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University of California, Davis
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8-Stage Rotating Drum Impactor Aerosol Sampler
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Scientists at the University of California, Davis have developed a self-contained 8-stage aerosol impaction sampler capable of long-term autonomous operation. A prototype of the newly developed instrument is in the final stages of construction and is available for support of sampling efficiency testing and commercial licensing. The current version of the University of California, Davis aerosol imp...
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University of California, Davis
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A Bioengineered Corneal Dressing to Enhance Wound Healing
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BACKGROUND: Corneal and conjunctival epithelial cell injury, degenerations, and dystrophic changes are relatively common corneal problems and may threaten vision. Ocular surface diseases, chemical and thermal burns, ocular surface tumors, immunological conditions, radiation injury, and certain inherited syndromes can severely compromise the ocular surface and cause catastrophic visual loss in othe...
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University of California, Davis
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A METHOD FOR ENHANCING OUTFLOW OF AQUEOUS HUMOR IN TREATMENT OF GLAUCOMA
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DESCRIPTION: Glaucoma is a leading cause of blindness andproduces elevated intraocular pressure leading to optic nervedamage.Scientists at the University of California have discovereda novel physiological mechanism that plays an important role inregulating intraocular pressure.They have identified a series ofchemical compounds which can exploit this mechanism in order toincrease aqueous humor ou...
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University of California, Davis
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A RAPID ELISA DIAGNOSTIC FOR VESICULAR STOMATITIS
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Vesicular stomatitis (VS) is a viral disease that affectscattle, pigs, and horses.The disease is commonly characterized byvesicular lesions on the epithelium of the mouth, feet, and teats. VS is difficult to diagnose because the pathological lesions arevirtually indistinguishable from that of foot-and-mouth disease(FMD). Researchers at the University of California have developed akit using a re...
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University of California, Davis
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ACID BATTERY WITH REPLACEABLE ELECTRODES
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DESCRIPTION: A commercial 100 amp lead acid battery can deliverup to 12 hp power for short periods of time, which is sufficientfor use in conventional gasoline powered cars.When used in seriesto power an electric car, however, these batteries can provide onlyenough power for the car to go about 60 miles before needing torecharge for three to four hours.A researcher at the University of Californi...
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University of California, Davis
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ADJUSTABLE MULTINOZZLE PAINT APPLICATOR
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University of California researchers have invented a multinozzle paint applicator with adjustable alignment for use in painting stripes on roadways and similar surfaces.When used in conjunction with a robotic or other positioning device, the UC applicator paints a set of three coincident juxtaposed stripes without overlapping bleed (or with a defined gap between the stripes) using a novel adjustme...
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University of California, Davis
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All-Optical Multi-Protocol Router Portfolio
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The platform technology for the Next Generation Internet has been invented by researchers at the University of California, Davis. This cost efficient technology vastly performs all other routers and consists of:
An ultra-low latency optical router;An apparatus and method for extracting and rewriting optical headers; andA chip-sized “beyond next generation� ul...
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University of California, Davis
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ALLOSTERIC INHIBITORS OF RETROVIRAL PROTEASES
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Among the approaches being studied for the specific in vivoinhibition of retroviruses (including treatment of HIV infectionsin AIDS patients) are those based on blocking the active cleavagesite of the viral aspartic protease.These involve the use ofsubstrate analogues that act as competitive inhibitors of theinteraction with the protein substrate.The lack of consensus inthe range of substrates a...
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University of California, Davis
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Alumina-Titania Nanocomposites from Plasma Sprayed Aluminum Titanate
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Nanocomposites of alumina and titania from plasma sprayed aluminum titanate powders were developed by researchers at the University of California, Davis. Using novel powder preparation and consolidation techniques, the composites can be consolidated to full density while retaining a nanocrystalline grain size. These materials have potential for low temperature/high strain rate superplastic forming...
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University of California, Davis
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Amino Acid and Peptide Conjugates of Amiloride
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Novel amiloride conjugates have been developed by researchers at the University of California, Davis. This invention includes compounds generated by conjugating amino acids and peptides to amiloride at the C(5)-amino goup or C(2)-guanidine moiety, furnishing inactive prodrugs that can be selectively activated by tissue endopeptidases.The C5-conjugates of the invention are highly selective and pote...
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University of California, Davis
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ANIMAL MODEL FOR HUMAN PAPILLOMA VIRUS
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The Human Papilloma virus (HPV) is a sexually-transmittedinfectious agent responsible for 500,000 to 1,000,000 new cases inthe U.S. each year.Previously, there has been no animal model forHPV infection that could be used to adequately test the efficacy orsafety of candidate HPV vaccines or to screen for other possibleHPV therapeutic agents.Thus, the development of suitable vaccinesand pharmaceut...
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University of California, Davis
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Anisotropic Thermal Conductivity in Carbon Nanotube Reinforced Ceramic Nanocomposites
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A ceramic composite material with improved thermal, electrical and mechanical properties has been developed by researchers at the University of California, Davis through the incorporation of carbon nanotubes into a ceramic matrix. Using novel powder preparation and consolidation techniques, single wall carbon nanotubes (SWCN) and nanopowders of alumina are combined into a composite with remarkable...
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University of California, Davis
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Antibodies Against Autoantigens of Primary Biliary Cirrhosis and Methods of Making and Using Them
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Researchers at the University of California, Davis have created a novel method of making an isolated human monoclonal antibody. This antibody binds a mitochondrial antigen bound by a human autoantibody found in patients with PBC. This method involves using a transgenic non-human animal that has the ability to make human antibodies. The present invention also provides an isolated protein bound by h...
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University of California, Davis
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APOPTOSIS-RELATED PLANT DISEASE RESISTANCE
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Researchers at the University of California have identified a gene and have developed a system for expressing a novel form of disease resistance in plants.The transformation vector in this system combines a non-plant gene with a constitutive plant promoter.When present in a transgenic plant, the gene product inhibits the apoptotic death of plant cells, thus protecting them from diseases whose etio...
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University of California, Davis
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APPARATUS AND METHOD FOR VISUAL-FIELD TESTING
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DESCRIPTION: Eye diseases such as glaucoma and optic neuropathiesaffect the field of vision.Visual field examination can oftendetermine the type, extent, and location along the visual pathwayof many eye diseases, so tests, such as perimetry testing, arecommonly performed to determine the subject's visual field rangeand sensitivity to light intensity, color, stimulus size, orspatial or temporal p...
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University of California, Davis
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APPARATUS AND METHOD FOR VISUAL-FIELD TESTING
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DESCRIPTION: Eye diseases such as glaucoma and optic neuropathiesaffect the field of vision.Visual field examination can oftendetermine the type, extent, and location along the visual pathwayof many eye diseases, so tests, such as perimetry testing, arecommonly performed to determine the subject's visual field rangeand sensitivity to light intensity, color, stimulus size, orspatial or temporal p...
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University of California, Davis
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AUTOMATED BIOSENSOR FOR MEASUREMENT OF MILK UREA
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In the dairy industry, there is considerable interest in optimizing nutritional input for the highest milk protein to feed cost ratio.In many areas there is also great concern about amounts of nitrogen in dairy waste.Excessive levels of nitrogen in feed cause high concentrations of systemic urea without a corresponding increase in milk protein.Measurement of milk urea nitrogen (MUN) allows the far...
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University of California, Davis
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AUTOMATIC LOW-PRESSURE WOUND IRRIGATION
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A University of California researcher has invented a device to provide a simple, quick, disposable sterile system for irrigating wounds that can be used by even the most inexperiencedemergency care providers.Unlike existing wound irrigation systems, this system combines lowcost, sterility, and ease of set-up and use with the reliable delivery of a constant and provenirrigation pressure.The system...
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University of California, Davis
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BACULOVIRAL INSECTICIDES WITH ENHANCED ACTIVITY
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Baculovirus insecticides as both natural viruses and recombinants are promising agents for the control of insect pests.However, in their present form, baculoviral insecticides do not perform well on certain crops in controlling larvae of the Noctuidae family, including some of the most destructive agricultural pests known.These include the tobacco budworm, the cotton bollworm, the cotton leafworm,...
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University of California, Davis
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Beam Formation Using Concentric Conical Focuser
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A new device for efficiently selecting particles of one size from an airflow and focusing these particles into a beam has been invented by UC Davis researchers.The University’s invention:
Detects and interacts with particles within a gas much better than comparable devices;Conducts online analysis of aerosols, including ultrafine aerosols with diameters as small as10 nano...
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University of California, Davis
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Beamformer for Joint Interference Rejection and Maximum Likelihood Equalization of Broadband Wireless Signals
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A wireless communications receiver that equalizes a frequency-selective channel and cancels co-channel interference has been developed by researchers at the University of California, Davis. The invention is most useful for broadband wireless channels with high data rates, i.e., those for which the channel bandwidth represents a non-negligible fraction of the center frequency.The UC Davis invention...
