growth
  University of California, Irvine researchers have developed a recombinant polynucleotide encoding Her2/neu target antigen. This recombinant polynucleotide contains two regions of the human Her2/neu molecule which demonstrated the lowest degree of homology with other known normal human proteins as the putative target antigen sequence for a genetic vaccination strategy. This target sequence was chos...
 University of California, Irvine High Resolution Optical Coherence Tomography Over a Greater Depth Range Using an Axicon Lens
  Researchers at the University of CA have developed a scanning OCT system to overcome these limitations. The invention incorporates an axicon lens into the sample arm of the interferometer. Using this axicon lens, 10um or better lateral resolution is maintained over a focusing depth of at least 6 mm. Thus high lateral resolution is simultaneously achieved with a greater depth of focus. The technolo...
 University of California, Irvine High Speed Fabrication of Highly Uniform Metallic Spheres
  An inexpensive method of generating highly uniform metallic balls from capillary stream break-up at ultra high speeds. Manufacture of solder balls (and other metallic balls), commonly used in the electronics industry, can be achieved using this method. Due to the nature of the droplet formation from the capillary stream break-up employed by this method, the resulting balls are highly uniform. The ...
 University of California, Irvine High-Isolation Tunable MEMS Capacitive Switch
  University researchers have developed a high isolation switch capable of obtaining C-band frequencies, without the need for changes in current process, and with minimum modifications is current switch designs....
 University of California, Irvine High-Resolution X-Ray Crystal Structures of Tritrichomonas Foetus Inosine Monophosphate Dehydrogenase as Lead Compound for Structure-Based Drug Design
  University of California, Irvine researchers utilized high-resolution x-ray crystallography to study the structure of a key enzyme in purine metabolism, inosine monophosphate dehyrogenase (IMPDH). IMPDH has been isolated and characterized from many sources, including human, and is an essential enzyme in the life cycle of the parasite. A unique complex of T. foetus IMPDH with inhibitors such as rib...
 University of California, Irvine hKCa3/KCNN3 Calcium Activated Potassium Channel: A Diagnostic Marker and Therapeutic Target for Heritable, Neurological and Psychiatric Diseases
  University of California, Irvine researchers have discovered SKCa3-1b and SKCa3-1c, two novel isoform variants of the SK3 (also known as KCNN3) gene. The SK3 gene is located on human chromosome 1q21 in a region containing a major susceptibility locus for familial schizophrenia and familial hemiplegic migraine associated with permanent cerebellar ataxia. Researchers have also found that these two n...
 University of California, Irvine Humid Air Turbine - Combined Cycle Hybrid
  University researchers have discovered that a cycle may be configured by combining the two previously described cycles in a synergistic manner such that the thermal efficiency of the resulting system is improved over that of the two individual cycles. Furthermore, this hybrid cycle can utilize existing turbomachinery without requiring development of new equipment as in the case of the HAT cycle....
 University of California, Irvine Humidity And Temperature Sensor Device For The Determination Of Oxygen Consumption In Medical Applications
  An anesthesiologist at the University of California, Irvine, has invented a device which makes continuous, on-line and rapid measurements of gas temperature and humidity.This novel device is inexpensive to construct and operate, simple to calibrate and use, non-toxic, and stable. Unlike other present slower devices, this device has a response time adequate even for cyclical gas flows that occur du...
 University of California, Irvine Imaging and Quantifying Transverse Flow Velocity Using Doppler Bandwidth in Functional Optical Coherence Tomography
  University researchers have demonstrated that standard deviation of the Doppler spectrum can also provide quantitative information on flow velocity. Using a simple geometric optics model, the linear dependence of the Doppler bandwidth on the flow velocity is theoretically derived and it is found that the effective numerical aperture (NA) of the optical objective in the sample arm determines the sl...
 University of California, Irvine Imaging Apparatus and Method for Simultaneous Measurement of Aero-Optical Interactions
  University researchers have developed a way to simultaneously measure the optical wavefront aberrations and the intervening turbulent flow. The imaging apparatus together with the analytical models of this invention are useful for designing, evaluating, and optimizing aero-optical systems....
 University of California, Irvine Improvement of Catalytic Efficiency and/or Specificity of Non-Native Substrates of Enzymes
  UC researchers have developed an innovative method and means to improve the performance of reporter molecules of enzyme activity. The reporter molecules are designed to be introduced into living cells when they are acted upon by intracellular enzymes. The reporter targets the substrate portion to a particular enzyme or class of enzymes, causing the substrate domain to be subsequently modified by t...
 University of California, Irvine In Situ Microthermometry For Biological Systems
  Researchers at the University of California have developed a microparticle biosensor that converts thermal energy into light in a very temperature-sensitive manner for use in an optical microthermometry system. It is the first non-invasive optical system for measuring temperature in situ and for mapping temperature in living organisms. The UC microthermometry system has a spatial resolution on the...
 University of California, Irvine Inhibition of Cortisol Biosynthesis and/or Function to Treat Memory Disorders resulting From Hippocampal Malfunction
  Researchers at the University of California, Irvine have shown that blocking these increases in adrenocortical hormones with a synthesis blocker prevents the memory loss induced by the damage to the hippocampus. Therefore, glucocorticoid-inhibiting drugs may have clinical applications in the treatment of memory disorders induced by damage to or malfunctioning of the hippocampus....
 University of California, Irvine Interconnect Technology for Nanowires and Nanotubes
  University researchers have developed a method to provide wireless interconnects for nanodevices. More specifically, communication to and from a nanodevice is provided with a nanostructure-based antenna, preferably formed with a single-wall nanotube (SWNT). The use of a nanostructure-based antenna eliminates the need to provide a physical communicative connection to the nanodevice, while at the sa...