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University of California, Davis
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Beta-Adrenergic Receptor Modulation of Wound Repair
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Researchers at the University of California, Davis, have discovered a way to treat skin wounds using beta-adrenergic agonists and beta antagonists. This invention covers the use of beta-adrenergic agonists to delay wound epithelialization and contraction, and treat medical conditions that require a wound's surface to remain open, such as in the treatment of restenosis. In addition, the present inv...
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University of California, Davis
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BIFUNCTIONAL CHELATORS FOR RADIODIAGNOSIS/ THERAPY AND METHOD FOR THEIR EFFICIENT RADIOLABELING
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BACKGROUND: Bifunctional chelating agents (BCAs) containreactive groups capable of both attaching to monoclonal antibodies(mAbs) and chelating metallic radioisotopes.SuchmAb-BCA-radioisotope complexes are used to detect cancer cells andto target cancer cells for therapeutic purposes. Although the mAbsare specific to cancer cells, the mAb-BCA-radioisotope complexescan also bind to non-cancer cell...
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University of California, Davis
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BIOENGINEERING OF FRUIT SWEETNESS
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To the consumer, the most important quality attributed to fruit is flavor.A consumer'spreference for flavor is dominated by sweetness - the degree of which is directly related to thetype and quantity of fruit-soluble sugars that are present within the fruit.Most fruit accumulateapproximately equal concentrations of two types of fruit-soluble sugars, fructose and glucose,with fructose being twice ...
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University of California, Davis
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BIOLOGICAL IMMUNOSUPPRESSANT COMPOUNDS FOR USE AGAINST INFLAMMATORY AND AUTOIMMUNE DISEASES
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Autoimmune and inflammatory diseases afflict a large number of patients every year.Accordingly, research is being conducted to eliminate or minimize the effects of these diseases.One of the biological molecules that plays an important role in the effects of these diseases is arachidonic acid, which is present in immune cell membranes.This compound is an important precursor to signalling compounds ...
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University of California, Davis
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BIOSYNTHETIC GENES FOR A POTENT ANTITUMOR AGENT
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The enediyne family of antitumor antibiotics comprises the most potent, most highly active antitumor agents ever discovered, with some members of this family being 1000 times more potent than adriamycin, one of the most effective antitumor antibiotics in current clinical use.However, the natural enediynes that have undergone testing so far have shown either a limited spectrum of activity or unpred...
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University of California, Davis
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Biphasic Catalysis Without The Use Of Fluorous Liquids
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A novel method employing biphasic catalysis without the use of fluorous liquids or water has been developed by University of California researchers. This method can be used for synthesizing products used in the production of pharmaceuticals, fine chemicals and some polymers while allowing expensive homogenous catalysts to be recovered and reused. Current and recently developed methods for using an...
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University of California, Davis
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BLEOMYCIN BIOSYNTHETIC GENES
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Bleomycins (BLMs) are a family of glycopeptide-derived anti-tumor antibiotics originally isolated from the fermentation broth of Streptomyces verticillus.BLMs exhibit strong anti-tumor activity and are one member of the family of anti-cancer drugs that is widely used for the treatment of lymphoma (particularly Hodgkin's disease), testicular tumors, various squamous cell carcinomas, and malignant e...
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University of California, Davis
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BLOCKING OVULE AND SEED FORMATION IN HIGHER PLANTS
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In many fruit crops, the presence of seeds is an undesirabletrait that makes human consumption more difficult or reduces theoverall attractiveness of the fruit.Some asexually-propagatedvarieties of seedless fruit have been developed to counter thisproblem, but only a few species have shown a potential forparthenocarpic varieties.Also, rudimentary structuresrepresenting the fully developed but ab...
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University of California, Davis
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CANDIDATE VACCINE FOR EQUINE ARTERITIS VIRUS (EAV)
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University of California researchers have cloned a cDNA encoding a major envelopeglycoprotein of Equine Arteritis Virus (EAV) and expressed a serologically-active form of theprotein using a viral expression system.Using Western immunoblotting assays, the researchersconfirmed that the cDNA-encoded protein strongly reacts with certain monoclonal antibodiesspecific to the natural EAV protein.This sug...
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University of California, Davis
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Carbon Nanotube and Niobium Toughened Ceramic Nanocomposites
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Through the incorporation of carbon nanotubes and a ductile metal into a ceramic matrix, researchers at University of California, Davis have produced a composite with dramatically improved fracture toughness. Using novel powder preparation and consolidation techniques single wall carbon nanotubes (SWCN), niobium metal and nanopowders of alumina are combined into a composite with remarkable mechani...
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University of California, Davis
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Carbon Nanotube Toughened Ceramic Nanocomposites
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Through the incorporation of carbon nanotubes into a ceramic matrix, researchers at University of California, Davis have produced a composite with dramatically improved fracture toughness. Using novel powder preparation and consolidation techniques single wall carbon nanotubes (SWCN) and nanopowders of alumina are combined into a composite with remarkable mechanical properties.The fracture toughne...
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University of California, Davis
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Carrier Tests for Point-Restriction Coat Color in the Domestic Cat
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Novel carrier tests for Point-restriction and albinism in the domestic cat have been developed by University of California, Davis researchers. Advantages of these carrier tests for coat color variants include:
The ability to detect carriers of these specific DNA mutations at time of birth;Reduced need for expensive production of unwanted cats from test crosses;Non-invasive, lower cost DNA m...
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University of California, Davis
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Cell-Growth-On-Bead Assay
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A novel “cell-growth-on-bead� assay for screening epithelial cells that attach and proliferate on beads conjugated with specific compounds such as peptides has been developed by scientists at the University of California, Davis.This assay has been shown to exhibit high sensitivity and specificity in the following applications:
Screening compound-bead librarie...
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University of California, Davis
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Charged Cyclodextrin Derivatives For Use In Plant Cell And Tissue Culture Growth Media
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The University of California is currently licensing new Charged Cyclodextrin Derivatives (CCD's). CCD's could be used in numerous applications, especially in plant tissue culture. CCD's have novel properties due to unique internal cavities that form inclusion complexes with various molecules. In plant tissue culture, CCD's favorably modulate the solubility of nutrients like ammonium, nitrate, pota...
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University of California, Davis
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Cold Spray Nanomaterials and Coatings
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Researchers at University of California, Davis and Perpetual Technologies have developed a two-step, cold-spray process to produce nano-structured metals, alloys and/or composites in the form of coatings, welds, and/or near net shape parts. The first step, powder synthesis, is achieved using mechanical alloying techniques, where a conventional grain size material (micron range grain size) is reduc...
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University of California, Davis
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Compact Proton Radiotherapy System
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Opportunity:A compact proton radiotherapy system that fits in a typical radiation oncology clinic and costs 1/10th of current proton therapy facilities (~$15M vs. $150M).Background:Proton radiotherapy has been used to treat tumors since the 1950’s. Protons minimize damage to surrounding tissue better than conventional radiation treatment using electrons or photons. Furthermore, ...
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University of California, Davis
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Consolidation of Nanocrystalline Materials with Minimal Grain Growth
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A novel approach for the consolidation of nanocrystalline metallic powders using the Equal Channel Angular Pressing (ECAP) method has been developed by researchers at the University of California, Davis. Conventional consolidation methods currently available (i.e., HIP) have demonstrated their limitations or drawbacks. Usually, isotropic microstructures and properties are observed after HIP, which...
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University of California, Davis
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CONSTITUTIVE PROMOTOR IN DICOT PLANTS
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A researcher at the University of California has obtained a DNA sequence of a promotor for high-level constitutive expression of desired proteins or RNAs in all major organs and tissues in dicot plants.Such promotor sequences that allow expression of foreign genes in plants are useful for producing genetically-engineered crop plants with superior crop yields, higher crop quality, shorter growth pe...
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University of California, Davis
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CONSTITUTIVELY-ACTIVE PLANT DISEASE RESISTANCE GENES
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Disease resistance in plants often involves single dominant genes that are thought toencode receptors for products of pathogen genes and are members of signal transductionpathways.The disease resistance response arising from such pathogen/receptor interactions isoften effective against a broad spectrum of pathogens and pests, but is only effective when bothreceptor and pathogen-derived molecules ...
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University of California, Davis
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Context Search: A Novel Search Method for Databases, Text Documents and Media Items
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A novel search method was developed to search for information in databases and other types of textual data by researchers at the University of California, Davis. Searches can be applied to:
Media itemsWeb pagesEmail messagesNews articlesScientific abstracts and articlesmedical recordsLegal documentsPatentsBusiness documents, etc.This revolutionary method will facilitate the development of a...