 University of California, Irvine Ion Optical Element for Use in Controlling Charged Particle Beams
  UC researchers have devised a solution that replaces the entire stack assembly with a single cylinder of conductive material. This volume conductive electrode can be used to control charged particle beams in TOF mass specs and other devices requiring precise control of charged particles....
 University of California, Irvine Isolation Of Biological Materials
  However, University of California researchers have combined several approaches to develop a novel chromosome isolation protocol. This method utilizes a series of straightforward chemical and physical conditions to quickly, isolate specific chromosomes with high efficiency.This new method for chromosome sorting improves efficiency and yields, by decreasing aggregation and accessibility concerns, wh...
 University of California, Irvine Laser Based Quantitative Optical Analyzer For Turbid Media
  New Instrumentation has recently been developed by researchers at the University of California that can be used to determine distinct optical properties of turbid media in-situ. The new method utilizes frequency domain photon migration (FDPM) as a non-invasive diagnostic technique. Measurements are performed by launching modified laser light into a scattering medium. Optical property variations wi...
 University of California, Irvine LEF-1 Internal Ribosome Entry Site
  University of California, Irvine researchers have found that LEF-1 mRNA exhibits internal ribosome entry site (IRES) activity through DNA and RNA transfections of a dicistronic vector containing the LEF-1 5' UTR sequences. Researchers found that the 5' UTR of human LEF-1 mRNA contains two independent IRES modules that are additive in their mediation of cap-independent translation of full length LE...
 University of California, Irvine Liquid Metal Magnetohydrodynamic Polymerase Chain Reaction Thermal Cycler
  In accordance with the present invention, an improved polymerase chain reaction thermal cycler can be implemented based on liquid metals. The invention is based on the realization that liquid metals have a comparable heat conductivity and capacity to that of metal and at the same time are not confined to having a pre-defined shape. This enables the use of sample test tubes from different vendors w...
 University of California, Irvine Method and Apparatus for Electroforming Tissue
  Researchers at the University of California have developed a technique that can be used to reshape cartilage tissue by combining mechanical deformation with the application of direct current (DC) electric fields. This concept of tissue electromechanical reshaping ("electroforming") is novel. The method also comprises the step of monitoring the stresses in the tissue and controlling the current flo...
 University of California, Irvine Method and Apparatus for Spatially Modulated Fluorescence Imaging and Tomography
  University of California researchers have developed a method and apparatus which can provide simultaneous surface and sub-surface mapping of media structure, function and composition. The method disclosed herein allows: Wide field imaging; Subsurface imaging/tomography (depth sensitivity to be assessed as a function of source spatial frequency, wavelength selection and/or amplitude modulation); Sp...
 University of California, Irvine Method and Apparatus for Tissue Reshaping by Radio Frequency Heating
  University of California researchers have developed a low cost alternative to laser reshaping. The invention is a method and apparatus for reshaping cartilage via radiofrequency (RF) energy. In the present technology, cartilage is heated by RF energy via electrodes in contact with the cartilage (inserted within or on the surface). The cartilage is heated until the stress relaxation temperature is ...
 University of California, Irvine Method and Apparatus of Using 3D Conductive Structures in Dielectrophoretic Separation Applications
  Researchers at the University of California, Irvine have developed novel 3D dielectrophoretic designs for high efficiency separation and have demonstrated such a system for filtration of submicron contaminants from lubricants. The system also allows for online monitoring of contaminant levels. The novel high throughput electrode designs could be used for other applications were separation, filtrat...
 University of California, Irvine Method for Mixing Small Fluid Volumes (Femto-microliters) Using Laser Pulses
  University researchers have developed a method of performing mixing functions with the following benefits: novel process does away with any extra mixing devices on the microfluidic chip; it can be used to mix any two fluids regardless of viscosity and flow speed; it can be a selective process (i.e., mixing can occur in small volumes); it is fast with mixing dynamics in the nano- to micro-second ti...
 University of California, Irvine Method for Quantitative Digital Color Imaging of Objects
  University of California researchers have developed a method for acquiring and analyzing polarization sensitive digital color images of objects. Polarization optics provide the user with the ability to discriminate between superficial and deeper structures in an object. Various linear transformations can be applied to the images to obtain information in alternate color spaces; this can be tailored...
 University of California, Irvine Method for the Robust Determination of the Fluid Mixing Efficiency
  University researchers have developed a method that allows the robust determination of the mixing efficiency of fluids that molecularly mix in processes or devices. The method offered by this invention takes advantage of the structure and dynamics of the outer-fluid interfaces in turbulent flows to monitor in real time the mixing efficiency at reduced spatial resolution requirements....
 University of California, Irvine Method of Fabrication of Self-enclosed Microchannels and/or Chambers With or Without Integrated Interconnects and Electrodes
  Researchers at the University of California, Irvine have developed a method of fabrication of self-enclosed microchannels and/or chamber with or without integrated interconnects and electrodes. The UC method allows reduction in costs and time because only a single development step is required to define all the walls of the microfluidic device. This allows for reduction of photopolymer that is wast...
 University of California, Irvine Method Of Inhibiting The Transport Of L-glutamate
  Researchers at the University of California, Irvine, have developed novel compounds that are potent and selective inhibitors of the high affinity transport of L-glutamate. These compounds will be used to investigate the mechanism of the transport system and will be evaluated for their therapeutic efficacy for the treatment of various neurological disorders such as ischemia, hypoglycemia, epilepsy,...
 University of California, Irvine Method to Characterize Exhaled Nitric Oxide from the Airways Using a Sequence of Breathhold Maneuvers
  Researchers at the University of California have developed a new technique to characterize airway NO, which requires a series of progressively increasing breath-hold times followed by exhalation of only the airway compartment. Using our new technique, we determined values (means + SE) in healthy adults (20-38 yr, n = 8) for the airway diffusing capacity [4.5 + 1.6 pl?s-1 ?parts per billion (ppb)-1...
 University of California, Irvine Method to Measure Microfluidic Flow Based on Electrical Admittance
  Researchers at the University of California have developed a method for measuring the flow rate of a conducting fluid in a microchannel that is simple in design and can be integrated to most of the microfluidic platforms. This flow sensor has a high signal-to-noise ratio, can measure of a wide range of liquids (including biochemical buffers and solutions containing biomolecules such as DNA and cel...
 University of California, Irvine Methods for Assessing the Condition of Bone In-Vivo Using Non-Ionizing Radiation
  University of California researchers have developed an optical method to characterize bone tissue viability. The optical properties of bone are strongly influenced by composition, structure and physiology. Disease alters these bone characteristics, and thus bone optical properties are parameters that gauge bone disease progression. The method involves 1) the use of non-ionizing radiation including...
 University of California, Irvine Methods for Assessing the Temperature of Deep Tissue in vivo Using Non-ionizing Radiation
  Researchers at the University of California, Irvine have invented a novel method to measure deep tissue temperatures non-invasively. It uses a non-invasive method for quantifying absorption and scattering values of tissue over a broad wavelength range (600 to 2500 nm). Using this method to give an absolute measure of the tissue absorption, it is possible to determine the concentrations of chromoph...
 University of California, Irvine Methods for Making 2D Nanoscale PN Junctions and Junction Arrays
  University researchers have developed methods to create a 2-D nanoscale structure with desirable controllability and design flexibility in the boron (and other dopant) distribution before thermal diffusion or ion implantation, resulting in the formation of nanostructured PN junction arrays. In addition, a novel processing method for a 2-D mask with periodic or quasi-periodic spacing between the bo...
 University of California, Irvine Methods for Treating Port Wine Stain Birth Marks, Hemangiomas and Other Conditions Caused By Aberrant Blood Vessels
  The present invention provides methods for treating port wine stain birthmarks, hemangiomas, and other lesions wherein aberrant blood vessels are present. A photosensitizing agent is administered to the patient. Thereafter, light energy (e.g., laser energy) is applied to the affected area of skin. Some of the light energy interacts with the photosensitizing agent and causes damage to the aberrant ...
 University of California, Irvine Methods Of Diagnosis Of Amyloidoses
  A method of diagnosing a disease with cerebrovascular deposition of amyloid, including Alzheimer's disease, hereditary cerebral hemorrhage with amyloidosis-Dutch type and other amyloidoses, in a mammal is disclosed in which a sample of cerebrospinal fluid is obtained, the level of immunoreactivity toward a monoclonal antibody raised against native PN-2/.beta.APP or other amyloid precursor protein ...
 University of California, Irvine Methods of Improving Memory and Cognition
  University of California, Irvine researchers have discovered a new method of improving memory by selectively modulating nuclear receptor cell signaling. The technology has been validated in several animal models of memory in both rats and mice....
 University of California, Irvine Micro-instrumentation Platform for Protein Crystallization
  University researchers have invented an integrated instrument designed to perform high-throughput crystallization experiments in proteins and other crystallizable media. The instrument utilizes a system of microfluidics, sensors, actuators, and computer instrumention to enable automated microcrystallization experiments to be performed with feedback assisted control. Use of microfluidics keeps the ...
 University of California, Irvine Micro-Magnetohydrodynamic Pump and Method for Operation of Same
  A micropump fabricated in a planar substrate is provided with a valving chamber which is communicated to a pumping chamber. The valving chamber has an inlet and outlet port. Both the valving chamber and pumping chamber have a liquid, electrically conductive piston disposed therein, which liquid piston is nonmiscible with the pumped working fluid and nonreactive with the substrate in which the cham...
 University of California, Irvine Microfluidic Devices for Controlled Viscous Shearing and Formation of Amphiphilic Vesicles
  Researchers at the University of California, Irvine, have developed a microfluidic device (i.e. ‘Lab-on-a-chip’) that controls viscous shearing of oil-water droplets on a micro- and nano-scale and allows the subsequent formation of amphiphilic vesicles (liposomes, polymer vesicles, micelles, etc.). The technology includes various microfluidic designs for diffe...
 University of California, Irvine Microscope Immersion Fluid Applicator
  Researchers at the University of California, Irvine have designed a simple device to deliver immersion fluid (oil, water, glycerin, etc.) onto the specimen without removing the specimen from the microscope stage. Many microscope manufacturers have developed microscopes designed so that each objective in the turret can be rotated into place with high repeatability of alignment so that the specimen ...
 University of California, Irvine Miniature Liquid-Fueled Combustion Chamber
  This invention allows direct injection of conventional liquid fuels (e.g., kerosene or alcohol) into a combustor that is only a few centimeters in length and less than a centimeter in transverse dimension with nearly 100% energy conversion. Operation at elevated pressures is possible. The concept works with continuous or intermittent combustion. The design allows for one gram per second or less of...
 University of California, Irvine Mixing Enhancement Using Propulsive Means
  A novel mixing enhancement method exploits a previously unknown flow instability to enhance mixing in a compressible jet flow or in a flow (gaseous of liquid) in contact with the compressible jet flow. No mechanical mixers and no actuators of any kind are used. Nozzle shapes are streamlined and simple. The invention is expected to impact the state of the art in many applications, including fuel in...
 University of California, Irvine Mobile Code for Computers
  We introduce a type-safe mobile code representation based on static single assignment form. This software is to be seen as an alternative to the JVM, over which it has several advantages: (1) it is better suited as input to optimizing dynamic code generators and allows CSE to be performed at the code producer's site; (2) it provides incorruptible referential integrity and uses "type seperation" to...
 University of California, Irvine Modulation Of Cell Growth And Growth Factor Signaling Through Removal Of Glypicans
  Glycosylphosphatidylinositol-(GPI-) anchored HSPG glypican-1 (glypican-1) is strongly expressed in human breast and pancreatic cancer - both by the cancer cells and in the case of pancreatic cancer the adjacent fibroblasts. Expression of glypican-1 is low in normal pancreas and breast tissue. Pancreatic cancer cell lines that express glypican-1 were treated with the enzyme phosphinositide-specific...