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University of California, Davis
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Cost Effective and Safe Particulate Matter Analysis
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Researchers at the University of California, Davis have developed a cheaper and safer method to extract particulate matter (PM) from Teflon collection filters using organic solvents and nitric acid.Inductively Coupled Plasma †Mass Spectrometry (ICP-MS) is a powerful and robust analysis method that can quantify the concentration of many elements in aqueous solution. However, it is diff...
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University of California, Davis
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Data Array Reduction and Analysis
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DNA microarray data analysis methods have been developed by University of California researchers. Application of these methods includes the:
Diagnosis of disease;Selection of treatment modality;Prediction of survival under different conditions;Discovery of different categories of disease, orDiscovery of different patient categories affecting treatment.The methods provide the ability to:Dist...
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University of California, Davis
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DECONTAMINATION OF MEAT AND POULTRY
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A researcher at the University of California has devised asafe and inexpensive system for greatly reducing the number ofpathogenic microorganisms present on the surface of animalcarcasses.With several cases of contaminated meat and poultryrecently receiving widespread public attention, there is a pressingneed for improved yet economical methods of pathogen reduction. The UC system meets this nee...
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University of California, Davis
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Detection of Bovine DNA in Cattle Feeds Via Fluorescent Polymerase Chain Reaction
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A novel technique for detecting unwanted mammalian DNA in ruminant feeds using a real time PCR assay has been developed by researchers at the University of California, Davis. To avoid transmission of bovine spongioform encephalopathy (BSE), the incorporation of certain mammalian protein in ruminant feeds was banned in the United States in 1997. However, certain barriers remain that inhibit the ide...
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University of California, Davis
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DETERMINATION OF GLOMERULAR FILTRATION RATE USING MAGNETIC RESONANCE IMAGING TECHNOLOGY
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DESCRIPTION: Magnetic resonance imaging (MRI) has revolutionizedmedical technology by providing detailed images of human anatomyand offers the possibility of human physiologic assessments. However, the expansion of this technology into areas of biochemicaland physiological assessments has yet to be realized.With regards to renal diseases, MRI has not been widely usedbecause MRI assessments are p...
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University of California, Davis
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Device and Method for In Vitro Wound Healing
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An improved in-vitro wound healing assay has been developed by University of California, Davis researchers. Novelties of this method include:
Reliable wound width of choice that has no variation within the wound or between wounds;Minimal intra-wound and inter-wound variability; and,No damage on the edges of the wound areas.The traditional method for in-vitro wound healing employs a sterile ...
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University of California, Davis
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DEVICE FOR APPLYING AERIAL SURVEY MARKERS TO ROADS
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Researchers at the University of California have developed a self-contained automated unit for applying two different styles of photogrammetic surveying markers to a roadway.Such markers are used as targets in aerial photosurveys for highway construction and landscaping, and are a necessary element for the very high precision work that may become increasingly important in future highway constructi...
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University of California, Davis
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DIAGNOSTIC METHOD AND APPARATUS FOR MONITORING THERMAL-MEDIATED LASER SURGERY IN SITU
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BACKGROUND: Birefringence spectra of tissue can provide physicians with detailedstructural images of turbid tissues, such as tendon tissue.Although methods exist to image thebirefringence of excised tissue specimens, these techniques require surgical remove of thespecimen and are limited by processing artifacts. DESCRIPTION: Researchers at the University of California have developed a method anda...
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University of California, Davis
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DIAGNOSTIC REAGENTS FOR EQUINE ARTERITIS VIRUS
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University of California scientists have developed a panel ofmonoclonal antibodies (MAbs) to the equine arteritis virus (EAV). The UC MAbs are likely to be useful for the detection of serumantibodies to EAV using the competitive enzyme-linked immunosorbentassay (cELISA).As displacement of a MAb from its epitope isquantified by cELISA, such an assay using EAV MAbs should be highlyspecific and sen...
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University of California, Davis
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Dietary Cancer Prevention
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A key gene related to dietary cancer prevention has been isolated by University of California, Davis researchers. Cancer prevention linked to the consumption of cruciferous vegetables has long been established. The high levels of compounds known as glucosinolates in cruciferous plants are the basis of their anticarcinogenic action, which works by inducing enzymes that detoxify carcinogens in the b...
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University of California, Davis
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DIPLOID PARTHENOGENESIS IN GYMNOSPERMS
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A pressing need for increased forest productivity to meet the ever-increasing demand for wood has led to interest in creating simpler and more rapid means of reproducing high-value genotypes for reforestation.Such methods as somatic embryogenesis and automated micropropagation systems have been favored as a way of multiplying such gymnosperms.It has been generally believed that diploid parthenogen...
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University of California, Davis
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Disease Markers: Mucin 5B Monoclonal Antibodies
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Two new monoclonal antibodies against human mucin 5B (MUC5B) have been developed by University of California, Davis investigators. Mucin 5B antibodies can be used as markers to study some cancers as well as airway diseases such as chronic obstructive pulmonary disease (COPD). These new MUC5B antibodies:
Are made against the peptide sequence, not the carbohydrates, of mucin 5B,Are made again...
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University of California, Davis
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DISTAL RADIUS FIXATION SYSTEM
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A researcher at the University of California has developed aself-contained fixation system for distal radius fractures andmalunion deformations.Current practice employs external fixationdevices for fractures but not for malunions.Most existingexternal fixation systems for distal radial fractures do not allowfor three-dimensional correction of fracture or maluniondeformities.The few systems that ...
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University of California, Davis
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Dry Flow Meter for Gas Measurement
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Scientists at the University of California, Davis, have developed a novel and highly efficient precision gas flow meter. Because of its precision and non-manual operation, the apparatus allows control of certain predetermined variables. For example, the gas flow rate can be continuously measured and recorded during a specified time frame. The new meter is capable of:
Gas collection and vent...
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University of California, Davis
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EDIBLE COATING FOR CRISPY TEXTURE IN PROCESSED FOODS
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University of California researchers have discovered that a sweet-corn extract can be usedto modify the texture of processed foods to improve their crispiness.The extract may be appliedas an edible coating or added directly to the food item prior to processing.After application ofthe extract, the item may be fried, toasted, dried, baked, and soaked while retaining the desiredtextural properties. ...
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University of California, Davis
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EDIBLE WATER-INSOLUBLE PROTEIN BASED FILMS FOR USE IN ENHANCING FOOD QUALITY AND PRESERVATION
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Dried food systems, intermediate moisture foods, and fresh produce exhibit potential forimprovement through the use of edible films.Many baked products are susceptible to oxidationfrom the atmosphere and to moisture uptake from the atmosphere or from moist fillings,toppings or ingredients.Many dried and baked products are also susceptible to flavor/aromaloss and lipid migration between food compo...
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University of California, Davis
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Efficient Production of 14C-Vitamin B12 for Human Microdosing and Other Applications
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A novel and an efficient method for producing isotopically-labeled forms of vitamin B12 (cobalamins) has been developed by scientists at the University of California, Davis. This invention is coupled to the development of a new set of clinical and diagnostic technologies related to vitamin B12 deficiency and metabolism. Determination of 57Co-B12 is not particularly sensitive or quantitative (i.e.,...
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University of California, Davis
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Efficient XML Node Identification and Indexing Scheme
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A novel approach to the indexing of node-labeled, tree-structured data such as XML data has been developed by researchers at the University of California, Davis. The approach is based on a new node identification scheme that effectively encodes complete rooted data paths as they occur in a data source. The node identification scheme and several further optimizations provide for very storage-effici...
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University of California, Davis
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Electrically Conductive, Carbon Nanotube Reinforced, Ceramic Nanocomposites
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Through the incorporation of carbon nanotubes into a ceramic matrix, researchers at University of California, Davis have produced a composite material with improved electrical and mechanical properties. Using novel powder preparation and consolidation techniques single wall carbon nanotubes (SWCN) and nanopowders of alumina are combined into a composite with remarkable properties.The improved elec...
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University of California, Davis
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Element Coded Affinity Tags (ECAT) for Protein Identification
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A method for protein analysis using Element Coded Affinity Tags (ECAT) has been developed by UC Davis researchers. The method identifies identical proteins from differing treatments (induced vs. non-induced, natural vs. chemical oxidation, etc.) using a range of element-coded metal chelates as mass affinity tags. The method tags the proteins and purifies tagged peptides through an antibody affinit...
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University of California, Davis
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Emulsions for Microbial Control
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Researchers at the University of California have developed a new type of invert emulsion formulation that ensures longer, more stable shelf life for improved storage and delivery of microbial agents for the control of plant pathogens and insects (biocontrol agents). Examples of applications which have been successful are:
Lagenidium giganteum for mosquito controlFusarium lateritium for Euty...