 University of California, Irvine Molecular Imprinting for the Recognition of Peptides in Aqueous Solution
  Researchers at the University of California, Irvine, have developed MIPs, wherein the template comprises either a) peptide or amino acid sequence that has an N-terminal histidine or b) histamine. The MIPs were prepared in aqueous systems using reagents that are water soluble at the relevant concentrations. The technology covers methods for using MIPs as receptors or adsorbents for, or to determine...
 University of California, Irvine Monoclonal Antibody Produced Against Native Beta Amyloid Precursor Protein
  Immunopurification of Protease Nexin-2 and .beta. amyloid precursor protein is disclosed. Methods of detecting Protease Nexin-2 and the use of these methods in the diagnosis of Alzheimer's disease and other conditions are also disclosed. Additionally, pharmaceutical preparations including Protease Nexin-2 or modified forms thereof are disclosed. Medical uses for the pharmaceutical preparations are...
 University of California, Irvine Monte Carlo Solutions of Inverse Problems in Particle Transport
  A novel and efficient method of providing solutions to inverse photon migration problems in heterogeneous turbid media. The method extracts derivative information from a single Monte Carlo simulation to permit the rapid determination of rates of change in the detected photon signal with respect to perturbations in background tissue optical properties. This information is then fed into a nonlinear ...
 University of California, Irvine Multi Stage Control Architecture for Error Suppression in Micromachined Gyroscopes
  In contrast, The University's invention is the integration of self-calibration capabilities to identify non-idealities, active electronic "trimming" in the form of a feed-forward control, and feedback control for additional error suppression in a multi stage control architecture. With low costs and small sizes of existing microprocessors on the market, this type of control architecture can be buil...
 University of California, Irvine Nanowires as Fast Chemical Sensors
  University researchers have developed a method of measuring the dynamic impedance of a nanowire such as, but not limited to, a carbon nanotube in order to determine if a molecule has bound to the wire. The method can measure molecular species fast, on a timescale of 1 / measurement frequency (potentially ns to ps range)....
 University of California, Irvine Nanowires as Fast Chemical Sensors
  University researchers have developed an InGaP/GaAs heterojunction bipolar transistor (HBT) monolithic microwave integrated circuit (MMIC) broadband power amplifier with a novel tunable output matching circuit is first proposed and implemented. The 3-stage MMIC broadband power amplifier is realized by using the novel HBT structure and layout, applying broadband and compensating matching technique ...
 University of California, Irvine Neuropeptide S (NPS) as a Treatment for Anxiety, Sleep Disorders, Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder, and Asthma
  University of California, Irvine researchers have shown that central administration of NPS increases locomotor activity in mice and decreases paradoxical (REM) sleep and slow wave sleep in rats. NPS was further shown to produce anxiolytic-like effects in mice exposed to different stressful paradigms....
 University of California, Irvine New Clinical Bymixer for Fast-Response, Adjustable Measurement of Mixed Expired Gas Fractions in the Anesthesia Circle Circuit
  University of California, Irvine researchers have developed a new bymixer from common components that solves these problems. The technology incorporates a novel, parallel design into a new clinical bymixer, which by-passes a constant fraction of total flow through a mixing chamber. The bymixer provides accurate measurement of mixed expired gas fractions in the anesthesia circle circuit, over a wid...
 University of California, Irvine New Hybrid Organic-Inorganic Adsorbents
  Researchers at the University of California, Irvine, have developed a simple, single step sol-gel polymerization process for synthesizing hybrid organic-inorganic materials with potential applications for environmental and industrial processes. The materials possess robust mechanical properties, a high surface area, very high loading of active functional groups and very high uptake capacity....
 University of California, Irvine New Multiphase LLC Resonant Voltage Regulators for Next Generation Microprocessors
  University researchers have developed a new multiphase LLC resonant converter to address these next generation needs. Compared to today's buck type Voltage Regulators (VR), the proposed VR features zero voltage switching for both inverter and rectifier switches, a wide load range, a limited frequency range, a faster dynamic response, high efficiency, automatic current sharing ability, no additiona...
 University of California, Irvine New Protein Resistant and Biodegradable Biopolymer
  University of California, Irvine, researchers have developed a protein resistant biopolymer made from readily available starting materials such as carbohydrates or other polyhydroxyl compounds. These biopolymers are biodegradable and have many sites along the chain that may be functionalized. These biopolymers have a greater advantage than PEG since PEG may only be modified on the chain ends to in...
 University of California, Irvine Newly Discovered Tumor Suppressor Genes
  A novel cDNA has been isolated that is overexpressed in non-tumorigenic Wilm's tumor cells. University of California scientists performed a subtractive cDNA/RNA hybridization between a tumorigenic parent (G401) and a non-tumorigenic microcell hybrid of G401, which led to the discovery. They found that genes isolated from other species, both plant and animal, have remarkable similarity (100% identi...
 University of California, Irvine Nickel Diimine Cyclophane Catalysts for High Temperature Gas Phase Olefin Polymerization
  University of California, Irvine, researchers have developed cyclophane-based transition metal alpha diimine catalysts that shows significantly improved thermal stability and produces high MW polyethylenes with phenomenally high yields at temperature ranges suitable for industrial gas phase olefin polymerization....
 University of California, Irvine Non-Invasive Quantitative In Vivo Monitoring of Methemoglobin Formation and Reduction Using Broadband Diffuse Optical Spectroscopy (DOS)
  Researchers at the University of California have developed a method based on broadband diffuse optical spectroscopy (DOS) to dynamically monitor in vivo concentrations of multiple chromophores such as MetHb, MB, Hb-O2, Hb-R, and water in tissue non-invasively. The technique makes it possible to non-invasively quantify real-time changes in multiple chormophores with sub-micromolar sensitivity and s...
 University of California, Irvine Non-Resonant Micromachined Gyroscope with Structural Mode-Decoupling
  University researchers have developed a 4 degrees-of-freedom (DOF), non-resonant micromachined gyroscope that addresses two major MEMS gyro design challenges: eliminating the mode-matching requirement, and minimizing instability and drift due to mechanical coupling between the drive and sense modes. This gyro design can be fabricated in any standard surface or bulk micromachining process....
 University of California, Irvine Novel And Selective Inhibitors Of HIV-1 Integrase
  In the ongoing battle against the human immunodeficiency virus (HIV), researchers at the University of California, Irvine, have synthesized novel compounds that inhibit the protein HIV Integrase and prevent the virus from replicating, thus providing an alternative to currently available AIDS therapy. Current therapies target the HIV proteins Reverse Transcriptase and Protease, but both these thera...
 University of California, Irvine Novel Antimicrobial Peptides From Bovine Neutrophils
  A patent application has been filed directed to broad-spectrum antimicrobial compounds and to methods of their use to inhibit or prevent microbial growth. In one embodiment, the antimicrobial compound is a thirteen amino acid peptide purified from bovine neutrophil granules. The peptide is distinguished by its abundance of tryptophan and proline and by the amidation of its carboxy terminus. The in...
 University of California, Irvine Novel Cytodiagnostic Markers For Cancer
  Researchers at the University of California, Irvine, have used tissues from cervical biopsies to show that PML and its associated nuclear bodies exhibit changes in both size and number throughout the continuum of cervical neoplasia. Differences in the pattern of PML reflect the aggressiveness of the tumor. In addition, PML and loss of the partnership with the specific polypeptide parallels the pro...
 University of California, Irvine Novel Device For Determining The Viability Of Human Myocardium Or Other Animal Tissues
  The last decade of cardiac surgery has witnessed significant strides towards better understanding and better management of previously lethal cardiac pathology. Such developments have led to a general recognition of previously unknown conditions such as myocardial stunning and hibernation in which the injured myocardium is in a state of suspended animation. Unfortunately, such states can easily be ...
 University of California, Irvine Novel Retinoblastoma Binding Protein-Related Gene And Potential Use As Cancer Vaccine
  Researchers at the University of California, Irvine, used human IgG antibodies to identify a novel retinoblastoma binding protein-related gene (RBP1L1) that encodes a nonameric antigen epitope. The epitope was recognized by IgG antibodies that were isolated from breast cancer patients. RBP-CT mRNA is expressed at high levels in various human carcinomas and in normal testis and expression is limite...
 University of California, Irvine Novel, Stand-alone, Closed Ventilating Circle Circuit with CO2 Absorption and Sensitive Spirometry Measures Pulmonary O2 Uptake During Anesthesia
  University of California, Irvine researchers have developed a novel, closed circle, ventilating circuit which can be a calibrating standard for VO2 measurement during anesthesia, particularly VO2 per breath. This stand-alone circuit facilitates normal mechanical ventilation, absence of physiological gas leaks, complete CO2 absorption, and the ability to measure small changes (1 ml) in circuit end-...
 University of California, Irvine Nrf1 Deficient Mice as a Model for Liver Cancer and Non-Alcoholic Steatohepatitis
  University of California-Irvine researchers have developed a Cre-lox mouse model that has a conditional mutation of the Nrf1 gene. Researchers have found that deficiency of the Nrf1 gene in liver results hepatic cell death, proliferation, fat accumulation, oxidative stress, and inflammation, followed by the appearance of dysplastic cells and ultimately cancer. The changes observed closely mimics t...
 University of California, Irvine One Cycle Control Of Bipolar Switching Power Amplifiers
  Researchers at the Power Electronics Laboratory at University of California, Irvine, received a U.S. patent for a device that uses one cycle control for controlling DC-to-AC switching converters. This is achieved by forcing the average of a controlled switched variable to be exactly equal to the control reference in each switching cycle. Potential subharmonic oscillations in a switching power ampl...
 University of California, Irvine Optimal Spatial Sub-channel Resources Allocation Mechanism for Sustainable Bit Rate Wireless Conduits
  University researchers have developed an optimal algorithm that optimizes the transmitting power and bits-per-symbol allocation to each of the transmitting antennas in a multiple-input-multiple-output wireless system, so that an overall constant bit rate can be maintained with minimal power consumption. A Leaky Bucket-based power budget algorithm is also devised to smooth out total power allocatio...
 University of California, Irvine Oral Based Lab-on-a-Chip ("Lollilab")
  Researchers at the University of California, Irvine, have developed technology that overcomes these limitations. The invention seamlessly integrates the interface between a human subject and the microchip instrument. Affectionately called LolliLab(tm) , the technology utilizes a lollipop-like apparatus as a medical instrumentation platform for housing a micro-medical lab-on-a-chip device for monit...
 University of California, Irvine Phage-displayed Peptide Library with Affinity for Bacterial Elongation Factor Tu
  A peptide library with a diversity of ~ 4.7X1011 different peptides was constructed containing both linear and disulfide-constrained peptides. Phage-displayed peptides with high affinity for EF-Tu were selected from the library. Phage display was also used to rapidly assess the contribution of specific side chains to EF-Tu binding through combinatorial libraries of alanine and homolog substitution...
 University of California, Irvine Pharmacological Role of Prolactin-Releasing Peptide in Controlling Absence Seizures
  University of California, Irvine researchers have found that prolactin releasing peptide (PrRP) modulates the activity of the brain's reticular thalamic nucleus (RTN). The RTN is characterized by prominent PrRP receptor expression which is critical in the regulation of the non-convulsive type of epilepsy called absence seizures. Injection of PrRP into animals significantly decreased spike-and-wave...