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University of California, Davis
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Enhanced Nano-Materials Produced More Efficiently
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A composite ceramic material with significantly improved fracture toughness and hardness was produced by researchers at University of California, Davis through the incorporation of silicon carbide whiskers into a ceramic matrix. Using novel powder preparation, and consolidation techniques, silicon carbide whiskers and nanopowders of alumina are combined into a composite with remarkable mechanical ...
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University of California, Davis
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Enzyme Catalyzed Metallic Nanoparticle Synthesis at Room Temperature
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Metallic nanoparticles are a core component of modern nanotechnology, yet their production still suffers major limitations. The heart of this new approach lies in the precise control of the number of nucleation sites by placing the metal ions to be reduced at the active sites of enzymes that catalyze their reduction. Such nucleation control has been extremely difficult to achieve in typical soluti...
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University of California, Davis
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Epilepsy Photodynamic Therapy
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A novel photodynamic adjunct to epilepsy surgery is being developed by University of California, Davis researchers. For more than 2,000,000 worldwide epilepsy sufferers, current resective surgery practices potentially remove healthy brain tissue along with the affected area, and no method currently exists to selectively label epileptic tissue to prevent removal of healthy brain tissue.The UC Davis...
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University of California, Davis
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Eukaryotic Cell Preservation
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A novel method for the preservation of eukaryotic cells has been developed by the University of California, Davis researchers. The method uses a novel technique for preserving eukaryotic cells such as, mesenchymal stem cells and fibroblasts. The first step consists of the incorporation of a cryoprotectant into the cells. The second step is an air-drying step producing cells of increased storage ca...
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University of California, Davis
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Expression Vector System With C-Terminal-Free Thiol
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An expression vector that systematically incorporates a C-terminal-free thiol for polypeptide dimerization or conjugation, such in the engineering of antibodies, has been developed by University of California, Davis researchers. The system incorporates a C-terminal-free thiol group into the recombinant product that can be used for site-specific conjugation or stable dimerization. A broad spectrum ...
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University of California, Davis
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EYELID CLOSURE DEVICE
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Corneal exposure is a frequent source of morbidity in both in-patient and out-patientpopulations.Corneal exposure, with its attendant risk of corneal keratopathy, results from thetotal or partial loss of eyelid closure.Metabolic derangement, artificial respiration, immunologicdysfunction, impaired mental status, and facial injuries can all leave a patient vulnerable toophthalmologic complications...
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University of California, Davis
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Fabrication of Electro-Magneto-Opto-Chem-Mechanical Systems Using Si, SiGe, SiGeC and Chemical Endpoint Detection
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A novel process for fabricating discrete and/or integrated electro-opto-chem-mechanical systems or components on silicon-based materials has been developed by researchers at the University of California, Davis. This method combines the chemical etch-stop properties of Si, SiGe, and SiGeC, with electromagnetic, optical, chemical, and mechanical features to create components for integrated circuits ...
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University of California, Davis
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Fabrication of Optical Components Using Si, SiGe, SiGeC, and Chemical Endpoint Detection
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A novel process for fabricating discrete and integrated optical components on silicon-based materials has been developed by researchers at the University of California, Davis. This method combines the epitaxial and selective etch properties of Si, SiGe, and SiGeC, with the optical capabilities of various media to create silicon based optical components.The ultra-thin silicon layers of today's inte...
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University of California, Davis
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Fiber Reinforced Metal Matrix Composites
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The reinforcement of metals and alloys with other materials such as fibers or ceramic particulates has long been known and has strong utility in many industries that utilize structural metal components. The addition of inert materials was found in 1910 to improve the elevated temperature properties of metals and alloys. Since then, a large number of dispersion strengthened materials have been succ...
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University of California, Davis
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Fibrinogen Domain as a Target for Apoptosis
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Researchers at the University of California, Davis have isolated a domain on fibrinogen that induces apoptosis of endothelial cells. This fibrinogen domain effectively blocks proliferation of cultured bovine artery endothelial cells. Features and uses of this fibrinogen domain include:
Possible new anti-angiogenic cancer therapeutic;Excellent stability due to its human origin, with no expec...
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University of California, Davis
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Flask For Drying Biological Materials
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Dried biological materials are becoming increasingly useful in agriculture, biotechnology and medicine:
Freeze Dried Human Blood products and VaccinesFreeze Dried Bacteria for AgricultureBiosensors requiring Long Term StorageA device is described here which permits drying (freeze-drying, air-drying, foam drying) under sterile conditions and which allows for processing under defined conditio...
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University of California, Davis
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FLUIDIC INTERCONNECTS FOR MODULAR ASSEMBLY OF CHEMICAL MICROSYSTEMS
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BACKGROUND: Traditional analytical instruments are large, expensive, and relegated tothe laboratory.Hence, there is increasing interest in replacing these instruments with small andinexpensive handheld units.Concomitant with this miniaturization is the need for miniaturefluidic interconnects.One of the challenges is bridging the scale from the micron scale ofmicrofabricated structures to the mill...
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University of California, Davis
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Fully Dense Nanostructured Metal Alloys and Metal Matrix Composites
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Researchers at the University of California, Davis have developed a way to synthesize bulk, fully dense nanostructured metal alloys and discontinuously reinforced aluminum metal matrix composites. These nanostructured materials have improved material properties, compared to their coarse-grained counterparts. Resulting Material Characteristics
Better corrosion resistance;Improved wear resist...
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University of California, Davis
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FUNCTIONAL ASSEMBLY OF INTACT ANTIBODIES SECRETED BY RECOMBINANT YEAST PICHIA PASTORIS
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BACKGROUND:Several recombinant antibodies have been produced in bacteria or phages as engineered fragments: Fab, Fv, scFV, and diabody. Yeast has long been used as a host for recombinant protein production because of the advantages it offers as a unicellular eukaryote. However, it has not been possible to harness the full potential of the prototypical yeast Saccharomyces cerevisiae for commercial ...
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University of California, Davis
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Functional Coatings
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Enhanced corrosion, wear, and oxidation characteristics may be obtained by using the functional coatings developed by researchers at University of California, Davis.In one particular application of this invention, thermal barrier coatings (TBCs) have an extended life.A TBC typically consists of a ceramic coating adjacent to a metallic coating, resulting in a mismatch in the coefficient of thermal ...
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University of California, Davis
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Functionally Graded Materials Production
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A novel technique for producing functionally graded materials (FGM) has been developed by researchers at the University of California, Davis. A monolithic material can be created with layers of materials which vary in composition. For example, a shaped body of material can have an initial layer of metal, a final top layer of ceramic, and a number of layers of ceramic-metal composite materials betw...
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University of California, Davis
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Gallic Acid Biosynthetic Pathway for Inhibiting the Production of Aflatoxins by A. flavus
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An established chemical production pathway for a compound, gallic acid, which can contribute to the reduction of aflatoxin contamination, has been identified by University of California, Davis researchers. Infection of agricultural crops by specific strains of the fungus Aspergillus flavus results in the production and accumulation of certain types of noxious compounds known as aflatoxins. Aflatox...
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University of California, Davis
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GENE FOR RESISTANCE TO BACTERIAL BLIGHT DISEASE
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The most effective, economical, and environmentally safe meansof disease control for crop plants is the utilization of geneticresistance.Since the identification and development ofdisease-resistant plant varieties can take years, and oftendecades, of research using conventional breeding methods, there hasbeen considerable interest in using molecular cloning methods toaccelerate the development o...
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University of California, Davis
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GENERAL PROTEIN DEGRADATION SIGNAL IN PLANTS
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Researchers at the University of California have identified a small DNA sequence that, when attached in-frame to the coding sequence of another protein, can be used to modify the resulting protein product so that it rapidly degrades in plants.Rapid degradation directed by this sequence has been demonstrated with luciferase in transgenic Arabidopsis seedlings directly by pulse chase analysis.Lucife...
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University of California, Davis
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Genotyping of the cad-n1 Mutation in Loblolly Pine
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The genetic sequence responsible for cinnamyl alcohol dehydrogenase (CAD) deficiency in loblolly pine trees (Pinus taeda L.) has been discovered by researchers at the University of California, Davis. The loblolly pine is the most important commercial tree species in the United States harvested for pulp and solid wood products. However, the extraction of lignin from its wood during the production o...
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University of California, Davis
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GLUCOSE EMULATING RADIOPHARMACEUTICAL FOR CONVENTIONAL GAMMA CAMERA IMAGING
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Glucose transport protein is present on every living cell'smembrane, and its concentration is up- and down-regulated with thecell's need for glucose. Thus a tracer of this transport protein isa tracer of glucose metabolism itself.Studies with radioactivefluordeoxyglucose, a glucose tracer in positron emission tomography(PET), show a unique utility for the diagnosis of most cancers, forindicating...