 University of California, Irvine Phase-resolved Functional OCT: Imaging of Stokes Vectors, Structure, Blood Flow Velocity, Standard Deviation, & Birefringence in Biological Sample
  Researchers at the University of California have developed a phase-resolved functional OCT system that combines ODT and PS-OCT. This technology enables simultaneous imaging of the Stokes vectors, Muller matrix, structure, Doppler frequency shift, standard deviation, and birefringence of the sample. The detection scheme implemented in the F-OCT system allows polarization diversity averaging in the ...
 University of California, Irvine Photonic Slab with Axially Frozen Mode
  University researchers have invented a photonic slab design that can be used to enhance the capability and performance of microwave, millimeter wave, and submillimeter wave antennas, delay lines, nonlinear and nonreciprocal elements. It can also be used in integrated microwave circuitry....
 University of California, Irvine Platelet Aggregation Inhibitors
  Researchers at the University of California have discovered specific creatine kinase inhibitors that inhibit thrombin-induced aggregation of platelets. These creatine kinase inhibitors could be used to treat a disease or disorder that is caused by pathological platelet aggregation....
 University of California, Irvine Polymeric Valves for Controlled Drug Delivery
  Researchers at the University of California have developed a micro- release technology with the aforementioned features. The method relies on micro reservoirs covered with polymer based valves which serve as the gates to these reservoirs. The valve is a layered structure made in the shape of a flap anchored on one side of the reservoir opening. The substrate which consists of one or more reservoir...
 University of California, Irvine Position-Specific Insertion Vectors And Method Of Using Same
  By introducing certain sequences into the retrovirus, researchers at the University of California, Irvine, have developed a vector with position specific insertion capability. Because this vector would insert into a specific innocuous location of the genome, disruption of host cell functions would be avoided. This breakthrough would address problems caused by random insertion. There would also be ...
 University of California, Irvine Post-Release Capacitance Enhancement in Micromachined Devices
  University researchers have developed a post-release assembly technique aimed to increase the sensing and actuation capacitances in micromachined devices, in order to enhance the performance and noise characteristics beyond the fabrication process limitations. The approach is based on attaching the stationary electrodes of the device to a moving stage that locks into the desired position to minimi...
 University of California, Irvine Posterior Lumbar Interbody Fusion Expandable Cage with Lordosis
  University of California, Irvine researchers have developed a PLIF expandable spinal fusion cage. The spinal fusion cage is comprised of two half-cages which are identical, and a hollow plunger. The plunger can be filled with graft prior to insertion. The plunger is used to expand the cage by pushing the two half-cages apart by means of an inserter which is designed to maintain the graft in the pl...
 University of California, Irvine Prevention Of Ice Formation On Tissue Surfaces Caused By Cooling During Laser Surgery
  Researchers at the University of California have devised a means of dynamically controlling the water vapor content of the ambient air around the laser-skin contact area. The apparatus minimizes the formation of ice crystals as cryogen is introduced to the same area for maintaining comfortable skin temperatures. The UC system can easily be added on to any cryogen cooling system for laser surgery....
 University of California, Irvine Protocol And Software Organization Method For Real-Time Fault-Tolerant Multicasts In Computer Networks
  The present invention is based on the notion of the official release time (ORT). Under this technique, the sender attaches the ORT to the message being multicast, thereby asking every receiver to process the message at or after the ORT. The ORT is chosen such that the probability of the multicast being completed by that time with a conclusion of success or failure subject to reasonably bounded lim...
 University of California, Irvine Providing Software for Distributed Computing on the Internet/Intranet Using Mobile Agents
  University of California, Irvine, researchers have developed a method and apparatus for providing software to conduct distributed computing on the Internet or Intranet using the user's network of workstations. This is based on the principle of autonomous mobile agents. Software provided by the present invention is agent-based, scalable, versionless, installation-free, pay-per-use, and distributed....
 University of California, Irvine R6G9 Treatment Improves Viral-Induced Neurological Disease
  Researchers at the University of California, Irvine have identified a monoclonal antibody-based method that decreases immune cell infiltration into the CNS and improves neurological function in a mouse model of MS....
 University of California, Irvine Radioactive Bone Cement (Polymethylmethacrylate) for Treatment of Tumors in Bone
  University of California researchers have developed a radioactive bone cement to treat tumors internally. The present invention provides apparatus and methods for internal radiation therapy and may be used to provide localized irradiation of tissue in the vicinity of a tumor, as well as to simultaneously strengthen, fill, and repair bone....
 University of California, Irvine Reagents and Methods for Diagnosis of Attention Deficit Hyperactivity Disorder
  University of California Researchers have identified a strong linkage disequilibrium (LD) between the 7R-allele of the DRD4 gene and surrounding single nucleotide polymorphisms (SNPs) in population samples and samples of individuals diagnosed with ADHD. By using PCR-based resequencing, researchers have identified markers within this large LD block that can be used to specify the presence or absenc...
 University of California, Irvine Real-Time Tomographic Imaging Of Blood Flow
  Researchers at the University of California have devised a rapid, noninvasive method to image blood flow near the tissue surface in three dimensions with resolutions of 2 to 10 microns. Using a sophisticated method for image acquisition based on laser Doppler flowmetry, the UC technology can acquire structural and velocity images about tenfold faster than previous methods. Real-time imaging can be...
 University of California, Irvine RF MEMS Technology for Fabricating RF MEMS Switches
  University researchers have invented a low-cost, high performance, and substrate independent RF MEMS technology for RF MEMS switch fabrication with high yield and reliability. It is compatible with well established printed circuit board (PCB) technology and allows the choice of any substrate with desired electrical and mechanical properties for a specific communication application, to enhance its ...