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University of California, Davis
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Glucosinolate Accumulation in Plants
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Glucosinolates are natural compounds synthesized by plants of the crucifer family, including nutritionally important Brassica crops such as broccoli and cauliflower. Products derived from glucosinolate breakdown exert a variety of biological activities in plants, animals, and humans, which range from the participation in plant defense against pathogens and herbivores to the prevention of cancers. ...
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University of California, Davis
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Ground Transport Control System
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An ultra high-speed digital guidance system for ground transportation has been developed by researchers at the University of California, Davis. The system has an operational rate from 0-150 mph. It allows for stopping or docking as well as high-speed control of vehicles.This innovative system can receive input from a variety of sources to control the vehicle: magnetic markers, continuous magnetic ...
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University of California, Davis
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Guaranteed Connection Schemes in Optical WDM Mesh Networks
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Optical network providers can now offer service level agreements assuring both continuous quality and guaranteed levels of protection from connectivity interruptions in mesh net operations thanks to two innovations by researchers at the University of California, Davis. One innovation accounts for the variables related to network failures and proposes a means to repair connectivity breaks in variab...
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University of California, Davis
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GYMNOSPERM CLONING AND SCALEUP
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Researchers at the University of California have developed a process to clone and produce gymnosperms en masse, aiding in breeding and in tree improvement programs, as well the domestication of important species.Most frequently natural and artificial crosses produce only one embryo.This invention captures the genetic gains inherent in a successful cross, in large numbers of that genotype, which ca...
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University of California, Davis
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Hand Portable Single Particle Sensor
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An ultra-sensitive hand portable device capable of detecting and analyzing individual airborne particles is under advanced development by University of California, Davis researchers. This sensing device is available for industrial support of its final research development phase or commercial licensing.The optimized version of the University of California, Davis device will replace the current gene...
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University of California, Davis
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Helicobacter Diagnostic Antigens for Mice
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Unique and immunoreactive murine (mouse) Helicobacter bilis recombinant antigens have been discovered by University of California, Davis researchers. H. Bilis infection is a widespread maintenance issue in research mouse colonies. Nearly 30 million mice are used annually for biomedical research, and mice are the predominant mammalian models in genomics research, making the potential market for rod...
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University of California, Davis
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High Power Density Supercapacitors
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Researchers at the University of California, Davis have developed high power density supercapacitors with significantly small equivalent series resistance (ESR). These devices have achieved a maximum specific power density of 30kW/kg and exhibited rectangular cyclic voltammograms even at a high scan rate of 1000 mV/s. The latest results show incredible frequency response: a knee frequency of about...
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University of California, Davis
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High-throughput Screening of Neuraminidase Inhibitors
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A novel fluorogenic substrate that can be immobilized on solid support for high-throughput screening of neuraminidase inhibitors has been developed by researchers at the University of California, Davis. Notable features of this on-bead screening process include:
Ability to be use in large combinatorial libraries of compounds to find enzyme inhibitory properties; and,Rapid identification of ...
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University of California, Davis
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HIGH-YIELD PRODUCTION OF 3-KETOGLYCOSIDES
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3-Ketoglycosides (3KGs) have been used as precursors in the synthesis of a number of commercially-important products, such as food preservatives, food conditioners, photographic antioxidants, antibiotics, and rare and novel carbohydrates. 3KGs are obtained by a specific dehydrogenation reaction occuring at the C-3 position of any glucoside or galactoside.The resulting keto group confers two new pr...
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University of California, Davis
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HIGHLINE ALFALFA CULTIVAR
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University of California researchers have developed a new alfalfa cultivar (known as"Highline") adapted for irrigated production areas in relatively hot regions such as the Imperialand Central Valleys of California.The Highline cultivar is intended for hay, haylage,greenchop, and dehydration applications, and is highly resistant to Fusarium wilt (Fusariumoxysporum), pea aphid (Acyrthosi...
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University of California, Davis
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Honey Bee Pollen Foraging Pheromone
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A synthetic honey bee pollen foraging pheromone that increases the number of pollen foragers in a bee colony has been developed by researchers at the University of California, Davis. The UC Davis pollen foraging pheromone provides advantages to both commercial beekeepers and crop producers; the pheromone increases both the vigor of the bee colony and the number of plants pollinated.Application of ...
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University of California, Davis
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HYBRID ANTI-SCATTER GRID/DETECTOR FOR X-RAY IMAGING
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DESCRIPTION: X-ray detection is typically a two-step process.Anx-ray scintillation screen absorbs x-rays and emits visible light,and then a light sensitive receptor records the light image.Theanti-scatter grid is a separate component in the imaging chain thatis positioned between the object being imaged and the x-raydetector in order to reduce the amount of scattered radiationreaching the detect...
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University of California, Davis
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IL-4 Receptor Antagonists for Companion Animals
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UC Davis researchers discover the existence of an antagonist to IL-4 receptor in companion animals.There is mounting evidence that animals are genetically predisposed to allergy or hypersensitivity. Using the information developed by UC researchers, such individual animals could be identified at an early stage. An IL-4 receptor antagonist could then be used to immunomodulate IL-4 mediated response...
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University of California, Davis
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IMMUNOASSAY ON A COMPACT DISC (CD): SUPPORT WITH INTERACTIVE DATA STORAGE
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There are significant obstacles to performing clinical or diagnostic immunoassays on large numbers of analytes given the expense, the waste of reagents (including clinical samples, e.g. patient blood), and the limits on the number of multianalytes that can be processed in a given protocol.Present techniques tend to be very costly and inefficient when a very large number of assays are required, suc...
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University of California, Davis
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Improved Cotton Fiber Yield and Quality
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University of California, Davis researchers have characterized cotton transcription factors essential to controlling cotton fiber gene expression, of such traits as yield, length, fineness, uniformity and strength. The transcription factors offer an opportunity to create novel transgenic cotton plants with needed improvements in fiber quantity and quality to meet the multiple challenges of increas...
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University of California, Davis
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Improved Regeneration and Transformation of Cotton
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New and improved somatic embryogenesis methods of regeneration and transformation of cotton have been developed by UC Davis investigators. This unique system for generating transgenic cotton in elite genetic backgrounds is efficient and near genotype-independent. This system:
Improves the initial induction media;Decreases recovery of transgenic plantlets to several months and vastly increas...
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University of California, Davis
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IMPROVED ROBOTIC TACTILE SENSING SYSTEM
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University of California researchers have developed a simpleyet novel tactile sensing system for robotic and othermanufacturing applications.The UC system differs from existingtactile positioning systems in that it obtains a completelocalization of the targeted object in a single contact,eliminating the need for awkward repositioning of the sensors andmultiple measurements.The tactile sensing to...
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University of California, Davis
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IMPROVED TAXANE PRODUCTION
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BACKGROUND:Taxanes, a family of naturally-occurring compounds found in conifers, have acquired great importance as a source of pharmaceuticals.The best known member of the family, paclitaxel (sold under the trademark "Taxol"), has been approved by the U.S. Food and Drug Administration as an anti-cancer compound, and is widely used in chemotherapy.Other taxanes are also being considered for...
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University of California, Davis
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IMPROVED TAXANE PRODUCTION
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BACKGROUND:Taxanes, a family of naturally-occurring compounds found in conifers, have acquired great importance as a source of pharmaceuticals.The best known member of the family, paclitaxel (sold under the trademark "Taxol"), has been approved by the U.S. Food and Drug Administration as an anti-cancer compound, and is widely used in chemotherapy.Other taxanes are also being considered for...
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University of California, Davis
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IMPROVED TISSUE HOLDER FOR HISTOLOGICAL, IMMUNOCYTOCHEMICAL, AND IN SITU PROCEDURES
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The new syringe-style tissue holders are an inexpensive andconvenient device for use in histological, immunocytochemical, andin situ procedures using tissue pieces.Generally, the holderscurrently used consist of an open-ended plastic holder with a nylonor metal screen covering the bottom.These tissue holders have anumber of inherent problems.Tissue is placed into the holder viathe open end and t...
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University of California, Davis
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IMPROVED ULTRASOUND COLOR-FLOW IMAGING FOR VASCULAR ARCHITECTURE AND TUMOR ASSESSMENT
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DESCRIPTION: Diagnostic ultrasound techniques are of growingimportance in medicine because they are non-invasive, non-ionizing,and inexpensive compared to other sensing and imaging methods. However, ultrasound methods are currently limited by inadequateresolution and sensitivity.In particular, the promise ofcolor-flow imaging that provides spatial velocity estimates forblood flow has yet to be f...
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University of California, Davis
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Improving Cotton Yield and Production
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Cotton genes isolated by a University of California, Davis researcher can be modified to enhance the commercial value of cotton fiber quality and yield. The genes are associated with the regulation of cotton fiber expansion and extensibility of the cotton cell wall. Modifications of these genes can be used in transgenic plants under the control of specific promoters to improve cotton fiber quality...