 University of California, Irvine Robust Micromachined Gyroscopes with 2-DOF Sense-Mode Oscillator
  University researchers have developed a new robust micromachined gyroscope with 2 degrees-of-freedom (DOF) sense-mode oscillator that addresses two major MEMS gyroscope design challenges: the requirement of precisely matching drive and sense resonance modes, and inherent instability and drift due to mechanical coupling between the drive and sense modes. The device measures angular rate of an objec...
 University of California, Irvine Screening and Therapeutic Methods for Promoting Wakefulness and Sleep
  University of California, Irvine researchers have found that injection of Prolactin Releasing Peptide (PrRP) in mammals promotes wakefulness and also suppresses spike wave discharges during absence seizures. PrRP receptor activation in response to PrRP agonists specifically reduces AMPA receptor mediated oscillatory activity in the RTN. This mediated oscillatory activity is implicated in absence s...
 University of California, Irvine Second Harmonic Optical Coherence Tomography
  Researchers at the University of California have developed a technology that combines the molecular contrast of second harmonic generation (SHG) with coherence gating of OCT. Compared with conventional OCT performed at fundamental wavelength, SH-OCT offers enhanced molecular contrast and spatial resolution. It is also an improvement over existing second harmonic scanning microscopy technology, as ...
 University of California, Irvine Selective Inhibition of Enzyme Isoforms of Nitric Oxide Synthetase
  University of California, Irvine researchers have discovered a method to design and use selective inhibitors against a family of nitric oxide synthetase isoforms that control the production of nitric oxide (NO). X-ray crystallography was utilized to generate isoform specific NOS-inhibitor complexes with unique structural characteristics. An overproduction of NO has been linked to several diseases,...
 University of California, Irvine Selective Inhibitors of Monoacylglycerol Lipase as a Treatment for Neurological Disorders
  University of California, Irvine researchers have developed a novel class of compounds that selectively inhibit the hydrolysis of 2-AG. When injected directly into the periaqueductal gray matter (PAG) of the midbrain, these compounds elevate endogenous 2-AG levels and enhance the non-opioid component of stress-induced analgesia in a CB1-dependent manner.These inhibitors were developed under the as...
 University of California, Irvine Self-Preserving Multipurpose Ophthalmic Solutions Incorporating A Polypeptide Antimicrobial
  Researchers at the University of California, Irvine (UCI) have developed a platform technology for a new class of antimicrobials that have broad spectrum activities against bacteria, fungi, viruses and protozoa. These compounds, termed "defensins," are microbicidal peptides that show promise as systemic ad topical antimicrobials, antisepsis agents, disinfectants, preservatives, and adjuvants. An a...
 University of California, Irvine SENSE-optimized MRI RF Coil Design with Target Field Method
  University researchers have developed a method that solves the inverse problem, where the best coil topography is calculated based on the performance criteria specified by the designer. Prior art uses basic coil geometries, such as circular or rectangular, whereas our coil structure can assume any arbitrary shape to get the best performance. The coil design criteria proposed begins with finding th...
 University of California, Irvine Smart Probe With Station For Real Time, Non-Invasive Metrology of Microfluidic Chips
  A smart computer controlled bio-microfluidic probe station, which facilitates real-time non-invasive measurements of quantitative, cross sectional information of biological fluid flow at various locations within a bio-fluidic chip. This station would allow for automated, high-throughput testing and evaluation of microfluidic chips during and after manufacturing....
 University of California, Irvine Smart, Scalable Monte Carlo Algorithms for Biology and Medicine
  Researchers at the University of California, Irvine are developing a novel Monte Carlo algorithm that converges much more rapidly than conventional simulation methods. The new algorithm achieves these gains through estimates of weighted averages of the solution of the RTE over an arbitrary decomposition of the problem phase space. By adjusting the subregion sizes appropriately in this decompositio...
 University of California, Irvine Therapeutic Targets and Animal Model of Serotonin Regulated Diseases
  Researchers at the University of California, Irvine have utilized C. elegans model animal system to identify and analyze genes and molecular pathways that control serotonin synthesis in specific serotonergic neurons. Two transient receptor potential V (TRPV) cationic channel genes were discovered that, when mutated, dramatically reduced the transcription of the key serotonin synthesis enzyme trypt...
 University of California, Irvine Three-Phase Boost Type Grid-Connected Inverters
  University researchers have developed a new one-cycle controlled (OCC) three-phase boost type, grid-connected inverter. This inverter can also be controlled by the conventional Pulse Width Modulation (PWM) control method.With the OCC method, the circuit shows the advantages of simple circuitry, good stability and fast dynamic response. Experiments have been done with a 1.5kW laboratory prototype t...
 University of California, Irvine Tissue Viability Monitor
  The last decade of cardiac surgery has witnessed significant strides towards better understanding and better management of previously lethal cardiac pathology. Such developments have led to a general recognition of previously unknown conditions such as myocardial stunning and hibernation in which the injured myocardium is in a state of suspended animation. Unfortunately, such states can easily be ...
 University of California, Irvine Top-Gate Carbon Nanotube Field Effect Transistor
  This invention solves six potential problems with incorporating CNT's into next generation electronics: controlled growth (location, orientation, and diameter) of the CNT; low contact resistance between the CNT and electrode; local capacitive coupling between the CNT and gate; limited parasitic capacitance between the CNT and drain and source; integration of multiple transistors on a single chip; ...
 University of California, Irvine Torsional Z-axis Surface-Micromachined Gyroscope
  University researchers have developed a novel gimbal-type torsional z-axis micromachined gyroscope with a non-resonant actuation scheme,that measures angular rate of an object with respect to the axis normal to the substrate plane (the z-axis). The design concept is based on employing a 2 degrees-of-freedom (2-DOF) drive-mode oscillator comprised of a sensing plate suspended inside two gimbals. By...