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University of California, Davis
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IN-LINE POLYMERIC CONSTRUCT FOR MODULATORS, FILTERS, SWITCHES AND OTHER ELECTR-OPTIC DEVICES
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A coplanar waveguide polymeric in-line fiber construct (CPW-PILF) formed on an optic half coupler substrate base or D-fiber wherein the surface is polished down through the cladding on the optical fiber so as to form an evanescent coupling region on the surface. Co-planar, spaced-apart electrodes are deposited on the surface with their gap aligned over the coupling region, and an electro-optic (EO...
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University of California, Davis
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Increased Shelf Life for Lettuce
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Technology to increase the shelf life of lettuce, from harvest to table, is being developed by University of California researchers. The gene for the first enzyme in the metabolic pathway that results in tissue browning in iceberg, butter leaf and romaine lettuce has been isolated and sequenced. Using the information developed by UC researchers, the enzyme can be manipulated using genetic engineer...
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University of California, Davis
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Increased Transgene Integration Efficiency
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A more efficient method of developing transgenic non-human animals has been developed by researchers at the University of California, Davis. The method involves introducing a transgene and recombinase into a pronuclear stage embryo or cell, forming a recombinant, and letting the embryo progress to term or introducing the recombinant cell, or nucleus, into a non-human animal's oocyte and letting it...
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University of California, Davis
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Inhibitor of Tumor Progression
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A protein that suppresses the cellular levels of ErbB3, a protein involved in the progression of some solid tumors, has been identified and characterized by researchers at the University of California, Davis. Animal studies to validate ErbB3 suppression are currently underway.The University of California, Davis invention:
May be employed to suppress tumor progression in cancer patients.May ...
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University of California, Davis
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Inorganic Fluorescent Labels
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New highly efficient inorganic fluors for use in biological fluorescent labeling have been developed by University of California investigators. The inorganic particles are created by a novel chemical coating process and can be attached by simple chemical methods.
The particles have been successfully applied as labels for immunoassaysThe optical properties are very attractive for labeling in...
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University of California, Davis
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INSECT CONTROL USING JUVENILE HORMONE ESTERASE
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Juvenile hormone is a critical regulatory compound in insects and possibly other invertebrates.A reduction in its titer at inappropriate times can lead to the animals' death or disrupted development.In the agriculturally destructive lepidopterous insect family a highly specific, aggressive enzyme known as juvenile hormone esterase (JHE) causes insects to stop feeding and undergo metamorphic change...
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University of California, Davis
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Integrated PET-MRI Scanner for Simultaneous Imaging
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University of California, Davis researchers have developed new devices and methods for acquiring simultaneous magnetic resonance imaging (MRI) and positron emission tomography (PET) images from patients.Currently, no combined PET and MRI scanners exist. PET is a powerful imaging modality that uses isotopes attached to specific molecules to provide exceptionally sensitive assays of a wide range of ...
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University of California, Davis
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ISO-ORIENTATION CONTROL FOR ROBOTIC MANIPULATORS
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University of California researchers have designed a robotic control mechanism for a manipulator mounted on a laterally-extensible arm that maintains a predetermined manipulator orientation and distance relative to a working surface regardless of the kinematic configuration of its robotic linkage.In addition, the UC mechanism has special design features that allow retraction of the manipulator to ...
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University of California, Davis
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Label Free Bioamplifier
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Scientists at the University of California, Davis, have developed a highly sensitive novel material for label free amplification of a broad range of biochemical recognitions. The platform is applicable to detecting ligand-receptor interactions, membrane receptor interactions, antigen-antibody interactions, as well as small molecules at low concentrations. This photonic crystal biosensor relies on ...
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University of California, Davis
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Label-Free Biosensor
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Researchers at University of California, Davis have developed a novel label-free biosensor that consists of biorecognition layer on aluminum oxide (Al2O3, alumina) interfaces, which include planar and microstructured nanoporus alumina substrates, and a microwave electromagnetic bandgap (EBG) resonator transducer. EBG materials are artificial periodic structures in which the propagation of electrom...
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University of California, Davis
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Laser Guided Radiation Wound Probe
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A novel laser guided radiation wound probe has been developed by University of California, Davis researchers. In the event of a terrorist dirty bomb attack or accidental explosion of a high activity and high specific activity (HASA) radiation source, this probe allows for precise detection of embedded sources of radiation. Notable advantages of this detection device provide medical staff the abili...
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University of California, Davis
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LATE ROSS CLINGSTONE PEACH CULTIVAR
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The Ross clingstone peach cultivar has increased in popularity since its release by the University of California in the late 1970s, to the point that it is now the most heavily planted canning peach in California.The productivity, regularity of bearing, uniformity of fruit size, and post-processing quality of the Ross cultivar are responsible for its widespread acceptance among growers and canneri...
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University of California, Davis
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LETTUCE DISEASE RESISTANCE GENE FAMILIES
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University of California researchers have cloned and sequencedtwo families of genes that are disease resistance gene homologs. Capitalizing on the tendency of resistance genes to be clustered inplants in homologous families, the UC researchers were able toobtain over 20 related DNA sequences. The UC sequences have the potential to provide selectablegenetic markers for creating new lettuce variet...
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University of California, Davis
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Ligands for Alpha-4-Beta-1 Integrin
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Highly potent ligands for activated alpha-4 beta-1 integrin have been identified by University of California, Davis researchers. These ligands can potentially be used as targeting agents for cancer as well as anti-inflammatory agents for autoimmune diseases. Notable applications of these alpha-4 beta-1 ligands include:
Targeting therapy for imaging of cancers including lymphoid malignancies...
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University of California, Davis
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LONG WAVELENGTH PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY AND DIAGNOSIS OF TUMORS
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Photodynamic therapy (PDT) shows great promise as a method forcancer diagnosis and treatment.PDT involves the administration ofa photosensitizer -- a therapeutically inactive, photosensitivecompound which tumor cells selectively take up and retain --followed by illumination of the tumor or lesion with visible light. Photoactivation causes the photosensitizer to generate cytotoxicsinglet oxygen ...
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University of California, Davis
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Magnetic Quantum Dots for Use in Imaging
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Researchers at the University of California, Davis have invented nanoparticle quantum-dot compositions, and associated methods, for use in clinical and therapeutic imaging. The nanoparticles are dual-mode agents, being visible via both optical methods and magnetic resonance imaging (MRI). This advance permits the combination of positive features associated with optical imaging and magnetic resonan...
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University of California, Davis
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Magnetic Resonance Imaging Probes of Membrane Potential
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Novel magnetic resonance imaging (MRI) probes used to evaluate membrane potential and other electrical activity in biological systems have been developed by a University of California, Davis researcher. Currently, abnormal changes in electrical signaling within biological systems have been shown to directly preceed and follow the onset of pathological conditions such as epilepsy or cardiovascular ...
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University of California, Davis
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MANIPULATION OF FLOWERING IN SHORT-DAY PLANTS
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In the majority of flowering plant species, including nearlyall crop plants and horticultural species, the transition toflowering is regulated by daylength (photoperiodism).Thisphotoperiodic regulation has considerable economic significancesince flower and seed yields can vary dramatically depending on thetiming of the transition.The inhibition of premature floweringand the stimulation of flower...
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University of California, Davis
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Measuring and Treating Lymphedema
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The swollen limbs of Lymphedema patients can now be measured by an accurate, reliable and portable system, now available from University of California, Davis researchers.At some point in time, from 20% to 40% of the more than two million Breast Cancer Survivors in the United States will develop Lymphedema. Lymphedema is both an acute and chronically painful condition associated with significant an...
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University of California, Davis
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Measuring Atomic Level Biochemical Events
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Measuring subtle change on the atomic level is now possible with a revolutionary technical development from University of California, Davis researchers. This technology permits the quantitative detection of:
Molecular binding,Nucleic acid hybridization,Protein interaction with small as well as large molecules,Macromolecular structures changes, orSurface alterations of a few percent of one m...
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University of California, Davis
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Mechanical Simulator for ERCP Training
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Researchers at the University of California, Davis have invented a mechanical simulator that would allow endoscopists to use a real endoscope and subsequent accessories to perform endoscopic retrograde cholangiopancreatography (ERCP) procedures without the need for a live patient. The invention substitutes a pin-hole camera in place of fluoroscopy X-ray beams to monitor events in the bile duct. Th...
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University of California, Davis
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Media for Stem Cell Differentiation into a Hepatocyte Lineage
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Cell culture conditions for differentiating mouse and human embryonic stem cells toward a hepatocyte lineage have been discovered by researchers at the University of California, Davis. These newly described culture conditions also act to maintain primary hepatocyte function. This invention provides for human hepatocyte cell lines that are capable of indefinite replication, while maintaining their ...
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University of California, Davis
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Membrane-Protein on a Chip Technology
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Technology enabling the functional analysis of membrane and membrane-associated proteins in their near-native microenvironments has been developed by UC Davis researchers. Current protein chips are created using solid-state chemistries and employ purified proteins. These approaches cannot be easily applied to designing microarrays of membrane proteins which require highly specific lipidic microenv...
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University of California, Davis
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Metallically Electrically Conductive Si-Ti-C-N Ceramics
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A ceramics composite material with improved electrical and mechanical properties has been produced by researchers at the University of California, Davis during consolidation through an in situ reaction of amorphous polymer precursor-derived silicon carbon-nitride and nano-TiO2. Using novel powder preparation and consolidation techniques, single wall carbon nanotubes (SWCN) and nanopowders of alumi...
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University of California, Davis
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Method and Apparatus for Fabricating Structures on Silicon Based Substrates
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A novel process for fabricating discrete and integrated circuit devices in silicon-based materials has been developed by researchers at the University of California, Davis. This method combines chemically selective endpoint detection with cyclical layer deposition and chemo-mechanical polishing (CMP) techniques to create discrete structures on silicon substrates.The ultra-thin silicon layers of to...
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University of California, Davis
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Method and Apparatus for Fabricating Structures on Silicon Based Substrates
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A novel process for fabricating discrete and integrated circuit devices in silicon-based materials has been developed by researchers at the University of California, Davis. This method combines chemically selective endpoint detection with cyclical layer deposition and chemo-mechanical polishing (CMP) techniques to create discrete structures on silicon substrates.The ultra-thin silicon layers of to...
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University of California, Davis
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Method and Apparatus for Fabricating Three-Dimensional Structures on Silicon Based Substrates
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A novel process for fabricating discrete and integrated 3-D circuit devices on silicon-based materials has been developed by researchers at the University of California, Davis. This method combines chemically selective endpoint detection with patterned cyclical layer deposition to create three-dimensional structures on silicon substrates.The ultra-thin silicon layers of today's integrated circuits...
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University of California, Davis
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Method For Co-Fabricating Strained and Relaxed Crystalline and Poly Crystalline Structures
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A novel process for co-fabricating strained and relaxed crystalline and poly crystalline structures on a single silicon-based substrate has been developed by researchers at the University of California, Davis.The ultra-thin silicon layers of today's integrated circuits are responsible for the dramatic advances in computer system performance over the past 20 years. However, continuing innovation ha...
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University of California, Davis
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Method for Creating Transgenic Pigs
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A novel method to produce undifferentiated porcine embryonic germ cells with characteristics identical to embryonic stem cells has been developed by researchers at the University of California, Davis. Embryonic stem cells are widely used to introduce genetic modifications and mutations in mice; however, attempts to isolate embryonic stem cells from pigs to create transgenic pigs have been met with...
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University of California, Davis
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METHOD FOR CRYOPRESERVING HUMAN TISSUE
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BACKGROUND: Freezing is commonly used to preserve human tissueand cells for use in various medical applications, but significantloss of function occurs with current methods. DESCRIPTION: Researchers at the University of California havedeveloped a particularly effective method for the cryopreservationof human tissue and cells.The method achieves extraordinarilyhigh viability of cryopreserved tiss...
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University of California, Davis
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Method for Preserving Cut Flowers and Potted Plants
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A method for preserving the life of cut flowers and potted plants has been developed by University of California researchers. The method preserves plant appearance, extending both shipping and commercial marketing time periods for plants that have been harvested for commercial sale. The method is particularly effective for the control of leaf yellowing in plants, an occurrence which typically redu...
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University of California, Davis
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Method for Regulating Apoptosis
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A method for inhibiting cellular apoptosis through the regulation of mitochondrial fission and fusion has been identified by researchers at the University of California, Davis. The method for identifying small molecule inhibitors of mitochondrial fission fusion is described. Such compounds can be capable of regulating cellular apoptosis via their effects on mitochondrial membrane dynamics.UC Davis...
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University of California, Davis
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Method for Remote Signature/Attestation
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Researchers at the University of California, Davis, have created a new method for remote signature/attestation of death certificates that uses a person's voice as a biometric signature.This method varies from digital certificates as it does not require enrollment of users, it scales to a high number of users at a low cost, and its biometric qualities can be analyzed to determine authenticity retro...
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University of California, Davis
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Method for Testing and Detecting Equine Allergic Reactions
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A method for testing and detecting equine allergic reactions has been developed by University of California researchers. Allergies to common environmental antigens are a widespread equine health and management issue. The skin testing method currently used to detect allergen specificity frequently results in false positives. The University of California method:
Will enable the large-scale, e...
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University of California, Davis
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Method of Dosing Gases into Calorimeter Cell
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Researchers at the University of California, Davis have invented an adapter which allows for simultaneous surface area analysis and calorimetry. This enables one to use conventional surface area analyzer for dosing gases into calorimeter cell and simultaneously measuring the heat of gas-solid interaction and the amount of gas reacted by tiny increments. Another advantage of using this conventional...
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University of California, Davis
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Methods for Creating Zeolites from Nano-Composites Using Non-Thermal Calcination
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A novel method for producing micro-porous zeolites through non-thermal calcination has been discovered by researchers at the University of California, Davis. Zeolites are porous, inorganic solids that have the ability to interact with atoms, ions and molecules in a variety of chemical and electronic applications. They are currently utilized in catalytic reactions, fluid separation, adsorption of i...
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University of California, Davis
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Micro-patterning Biosensors for Drug Screening and Discovery
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High-density micro-arrays of lipid bilayer membranes intended for applications in biological sensing, detection, and high throughput screening of membrane protein targeting drugs have been developed by researchers at the University of California, Davis. Envisioned uses also include toxin recognition, cell adhesion, and determination of biocompatible materials. A new chip fabrication method creates...
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University of California, Davis
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MICROFABRICATED OPTICAL TRAP AND MANIPULATOR
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DESCRIPTION: Optical tweezers can manipulate microscopicparticles such as single cells, organelles, and genomes and havestimulated new research in many areas of cellular and molecularbiology.The current state of the art, as embodied by Ashkin'soptical trap (U.S. Patent No. 4,893,886), uses a single, stronglyfocused infrared laser beam to hold the particle.Relativetranslation of the laser beam co...
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University of California, Davis
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MICROJOINERY: MICROFABRICATION AND ASSEMBLY TECHNOLOGY FOR MICROSYSTEMS
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BACKGROUND:A typical problem in the microfabrication ofcomplicated systems is that different MEMS devices are processincompatible, i.e. the fabrication of one device destroys orimpedes the fabrication of another device.Therefore it isadvantageous to microfabricate components separately, using theprocesses best suited for each component, and then assemble them toform the complete microsystem.This ...
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University of California, Davis
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MTB: Motion-Tracked Binaural Sound Capture and Reproduction
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A radically new method to improve the realism of sound with all its spatial characteristics has been developed by researches at the University of California, Davis. This invention has a broad range of applications for either live or recorded sound. This new technology accounts for dynamic effects caused by the motion of a listener. In remote listening of live sounds, as well as in listening to rec...
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University of California, Davis
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Multi-Functional Contraceptive Compounds
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Multi-functional contraceptive compounds have been developed by University of California, Davis researchers. This invention relates to methods, compositions and devices involved in inhibiting fertilization by using compounds that interact with sperm. The interaction of the compounds with the head of the sperm can prevent the sperm from interacting with the zona pellucida, effectively preventing fe...
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University of California, Davis
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Multiplex Analysis of Proteins
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An assay for multiple proteins in a single reaction vessel via a rapid, efficient, and quantitative process has been developed by University of California, Davis investigators. This multiplex analysis system has applications in disease diagnosis and prognosis, and in monitoring therapy.The novel features of the invention for multiplex detection of cellular proteins in disease include:
High ...
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University of California, Davis
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Nano-porous Fibers and Protein Membranes
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Nanometer fibers containing nanometer-size pores have been developed by UC Davis researchers. The material can be synthesized from both natural and synthetic polymers, resulting in fibers with diameters in the range of 102 nm. These fibers have surface areas that are three to four orders of magnitude higher than conventional high specific surface materials. Enzymes and proteins can be incorporated...
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University of California, Davis
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Nanocables and Nanotransistors
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Nanocables offer enormous opportunities to explore intriguing properties at nanoscale dimensions and demonstrate a wide range of potentially useful applications with the unique nanocable geometry. Researchers at University of California at Davis have created single nanocables with uniform, precisely controlled layers. The technology of creating metal/semiconductors and metal/semiconductors/metal n...
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University of California, Davis
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Nanocrystalline Barium Titanate Dielectric
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Fully-dense nanocrystalline compacts of barium titanate have been produced by researchers at the University of California, Davis by means of utilizing novel powder preparation and consolidation techniques.The fully-dense nanocrystalline barium titanate (BaTiO3) has unexpected dielectric properties. A room temperature permittivity of this novel material is 40% higher than the best previously report...