 University of California, Irvine Total Ankle Arthroplasty
  A University of California researcher has developed a total ankle arthroplasty comprising a three-component prosthesis with a medial or lateral incision. The three components are comprised of: a tibial prosthesis, a talar component, and a bearing positioned between the tibial and talar components. However, unlike current ankle replacements, the natural curvature of the distal tibia is maintained r...
 University of California, Irvine Transgenic Animal Models For Alzheimer's Disease
  The present invention provides non-human, transgenic animals for use as a model for the study of Alzheimer's Disease. The animals exhibit pathology associated with Alzheimer's Disease. The phenotype is conferred in the animals by the introduction of an amyloid-containing polypeptide fragment of amyloid precursor protein, through the introduction of the DNA into the germ and somatic cells of the an...
 University of California, Irvine Treatment For Circadian Performance Deficits By Upmodulation Of Central Glutamate Receptors
  Researchers at the University of California, Irvine, have tested certain compounds on rats that were subjected to maze tests during their normal sleep periods. The application of the drug caused a significant increase in the speed with which the animals completed the test....
 University of California, Irvine Treatment of Bladder and Urinary Tract Cancers Using Chalcone and Flavone Derivatives
  Researchers at the University of California, Irvine have demonstrated that naturally occurring phytochemicals, certain chalcones and flavones, found in a plant extract can potently inhibit bladder cancer cell growth in a time and dose-dependent manner in cell cultures. These phytochemicals induce activation of caspase 9 and 3 and induce cleavage of PARP in bladder cancer T24 cells. Both the activa...
 University of California, Irvine Ultrasound Transducer Quilt and Method for Enhancement of Angiogenesis, to Treat Thrombosis, Ischemia, Restenosis, and Diabetic Neuropathy
  University of California, Irvine researchers have developed a novel ultrasound transducer which exposes a large area of tissue to ultrasound. The device is a quilt (QUILT) with multiple transducers embedded in it. The frequency of the transducers is variable and the distance between the transducers is also variable. Use of the QUILT indicates that diagnostic ultrasound promotes angiogenesis....
 University of California, Irvine Unnatural Amino Acids That Mimic Peptide Beta-Strands
  Researchers at the University of California, Irvine, have synthesized a non-natural amino acid. This amino acid and its derivatives mimic tripeptide beta-strands. When incorporated into peptides, peptidomimetics or proteins all three types of structures will dimerize by means of beta-sheet interactions. A logical extension of this work is to use this amino acid in agents designed to block the beta...
 University of California, Irvine Use Of Infectious And Pathogenic Clone Of A Lung Cancer-Inducing Retrovirus For Generation Of Therapeutic Reagents And Diagnostic Tests
  Researchers at the University of California, Irvine have isolated the first infectious molecular clone of JSRV and have developed techniques for production of infectious JSRV that allowed the researchers to prove that JSRV alone was sufficient to induce BAC in sheep....
 University of California, Irvine Use of Laser-Induced Fluorescence for Determination of Root Canal Pathology and Localization of Pathological Tissues to Facilitate Endodontic Therapy
  Researchers at the University of California, Irvine have developed a fiber-optic system for determination of root canal pathology and for the detection and localization of pathological tissues. The system, using specialized equipment and techniques, can perform multi-wavelength excitation and emission spectra of all root canal components. Using this novel approach, a fiber optic can be placed in t...
 University of California, Irvine Use Of Perillyl Alcohol In Organ Transplantation
  Utilizing both these immunosuppressive mechanisms, UCLA scientists have determined that perillyl alcohol, a widely-known anti-carcinogen, can be used to reduce graft rejection. By inhibiting activation of the p2l ras oncogene, perillyl alcohol blocks activation of the pathway necessary for lymphocyte proliferation and thus activation. In addition, perillyl alcohol can also reduce the side effects ...
 University of California, Irvine Vascularized Artificial Tissue
  University researchers have developed a technique to prevascularize a thick tissue in vitro using a biodegradable microfluidic network, for subsequent implant. The ultimate shape of the tissue could be controlled such that the tissue could be used to repair tissue defects following trauma or surgery. Small biodegradable microfluidic channels are constructed using microfabrication technology. The c...
 University of California, Irvine Visual Neural Classifier
  Scientists at the University of California have developed a visual neural classifier that uses funnel-shaped dimensionality reduction networks with two-neuron hidden layers. This type of network can approximate, to any desired precision, an arbitrarily complex function and then classify this function into a visually meaningful, explanatory, and interactive display....
 University of California, Irvine Wide-Bandwidth Micromachined Gyroscope To Measure The Angular Rotation Of An Object
  A novel design concept providing 15-fold increases in bandwidth has been developed for micromechanical gyroscopes. In addition to increased bandwidth, the device also demonstrates improved durability during fabrication and packaging, and robustness in the expected temperature fluctuations the device will experience. Consequently, tight fabrication tolerances, control system complexity, and packagi...
 University of California, Irvine Wnt, Fz, and BMP-6 Receptors for the Treatment and Detection of Colon Cancer
  University of California, Irvine, researchers have found that factors of the Wnt signaling pathway are associated with colon carcinogenesis and may therefore be useful for prognosis, diagnosis or treatment of colon cancer. These factors include isolated polynucleotides and polypeptides of full-length lymphoid enhancer factor-1 (LEF-1). Researchers have also found that full-length LEF-1 and other f...
 University of California, Irvine Yeast Retrotransposons as a Model to Study HIV and Screen for HIV Anti-Retro Therapeutics
  From a screen of 4,457 S. cerevisae knockout strains, University of California, Irvine (UCI) researchers have discovered over one hundred host factor genes that affect the replication of the retrovirus-like element Ty3. Of these, 64 exhibited increased and 66 decreased Ty3 transposition compared with the parental strain. Previous studies for Ty host factors have reported a large number of genes, i...
San Carlos, CA 94070 P: 650-596-2776 ©2003-2009 PartnerAlliances, LLC