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University of California, Davis
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Nanoparticle Enhanced X-ray Therapy (NEXT)
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Researchers at the University of California, Davis have invented, and demonstrated the working principle of, a new radiation therapeutic method, which uses gold nanoparticles as x-ray radiation sensitizers. For instance, when tested with an x-ray tube operated at 100keV on a 5,000 base-pair supercoiled DNA decorated with 100 gold nanoparticles, the equivalent radiation dosage delivered to the nano...
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University of California, Davis
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Nanoparticle Fluors and Functionalization Techniques for use in Fluorescent Labeling
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New, highly efficient nanoparticle phosphors for use in biological fluorescent labeling have been developed by researchers at the University of California, Davis. In this novel method, nanoparticles of silica, yttria or gadolinium oxide are created through a one-step, gas-phase synthesis process allowing for the introduction of lanthanide elements into the resulting particles.A novel technique was...
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University of California, Davis
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Nanostructured, multi-scale materials with desired ductility/plasticity
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BENEFITCreate high strength, ultra hard bulk materials with plasticity/ductility tailored to meet application requirements.DESCRIPTIONNanocrystalline materials exhibit strengths unachievable with conventional coarser-structured materials, but they also exhibit limited ductility and plasticity. Researchers at UC Davis have developed a technology to design, develop and manufacture novel materials. T...
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University of California, Davis
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NEMATODE-RESISTANT TRANSGENIC PLANTS
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Various species of nematodes attack the roots of plants,limiting the effectiveness of fertilizers and lowering yields ofmany crops.The three of the most damaging species of plantparasitic nematodes infect hundreds of important crop species andcause billions of dollars in annual losses worldwide.At present,methyl bromide is the only practical nematode-control agentavailable, but this particular c...
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University of California, Davis
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New Lightweight Amorphous Aluminum Alloys
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A novel alloy has been produced by researchers at the University of California, Davis. These metals are unlike the traditional metals; they represent a new class of mechanically alloyed amorphous metals. This invention employs a new technique, which uses powder to make glass-like metals. Some of the benefits of our invention include the following:
LightweightGlass-like features without the ...
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University of California, Davis
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New Technology for Vinyl Acetate Monomer
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The University of California, Davis has acquired a number of U.S. and foreign patents involving processes and catalytic materials for producing vinyl acetate monomer.VAM is a key raw material in the production of emulsion polymers and polyvinyl alcohol (PVOH), which are used in a variety of applications including adhesives, building products, ceramics, textiles, coatings and paper products.The cur...
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University of California, Davis
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NEW WALNUT CULTIVAR WITH A RED SEED COAT
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University of California researchers have developed a new walnut cultivar that is distinguished by an attractive and distinctive red seed coat (pellicle).This cultivar, named the "Robert Livermore," has been made available for commercial release.The unusual seed coat color of the Livermore, rated at 41-42 on the Munsell scale, was derived from a controlled-pollination cross between UC's Ho...
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University of California, Davis
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Nitrogen Fixation Gene Sequences Involved in Rhizobial and Mycorrhizal Symbioses
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A gene (dmi 1) serving as a master control element in rhizobial and mycorrhizal symbioses in the legume plant Medicago truncatula has been identified, sequenced, and mapped by researchers at the University of California, Davis, working with researchers from INRA. Previous research on symbiotic nitrogen fixation in higher plants has led to the identification of several induced genes, termed â...
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University of California, Davis
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NITROGEN OXIDES-FREE MICROWAVE PLASMA SYSTEM FOR IMPROVED AIR POLLUTION CONTROL
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Control of toxic air contaminants from industrial processesand hazardous waste site remediation activities poses a significanttechnological challenge.At contaminant concentrations of partsper million or lower, the cost per unit mass of air treated byconventional methods increases dramatically.Use of adsorbents isapplicable under low concentration conditions, but requiresregeneration or disposal....
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University of California, Davis
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Non-destructive, Non-invasive Single-Cell Raman Spectroscopy
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A novel method of single-cell and laser-tweezers Raman spectroscopy for the non-destructive, non-invasive analysis of cells, particles (e.g., lipoproteins), and subcellular components has been developed by researchers at the University of California, Davis and Lawrence Livermore National Laboratory. Raman spectroscopy of a single, non-affixed cell is a novel technology that yields a defining bio-m...
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University of California, Davis
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Novel Approach to Encoding Libraries
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A novel partial Alloc-deprotection (PAD) approach that can be used to establish a new ladder-synthesis method for encoding one-bead one-compound (OBOC) combinatorial libraries, has been developed by researchers at the University of California, Davis. This method differs from the conventional ladder-synthesis method in the following:
Only one building block, instead of a mixture of two build...
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University of California, Davis
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Novel Cytokine Receptor for Treatment and Diagnosis of Bone and Cartilage Disorders
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A novel cytokine receptor, IL-17RL, has been discovered by UC Davis investigators. IL-17RL is a receptor for members of the IL-17 cytokine family, particularly IL-17B, which is involved in catabolic degradation of bone and cartilage. The present invention provides pharmaceutical compositions for slowing or ameliorating bone and cartilage pathologies, and methods for diagnosing cartilage disorders....
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University of California, Davis
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Novel Cytokine Receptor for Treatment and Diagnosis of Prostate Cancer
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A novel cytokine receptor, IL-17RL, has been discovered by UC Davis Investigators. IL-17RL function is known to be a critical factor in androgen sensitivity and its loss has been correlated with the androgen insensitivity associated with more invasive, metastatic, high Gleason scoring carcinomas. Normal to low Gleason grade tissues express IL-17RL, therefore antibodies directed to IL-17RL make an ...
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University of California, Davis
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Novel Encoding Method for Combinatorial Libraries
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A novel and highly efficient mass encoding method for “one-bead one-compound� small molecule combinatorial libraries has been developed by scientists at the University of California, Davis.The major limitations of current chemical encoding methods are:
The interference of coding tags on screening; and,The use of orthogonal synthetic chemistry involving twice ...
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University of California, Davis
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Novel Hierarchical Optical Switch Architecture
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A novel method and apparatus for hierarchical optical switching has been invented by researchers at the University of California, Davis. This powerful tool will resolve perpetual Internet backbone problems by providing a scalable, cost-effective solution that empowers service providers to offer a range of new, diverse, just-in-time services. Because Internet bandwidth demand is expected to double ...
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University of California, Davis
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Novel Human Anti-MUC-1 scFv Antibodies for Cancer Diagnosis and Treatment
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Novel single chain variable fragment (scFV) antibodies against human Mucin-1 (MUC-1) have been developed by researchers at University of California, Davis to diagnose and treat adenocarcinoma cells, such as human breast, prostate and ovarian cancer cells.This method is superior to current methods for optimal diagnosis and treatment of these cancers. For example, while radioimmunotherapy using inta...
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University of California, Davis
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Novel Method For Screening Combinatorial Libraries
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A novel method for screening combinatorial bead libraries that would greatly expand the identification of new drug leads and drug targets and speed the development of commercial clinical treatments for human diseases has been developed by researchers at the University of California, Davis. Combinatorial bead libraries constitute a powerful tool for identifying novel drug leads and drug targets. Ho...
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University of California, Davis
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Novel Method Of Inhibiting Cellular Proliferation
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A novel method for inhibiting proliferating cells that could result in a clinical treatment for human cancer has been developed by University of California researchers.The University of California method utilizes an inhibitor peptide that selectively disrupts chromosome segregation in proliferating cells, such as carcinoma cells. This method is superior to current treatment methods of cancer invol...
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University of California, Davis
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Novel Peptide Inhibitors of HIV
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Novel and effective peptide-based anti-HIV therapeutic agents have been developed by University of California, Davis researchers. Currently, highly active antiretroviral therapy (HAART) for HIV-infected individuals is targeted against the viral protease and reverse transcriptase. Although current HAART combinations have had some success, significant problems remain:
Drug-resistant virus var...
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University of California, Davis
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Novel Peptides from Scorpion Venom
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Two new families of neurotoxins have been identified by researchers at the University of California, Davis. In addition to their simple structure, they have the added advantages of:
Increased stabilityEasy synthesis in an industrial scale.These peptides possess a variety of neurotoxic modes of action, some of which include binding to Site 3 of rat brain sodium channels; others have no sodiu...
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University of California, Davis
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Novel Receptor-Binding Cyclic Peptides
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The present invention provides novel receptor-binding cyclic peptides (e.g., antagonists) that advantageously display high receptor binding affinity and selectively. More particularly, the present invention provides integrin-binding cyclic peptides, methods for identifying receptor-binding cyclic peptides and for using the cyclic peptides of the present invention for imaging a tumor, organ, or tis...
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